http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Prognostic Involvement of Nucleophosmin Mutations in Acute Myeloid Leaukemia
Shahab, Sadaf,Shamsi, Tahir Sultan,Ahmed, Nuzhat Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.10
Nucleophosmin (NPM1) is a protein of highly conserved nature which works as a molecular chaperone and is mostly found in nucleoli. NPM also involved in the maturation of preribosomes and duplication of centrosomes. Furthermore, it is also active in control and regulation of the ARF-p53 tumor suppressor pathway. A high rate of incidence and prognostic involvement is reported by various authors in AML patients. In AML it behaves as a favorable prognostic marker. NPM mutations are more frequently associated with normal-karyotype AML and are usually absent in patients having abnormal or poor cytogenetic. NPM mutations are not frequent in other hematopoietic tumors. Two main types of mutations have been described to date. Both of these cause abnormal cytoplasmic localization of NPM1. Their high incidence rate in normal karyoptype and their favorable nature m ake those mutations hot spot or front face mutations which should be checked before treatment starts.
Outcome of Inversion 16 in TKD Positive and Negative Acute Myeloid Leukemia Patients
Shahab, Sadaf,Zahid, Danish,Ahmed, Shariq,Nadeem, Muhammad,Farzana, Tasneem,Taj, Mehwesh,Ahmed, Nuzhat,Shamsi, Tahir S Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.4
Shahab Saedi,Sayed S. Madaeni,Keyumars Hassanzadeh,Ahmad Arabi Shamsabadi,Saeed Laki 한국공업화학회 2014 Journal of Industrial and Engineering Chemistry Vol.20 No.4
In the present study, asymmetric gas separation membranes of polyethersulfone (PES) and polyethersulfone/polyurethane (PU) were prepared with different blend compositions. The prepared membranes were investigated for the separation of carbon dioxide from methane. The effect of PU on the microstructure and d-spacing of the membranes was studied by X-ray diffraction analysis and the miscibility of PES and PU was investigated using Differential Scanning Calorimetry (DSC). The thermal properties of PES and PES/PU were compared using Thermal Gravimetric Analysis (TGA). The effect of PES/PU blend composition on the morphology and porosity of the membrane was investigated by Scanning Electron Microscopy (SEM) and porosity experiments. Density Functional Theory (DFT) calculations were used to investigate the relative affinity of CO2, CH4 and H2O for PES and PU. Moreover, the effect of PU on the casting solution viscosity, gas sorption and mechanical properties of the PES membrane was investigated. For comparing gas separation performance of PES and PES/PU membranes, pure and mixed gas experiments were carried out. The obtained results indicated that the presence of PU in the casting solution increases the d-spacing and fractional free volume, and decreases the membrane porosity; Tg and thermal resistance, membrane gas sorption as well as CO2 induced plasticization by decreasing Langmuir capacity, and also increases strength at yield and elongation at yield of PES membrane. The presence of PU decreases the CO2 permeance and enhances the CO2/CH4 selectivity and plasticization pressure of the PES membrane. Furthermore, the presence of the PU changes the membrane behavior against the feed pressure, feed temperature and feed composition in the mixed gas experiments.
Overall Survival in Acute Myeloid Leukaemia Patients with and without Internal Tandem Duplication
Shahab, Sadaf,Qadar, Zeeshanul,Nadeem, Muhammad,Zahid, Danish,Ansari, Saqib,Farzana, Tasneem,Taj, Mehwesh,Borhany, Munira,Ahmed, Nuzhat,Shamsi, Tahir S. Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.1
Nanostructured polysaccharide-based carriers for antimicrobial peptide delivery
Shahab Mohtashamian,Soheil Boddohi 한국약제학회 2017 Journal of Pharmaceutical Investigation Vol.47 No.2
In recent decade, antimicrobial resistance is a serious international concern resulted by misuse of antibiotics. Some dangerous pathogenic strains such as Methicillin- resistant Staphylococcus aureus are resistant to the wide range of conventional antibiotics. Antimicrobial peptides (AmPs) are remarkable antibacterial drugs, which can be used instead of conventional antibiotics due to their membrane targeting activity especially against both gramnegative and gram-positive multidrug-resistant strains of pathogenic bacteria. Target delivery of AmPs is necessary because of short half-life and relative toxicity against healthy cells. Polysaccharide-based nanostructured carriers such as nanoparticles and layer-by-layer thin films are widely used due to their biocompatibility, stimuli-responsive properties, and strong affinity to bond with proteins and peptides. In this review, we focus on some prominent polysaccharide-based AmP delivery systems and describe some advantage and disadvantage of each carrier. We also introduce some novel AmP nanocarriers due to the two main strategies of combat against antibacterial resistance. Among these novel carriers, polysaccharide-based nanogels have incredible properties such as high loading capacity, stimuli responsive release behavior, simple largescale production, and thermodynamically stability, which could be a promising candidate for controlled release of AmPs.
