Association Between Drinking and Obesity in Pre- and Postmenopausal Women: Korea National Health and Nutrition Examination Survey 2010-2012

Bang, Sol Hee,Choi, Mi Ran,Kwak, Su Min,Choi, In Young,Rho, Mi Jung,Jung, Dong Jin,Han, Kyungdo,Kim, Dai-Jin Mary Ann Liebert 2016 Journal of women's health Vol.25 No.11

큰 종횡비를 갖는 사각 채널에서 곡관부 가이드 베인 형상변화에 따른 유동 및 열전달 특성

한솔(Sol Han),손호성(Ho-Seong Sohn),방민호(Minho Bang),우타관(Ta-Kwan Woo),조형희(Hyung Hee Cho) 한국유체기계학회 2015 한국유체기계학회 학술대회 논문집 Vol.2015 No.12

발아현미 선식의 품질 및 이화학적 특성

방애솔(Yae-Sol Bang),장은희(Eun Hee Jang),정현정(Hyun-Jung Chung) 한국식품과학회 2017 한국식품과학회지 Vol.49 No.5

본 연구에서는 다양한 조건에서 선식을 제조한 후 선식의 이화학적 특성, 기능성 특성, 미생물 안전성 검사 및 관능적 특성을 살펴보았다. 선식 제조 조건으로 로스팅 시간과 온도를 다르게 하여 제조하였고, 산업적인 활용을 위해 입자사이즈는 두 가지 형태로 제조하였다. 또한 기능성과 영양적 가치를 높이기 위하여 귀리, 수수, 조를 발아시켜 첨가하였다. 선식의 수분함량은 로스팅 시간이 길어질수록 낮았으며 발아곡류를 첨가하여 제조한 선식에서 다소 높은 수분함량을 나타냈다. 140 mesh로 제조한 선식은 100 mesh로 제조한 선식에 비해 높은 수분함량과 다소 낮은 조단백과 조지방 함량을 나타냈다. 선식의 색도 역시 로스팅 시간이 길어질수록 명도가 감소함을 확인할 수 있었다. 선식 점도는 발아곡류를 첨가한 시료에서 70 cP 이상의 점도를 나타냈다. 선식의 pH는 약산성의 범위를 나타냈으며, DSC를 이용하여 측정한 호화도는 로스팅 온도가 높을수록 호화도가 높아 선식의 호화엔탈피는 낮게 나타났다. DPPH 라디칼 소거능은 긴 로스팅 시간에서 처리한 선식과 발아곡류를 첨가한 선식이 높게 나타났다. 관능평가에서도 긴 로스팅 시간에서 처리한 선식이 높은 고소한 향을 나타냈다. 결과적으로 본 연구에서 로스팅 조건, 입자사이즈, 발아곡류 첨가는 선식의 품질에 영향을 미치는 것을 확인할 수 있었다. The quality and physicochemical characteristics of newly developed Sunsik products were investigated. Sunsik A, B, and C were prepared under different roasting temperatures and times (A: 220oC, 15 min; B: 220℃, 25 min; C, D, E: 230℃, 15 min). Sunsik D was prepared using grain flours passed through a 100 mesh screen, whereas the other products were passed through a 140 mesh screen. Sunsik E was prepared by the addition of germinated grains. The moisture content of Sunsik products ranged from 3.24-7.10%. The viscosity and sugar content ranged from 57-74 cP and 1.5-1.7oBx, respectively. The pH values were similar among the samples. Sunsik D had the highest gelatinization enthalpy, whereas Sunsik C had the lowest. The viable cell counts were in the range from 3-4 log CFU/g and coliform groups were not detected. Sunsik B and E had higher scores for savory flavor and sweet taste than other Sunsik products.

