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Ghafarian Eidgahi Moghadam Mohsen,Shahmardan Mohammad Mohsen,Norouzi Mahmood 한국유변학회 2022 Korea-Australia rheology journal Vol.34 No.4
Magnetically optimization of mini-MR damper with focused on MR fluid properties and damper construction is investigated using dissipative particle dynamics method as a molecular scale modeling technique. To select a suitable MR fluid, the effect of diameter and weight of magnetic particles on damping force of 10 N as set point is studied. The results show damping force increases by increasing diameter of magnetic particles and finally trends to a constant value while changes nonparabolic by enhancement of their weight. The results of studies on structural parameters of damper show that by increasing gap size of flow passage, damping force increases while enhancement in inner diameter of cylinder and piston length has reverse effect. Optimum design of MR damper completed by investigation on electrical coils in terms of their arrangement and step wise distribution of magnetic fi eld strength as our major innovation. To optimum operating conditions of MR damper at minimum electrical energy consumption and hysteresis level, the scenario of three segment coils in length of 3, 5, and 7 mm at base relative magnetic strength of 40% with 15% difference in steps by utilizing 140CG MR fluid as agent fluid are selected.
Survivin, a Promising Gene for Targeted Cancer Treatment
Shamsabadi, Fatemeh T,Eidgahi, Mohammad Reza Akbari,Mehrbod, Parvaneh,Daneshvar, Nasibeh,Allaudin, Zeenathul Nazariah,Yamchi, Ahad,Shahbazi, Majid Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.8
Drawbacks of conventional cancer treatments, with lack of specificity and cytotoxicity using current approaches, underlies the necessity for development of a novel approach, gene-directed cancer therapy. This has provided novel technological opportunities in vitro and in vivo. This review focuses on a member of an apoptosis inhibitor family, survivin, as a valuable target. Not only the gene but also its promoter are applicable in this context. This article is based on a literature survey, with especial attention to RNA interference as well as tumor-specific promoter action. The search engine and databases utilized were Science direct, PubMed, MEDLINE and Google. In addition to cell-cycle modulation, apoptosis inhibition, interaction in cell-signaling pathways, cancer-selective expression, survivin also may be considered as specific target through its promoter as a novel treatment for cancer. Our purpose in writing this article was to create awareness in researchers, emphasizing relation of survivin gene expression to potential cancer treatment. The principal result and major conclusion of this manuscript are that survivin structure, biological functions and applications of RNA interference systems as well as tumor-specific promoter activity are of major interest for cancer gene therapy.