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Shahbazi Fatemeh,Hosseini Mahmood 한국강구조학회 2024 International Journal of Steel Structures Vol.24 No.1
In urban environments, in many cases, buildings with unequal story plan sizes are desired, resulting in non-uniform mass/ stiff ness distributions along the buildings’ height. In this study, three groups of 12-story steel buildings with uniform, ascending, and descending story plan size distribution (PSD) along their height, but having the same total architectural space, were investigated to determine how this distribution aff ects their seismic performance. First, three site conditions—stiff , medium, and soft—were considered, and all buildings were designed by considering moment frames with concentrical bracings as their lateral load-bearing systems. Then, for each site class, seven appropriate sets of accelerograms were selected, and using nonlinear time history analyses, the buildings’ seismic performance levels were compared based on the formation of plastic hinges (PHs). Results show that non-uniform PSD can be quite eff ective on the seismic performance of buildings’ structures, so that on hard and soft sites, the number of PHs exceeding the collapse prevention performance level in buildings with ascending and descending PSD, respectively, decreases by approximately 30–45% and 20–40% compared with the uniform buildings. Therefore, it is explicitly concluded that employing buildings with uniform plan sizes does not necessarily lead to a higher seismic performance level.
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Survivin, a Promising Gene for Targeted Cancer Treatment
Shamsabadi, Fatemeh T,Eidgahi, Mohammad Reza Akbari,Mehrbod, Parvaneh,Daneshvar, Nasibeh,Allaudin, Zeenathul Nazariah,Yamchi, Ahad,Shahbazi, Majid Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.8
Drawbacks of conventional cancer treatments, with lack of specificity and cytotoxicity using current approaches, underlies the necessity for development of a novel approach, gene-directed cancer therapy. This has provided novel technological opportunities in vitro and in vivo. This review focuses on a member of an apoptosis inhibitor family, survivin, as a valuable target. Not only the gene but also its promoter are applicable in this context. This article is based on a literature survey, with especial attention to RNA interference as well as tumor-specific promoter action. The search engine and databases utilized were Science direct, PubMed, MEDLINE and Google. In addition to cell-cycle modulation, apoptosis inhibition, interaction in cell-signaling pathways, cancer-selective expression, survivin also may be considered as specific target through its promoter as a novel treatment for cancer. Our purpose in writing this article was to create awareness in researchers, emphasizing relation of survivin gene expression to potential cancer treatment. The principal result and major conclusion of this manuscript are that survivin structure, biological functions and applications of RNA interference systems as well as tumor-specific promoter activity are of major interest for cancer gene therapy.
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Microporous metal–organic frameworks: Synthesis and applications
Mahnaz Ahmadi,Maryam Ebrahimnia,Mohammad-Ali Shahbazi,Rüstem Keçili,Fatemeh Ghorbani-Bidkorbeh 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.115 No.-
Metal-organic frameworks (MOFs) have emerged as porous hybrid materials composed of metal ions andorganic ligands. MOFs have attracted the attention of many researchers due to their promising characteristics,including high porosity, surface area, and drug loading capacity, tunable pore size and structure,good biodegradability and biocompatibility, and ease of functionalization. MOFs are categorized intothree groups based on their pore widths, including microporous, mesoporous, and macroporous MOFs. MOFs with micropores have shown special features. The internal pore widths of microporous MOFsare less than 2 nm, which leads to their high porosity and surface area. Microporous MOFs could be synthesizedthrough different strategies, including modulator-induced defect-formation, structure-directingagents, pillared-layer assembly, bridging helical chain secondary building units, coordination capabilitiesof P@O moieties in the structure of a ligand, and using octahedral cage-like building units. Because oftheir unique properties, microporous MOFs have shown great potential for many applications such asseparation, storage, catalysis, and sensing. A description of synthesis approaches and applications ofmicroporous MOFs in recent years is provided in this review.
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