Weldability of Aluminum Alloy and Hot Dip Galvanized Steel by AC Pulse MIG Brazing

Yong-Hyuk Kwon,Sol-Choi,Hye-Seul Yoon,Hee-Seon Bang 대한용접·접합학회 2021 대한용접·접합학회지 Vol.39 No.2

This study investigates the weldability of dissimilar materials, such as Al6061-T6 aluminum alloy and hot dip galvanized (GI) steel, via AC pulse metal inert gas (MIG) brazing. Notably, the brazing mechanism was investigated for different electrode negative (EN) ratios. The results showed that as the amount of deposition increased with the EN ratio, throat thickness, wetting length, and leg length also tended to increase. Furthermore, it was confirmed that as the EN ratio increased, a thin intermetallic compound (IMC) layer was deposited due to the suppression of IMC growth caused by the low heat input at the joint interface.

Chronic saponin treatment attenuates damage to the pancreas in chronic alcohol-treated diabetic rats

Choi, Mi Ran,Kwak, Su Min,Bang, Sol Hee,Jeong, Jo-Eun,Kim, Dai-Jin The Korean Society of Ginseng 2017 Journal of Ginseng Research Vol.41 No.4

Background: Chronic heavy alcohol consumption may raise the risk of developing type 2 diabetes mellitus. Saponins inhibit apoptosis of pancreatic islet cells and reduce lipid parameters. The present study was designed to investigate the effect of saponin on chronic ethanol-treated diabetic rats. Methods: Long-Evans Tokushima Fatty (LETO) and Otsuka Long-Evans Tokushima Fatty (OLETF) rats were pair-fed a Lieber-DeCarli diet with and without 5% ethanol for 12 wks. Two weeks after starting the pair-feeding with the Lieber-DeCarli diet, intraperitoneal injection of saponin was performed for 10 wks. To perform the experiments, rats were divided as follows: LETO-Control (LC), LETO-Ethanol (LE), LETO-Ethanol-Saponin (LES), OLETF-Control (OC), OLETF-Ethanol (OE), and OLETF-Ethanol-Saponin (OES). Results: The weights of epididymal and mesenteric fat tissue in LES and OES rats were the lightest from among the LETO and OLETF groups, respectively. The secretion of alanine aminotransferase and cholesterol in OES rats decreased significantly compared to their secretion in OC and OE rats, respectively. The islets of the pancreas in LE and OE rats showed clean, unclear, and smaller morphology compared to those of LC, LES, OC, and OES rats. In addition, the expression of insulin in the islets of the pancreas in LC, LES, OC, and OES rats was higher than in LE and OE rats. Conclusion: Saponin may not only be helpful in alleviating the rapid progress of diabetes due to chronic alcohol consumption in diabetic patients, but may also show potential as an antidiabetic drug candidate for diabetic patients who chronically consume alcohol.

Chronic saponin treatment attenuates damage to the pancreas in chronic alcohol-treated diabetic rats

Mi Ran Choi,Su Min Kwak,Sol Hee Bang,Jo-Eun Jeong,Dai-Jin Kim 고려인삼학회 2017 Journal of Ginseng Research Vol.41 No.4

Background: Chronic heavy alcohol consumption may raise the risk of developing type 2 diabetes mellitus. Saponins inhibit apoptosis of pancreatic islet cells and reduce lipid parameters. The present study was designed to investigate the effect of saponin on chronic ethanol-treated diabetic rats. Methods: LongeEvans Tokushima Fatty (LETO) and Otsuka LongeEvans Tokushima Fatty (OLETF) rats were pair-fed a LiebereDeCarli diet with and without 5% ethanol for 12 wks. Two weeks after starting the pair-feeding with the LiebereDeCarli diet, intraperitoneal injection of saponin was performed for 10 wks. To perform the experiments, rats were divided as follows: LETO-Control (LC), LETO-Ethanol (LE), LETOEthanol-Saponin (LES), OLETF-Control (OC), OLETF-Ethanol (OE), and OLETF-Ethanol-Saponin (OES). Results: The weights of epididymal and mesenteric fat tissue in LES and OES rats were the lightest from among the LETO and OLETF groups, respectively. The secretion of alanine aminotransferase and cholesterol in OES rats decreased significantly compared to their secretion in OC and OE rats, respectively. The islets of the pancreas in LE and OE rats showed clean, unclear, and smaller morphology compared to those of LC, LES, OC, and OES rats. In addition, the expression of insulin in the islets of the pancreas in LC, LES, OC, and OES rats was higher than in LE and OE rats. Conclusion: Saponin may not only be helpful in alleviating the rapid progress of diabetes due to chronic alcohol consumption in diabetic patients, but may also show potential as an antidiabetic drug candidate for diabetic patients who chronically consume alcohol.

