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Punfa, Wanisa,Suzuki, Shugo,Pitchakarn, Pornsiri,Yodkeeree, Supachai,Naiki, Taku,Takahashi, Satoru,Limtrakul, Pornngarm Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.21
Background: The encapsulation of curcumin (Cur) in polylactic-co-glycolic acid (PLGA) nanoparticles (Cur-NPs) was designed to improve its solubility and stability. Conjugation of the Cur-NPs with anti-P-glycoprotein (P-gp) antibody (Cur-NPs-APgp) may increase their targeting to P-gp, which is highly expressed in multidrugresistance (MDR) cancer cells. This study determined whether Cur-NPs-APgp could overcome MDR in a human cervical cancer model (KB-V1 cells) in vitro and in vivo. Materials and Methods: First, we determined the MDR-reversing property of Cur in P-gp-overexpressing KB-V1 cells in vitro and in vivo. Cur-NPs and Cur-NPs-APgp, in the range 150-180 nm, were constructed and subjected to an in vivo pharmacokinetic study compared with Cur. The in vitro and in vivo MDR-reversing properties of Cur-NPs and Cur-NPs-APgp were then investigated. Moreover, the stability of the NPs was determined in various solutions. Results: The combined treatment of paclitaxel (PTX) with Cur dramatically decreased cell viability and tumor growth compared to PTX treatment alone. After intravenous injection, Cur-NPs-APgp and Cur-NPs could be detected in the serum up to 60 and 120 min later, respectively, whereas Cur was not detected after 30 min. Pretreatment with Cur-NPs-APgp, but not with NPs or Cur-NPs, could enhance PTX sensitivity both in vitro and in vivo. The constructed NPs remained a consistent size, proving their stability in various solutions. Conclusions: Our functional Cur-NPs-APgp may be a suitable candidate for application in a drug delivery system for overcoming drug resistance. The further development of Cur-NPs-APgp may be beneficial to cancer patients by leading to its use as either as a MDR modulator or as an anticancer drug.
Effect of doping on metal doped semiconductor
Bhatt Mahesh Datt,Shugo Suzuki,Takeaki Sakurai,Katsuhiro Akimoto 한국물리학회 2011 Current Applied Physics Vol.11 No.2
The effect of doping on position of interface states for metal doped bathocuproine (BCP) was studied with density functional theory (DFT). The doping of Ca atoms with BCP induces the formation of interface states with shift in their relative positions from Fermi level and approximately no shift in HOMO position of BCP molecule. The shift in the position of interface states towards higher binding energy was believed to be due to the presence of doping excess electrons from Ca at the interface. The analysis of modification in intensity of LUMO or EF or interface states, suggests the formation of multiply charged anions in heavily doped film. It clearly gives the direct evidence for the origin of the doping interface states in organic molecules. The effects of Ca doping on electrical properties were discussed.
Barrier formation at organic-metal interfaces studied by density functional theory
Bhatt Mahesh Datt,Shugo Suzuki,Takeaki Sakurai,Katsuhiro Akimoto 한국물리학회 2011 Current Applied Physics Vol.11 No.3
The barrier formation at organic-metal interfaces was studied with density functional theory (DFT). We analyzed the induced density of states in the organic molecular gap and showed that it is high enough to control the barrier formation. We calculated the interface Fermi level for contact of BCP with various metals e.g. Ca, Mg, Al, Ag, and Au surfaces. We found our calculated result in consistent with experimental (UPS) result and concluded that the barrier formation is due to the charge transfer between the metal and the states induced in BCP molecular gap.
Ellagic Acid Inhibits Migration and Invasion by Prostate Cancer Cell Lines
Pitchakarn, Pornsiri,Chewonarin, Teera,Ogawa, Kumiko,Suzuki, Shugo,Asamoto, Makoto,Takahashi, Satoru,Shirai, Tomoyuki,Limtrakul, Pornngarm Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.5
Polyphenolic compounds from pomegranate fruit extracts (PFEs) have been reported to possess antiproliferative, pro-apoptotic, anti-inflammatory and anti-invasion effects in prostate and other cancers. However, the mechanisms responsible for the inhibition of cancer invasion remain to be clarified. In the present study, we investigated anti-invasive effects of ellagic acid (EA) in androgen-independent human (PC-3) and rat (PLS10) prostate cancer cell lines in vitro. The results indicated that non-toxic concentrations of EA significantly inhibited the motility and invasion of cells examined in migration and invasion assays. The EA treatment slightly decreased secretion of matrix metalloproteinase (MMP)-2 but not MMP-9 from both cell lines. We further found that EA significantly reduced proteolytic activity of collagenase/gelatinase secreted from the PLS-10 cell line. Collagenase IV activity was also concentration-dependently inhibited by EA. These results demonstrated that EA has an ability to inhibit invasive potential of prostate cancer cells through action on protease activity.