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Therapeutics targeting the fibrinolytic system
Haili Lin,Luning Xu,Shujuan Yu,Wanjin Hong,Mingdong Huang,Peng Xu 생화학분자생물학회 2020 Experimental and molecular medicine Vol.52 No.-
The function of the fibrinolytic system was first identified to dissolve fibrin to maintain vascular patency. Connections between the fibrinolytic system and many other physiological and pathological processes have been well established. Dysregulation of the fibrinolytic system is closely associated with multiple pathological conditions, including thrombosis, inflammation, cancer progression, and neuropathies. Thus, molecules in the fibrinolytic system are potent therapeutic and diagnostic targets. This review summarizes the currently used agents targeting this system and the development of novel therapeutic strategies in experimental studies. Future directions for the development of modulators of the fibrinolytic system are also discussed.
Xiaolei Liu,Hongtao Cui,Xiaojing Hao,Shujuan Huang,Gavin Conibeer 한국물리학회 2017 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.71 No.12
Molybdenum (Mo) thin films are still a dominant choice for the back contact layer of Cu(In,Ga)Se2 (CIGS) and Cu2ZnSnS4 (CZTS) solar cells. This paper presents a review of Mo back contacts for CIGS and CZTS solar cells, including the requirements for a good back contact, the reason for the choice of Mo, and post-treatment. Additionally, a Mo bilayer back contact was fabricated by varying the argon (Ar) pressure during sputtering to provide both low resistivity and good adhesion to the soda-lime glass substrate. The effects of vacuum thermal annealing on the electrical, morphological and structural properties of the Mo bilayer were also investigated. Vacuum thermal annealing was seen to densify the Mo bilayer, reduce the sheet resistance, and improve the bilayer’s adhesion to the soda-lime glass. The Mo bilayer back contact with a low sheet resistance of 0.132 / and strong adhesion was made for chalcogenide- and kesterite-based solar cells.
Spatial Distribution of Lead Iodide and Local Passivation on Organo-Lead Halide Perovskite
Chen, Sheng,Wen, Xiaoming,Yun, Jae S.,Huang, Shujuan,Green, Martin,Jeon, Nam Joong,Yang, Woon Seok,Noh, Jun Hong,Seo, Jangwon,Seok, Sang Il,Ho-Baillie, Anita American Chemical Society 2017 ACS APPLIED MATERIALS & INTERFACES Vol.9 No.7
<P>We identify nanoscale spatial distribution of PbI2 on the (FAPbI(3))(0.85)(MAPbBr(3))(0.15) perovskite thin film and investigate the local passivation effect using confocal based optical microscopy of steady state and time-resolved photoluminescence (PL). Different from a typical scanning electron microscope (SEM) morphology study, confocal based PL spectroscopy and microscopy allow researchers to map the morphologies of both perovskite and PbI2 grains simultaneously, by selectively detecting their characteristic fluorescent bands using band-pass filters. In this work, we compare the perovskite samples without and with excess PbI2 incorporation and unambiguously reveal PbI2 distribution for the PbI2-rich sample. In addition, using the nanoscale time-resolved PL technique we show that the PbI2-rich regions exhibit longer lifetime due to suppressed defect trapping, compared to the PbI2-poor regions. The measurement on the PbI2-rich sample indicates that the passivation effect of PbI2 in perovskite film is effective, especially in localized regions. Hence, this finding is important for further improvement of the solar cells by considering the strategy of excess PbI2 incorporation.</P>