요부수핵탈출증에서 Thermography의 진단적 가치

신현택,신승우,송재철,정석희,이종수,김성수,신현대 경희대학교 동서의학연구소 2001 東西醫學硏究所 論文集 Vol.2000 No.-

Objectives : Lumbar radiculopathy is a common disease in oriental rehabilitation medicine. It can be diagnosed by physical examination, plain X-ray, Myelography, CT, MRI, EMG etc. But those methods are not useful in observing the clinical procedure. Objectvie evaluating the clinical procedure is very important in treatment of lumbar radiculopathy. Mehthods : We studied the clinical efficacy of thermography in lumbar radiculopathy during conservative managements. We studied 36 patients with lumbar radiculopathy convinced by MRI. The had low back pain and radiating pain on one side. Thermography had taken before an after 4 weeks treatments, and compared with clinical procedure Results and conclusions : Thermography is not pertinent as a primary diagnostic method in lumbar radiculopathy, but useful in observing the clinical procedure. And it can be recommended as a objective evaluation for lumbar radiculopathy.

비만증 환자에서 한약제에 의한 체중 감소효과

Oh, Seung-Joon,Jeong, In-Kyung,Kim, Young-Seol,Choi, Young-Kil,Paeng, Jeong-Ryung,Bae, Jung-Hwan,Shin, Hyun-Dae 경희대학교 동서의학연구소 1999 INTERNATIONAL SYMPOSIUM ON EAST-WEST MEDICINE Vol.1999 No.1

Seung-Joon Oh, In-Kyung Jeong, Young-Seol Kim, Young-Kil Choi, Jeong-Ryung Paeng¹, Jung-Hwan Bae and Hyun-Dae Shin²Department of internal Medicine, College Medicine, Endocrine Research Institute¹. Department of Rehabilitation, College of Oriental Medicine², Seoul, korea. Bady Fat Reduction Effects of Red Ginseng Compound Preparation on the Patients with Obesity. Proceedings of International Symposium on East-West Medicine, Seoul. 244-254, 1999.-Obesity can be defined as a metabolic disease due to an increased state of fat tissues caused by an imbalance of calorie intake and use. Recently, in Korea by improvement and westernization of food intake, along with decrease in exercise activities, the prevalence of obesity has increased greatly. Our objectives were to study stability and effects of decrease in body fat by administering red ginseng compound preparation (known to have body fat decreasing effects in laboratory animals) to obesity patients on low calorie diets. Changes in weight and body fat were measured while carrying out calorie-restricted diets on patients for 4 weeks, then administering red ginseng compound preparation for another 4 weeks. The patients were 20 people whose BMI were 25kg/㎡ or over and whose percent body fat was also 30% or over when tested by bioelectrical conductivity. 1. Changes in weight were from 70.04kg(base line) to 67.43kg(after taking red ginseng compound preparation). 2. In similar sense, BMI decreased from 27.12kg/㎡(base line) to 26.56kg/㎡(after dieting), and further to 26.01kg/㎡ (after taking red ginseng compound preparation). The BMI seemed to decrease significantly compared to the baseline after the use of red ginseng compound. 3. Waist hip ratio was changed from 0.8858(base line) to 0.8728, but it was statistically insignificant. 4. The percent body fat was 35,16%(base line), 33.87%(after dieting), and 31.68%(after taking red ginseng compound preparation). 5. Complete blood cell count and blood chemisrty remained unaffected by the administration. 6. In concern to endocrinologic studies, T3 decreased from 118.7 to 98.2ng/dL, and T4 increased from 8.8 to 9.2㎕/ dL. Epinephrine showed a tendency to decreased from 0.27 to 0.25 ng/mL, and norepinephrine increased from 0.39 to 0.44ng/mL. 7. Leptin was not changed. 8. Some patients complained adverse effects; constipation(5 patients, may be due to diet therapy), fatigue (2 patients), pruritus(2 patients), flushing(s patients), dizziness(3 patients) and epigastric discomfort(2 patients). However their symptoms were mild, so medication did not stopped. In conclusion, loss of weight without significant side effects was observed during low calorie diet and red ginseng compound preparation administration. This is thought to be in relation to sympathetic nerve system rather than adrenal gland. Also, further long0term studies should be required, since the observed results were based on short-term changes in weight.

