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Gadobutrol-dendrimer effects on metastatic and apoptotic gene expression
Kebriaezadeh, Abbas,Ashrafi, Sepehr,Rasouli, Rahimeh,Ebrahimi, Seyed Esmaeil Sadat,Hamedani, Morteza Pirali,Assadi, Artin,Saffari, Mostafa,Ardestani, Mehdi Shafiee Techno-Press 2016 Advances in nano research Vol.4 No.2
Dendrimers are one of the most appropriate nanocaries for imaging moieties in imaging applications.The purpose of this study was the evalution of cytotoxicity and inducing apoptosis of dendrimers. This study was conducted in order to investigate the metastasis suppression effect of dendrimer in human breast MCF-7 cell line and finding the nanoparticle protein corona in biological enviromental. Dendrimer cytotoxicity effect was assessed by MTT assay. The mRNA experession level of KAI1 as a metastasis suppressor gene, Bax as Pro- apoptotic gene, Bcl-2 as an anti-apoptotic gene and GAPDH as a housekepping gene were determined by real-time PCR assays.concentration-dependent nanoparticle cytotoxicity effect was proofed at range of 1-2 mg/mL in 24 hours, significant upregulation of mRNA expression of Bax, was observed whereas expression of anti-apoptotic Bcl-2 was down-regulated, also expression of metastasis suppressor gene KAI1 was up-regulated. So far a few studies confirmed apoptosis enhancement effect of dendrimers in MCF-7 cell line via bax/bcl-2 pathways. dendrimer nanoparticles was able to act as metastase inhibitor via upregulation of KAI1 gene.
New PLA/PEI-functionalized Fe3O4 nanocomposite: Preparation and characterization
Meisam Shabanian,Mehdi Khoobi,Farideh Hemati,Hossein Ali Khonakdar,Seyed esmaeil Sadat ebrahimi,Udo Wagenknecht,Abbas Shafiee 한국공업화학회 2015 Journal of Industrial and Engineering Chemistry Vol.24 No.-
In this work, Fe3O4 nanoparticles were functionalized with hyperbranched polyethylenimine (PEI). The neat Fe3O4 nanoparticles (MNP) and functionalized Fe3O4 (MNP@PEI) were separately incorporated into a polylactic acid (PLA). Compared to the neat MNP, the functionalized nanoparticles (MNP@PEI) had better dispersion in the PLA matrix. The properties of the nanocomposites were strongly related to the dispersion and interaction between the nanoparticles and PLA matrix. The heat barrier effect and high nitrogen content of the MNP@PEI nanoparticles were found to be responsible for the improvement of the thermal and flame resistance properties.