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Shugo Kuraishi,Jun Takahashi,Keijiro Mukaiyama,Masayuki Shimizu,Shota Ikegami,Toshimasa Futatsugi,Hiroki Hirabayashi,Nobuhide Ogihara,Hiroyuki Hashidate,Yutaka Tateiwa,Hisatoshi Kinoshita,Hiroyuki Kat 대한척추외과학회 2016 Asian Spine Journal Vol.10 No.1
Study Design: Multicenter analysis of two groups of patients surgically treated for degenerative L4 unstable spondylolisthesis. Purpose: To compare the clinical and radiographic outcomes of posterolateral fusion (PLF) and posterior lumbar interbody fusion (PLIF) for degenerative L4 unstable spondylolisthesis. Overview of Literature: Surgery for lumbar degenerative spondylolisthesis is widely performed. However, few reports have compared the outcome of PLF to that of PLIF for degenerative L4 unstable spondylolisthesis. Methods: Patients with L4 unstable spondylolisthesis with Meyerding grade II or more, slip of >10° or >4 mm upon maximum flexion and extension bending, and posterior opening of >5 degree upon flexion bending were studied. Patients were treated from January 2008 to January 2010. Patients who underwent PLF (n=12) and PLIF (n=19) were followed-up for >2 years. Radiographic findings and clinical outcomes evaluated by the Japanese Orthopaedic Association (JOA) score were compared between the two groups. Radiographic evaluation included slip angle, translation, slip angle and translation during maximum flexion and extension bending, intervertebral disc height, lumbar lordotic angle, and fusion rate. Results: JOA scores of the PLF group before surgery and at final follow-up were 12.3±4.8 and 24.1±3.7, respectively; those of the PLIF group were 14.7±4.8 and 24.2±7.8, respectively, with no significant difference between the two groups. Correction of slip estimated from postoperative slip angle, translation, and maintenance of intervertebral disc height in the PLIF group was significantly (p <0.05) better than those in the PLF group. However, there was no significant difference in lumbar lordotic angle, slip angle and translation angle upon maximum flexion, or extension bending. Fusion rates of the PLIF and PLF groups had no significant difference. Conclusions: The L4–L5 level posterior instrumented fusion for unstable spondylolisthesis using both PLF and PLIF could ameliorate clinical symptoms when local stability is achieved.
M¨ossbauer Spectroscopy of Fe-doped Valence-fluctuating α-YbAlB4
Yui Sakaguchi,Shugo Ikeda,Hisao Kobayashi,Kentaro Kuga,Keita Sone,Satoru Nakatsuji 한국물리학회 2013 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.62 No.12
The magnetic properties of high-quality 25 at.% Fe doped α-YbAlB4 with an orthorhombicPbam structure were investigated by using magnetization measurements and 57Fe M¨ossbauer spectroscopy. The temperature dependence of the magnetization along the a-axis showed anomaliesat TN2 7.7 K and TN1 10.4 K. Broadenings of the peaks in the M¨ossbauer spectrum wereobserved at temperatures below 6 K, which were due to the magnetic hyperfine fields transferredfrom the Yb magnetic moments. The evaluated transferred magnetic hyperfine field almost disappearsaround TN2. The anomalous temperature dependence of the transferred magnetic hyperfinefield reveals that the magnetic structure and the ordered magnetic moments of the Yb ions showcomplex temperature dependences at temperatures below TN1.
Masashi Uehara,Jun Takahashi,Shugo Kuraishi,Masayuki Shimizu,Shota Ikegami,Toshimasa Futatsugi,Kaoru Aoki,Keijiro Mukaiyama,Nobuhide Ogihara,Hiroyuki Hashidate,Hiroki Hirabayashi,Hiroyuki Kato 대한척추외과학회 2015 Asian Spine Journal Vol.9 No.4
Study Design: Retrospective chart review. Purpose: A comparison of mini open foraminotomy (MOF) for cervical radiculopathy using either large tubular (LT) or TrimLine (TL) retractors. Overview of Literature: Posterior foraminotomy relieves compression of the cervical nerve root in radiculopathy patients. However, invasion of the paravertebral muscle may cause major problems in these patients. To address these problems, we performed MOF. Methods: Twenty cervical radiculopathy patients (16 male and 4 female) who underwent MOF between May 2004 and August 2011 were assigned to LT and TL groups. Each group contained 10 subjects. Surgical and clinical outcomes were compared. Results: The average operating time in the TL group was significantly shorter than that in the LT group. The final follow-up mean neck disability indices significantly improved compared to the preoperative values (LT group, 12.0±7.8 vs. 28.0±9.4; TL group, 6.0±5.9 vs. 21.9±10). The final follow-up neck pain visual analog scale (VAS) scores also decreased significantly from the preoperative of 8.0±1.5 and 2.5±2.5 to the final follow-up values of 2.2±2.2 and 1.0±2.5 in the LT and TL groups, respectively. The recovery rate for the neck pain VAS score was 70.0±31.9 in the LT group and 87.0±32.0 in the TL group, thus suggesting no significant difference between the two groups. Conclusions: MOF with the TL retractor is an easy and safe procedure. Furthermore, the use of the TL retractor allows for a minimally invasive and effective surgical treatment of cervical radiculopathy patients.
