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Yoshio Hirayasu,Shin-Ichi Sato,Norifumi Shuto,Miwa Nakano,Teruhiko Higuchi 대한신경정신의학회 2017 PSYCHIATRY INVESTIGATION Vol.14 No.1
Objective: The aim of the present study was to perform a subgroup analysis of data from a phase II global, multi-center, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of bitopertin, a glycine reuptake inhibitor that activates N-methyl- D-aspartate receptors by increasing the concentration of glycine in the synaptic cleft, in Japanese and non-Japanese patients with schizophrenia and predominant negative symptoms. Methods: Patients with schizophrenia and predominant negative symptoms on one or two antipsychotic drugs, including atypical antipsychotic drugs (olanzapine, risperidone, quetiapine, aripiprazole, and paliperidone) as the primary treatment, received bitopertin (10, 30, or 60 mg/day) or placebo once daily for 8 weeks as an add-on treatment. Efficacy was assessed using the Positive and Negative Syndrome Scale (PANSS) negative symptom factor score (NSFS). Results: The efficacy of bitopertin (10 mg and 30 mg) was similar between Japanese and non-Japanese patients. In the bitopertin 60-mg group, no difference from the placebo group was observed in Japanese or non-Japanese patients. The response to placebo was lower in Japanese patients, and there was a trend towards a greater difference in the change in PANSS NSFS between the placebo group and the 10- mg and 30-mg groups among Japanese patients. The safety profile of bitopertin was favorable in Japanese and non-Japanese patients. Conclusion: According to this subgroup analysis from a global phase II study of bitopertin, there was no difference in terms of efficacy and safety between Japanese and non-Japanese patients.
장광현,Hideyuki Doi,Yuichiro Nishibe,남귀숙,Shin-ichi Nakano 한국생태학회 2014 Journal of Ecology and Environment Vol.37 No.4
Feeding behavior of Temora turbinata was investigated through laboratory experiments with special emphasis on its foodpreference and consequent clearance rate on diatom and microbial components given as common natural food assemblageof coastal area (Uchiumi, Uwa Sea, Japan). Among available prey items, T. turbinata showed the highest clearancerate for Thalassiosira spp. (0.23 ± 0.08 L Temora-1 day-1) followed by Chaetoceros spp. (0.11 ± 0.03 L Temora-1 day-1), butclearance rates for other diatom, Nitzschia spp. was lower (0.03 to 0.07 L Temora-1 day-1). Bacterial abundances showed noresponse against 24-h feeding of T. turbinata. Feeding of T. turbinata on heterotrophic nanoflagellates (HNF) was apparentwhen clearance rates of T. turbinata on diatoms were relatively low, but T. turbinata did not consume HNF as well asciliates with Thalassiosira spp. of which clearance rate was highest. The results suggest that HNF and ciliates are possiblesupplementary prey item for T. turbinata, but their contribution as food sources can be limited by the presence of otherprey items such as preferable diatom species.
Chang, Kwang-Hyeon,Doi, Hideyuki,Nishibe, Yuichiro,Nam, Gui-Sook,Nakano, Shin-Ichi The Ecological Society of Korea 2014 Journal of Ecology and Environment Vol.37 No.4
Feeding behavior of Temora turbinata was investigated through laboratory experiments with special emphasis on its food preference and consequent clearance rate on diatom and microbial components given as common natural food assemblage of coastal area (Uchiumi, Uwa Sea, Japan). Among available prey items, T. turbinata showed the highest clearance rate for Thalassiosira spp. ($0.23{\pm}0.08L\;Temora^{-1}day^{-1}$) followed by Chaetoceros spp. ($0.11{\pm}0.03L\;Temora^{-1}day^{-1}$), but clearance rates for other diatom, Nitzschia spp. was lower (0.03 to $0.07L\;Temora^{-1}day^{-1}$). Bacterial abundances showed no response against 24-h feeding of T. turbinata. Feeding of T. turbinata on heterotrophic nanoflagellates (HNF) was apparent when clearance rates of T. turbinata on diatoms were relatively low, but T. turbinata did not consume HNF as well as ciliates with Thalassiosira spp. of which clearance rate was highest. The results suggest that HNF and ciliates are possible supplementary prey item for T. turbinata, but their contribution as food sources can be limited by the presence of other prey items such as preferable diatom species.
Hitoshi Kameyama,Yoshifumi Hashimoto,Yoshifumi Shimada,Saki Yamada,Ryoma Yagi,Yosuke Tajima,Takuma Okamura,Masato Nakano,Kohei Miura,Masayuki Nagahashi,Jun Sakata,Takashi Kobayashi,Shin-ichi Kosugi,To 대한대장항문학회 2018 Annals of Coloproctolgy Vol.34 No.2
Purpose: Small bowel obstruction (SBO) remains a common complication after pelvic or abdominal surgery. However, the risk factors for SBO in ulcerative colitis (UC) surgery are not well known. The aim of the present study was to clarify the risk factors associated with SBO after ileal pouch-anal anastomosis (IPAA) with a loop ileostomy for patients with UC. Methods: The medical records of 96 patients who underwent IPAA for UC between 1999 and 2011 were reviewed. SBO was confirmed based on the presence of clinical symptoms and radiographic findings. The patients were divided into 2 groups: the SBO group and the non-SBO group. We also analyzed the relationship between SBO and computed tomography (CT) scan image parameters. Results: The study included 49 male and 47 female patients. The median age was 35.5 years (range, 14–72 years). We performed a 2- or 3-stage procedure as a total proctocolectomy and IPAA for patients with UC. SBO in the pretakedown of the loop ileostomy after IPAA occurred in 22 patients (22.9%). Moreover, surgical intervention for SBO was required for 11 patients. In brief, closure of the loop ileostomy was performed earlier than expected. A multivariate logistic regression analysis revealed that the 2-stage procedure (odds ratio, 2.850; 95% confidence interval, 1.009–8.044; P = 0.048) was a significant independent risk factor associated with SBO. CT scan image parameters were not significant risk factors of SBO. Conclusion: The present study suggests that a 2-stage procedure is a significant risk factor associated with SBO after IPAA in patients with UC.