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Mandelic Acid 정량을 위한 은 나노입자에 의해 증가된 화학발광분석법
( Md R-mahmnur Alam ),( Mohammad Kamruzzaman ),김소연 ( So Yeon Kim ),조해진 ( Hae Jin Jo ),이상학 ( Sang Hak Lee ),김영호 ( Young Ho Kim ),최종하 ( Jong Ha Choi ) 한국공업화학회 2011 응용화학 Vol.15 No.1
A sensitive silver nanoparticles (Ag NPs) enhanced chemiluminescence (CL) method is reported for the determination of mandelic acid (MA). This method is based on the luminol-KIO4 system catalyzed by Ag NPs to produce CL spectra. Prepared Ag NPs were characterized by UV-visible spectra and TEM image. Under optimal condition, CL spectra of the system were responded linearly with the concentration of MA in the range of 2.5×10(-9) to 2.0×10(-8) mol L(-1)(r=0.9989) with a detection limit of 1.2×10(-10) mol L(-1). The relative standard deviation of 1.0×10(-7) mol L(-1) MA was found 1.45 (n=9).
임신 중절 적응증의 최근 경향 변화 ( 1993 - 2000 )
김지은(Ji Eun Kim),한정열(Jung Yeol Han),오동출(Dong Chul Oh),김연주(Yon Ju Kim),정영철(Young Chul Chung),정상희(Sang Hee Jung),최준식(June Seek Choi),박소연(So Yeon Park),안현경(Hyun Kyong Ahn),오민정(Min Jeong Oh),류현미(Hyun Mee R 대한산부인과학회 2001 Obstetrics & Gynecology Science Vol.44 No.11
N/A Objective : To evaluate the recent trend of indication for pregnancy termination. Method : From 1993 to 2000, 1,087 cases of termination out of 61,842 cases of deliveries in Samsung cheil hospital were analyzed. We reviewed retrospectively the data-base and charts of delivery, and analyzed the indication for pregnancy termination. Results : Among 61,842 cases of deliveries, indications of pregnancy termination were fetal structure anomalies in 399 cases (0.7%), IUFD in 261 cases (0.4%), PROM in 215 cases (0.4%), chromosomal anomalies in 138 cases (0.2%), anhydroamnios in 32 cases (0.05%), rubella infection of mother or fetus in 24 cases (0.04%), and others in 20 cases (0.03%). Autopsy was performed in 242 cases of fetal anomalies (60.7%), 116 cases of UIFD (44%), and 59 cases of fetal chromosomal abnormalities (43%). The cases of chromosomal anomaly as indication of termination increased and rubella infection of mother or fetus decreased recently, and it is statistically significant r=0.95(P=0.00) and r=-0.73(P=0.04). The fetal weight terminated due to PROM is significantly decreased (Y=517-26 x year P=0.002). Conclusion : The indications of termination for fetal chromosomal abnormalities were increased, but for rubella infections were decreased. In cases of PROM, the terminated fetal weight were significantly decreased. However, no change was observed in cases of fetal anomaly, IUFD,and PROM.
Park, Jin-Hee,Williams, Darren R.,Lee, Ji-Hyung,Lee, So-Deok,Lee, Je-Heon,Ko, Hyojin,Lee, Ga-Eun,Kim, Sujin,Lee, Jeong-Min,Abdelrahman, Aliaa,Mü,ller, Christa E.,Jung, Da-Woon,Kim, Yong-Chul American Chemical Society 2016 Journal of medicinal chemistry Vol.59 No.16
<P>The P2X7 receptor (P2X7R) has been reported as a key mediator in inflammatory processes and cancer invasion/metastasis. In this study, we report the discovery of novel P2X7R antagonists and their functional activities as potential antimetastatic agents. Modifications of the hydantoin core-skeleton and the side chain substituents of the P2X7R antagonist 7 were performed. The structure activity relationships (SAR) and optimization demonstrated the importance of the sulfonyl group at the R-1 position and the substituted position and overall size of R-2 for P2X7R antagonism. The optimized novel analogues displayed potent P2X7 receptor antagonism (IC50 = 0.11-112 nM) along with significant suppressive effects on IL-1 beta release (IC50 = 0.32-210 nM). Moreover, representative antagonists (12g, 13k, and 17d) with imidazole and uracil core skeletons significantly inhibited the invasion of MDA-MB-231 triple negative breast cancer cells and cancer cell migration in a zebrafish xenograft model, suggesting the potential therapeutic application of these novel P2X7 antagonists to block metastatic cancer.</P>
Kim, G. B.,Choi, S.,Danevich, F. A.,Fleischmann, A.,Kang, C. S.,Kim, H. J.,Kim, S. R.,Kim, Y. D.,Kim, Y. H.,Kornoukhov, V. A.,Lee, H. J.,Lee, J. H.,Lee, M. K.,Lee, S. J.,So, J. H.,Yoon, W. S. Hindawi Limited 2015 Advances in high energy physics Vol.2015 No.-
