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CEA, AFP, CA125, CA153 and CA199 in Malignant Pleural Effusions Predict the Cause
Wang, Xin-Feng,Wu, Yan-Hua,Wang, Mao-Shui,Wang, Yun-Shan Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.1
Determination of the cause of malignant pleural effusions is important for treatment and management, especially in cases of unknown primaries. There are limited biomarkers available for prediction of the cause of malignant pleural effusion in clinical practice. Hence, we evaluated pleural levels of five tumor biomarkers (CEA, AFP, CA125, CA153 and CA199) in predicting the cause of malignant pleural effusion in a retrospective study. Kruskal-Wallis or Mann-Whitney U tests were carried out to compare levels of tumor markers in pleural effusion among different forms of neoplasia - lung squamous cell carcinoma, adenocarcinoma, or small cell carcinoma, mesothelioma, breast cancer, lymphoma/leukemia and miscellaneous. Receiver operator characteristic analysis was performed to evaluate sensitivity and specificity of biomarkers. The Kruskal-Wallis test showed significant differences in levels of pleural effusion CEA (P<0.01), AFP (P<0.01), CA153 (P<0.01) and CA199 (P<0.01), but not CA125 (P>0.05), among the seven groups. Receiver operator characteristic analysis showed that, compared with other four tumor markers, CA153 was the best biomarker in diagnosing malignant pleural effusions of lung adenocarcinoma (area under curve (AUC): 0.838 (95%confidence interval: 0.787, 0.888); cut-off value: 10.2U/ml; sensitivity: 73.2% (64.4-80.8)%, specificity: 85.2% (77.8-90.8)%), lung squamous cell carcinoma (AUC: 0.716 (0.652, 0.780); cut-off value: 14.2U/ml; sensitivity: 57.6% (50.7-64.3)%, specificity: 91.2% (76.3-98.0)%), and small-cell lung cancer (AUC: 0.812 (0.740, 0.884); cut-off value: 9.7U/ml; sensitivity: 61.5% (55.0-67.8)%, specificity: 94.1% (71.2-99.0)%); CEA was the best biomarker in diagnosing MPEs of mesothelioma (AUC: 0.726 (0.593, 0.858); cut-off value: 1.43ng/ml; sensitivity: 83.7% (78.3-88.2)%, specificity: 61.1% (35.8-82.6)%) and lymphoma/leukemia (AUC: 0.923 (0.872, 0.974); cut-off value: 1.71ng/ml; sensitivity: 82.8% (77.4-87.3)%, specificity: 92.3% (63.9-98.7)%). Thus CA153 and CEA appear to be good biomarkers in diagnosing different causes of malignant pleural effusion. Our findings implied that the two tumor markers may improve the diagnosis and treatment for effusions of unknown primaries.
Flowering and flowering genes: from model plants to orchids
Shan-Li Wang,Hye Ryun An,Chii-Gong Tong,Seonghoe Jang 한국원예학회 2021 Horticulture, Environment, and Biotechnology Vol.62 No.2
Floral transition in model plants including Arabidopsis and rice has been studied extensively through molecular geneticapproaches. Many genetic factors in diff erent fl owering pathways, which depend mainly on photoperiod, vernalization,autonomous and ambient temperature are regulated coordinately to control fl oral induction. However, for the ornamentalplants orchids, the molecular mechanisms underlying the fl oral transition are still unclear. Recently, genes with potentialfl owering-related functions have been identifi ed in diff erent orchid species and their functional roles have also been characterized/examined using homologous or heterologous systems. In this review, we summarize the molecular networks offl owering genes and their regulation as revealed in model plants such as Arabidopsis and rice, and also describe the recentdiscoveries/studies on fl owering genes in several commercially representative orchid species providing a perspective onorchid fl owering research. In addition, our recent results through transgenic approaches with ectopic expression of Hd3a , arice fl origen gene for the induction of precocious fl owering in Phalaenopsis orchids are also discussed.
Dynamic Analysis of a 5D Fractional-order Hyperchaotic System
Shan Wang,Shan Wang 제어·로봇·시스템학회 2017 International Journal of Control, Automation, and Vol.15 No.3
In this paper, the fractional-order 5D hyperchaotic system is proposed based on the hyperchaotic Lorenzsystem. Fractional-order chaotic systems are often three- or four-dimensional. There are few results about highdimension fractional-order systems. For this 5D hyperchaotic system, the stability of equilibrium points is analyzedby means of the stability theory of fractional systems. Then the fractional bifurcation is investigated. It is foundthat the system admits bifurcations with varying fractional-order and parameters, respectively. Under differentbifurcation parameters, some conditions ensuring the bifurcations are presented. Finally, numerical simulations arepresented to confirm the given analytical results.
