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( Horng Yuan Wang ),( Shou Chuan Shih ),( Chien Yuan Hung ),( Chia Yuan Liu ),( Tze Yu Shieh ),( Ming Jen Chen ) 대한소화기학회 2014 Gut and Liver Vol.8 No.6
Background/Aims: In endoscopic submucosal dissection (ESD) training, only a flat target lesion can usually be simulated in the normal mucosa. This study aimed to evaluate the feasibility of simulated targets in the stomachs of live pigs for complete training. Methods: Six trained endoscopists with hands-on experience with ex vivo, isolated pig stomachs were enrolled in this pilot study. An endoscopic banding device was used to create a polyp that was snared, leaving an ulcerated lesion. This simulated target model was used to perform ESD in pigs. The en bloc resection rate, procedure time, complications, quality of resection, and participants` opinions on the simulated targets were compared with the conventional model. Results: En bloc resections were achieved in all six simulated targets and six conventional models. The mean size of the resected specimens was 32.2 mm (range, 20 to 39 mm) in the simulated target group and 23.5 mm (range, 11 to 40 mm) in the conventional group. The target model had a high quality of resection and had a high satisfaction rate for margin identification and correct peripheral marking. Conclusions: Good identification of the lesion and ease of periphery marking in the target model may improve resection quality. (Gut Liver 2014;8:619-624)
Evaluating an English Elite Program in Taiwan Using the CIPP Model
Yu-Chih Doris Shih,Yun-Pi Yuan 아시아테플 2019 The Journal of Asia TEFL Vol.16 No.1
To promote English language learning, universities in Taiwan have been setting up traditional and online English language self-study centers. English honors or elite programs are also being established to offer advanced training of the English language to students. A private university in northern Taiwan established the English Elite Program in 2008, providing courses in three different sections through traditional and distance learning modes. The distance learning courses aim to reduce students’ difficulties with conflicting schedules between the courses in their own departments and the program courses. In this study, the researchers evaluate the Elite Program using the Context, Input, Process, and Product (CIPP) model. Data were collected from program documents, questionnaires, classroom observations, graduates’ academic scores, and interviews of the instructors and graduates who received the program certificate. This study is helpful for program designers, teachers, students, and university administrators of this type of program and other similar foreign-language programs. This study also provides useful recommendations for universities planning to establish a similar program, particularly with the inclusion of distance learning courses.
Fabrication of 30 nm pitch imprint moulds by frequency doubling for nanowire arrays
Yu, Zhaoning,Wu, Wei,Jung, Gun-Young,Olynick, D L,Straznicky, J,Li, Xuema,Li, Zhiyong,Tong, William M,Liddle, J A,Wang, Shih-Yuan,Stanley Williams, R IOP Pub 2006 Nanotechnology Vol.17 No.19
<P>We report the fabrication of 30 nm pitch nanowire array imprint moulds by spatial frequency doubling a 60 nm pitch array generated by electron beam lithography. We have successfully fabricated nanowire arrays at a 30 nm pitch, which is targeted for the year 2020 by the International Technology Roadmap for Semiconductors, with an average line-width of 17 nm and a 3σ line width roughness (LWR) of 4.0 nm. In contrast to previously reported procedures, our spatial frequency doubling technique produces electrically isolated nanowires that are appropriate for crossbar circuits. </P>
( Ming-lung Yu ),( Chao-hung Hung ),( Yi-hsiang Huang ),( Cheng-yuan Peng ),( Chun-yen Lin ),( Pin-nan Cheng ),( Rong-nan Chien ),( Shih-jer Hsu ),( Chen-hua Liu ),( Jee-fu Huang ),( Chung-feng Huang 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: The current study aims to elucidate the treatment efficacy (defined as undetectable HCV RNA throughout 12 weeks of post-treatment follow-up, SVR12) and safety DCV/ASV plus ribavirin for 12 weeks in HCV-1b patients without NS5A RAS. Methods: This is a single-arm, open-label phase 2 study. Seventy directly acting antivirals (DAA)-naïve HCV-1b patients without L31/Y93 RAS are planned to receive daclatasvir (60 mg/ day) and asunaprevir (100 mg twice daily) plus weight-based ribavirin (1000-1200 mg/day) for 12 weeks. After treatment they were followed up for 12 weeks. Results: As of 31 Oct 2017, 58 eligible patients are allocated to treatment, with a mean age of 59.3 years and female predominance (67.2%, 39/58). The mean HCV RNA was 5.87+0.77 log10 IU/mL; 23 patients (39.7 %) had significant hepatic fibrosis (>F2). In the modified intention-to-treat analysis, the rate of undetectable HCV at week 1, week 2, week 4, week 8 and endof- treatment was 25 % (14/56), 84.8 % (39/46), 100 % (46/46), 100 % (38/38) and 100 % (27/27), respectively. Undetectable HCV RNA were observed in all of the patients with HCV RNA assessable 4 weeks (SVR4, 18/18) and 12 weeks (SVR12, 12/12) post treatment. None of the 18 patients who completed the 12-week treatment experienced relapse during post-treatment follow-up. The most common adverse event was fatigue (78.3 %), followed by pruritus (65.2 %) and dizziness (52.2 %), of which were considered as ribavirin related. None of the participating subjects withdrew treatment or follow-up throughout the trial peroid. Three serious adverse events were reported which included urosepsis, appendicitis and left ureteral stone. All were unrelated to the investigating drugs. Conclusions: 12 weeks of DCV/ASV plus ribavirin was highly effective and safe in HCV-1b patients without NS5A RAS in the interim analysis. The satisfactory results would be anticipated in the full patient set.