敗醬草가 癌細胞柱에 미치는 影響

申大澈,權貞南,金瑩均,韓宗鉉,김재석,김재섭 동의대학교 한의학연구소 1997 동의한의연구 Vol.1 No.-

The purpose of this study was to investigate effect of water extract of Patriniae Herba on the poliferation of human cancer cell-lines. The effects of Patriniae Herba on the poliferation of A43l, HeLa, MOLT-4, K562 cells, Balb/c 3T3 cells, mouse thymocytes, splenocytes and human lymphocytes were estimated by MTT colorimetric assay, The results were as follows; 1. Patriniae Herbs did not effect A43l, HeLa, MOLT-4, K562 cells. 2. The cytotoxicity of mitomycin C on MOLT-4 cells was increased by the combination of Patriniae Herba. 3. Patriniae Herba inhibited the proliferation of Balb/c 3T3 cells. 4. Patriniae Herba stimulated the proliferation of thymocytes. 5. Patriniae Herba stimulated the proliferation of splenocytes. 6. Patriniae Herba stimulated the proliferation of human lymphocytes.

축산페수처리를 위한 탈수기와 침전조 개발에 관한 연구

신대윤,최현규 조선대학교 환경공해연구소 1998 環境公害硏究 Vol.14 No.-

Centrifugal filter and filtration type sedimentation tank are built to investigate their capacity and the optimal condition to treat swine wastewater physical-mechamically. 1. As the result of the separation and the experiment of sludge which is over 0.2??of the diameter of the particles, in 180rpm of the rotation speed and 50 ??min of filtration velocity of centrifugal filter, 1.3-4.7kg of sludge, 60-70% of hydration rot per 1m^(3) of filtrates, was removed. 2. Removal rate of SS of filtrates through filtration type sedimentation tank was more than 90%, and BOD and COD more than 50% when filtrate had been kept for 6 months in air-tight container, it generated a little gas and little precipitation.

일과성 전 기억상실증으로 나타난 크로이츠펠트 : 야콥병 1례

신대수,이승희,이한샘,박성욱,박현영,장혁,장성조,김요식,조광호 圓光大學校 醫科學硏究所 2004 圓光醫科學 Vol.19 No.1

Cholestyramine과 Polyvinylpyrrolidone에 對한 Bilirubin 吸着의 Photoenhancement에 關한 硏究

신대현,Henning, D.,St-pierre, L. E. 충남대학교 자연과학연구소 1983 忠南科學硏究誌 Vol.10 No.2

Shifts in the visible spectrum of aqueous bilirubin (BR) solutions resulting from the addition of soluble polyvinypyrrolidone (PVP) suggest specific interactions. Hence, isotherms were determined for the adsorption of BR from aqueous bilirubin solution onto solid, crosslinked PVP and onto cholestyramine (CA) at 0, 10, 20 and 25℃. Although the adsorption onto PVP reaches equilibrium more rapidly than onto CA, the latter adsorbent has a larger capacity of adsorption. Furthermore the isotherms for PVP are independent of temperature while those for CA show an increase in the amount of BR adsorbed with an increase in temperature. Totally internal hydrogen bonded ZZ form of bilirubin can be converted under photoirradiation with blue filtered light to three forms: EZ, ZE and EE, all of which gives greater accessibility to the polar functional groups. Accordingly, I have attempted to discern whether the photolized-bilirubin could be adsorbed more rapidly on the two adsorbents than do the ZZ form, particularly on CA which has slower equilibrium, but greater adsorption capacity. The rate of adsorption of photolized-bilirubin on CA is seen to be considerably faster than that of the ZZ form. Thus the adsorption equilibrium could be improved by pre-irradiation of aqueous bilirubin solution. It will be determined if this phenomenon may aid the phototherapy treatment of hyperbilirubinaemia cases.

축산폐수처리를 위한 탈수기와 침전조 개발에 관한 연구

신대윤,최현규 조선대학교 환경연구소 1998 環境硏究 Vol.14 No.1

Centrifugal filter and filtration type sedimentation tank are built to investigate their capacity and the optimal condition to treat swine wastewater physical-mechamically. 1. As the result of the separation and the experiment of sludge which is over 0.2㎜ of the diameter of the particles, in 180rpm of the rotation speed and 50ℓ/min of filtration velocity of centrifugal filter, 1.3∼4.7㎏ of sludge, 60∼70% of hydration rot per 1㎥ of filtrates, was removed. 2. Removal rate of SS of filtrates through filtration type sedimentation tank was more than 90%, and BOD and COD more than 50% when filtrate had been kept for 6 months in air-tight container, it generated a little gas and little precipitation.