Wang, J.,Ji, H.F.,Wang, S.X.,Zhang, D.Y.,Liu, H.,Shan, D.C.,Wang, Y.M. Asian Australasian Association of Animal Productio 2012 Animal Bioscience Vol.25 No.8
The objective of this study was to evaluate the antioxidant capacity of Lactobacillus plantarum ZLP001 and its effects on growth performance and antioxidant status in weaning piglets. The survival in hydrogen peroxide and free radical-scavenging activity of Lactobacillus plantarum ZLP001 were analysed in vitro. The Lactobacillus plantarum ZLP001 showed high viability in 1.0 mmol/L hydrogen peroxide and high scavenging ability against hydroxyl, superoxide anion, and DPPH (1,1-diphenyl-2-picrylhydrazyl) radicals which was dose dependent. Ninety-six weaning piglets were selected ($7.45{\pm}0.79kg$) and divided into three groups comprising of negative control without any supplementation, treatment group with supplemented $6.8{\times}10^7$ Lactobacillus plantarum ZLP001 CFU/g of diet, and positive control with antibiotic treatment (chlorotetracycline, 80 mg/kg diet). The results showed that Lactobacillus plantarum ZLP001 supplementation enhanced feed conversion rates in piglets compared with control (p<0.05). Supplementation of Lactobacillus plantarum ZLP001 increased the concentration of superoxide dismutase (p<0.05), glutathione peroxidase (p<0.01) and catalase in serum (p<0.10), while decreased the concentration of malondialdehyde (p<0.05). The present study implies that the strain Lactobacillus plantarum ZLP001 had high antioxidant ability and its supplementation improved the growth performance and antioxidant status of weaning piglets, so it can be considered useful to alleviate oxidative stress and increase productive performance of pigs.
Wang, Cai Yi,Kim, Donghwa,Zhu, Yan Kui,Oh, Dong-Chan,Huang, Ri Zhen,Wang, Heng-Shan,Liang, Dong,Lee, Sang Kook American Society of Pharmacognosy 2019 Journal of natural products Vol.82 No.11
<P>Three new germacrane sesquiterpenoid-type alkaloids with an unusual Δ<SUP>8</SUP>-7,12-lactam moiety, glechomanamides A-C (<B>1</B>-<B>3</B>), and two pairs of 7,12-hemiketal sesquiterpenoid epimers (<B>4a</B>/<B>b</B>, <B>5a</B>/<B>b</B>) were isolated from <I>Salvia scapiformis</I>. Their structures were elucidated by spectroscopic methods including HRESIMS, IR, UV, and 1D and 2D NMR and also confirmed by single-crystal X-ray diffraction analysis. The chemical transformation of compounds <B>1</B>-<B>5</B> in a solution environment was analyzed by 2D NMR spectroscopy. The aza acetallactams (<B>1</B>-<B>3</B>) were stable in organic solvent, while single crystals of the hemiacetal esters (<B>4a</B>/<B>b</B>, <B>5a</B>/<B>b</B>) underwent a tautomeric equilibrium after being dissolved. Single crystals of <B>4a</B>, <B>4b</B>, and <B>5a</B> were obtained for the first time as their naturally occurring forms. Glechomanamide B (<B>2</B>) exhibited antiangiogenic activity by suppression of vascular endothelial growth factor (VEGF)-induced tube formation through modulation of VEGF receptor 2 (VEGFR2)-mediated signaling pathways in human umbilical vascular endothelial cells (HUVECs). In addition, compound <B>2</B> also showed the significant suppression of mRNA expression associated with glycolysis and angiogenesis biomarkers in high glucose (30 mM)-induced HUVECs. These findings suggest that compound <B>2</B> might be a potential lead compound candidate for the management of diabetic retinopathy.</P> [FIG OMISSION]</BR>
Electrocatalytic properties of Fe-based bulk metallic glasses for hydrogen evolution reaction
Shan Lin Wang,이승훈,김동현 한국화학공학회 2011 Korean Journal of Chemical Engineering Vol.28 No.8
The electrocatalytic activity of newly developed Fe-based bulk metallic glasses was evaluated by polarization and impedance measurements in deaerated 1M KOH solution at room temperature. The electrocatalytic activity as well as the glass-forming ability of the Fe_(73)C_3Si_(7.3)B_(8.5)P_(5.7)Mo_(2.5) alloy was improved by the partial substitution of Fe with 13.5 at% Co. In hydrogen evolution reaction, the metallic glasses exhibited higher activity than the activity of G14 (Fe_(60)B_(10)Si_(10)Co_(20)) metallic glass, which has been reported to be comparable to the activity of Pt electrode. The activity was further improved after a chemical pretreatment in 1 M HF solution for 1 min due to the formation of cobalt-rich layer with a large effective surface area.
Shan-Shan Chen,Xueqing Wang 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2015 NANO Vol.10 No.6
Fe3O4–graphene nanocomposites were prepared via a simple hydrothermal method. Ultrafine Fe3O4 nanoparticles were evenly anchored on graphene substrates. As anode material for Li-ion batteries (LIB), the nanocomposite showed high initial discharge and charge capacities of 1456 mAhg-1 and 739.9 mAhg-1 at high current density of 500 mAg-1. Additionally, the charge capacity was also retained at 698.3 mAhg-1 after 200 cycles, thereby indicating excellent cycling stability. The results suggested that the as-prepared Fe3O4–graphene nanocomposite is a promising candidate for practical application as a Li-ion battery anode material.