Shahab Shiraghaee,Joel Sundström,Mehrdad Raisee,Michel J. Cervantes 한국유체기계학회 2023 International journal of fluid machinery and syste Vol.16 No.2
The swirling flow under the part-load (PL) operation of hydraulic turbines causes the formation of a rotating vortex rope (RVR) inside the draft tube. The RVR precession induces pressure fluctuations and periodic loadings that can jeopardize the hydraulic machine's structure and performance. The behavior of these fluctuations is closely related to the characteristics of the RVR, which can vary for different PL conditions. A series of experiments have been performed to characterize the periodic behavior and stability of the RVR under various PL operating conditions. For this purpose, wall pressure measurements were conducted at two sections along the draft tube axis of a scaled-down model of the U9 Kaplan turbine. Spectral analyses were performed, and the periodic stability of the RVR was investigated based on the statistical analyses of the amplitude and frequency of the pressure oscillations. The results showed that the amplitude of the pressure oscillations increases with the decrease of the discharge while the stability of the RVR decreases. Upstream, the behavior and stability of the RVR asynchronous mode pressure oscillations are highly dependent on the flow conditions at the draft tube entrance. However, due to the downstream RVR dissipation, the effects imposed by the elbow become the dominant factor in the RVR behavior close to the elbow. The statistical method proposed in this study provided an in-depth view of the RVR instantaneous behavior, allowing a more accurate characterization of the phenomenon than only studying its spectral content.
Procedural outcomes of laparoscopic caudate lobe resection: A systematic review and meta-analysis
Shahab Hajibandeh,Ahmed Kotb,Louis Evans,Emily Sams,Andrew Naguib,Shahin Hajibandeh,Thomas Satyadas 한국간담췌외과학회 2023 Annals of hepato-biliary-pancreatic surgery Vol.27 No.1
A systematic review was conducted in compliance with PRISMA statement standards to identify all studies reporting outcomes of laparoscopic resection of benign or malignant lesions located in caudate lobe of liver. Pooled outcome data were calculated using random-effects models. A total of 196 patients from 12 studies were included. Mean operative time, volume of intraoperative blood loss, and length of hospital stay were 225 minutes (95% confidence interval [CI], 181–269 minutes), 134 mL (95% CI, 85–184 mL), and 7 days (95% CI, 5–9 days), respectively. The pooled risk of need for intraoperative transfusion was 2% (95% CI, 0%–5%). It was 3% (95% CI, 1%–6%) for conversion to open surgery, 6% (95% CI, 0%–19%) for need for intra-abdominal drain, 1% (95% CI, 0%–3%) for postoperative mortality, 2% (95% CI, 0%–4%) for biliary leakage, 2% (95% CI, 0%–4%) for intra-abdominal abscess, 1% (95% CI, 0%–4%) for biliary stenosis, 1% (95% CI, 0%–3%) for postoperative bleeding, 1% (95% CI, 0%–4%) for pancreatic fistula, 2% (95% CI, 1%–5%) for pulmonary complications, 1% (95% CI, 0%–4%) for paralytic ileus, and 1% (95% CI, 0%–4%) for need for reoperation. Although the available evidence is limited, the findings of the current study might be utilized for hypothesis synthesis in future studies. They can be used to inform surgeons and patients about estimated risks of perioperative complications until a higher level of evidence is available.
Board Structure and Likelihood of Financial Distress: An Emerging Asian Market Perspective
Shahab UD-DIN,Muhammad Yar KHAN,Anam JAVEED,Ha PHAM 한국유통과학회 2020 The Journal of Asian Finance, Economics and Busine Vol.7 No.11
This study examines the relationship between the attributes of board structure and the likelihood of financial distress for the non-financial sector of an emerging market characterized by concentrated ownership and family-controlled business. The present study utilized panel logistic regression to estimate the relationship between board structure attributes and the likelihood of financial distress. We used Altman Z-Score as a proxy for firm financial distress, as this tool measures the financial distress inversely. The study finds a significant relationship between board size and the likelihood of financial distress. The results show that a one-unit increase in board size would decrease the probability of financial distress by 3.4%. Further, we observe that a greater level of board independence is associated with a lower likelihood of financial distress. A one-unit increase in board independence would decrease the probability of financial distress by 20.4%. We also find a significant positive impact of leverage on the likelihood of financial distress. The present study contributes to the body of literature on board structure attributes and likelihood of financial distress in emerging markets, like Pakistan. Furthermore, the findings would be beneficial for corporate policymakers and investors in formulating corporate financial strategy and predicting business failure.