양측 상완 원위부에 발생한 Kimura씨 병의 치험 1례 : 증례보고 A case report

신현대,이광진,이승진 충남대학교 의과대학 지역사회의학연구소 1997 충남의대잡지 Vol.24 No.2

Angiolymphoid hyperplasia with eosinophilia(ALHE), or Kimura's disease, is an uncommon lesion of unknown etiology with a predilection for skin of the head and neck region. It usually presents as one or a few smooth-surfaced nodules which are often asymptomatic. Histologically the nodules reveal two components : abnormal proliferating vessels and a cellular infiltrate consisting of lymphocytes and eosinophils, involving both the dermis and the subcutaneous tissue. A case of sixteen years old boy is presented of an unusual lesion around the elbow joint followed from December 1994 to September 1997 at Chungnam national university hospital. We had marginally resected symetrically developed lesion around elbow joint measuring 3x5x7㎝, and then medicated with prednisolone 60mg per oral medication to postoperative 10 days.

Quinacrine 형광을 이용한 토마토 뿌리조직 마이크로솜의 수소이온이동 활성측정

신대섭,조광현,김영기 충북대학교 한국과학재단 지정 첨단원예기술개발 연구센터 2002 연구보고서 Vol.6 No.-

Quinacrine은 수소이온 농도변화에 민감한 형광 probe로서 양성자와 결합하지 않은 형광형이나, 양성자와 결합한 비형광형으로 존재한다. 따라서, quinacrine은 H+-ATPase에 의한 수소이온이동 활성측정에 이용된다. 본 연구에서는 토마토 뿌리조직에서 분리한 마이크로솜에서 quinacrine의 형광성을 이용한 H+-ATPase 활성측정의 최적 조건을 조사하였다. Quinacrine의 형광변화는 반응용액 중의 단백질 함량이 0.43㎍/㎕에서 25-26% 감소하여 10%의 quinacrine 형광을 감소시키는 데 약 100 nmol/min의 H+-ATPase 활성이 필요함을 알 수 있었다. Quinacrine의 최대 형광변화는 pH 7.0-7.2 범위와 2 mM Mg2+ 조건에서 일어났다. 이것은 기존에 보고한 H+-ATPase의 특성과 잘 일치하여, quinacrine의 형광변화가 H+-ATPase의 활성을 잘 반영하고 있음을 보인다. 원형질막 및 액포막 H+-ATPase들의 선택적 저해제인 vanadate와 NO3-는 각각의 효소에 의한 수소이온이동 활성을 저해하는데 성공적임을 확인하였다. 이상의 결과로 quinacrine이 토마토 뿌리조직에서 분리한 마이크로솜의 수소이온이동 활성측정에 유용하게 이용될 수 있음을 확인하였다. Quinacrine, a pH-sensitive fluorescence probe, which exists either as an unprotonated fluorescence form or protonated nonfluorescence form, can be used to measure the proton transport activity of H+-ATPase. Quinacrine was used to determine the optimal conditions for measuring the activity of microsomal H+-ATPases prepared from the roots of tomato plants. The amount of quinacrine fluorescence quenching obtained at 0.43 ㎍/㎕ of microsomal protein concentration was 25-26%, which shows that the enzyme activity of 100 nmol/min decreases 10% of quinacrine fluorescence. Maximal fluorescence quenching was obtained at pH 7.0-7.2 and 2 mM Mg2+. Because the activity of microsomal H+-ATPase is also maximal at these conditions, the quinacrine fluorescence well represents the activity of H+-ATPase. Vanadate and NO3-, specific inhibitors of plasma and vacuolar H+-ATPase, respectively, were successfully applied to inhibit the quinacrine fluorescence quenching mediated by the corresponding H+-ATPase. These results imply that quinacrine is a useful tool for measuring the proton transport activities of microsomes obtained from the root tissued of tomato plants.

운동실조를 동반하지 않은 급성외안근마비 1례

신대수,이승회,이한샘,박성욱,박현영,장혁,김요식,조광호 圓光大學校 醫科學硏究所 2004 圓光醫科學 Vol.19 No.2