Age-related Effects of Heroin on Gene Expression in the Hippocampus and Striatum of Cynomolgus Monkeys

Mi Ran Choi,Yeung-Bae Jin,Sol Hee Bang,Chang-Nim Im,Youngjeon Lee,Han-Na Kim,Kyu-Tae Chang,이상래,김대진 대한정신약물학회 2020 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.18 No.1

Objective: The aim of this study was to investigate differentially expressed genes and their functions in the hippocampus and striatum after heroin administration in cynomolgus macaques of different ages. Methods: Cynomolgus monkeys were divided by age as follows: 1 year (A1, n = 2); 3 to 4 years (A2, n = 2); 6 to 8 years (A3, n = 2); and older than 11 years (A4, n = 2). After heroin was injected intramuscularly into the monkeys (0.6 mg/kg), we performed large-scale transcriptome profiling in the hippocampus (H) and striatum (S) using RNA sequencing technology. Some genes were validated with real-time quantitative PCR. Results: In the hippocampus, the gene expression of A1H was similar to that of A4H, while the gene expression of A2H was similar to that of A3H. Genes associated with the mitogen-activated protein kinase signaling pathway (STMN1, FGF14, and MAPT) and -aminobutyric acid-ergic synapses (GABBR2 and GAD1) were differentially expressed among control and heroin-treated animals. Differential gene expression between A1S and A4S was the least significant, while differential gene expression between A3S and A2S was the most significant. Genes associated with the neurotrophin signaling pathway (NTRK1 and NGFR), autophagy (ATG5), and dopaminergic synapses (AKT1) in the striatum were differentially expressed among control and heroin-treated animals. Conclusion: These results suggest that even a single heroin exposure can cause differential gene expression in the hippocampus and striatum of nonhuman primates at different ages.

Decreased Serum Glutamate Levels in Male Adults with Internet Gaming Disorder: A Pilot Study

Soo-Hyun Paik,최미란,Su Min Kwak,Sol Hee Bang,Dai Jin Kim 대한정신약물학회 2018 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.16 No.3

Objective: Alteration in glutamatergic neurotransmission and dopaminergic dysfunction has been implicated in both the initiation and expression of addiction related behaviors. This pilot study was aimed to investigate the serum levels of glutamate and dopamine in adults with internet gaming disorder (IGD). Methods: We measured serum levels of glutamate and dopamine in male participants with IGD (n=26) and age-matched healthy controls (n=25). Clinical interviews were performed to identify IGD and to rule out psychiatric comorbidities. Serum levels of glutamate and dopamine were examined by enzyme immunoassays using ELISA Kits. Results: Serum levels of glutamate were lower among IGD than control (IGD: 24.184±12.303 g/ml; control: 33.676±12.413 g/ml; t=2.742, p=0.008), while levels of dopamine did not differ between. Serum glutamate and dopamine levels did not correlate with gaming hours and exposure to game in the IGD group. But serum glutamate levels were positively correlated with the dopamine levels (r=0.360, p=0.013). Conclusion: Our results suggest that altered glutamatergic neurotransmission may contribute to the pathophysiology of IGD.

