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      • SCIESCOPUSKCI등재

        Radio Resource Management Scheme for Heterogeneous Wireless Networks Based on Access Proportion Optimization

        Shi, Zheng,Zhu, Qi The Korea Institute of Information and Commucation 2013 Journal of communications and networks Vol.15 No.5

        Improving resource utilization has been a hot issue in heterogeneous wireless networks (HWNs). This paper proposes a radio resource management (RRM) method based on access proportion optimization. By considering two or more wireless networks in overlapping regions, users in these regions must select one of the networks to access when they engage in calls. Hence, the proportion of service arrival rate that accesses each network in the overlapping region can be treated as an optimized factor for the performance analysis of HWNs. Moreover, this study considers user mobility as an important factor that affects the performance of HWNs, and it is reflected by the handoff rate. The objective of this study is to maximize the total throughput of HWNs by choosing the most appropriate factors. The total throughput of HWNs can be derived on the basis of a Markov model, which is determined by the handoff rate analysis and distribution of service arrival rate in each network. The objective problem can actually be expressed as an optimization problem. Considering the convexity of the objective function, the optimization problem can be solved using the subgradient approach. Finally, an RRM optimization scheme for HWNs is proposed. The simulation results show that the proposed scheme can effectively enhance the throughput of HWNs, i.e., improve the radio resource utilization.

      • KCI등재

        Analysis of genetic diversity and distances in Asian cattle breeds using microsatellite markers

        Zheng Shi,이지홍,오동엽,여정수,이윤석 한국데이터정보과학회 2010 한국데이터정보과학회지 Vol.21 No.4

        This study defined the genetic diversity of five breeds of cattle in Asia by analyzing 6 microsatellite markers in 270 animals. Based on expected mean heterozygosity, the lowest genetic diversity was exhibited in Japanese black cattle (HE=0.5849), and the highest in Chinese yellow cattle (HE=0.8073). Average proportion of genetic variation due to interpopulation subdivision among these ve cattle breeds varied between 11.7 and 12.5%. The genetic distances were roughly divided into three groups: Japanese black cattle, Holstein, and the three remaining breeds. This clustering agrees with the origin and geographical distributions of these five cattle breeds.

      • KCI우수등재

        Analysis of genetic diversity and distances in Asian cattle breeds using microsatellite markers

        Shi, Zheng,Lee, Ji-Hong,Lee, Yoon-Seok,Oh, Dong-Yeub,Yeo, Jung-Sou The Korean Data and Information Science Society 2010 한국데이터정보과학회지 Vol.21 No.4

        This study defined the genetic diversity of five breeds of cattle in Asia by analyzing 6 microsatellite markers in 270 animals. Based on expected mean heterozygosity, the lowest genetic diversity was exhibited in Japanese black cattle (HE=0.5849), and the highest in Chinese yellow cattle (HE=0.8073). Average proportion of genetic variation due to interpopulation subdivision among these five cattle breeds varied between 11.7 and 12.5%. The genetic distances were roughly divided into three groups: Japanese black cattle, Holstein, and the three remaining breeds. This clustering agrees with the origin and geographical distributions of these five cattle breeds.

      • KCI등재
      • miR-340 Reverses Cisplatin Resistance of Hepatocellular Carcinoma Cell Lines by Targeting Nrf2-dependent Antioxidant Pathway

        Shi, Liang,Chen, Zhan-Guo,Wu, Li-li,Zheng, Jian-Jian,Yang, Jian-Rong,Chen, Xiao-Fei,Chen, Zeng-Qiang,Liu, Cun-Li,Chi, Sheng-Ying,Zheng, Jia-Ying,Huang, Hai-Xia,Lin, Xiang-Yang,Zheng, Fang Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.23

