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- 저자 : Shougang Chen (검색결과 3 건)
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Lin Chen,Dan-Qian Chen,Jing-Ru Liu,Jun Zhang,Nosratola D. Vaziri,Shougang Zhuang,Hua Chen,Ya-Long Feng,Yan Guo,Ying-Yong Zhao 생화학분자생물학회 2019 Experimental and molecular medicine Vol.51 No.-
Chronic kidney disease (CKD) increases the risk and prevalence of cardiovascular disease (CVD) morbidity and mortality. Recent studies have revealed marked changes in the composition of the microbiome and the metabolome and their potential influence in renal disease and CVD via the accumulation of microbial-derived uremic toxins. However, the effect of unilateral ureteral obstruction (UUO) on the gut microbiome and circulating metabolites is unknown. Male Sprague-Dawley rats were randomized to UUO and sham-operated control groups. Renal histology, colonic microbiota, and plasma metabolites were examined two weeks later. We employed 16S rRNA sequence and untargeted metabolomic analyses to explore the changes in colonic microbiota and plasma metabolites and their relationship with tubulointerstitial fibrosis (TIF). The UUO rats exhibited tubular atrophy and dilatation, interstitial fibrosis and inflammatory cell infiltration in the obstructed kidney. UUO rats showed significant colonic enrichment and depletion of genera. Significant differences were identified in 219 plasma metabolites involved in lipid, amino acid, and bile acid metabolism, which were consistent with gut microbiota-related metabolism. Interestingly, tryptophan and its metabolites kynurenine, 5-hydroxytryptophan and 5-hydroxytryptamine levels, which were linked with TIF, correlated with nine specific genera. Plasma tryptophan level was positively correlated with Clostridium IV, Turicibacter, Pseudomonas and Lactobacillales, and negatively correlated with Oscillibacter, Blautia, and Intestinimonas, which possess the genes encoding tryptophan synthase (K16187), indoleamine 2,3-dioxygenase (K00463) and tryptophan 2,3-dioxygenase (K00453) and their corresponding enzymes (EC:1.13.11.52 and EC:1.13.11.11) that exacerbate TIF. In conclusion, UUO results in profound changes in the gut microbiome and circulating metabolites, events that contribute to the pathogenesis of inflammation and TIF.
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Tengfei Liu,Wen Li,Chenyang Zhang,Wei Wang,Wenwen Dou,Shougang Chen 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.97 No.-
In this work, multi-layer stacked two-dimensional (2D) covalent organic framework of TpPa-1 wassynthesized as nanocontainer to fabricate self-healing epoxy coating. The corrosion inhibitor ofbenzotriazole (BTA) was loaded into porous TpPa-1 (Tp: 1,3,5-Triformylphrogroglucinol, Pa-1: 1,4-phenylenediamine), and the load capacity was further improved by electrostatic adsorption. Then, 0.5 wt. % BTA/TpPa-1 and 0.5 wt.% TpPa-1 were added to the epoxy coating, respectively. The electrochemicalImpedance Spectroscopy (EIS) test shown that after 60 days of immersion, the impedance of the BTA/TpPa-1/EP in low-frequency region was 6.45108V cm2, while the impedance corresponding to theTpPa-1/EP coating was 9.04107V cm2. In addition, in the localized electrochemical impedancespectroscopy (LEIS) test, as the immersion time was extended, the impedance of TpPa-1/EP coating at thedefect continued to decrease, while the impedance at the defect of the BTA/TpPa-1/EP coating shown anupward trend, showing self-healing performance. This was due to the pH change when the metal at thedefect is corroded, which caused the BTA to be released from the nanocontainer and adhered to the metalsurface to form a protectivefilm. The improvement of the anti-corrosion performance of BTA/TpPa-1/EPcoating mainly comes from two aspects: (1) The good dispersion of TpPa-1 in EP coating improves thephysical shielding effect of the coating; (2) The controlled release of BTA can Realize the continuousformation of the bare metal surface protective layer.
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Tianxiang Sun,Kai Jin,Wei Wang,Wen Li,Tong Wang,Tengxun Yang,Jia Cheng,Zhipeng Zhao,Shougang Chen 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.128 No.-
Here, a long-term anti-corrosive epoxy (EP) coating based on nano-hybrid filler was developed. The surfaceof graphene oxide (GO) was aminated with (3-aminopropyl) triethoxysilane (APTES), and then theporous covalent organic framework (COF) was in-situ grown on amino functionalized graphene oxide(FGO) nanosheets by Schiff-based reaction to prepare FGO-COF nanofillers. Different characterizationmethods proved the successful modification of GO nanosheets with COF particles. The excellent waterresistance of composite coatings was characterized through contact angle, adhesion, and water uptaketests. Transmission electron microscope (TEM) and molecular dynamics (MD) methods showed thatthe grafting of COF enhanced the dispersion and compatibility of GO in the coating. EIS measurements,salt spray analysis and cathodic delamination test indicated the significant improvements in the protectiveproperties of the composite coatings compared with pure EP coating. The low-frequency impedancemodulus of 1% FGO-COF composite coating reached higher than 6.8 109 Xcm2 after immersed in seawater for 60 days. In addition, the 1% FGO-COF composite coating performed only 34% delamination ratioafter 120 h cathodic delamination test.
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