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Leijtens, Tomas,Lim, Jongchul,Teuscher, Joë,l,Park, Taiho,Snaith, Henry J. WILEY‐VCH Verlag 2013 ADVANCED MATERIALS Vol.25 No.23
<P><B>Transient mobility spectroscopy (TMS)</B> is presented as a new tool to probe the charge carrier mobility of commonly employed organic and inorganic semiconductors over the relevant range of charge densities. The charge density dependence of the mobility of semiconductors used in hybrid and organic photovoltaics gives new insights into charge transport phenomena in solid state dye sensitized solar cells.</P>
Integrin-Mediated Interactions Control Macrophage Polarization in 3D Hydrogels
Cha, Byung-Hyun,Shin, Su Ryon,Leijten, Jeroen,Li, Yi-Chen,Singh, Sonali,Liu, Julie C.,Annabi, Nasim,Abdi, Reza,Dokmeci, Mehmet R.,Vrana, Nihal Engin,Ghaemmaghami, Amir M.,Khademhosseini, Ali Wiley (John WileySons) 2017 Advanced healthcare materials Vol.6 No.21
Seo, Jungmok,Shin, Jung-Youn,Leijten, Jeroen,Jeon, Oju,Bal Ö,ztü,rk, Ayç,a,Rouwkema, Jeroen,Li, Yuancheng,Shin, Su Ryon,Hajiali, Hadi,Alsberg, Eben,Khademhosseini, Ali American Chemical Society 2018 ACS APPLIED MATERIALS & INTERFACES Vol.10 No.16
<P>Biophysical cues can potently direct a cell’s or tissue’s behavior. Cells interpret their biophysical surroundings, such as matrix stiffness or dynamic mechanical stimulation, through mechanotransduction. However, our understanding of the various aspects of mechanotransduction has been limited by the lack of proper analysis platforms capable of screening three-dimensional (3D) cellular behaviors in response to biophysical cues. Here, we developed a dynamic compression bioreactor to study the combinational effects of biomaterial composition and dynamic mechanical compression on cellular behavior in 3D hydrogels. The bioreactor contained multiple actuating posts that could apply cyclic compressive strains ranging from 0 to 42% to arrays of cell-encapsulated hydrogels. The bioreactor could be interconnected with other compressive bioreactors, which enabled the combinatorial screenings of 3D cellular behaviors simultaneously. As an application of the screening platform, cell spreading, and osteogenic differentiation of human mesenchymal stem cells (hMSCs) were characterized in 3D gelatin methacryloyl (GelMA) hydrogels. Increasing hydrogel concentration from 5 to 10% restricted the cell spreading, however, dynamic compressive strain increased cell spreading. Osteogenic differentiation of hMSCs was also affected by dynamic compressive strains. hMSCs in 5% GelMA hydrogel were more sensitive to strains, and the 42% strain group showed a significant increase in osteogenic differentiation compared to other groups. The interconnectable dynamic compression bioreactor provides an efficient way to study the interactions of cells and their physical microenvironments in three dimensions.</P> [FIG OMISSION]</BR>