Effects of acute and chronic methamphetamine administration on cynomolgus monkey hippocampus structure and cellular transcriptome

Choi, Mi Ran,Chun, Ji-Won,Kwak, Su Min,Bang, Sol Hee,Jin, Yeung-Bae,Lee, Youngjeon,Kim, Han-Na,Chang, Kyu-Tae,Chai, Young Gyu,Lee, Sang-Rae,Kim, Dai-Jin Elsevier 2018 Toxicology and applied pharmacology Vol.355 No.-

<P><B>Abstract</B></P> <P>Methamphetamine (MA), a psychostimulant abused worldwide, gives rise to neurotoxicity in the hippocampus, resulting in cognitive impairments and hippocampal volume reduction. The cellular and molecular mechanisms associated with hippocampal impairments due to MA remain unknown. The aim of this study was to investigate the effects of MA on structural alterations and gene expressions in the hippocampus. We analyzed the pattern of volumetric changes in the hippocampus using magnetic resonance imaging (MRI) after acute and chronic administration of MA to cynomolgus macaques. In addition, we performed large-scale transcriptome profiling in the hippocampus using RNA-Seq technology. The hippocampus in response to acute and chronic MA exhibited a significant volumetric atrophy compared with the hippocampus of controls. The genes associated with cytoskeleton organization and phagocytosis were downregulated in the acute MA-treated group compared to the control group. On the other hand, genes associated with synaptic transmission, regulation of neuron differentiation and regulation of neurogenesis were downregulated in the chronic MA-treated group. We confirmed that expression patterns for <I>ADM</I>, <I>BMP4</I>, <I>CHRD</I>, <I>PDYN</I>, <I>UBA1</I>, profilin 2 (<I>PFN2</I>), <I>ENO2</I> and <I>NSE</I> mRNAs were similar to the results from RNA-Seq based on quantitative RT-PCR. In particular, PFN2 mRNA and protein expression levels, which play important roles in actin cytoskeleton dynamics, were decreased by acute and chronic MA administration. These results not only aid the understanding of cellular and molecular mechanisms regulated by MA in the hippocampus but also suggest basic information aiding biomarker and novel drug development for treating hippocampal impairment caused by MA abuse.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Methamphetamine caused volumetric atrophy in the hippocampus of cynomolgus monkeys. </LI> <LI> Methamphetamine altered genes related to synaptic plasticity and neurogenesis. </LI> <LI> Methamphetamine induced alterations of genes related to cytoskeleton organization. </LI> <LI> Profilin 2 at both mRNA and protein levels was decreased by methamphetamine. </LI> </UL> </P>

Isolation of Megastigmane Sesquiterpenes from the Silkworm (Bombyx mori L.) Droppings and Their Promotion Activity on HO-1 and SIRT1

Ji-Hae Park,Do-Gyeong Lee,Seung-Woo Yeon,Hyuk-Sang Kwon,Jong-Hee Ko,Dong-Jin Shin,Han-Sol Park,Yong-Soon Kim,Myun-Ho Bang,NAM-IN BAEK 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.4

The silkworm (Bombyx mori L.) droppings were extracted with 80% aqueous MeOH, and the concentrated extract was partitioned in succession with EtOAc, n-BuOH, and H_2O. From the EtOAc fraction, five megastigmane sesquiterpenes were isolated through repeated silica gel and ODS column chromatography. According to the results of spectroscopic data, such as NMR, MS, and IR, the chemical structures of the isolated compounds were determined as (3S,5R,8R)-3,5-dihydroxymegastigma-6,7-dien-9-one (1), (S)-dehydrovomifoliol (2), (6R,7E,9R)-9-hydroxy-4,7-megastigmadien-3-one (3), (3S,5R,6S,7E)-3,5,6-trihydroxy-7-megastigmen-9-one (4), (6R,9R)-9-hydroxy-4-megastigmen-3-one (5). Compounds 2 through 5 were isolated for the first time from silkworm droppings. GC/MS analysis indicated silkworm powder contained compound 3, and mulberry leaves contained compound 4. Compounds 1 and 5 increased the expression of heme oxygenase-1 and SIRT1 in HepG2 and HEK239 cells, respectively. Heme oxygenase-1 is considered to be an antioxidant enzyme that catabolizes heme to carbon monoxide, free iron and biliverdin, while SIRT1 is the mammalian homologue of the yeast silent information regulator (Sir)-2, which are involved in the suppression of inflammatory mediators or factors that may be used to improve atopy-related symptoms.