        Many chemotherapeutic agents have been successfully used to treat hepatocellular carcinoma (HCC); however, the development of chemoresistance in liver cancer cells usually results in a relapse and worsening of prognosis. It has been demonstrated that DNA methylation and histone modification play crucial roles in chemotherapy resistance. Currently, extensive research has shown that there is another potential mechanism of gene expression control, which is mediated through the function of short noncoding RNAs, especially for microRNAs (miRNAs), but little is known about their roles in cancer cell drug resistance. In present study, by taking advantage of miRNA effects on the resistance of human hepatocellular carcinoma cells line to cisplatin, it has been demonstrated that miR-340 were significantly downregulated whereas Nrf2 was upregulated in HepG2/CDDP (cisplatin) cells, compared with parental HepG2 cells. Bioinformatics analysis and luciferase assays of Nrf2-3'-untranslated region-based reporter constructor indicated that Nrf2 was the direct target gene of miR-340, miR-340 mimics suppressing Nrf2-dependent antioxidant pathway and enhancing the sensitivity of HepG2/CDDP cells to cisplatin. Interestingly, transfection with miR-340 mimics combined with miR-340 inhibitors reactivated the Nrf2 related pathway and restored the resistance of HepG2/CDDP cells to CDDP. Collectively, the results first suggested that lower expression of miR-340 is involved in the development of CDDP resistance in hepatocellular carcinoma cell line, at least partly due to regulating Nrf2-dependent antioxidant pathway.

      • KCI등재

        기획주제(企劃主題) : 동아시아 한자(漢字),한자교육(漢字敎育)의 현황(現況)과 과제(課題); 漢字結構分析的曆史演變 -試論六書、偏旁與部件之更替

        ( Zheng Yu Shi ) 한국한자한문교육학회 2013 漢字 漢文敎育 Vol.30 No.-

        한자의 구조 분석 중 육서와 편방, 부건의 구체적 함의와 상호 관계 등의 문제는 항상 한자의 이론 연구와 교육 실천에 있어서 어려운 문제였다. 필자는 어떠한구조 분석법이라도 모두가 상상에서 나온 것이 아니라, 육서와 편방, 부건의 출현이 한자의 변천 과정 중 몇 차례 있었던 대변화의 시기와 맞물려 있다고 생각하여, 이 문제들을 이해하는데 도움을 주고자 하였다. 이를 위해 필자는 한자 발전의 각도에서 이 세 가지 용어의 기원과 발전 맥락을 분석하고, 이와 함께 이 세 가지가 내포하고 있는 함의와 관계에 대해 정리하였다. The author of this paper combined the six categories of Chinese characters, radicals, components and the evolution of Chinese characters font to investigate the difference between the three and their inner links based on the diachronic analysis method and drew the following conclusions: The six categories of Chinese characters, radicals and components were three different structure analysis methods used on different font during the different historical period of the Chinese characters font evolution. The six categories of Chinese characters was the one of the three methods which was created by a man whose surname was Bao in Zhou dynasty to analyse the ancient Chinese character structure so that can let the temporal students initiate Chinese characters; The radicals were obtained from the disposable analysis of temporal font of the period from the official script to the regular script; The components came from the multiple stereoscopic segmentation of Chinese characters, which are the ways to simplify them and process their information. The six categories of Chinese characters, radicals and the components are relatively independent and have some certain gradualism and inheritance as well.

      • A novel design method for improving collapse resistances of multi-story steel frames with unequal spans using steel braces

        Zheng Tan,Wei-hui Zhong,Bao Meng,Shi-chao Duan,Hong-chen Wang3,Xing-You Yao,Yu-hui Zheng 국제구조공학회 2023 Steel and Composite Structures, An International J Vol.47 No.2

        The bearing capacities resisted by the two-bay beams of multi-story planar frames with unequal spans under column removal scenarios differ considerably owing to the asymmetric stress on the left and right beams connected to the failed column and cause the potential for beams with larger span-to-depth ratios to be unable to exert effectively, which is disadvantageous for resisting the vertical load in unequal-span frame structures. To address this problem, the structural measure of adding braces to the weak bays of multi-story unequal-span frames was proposed, with the objective of achieving a coordinated stress state in two-bay beams with unequal spans, thereby improving the collapse resistance of unequal-span frame structures. Before conducting the numerical simulation, the modeling methods were verified by previous experimental results of two multi-story planar frames with and without steel braces. Thereafter, the effects of the tensile and compressive braces on the collapse behavior of the frame structures were elucidated. Then, based on the mechanical action laws of the braces throughout the collapse process, a detailed design method for improving the collapse resistance of unequal-span frame structures was proposed. Finally, the proposed design method was verified by using sufficient example models, and the results demonstrated that the design method has good application prospects and high practical value.