Effect of doping on metal doped semiconductor
Bhatt Mahesh Datt,Shugo Suzuki,Takeaki Sakurai,Katsuhiro Akimoto 한국물리학회 2011 Current Applied Physics Vol.11 No.2
The effect of doping on position of interface states for metal doped bathocuproine (BCP) was studied with density functional theory (DFT). The doping of Ca atoms with BCP induces the formation of interface states with shift in their relative positions from Fermi level and approximately no shift in HOMO position of BCP molecule. The shift in the position of interface states towards higher binding energy was believed to be due to the presence of doping excess electrons from Ca at the interface. The analysis of modification in intensity of LUMO or EF or interface states, suggests the formation of multiply charged anions in heavily doped film. It clearly gives the direct evidence for the origin of the doping interface states in organic molecules. The effects of Ca doping on electrical properties were discussed.
Punfa, Wanisa,Suzuki, Shugo,Pitchakarn, Pornsiri,Yodkeeree, Supachai,Naiki, Taku,Takahashi, Satoru,Limtrakul, Pornngarm Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.21
Background: The encapsulation of curcumin (Cur) in polylactic-co-glycolic acid (PLGA) nanoparticles (Cur-NPs) was designed to improve its solubility and stability. Conjugation of the Cur-NPs with anti-P-glycoprotein (P-gp) antibody (Cur-NPs-APgp) may increase their targeting to P-gp, which is highly expressed in multidrugresistance (MDR) cancer cells. This study determined whether Cur-NPs-APgp could overcome MDR in a human cervical cancer model (KB-V1 cells) in vitro and in vivo. Materials and Methods: First, we determined the MDR-reversing property of Cur in P-gp-overexpressing KB-V1 cells in vitro and in vivo. Cur-NPs and Cur-NPs-APgp, in the range 150-180 nm, were constructed and subjected to an in vivo pharmacokinetic study compared with Cur. The in vitro and in vivo MDR-reversing properties of Cur-NPs and Cur-NPs-APgp were then investigated. Moreover, the stability of the NPs was determined in various solutions. Results: The combined treatment of paclitaxel (PTX) with Cur dramatically decreased cell viability and tumor growth compared to PTX treatment alone. After intravenous injection, Cur-NPs-APgp and Cur-NPs could be detected in the serum up to 60 and 120 min later, respectively, whereas Cur was not detected after 30 min. Pretreatment with Cur-NPs-APgp, but not with NPs or Cur-NPs, could enhance PTX sensitivity both in vitro and in vivo. The constructed NPs remained a consistent size, proving their stability in various solutions. Conclusions: Our functional Cur-NPs-APgp may be a suitable candidate for application in a drug delivery system for overcoming drug resistance. The further development of Cur-NPs-APgp may be beneficial to cancer patients by leading to its use as either as a MDR modulator or as an anticancer drug.
Ito, Toshiyuki,Oshita, Shugo,Nakabayashi, Takakazu,Sun, Fan,Kinjo, Masataka,Ohta, Nobuhiro Korean Society of Photoscience 2009 Photochemical & photobiological sciences Vol.8 No.6
Fluorescence lifetime images of HeLa cells expressing enhanced green fluorescent protein (EGFP) have been measured as apoptosis is induced by tumor necrosis factor-$\alpha$ (TNF-$\alpha$) in combination with cycloheximide. The fluorescence lifetime of EGFP is found to decrease after the induction of apoptosis, indicating that the change in environment occurs around the chromophore of EGFP with the apoptosis process. The fluorescence lifetime imaging technique can be used to perform in vivo observation of cell death processes. Fluorescence lifetime measurements are useful to examine the induction of the apoptosis process, even when a morphological change of each cell cannot be observed because of a low spatial resolution.
Barrier formation at organic-metal interfaces studied by density functional theory
Bhatt Mahesh Datt,Shugo Suzuki,Takeaki Sakurai,Katsuhiro Akimoto 한국물리학회 2011 Current Applied Physics Vol.11 No.3
The barrier formation at organic-metal interfaces was studied with density functional theory (DFT). We analyzed the induced density of states in the organic molecular gap and showed that it is high enough to control the barrier formation. We calculated the interface Fermi level for contact of BCP with various metals e.g. Ca, Mg, Al, Ag, and Au surfaces. We found our calculated result in consistent with experimental (UPS) result and concluded that the barrier formation is due to the charge transfer between the metal and the states induced in BCP molecular gap.
Ellagic Acid Inhibits Migration and Invasion by Prostate Cancer Cell Lines
Pitchakarn, Pornsiri,Chewonarin, Teera,Ogawa, Kumiko,Suzuki, Shugo,Asamoto, Makoto,Takahashi, Satoru,Shirai, Tomoyuki,Limtrakul, Pornngarm Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.5
Polyphenolic compounds from pomegranate fruit extracts (PFEs) have been reported to possess antiproliferative, pro-apoptotic, anti-inflammatory and anti-invasion effects in prostate and other cancers. However, the mechanisms responsible for the inhibition of cancer invasion remain to be clarified. In the present study, we investigated anti-invasive effects of ellagic acid (EA) in androgen-independent human (PC-3) and rat (PLS10) prostate cancer cell lines in vitro. The results indicated that non-toxic concentrations of EA significantly inhibited the motility and invasion of cells examined in migration and invasion assays. The EA treatment slightly decreased secretion of matrix metalloproteinase (MMP)-2 but not MMP-9 from both cell lines. We further found that EA significantly reduced proteolytic activity of collagenase/gelatinase secreted from the PLS-10 cell line. Collagenase IV activity was also concentration-dependently inhibited by EA. These results demonstrated that EA has an ability to inhibit invasive potential of prostate cancer cells through action on protease activity.