<P>We report the development of a CaMoO4crystal low temperature detector for the AMoRE neutrinoless double beta decay(0νββ)search experiment. The prototype detector cell was composed of a 216 g CaMoO4crystal and a metallic magnetic calorimeter. An overground measurement demonstrated FWHM resolution of 6–11 keV for full absorption gamma peaks. Pulse shape discrimination was clearly demonstrated in the phonon signals, and 7.6 σof discrimination power was found for theαandβ/γseparation. The phonon signals showed rise-times of about 1 ms. It is expected that the relatively fast rise-time will increase the rejection efficiency of two-neutrino double beta decay pile-up events which can be one of the major background sources in0νββsearches.</P>
A p53/miRNA-34 axis regulates Snail1-dependent cancer cell epithelial–mesenchymal transition
Kim, Nam Hee,Kim, Hyun Sil,Li, Xiao-Yan,Lee, Inhan,Choi, Hyung-Seok,Kang, Shi Eun,Cha, So Young,Ryu, Joo Kyung,Yoon, Dojun,Fearon, Eric R.,Rowe, R. Grant,Lee, Sanghyuk,Maher, Christopher A.,Weiss, Ste The Rockefeller University Press 2011 The Journal of cell biology Vol.195 No.3
<▼1><P>Expression of the essential EMT inducer Snail1 is inhibited by miR-34 through a p53-dependent regulatory pathway.</P></▼1><▼2><P>Snail1 is a zinc finger transcriptional repressor whose pathological expression has been linked to cancer cell epithelial–mesenchymal transition (EMT) programs and the induction of tissue-invasive activity, but pro-oncogenic events capable of regulating Snail1 activity remain largely uncharacterized. Herein, we demonstrate that p53 loss-of-function or mutation promotes cancer cell EMT by de-repressing Snail1 protein expression and activity. In the absence of wild-type p53 function, Snail1-dependent EMT is activated in colon, breast, and lung carcinoma cells as a consequence of a decrease in miRNA-34 levels, which suppress Snail1 activity by binding to highly conserved 3′ untranslated regions in Snail1 itself as well as those of key Snail1 regulatory molecules, including β-catenin, LEF1, and Axin2. Although p53 activity can impact cell cycle regulation, apoptosis, and DNA repair pathways, the EMT and invasion programs initiated by p53 loss of function or mutation are completely dependent on Snail1 expression. These results identify a new link between p53, miR-34, and Snail1 in the regulation of cancer cell EMT programs.</P></▼2>
Status of the KSTAR superconducting magnet system development
Kim, K.,Park, H.K.,Park, K.R.,Lim, B.S.,Lee, S.I.,Chu, Y.,Chung, W.H.,Oh, Y.K.,Baek, S.H.,Lee, S.J.,Yonekawa, H.,Kim, J.S.,Kim, C.S.,Choi, J.Y.,Chang, Y.B.,Park, S.H.,Kim, D.J.,Song, N.H.,Kim, K.P.,So International Atomic Energy Agency 2005 Nuclear fusion Vol.45 No.8
<P>The aim of the Korea superconducting tokamak advanced research (KSTAR) project is to develop a steady-state-capable advanced superconducting tokamak for establishing a scientific and technological basis for an attractive fusion reactor. Since the KSTAR mission includes the achievement of a steady-state-capable operation, the use of superconducting coils is an obvious choice for the magnet system. The KSTAR superconducting magnet system consists of 16 toroidal field (TF) and 14 poloidal field (PF) coils which include 8 central solenoid coils. Both the TF and PF coil systems use internally-cooled cable-in-conduit conductors (CICC). The TF coil system provides a magnetic field of 3.5 T at the plasma centre and the PF coil system provide a flux swing of 17 V s. The major achievement in the KSTAR magnet system development includes the development of CICC, a full size TF model coil, a background magnetic field generation coil system and the construction of a large scale superconducting magnet and the CICC test facility. TF and PF coils are at the stage of fabrication for the KSTAR completion in the year 2007.</P>
A review on change in plant proteome following biotic stress.
R. Krishna,Ravi Gupta,Chul Woo Min,So Wun Kim,Sun Tae Kim 한국육종학회 2015 한국육종학회 심포지엄 Vol.2015 No.07
Different biotic agents such as bacteria, fungi, nematode and virus interact with plants, and causes significant annual crop loss. The plants interact with these pathogen and undergo various changes at physiological, biochemical and molecular levels. The omics technique is a powerful way which provides important information related to molecular changes occurring during plant-pathogen interaction. Several studies have been conducted and revealed either up or down-regulation of many genes involved in metabolism, energy, photosynthesis, signaling, defense and ROS upon pathogen interaction. In this review, we highlight recent progress in proteomic studies of plant-pathogen interaction, which could be useful for controlling disease and development of molecular markers for early detection of different diseases.