      • Clinical Outcomes of Downregulation of E-cadherin Gene Expression in Non-small Cell Lung Cancer

        Zheng, Shi-Ying,Hou, Jing-Yu,Zhao, Jun,Jiang, Dong,Ge, Jin-Feng,Chen, Sheng Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.4

        Objective: To investigate the promoter methylation status of the E-cadherin gene in non-small cell lung cancer (NSCLC) and its association with clinical pathological parameters, and to explore the relationship between downregulation of E-cadherin gene expression and the methylation status of its promoter region. Methods: Nested methylation-specific PCR was performed to examine CpG methylation within the 5' CpG island of the E-cadherin gene in lung cancer and para-cancerous tissue from 37 patients with primary non-small cell lung cancer. Quantitative real-time PCR was performed to measure the level of E-cadherin mRNA. Results: Of thirty-seven cases, 12 (32.4%) samples showed aberrant CpG methylation in tumor tissues compared with the corresponding normal tissues. In addition, a reduction in E-cadherin mRNA levels was observed in 11 of the 12 (91.7%) tumor tissues carrying a methylated E-cadherin gene. However, only 10 (43.5%) cases displayed reduced mRNA levels in tumor tissues from the remaining 23 cases (excluding 2 samples from which mRNA was unavailable) without methylation events. Downregulation of E-cadherin gene expression significantly correlated with the promoter methylation status of this gene. Conclusion: These results provide strong evidence that the methylation status of E-cadherin gene contributes to a reduction in the expression of E-cadherin mRNA, and may play a role in the development and progression of NSCLC.

      • KCI등재

        Radio Resource Management Scheme for Heterogeneous Wireless Networks based on Access Proportion Optimization

        Zheng Shi,Qi Zhu 한국통신학회 2013 Journal of communications and networks Vol.15 No.5

        Improving resource utilization has been a hot issue in heterogeneouswireless networks (HWNs). This paper proposes a radioresource management (RRM) method based on access proportionoptimization. By considering two or more wireless networks inoverlapping regions, users in these regions must select one of thenetworks to access when they engage in calls. Hence, the proportionof service arrival rate that accesses each network in the overlappingregion can be treated as an optimized factor for the performanceanalysis of HWNs. Moreover, this study considers usermobility as an important factor that affects the performance ofHWNs, and it is reflected by the handoff rate. The objective of thisstudy is to maximize the total throughput of HWNs by choosingthe most appropriate factors. The total throughput of HWNs canbe derived on the basis of a Markov model, which is determinedby the handoff rate analysis and distribution of service arrival ratein each network. The objective problem can actually be expressedas an optimization problem. Considering the convexity of the objectivefunction, the optimization problem can be solved using thesubgradient approach. Finally, an RRM optimization scheme forHWNs is proposed. The simulation results show that the proposedscheme can effectively enhance the throughput of HWNs, i.e., improvethe radio resource utilization.

      • No Association Between Tea Consumption and Risk of Renal Cell Carcinoma: A Meta-analysis of Epidemiological Studies

        Hu, Zheng-Hui,Lin, Yi-Wei,Xu, Xin,Chen, Hong,Mao, Ye-Qing,Wu, Jian,Xu, Xiang-Lai,Zhu, Yi,Li, Shi-Qi,Zheng, Xiang-Yi,Xie, Li-Ping Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.3

        Objective: To evaluate the association between tea consumption and the risk of renal cell carcinoma. Methods: We searched PubMed, Web of Science and Scopus between 1970 and November 2012. Two evaluators independently reviewed and selected articles based on predetermined selection criteria. Results: Twelve epidemiological studies (ten case-control studies and two cohort studies) were included in the final analysis. In a meta-analysis of all included studies, when compared with the lowest level of tea consumption, the overall relative risk (RR) of renal cell carcinoma for the highest level of tea consumption was 1.03 (95% confidence interval [CI] 0.89-1.21). In subgroup meta-analyses by study design, there was no significant association between tea consumption and renal cell carcinoma risk in ten case-control studies using adjusted data (RR=1.08, 95% CI 0.84-1.40). Furthermore, there was no significant association in two cohort studies using adjusted data (RR=0.95, 95% CI 0.81-1.12). Conclusion: Our findings do not support the conclusion that tea consumption is related to decreased risk of renal cell carcinoma. Further prospective cohort studies are required.

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