In-decorated NiO Nanoigloos Gas Sensor with Morphological Evolution for Ethanol Sensors

Seung Yeop Yi,Chong Yun Kang,Young Geun Song,Gwang Su Kim 한국센서학회 2019 센서학회지 Vol.28 No.4

We investigated the facile and effective strategy for sensitive and selective C2H5OH sensors based on the In-decorated NiO nanoi- gloos. The In-decorated NiO nanoigloos is fabricated by RF sputtering using 750 nm-diameter polystyrene beads using a soft-template. The morphological evolution based on the Van der Drift model was generated through a heterojunction between In metal and NiO, resulting in a pyramidal rough surface. Upon decorating the In on the NiO surface, high sensitivity and selectivity to C2H5OH wereobserved, and gas sensing mechanism was demonstrated by a high surface-to-volume and double Schottky barrier. We are confidentthat the method presented in this study will have a significant impact on the fabrication of effective nanostructures and their application for the gas sensors.

Venous Thromboembolism in Korean Patients Undergoing Major Orthopedic Surgery: A Prospective Observational Study using Computed Tomographic (CT) Pulmonary Angiography and Indirect CT Venography

Cha, Seung-Ick,Lee, Shin-Yeop,Kim, Chang-Ho,Park, Jae-Yong,Jung, Tae-Hoon,Yi, Jae-Hyuck,Lee, Jongmin,Huh, Seung,Lee, Hyun-Joo,Kim, Shin-Yoon The Korean Academy of Medical Sciences 2010 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.25 No.1

<P>In patients undergoing major orthopedic surgery, data of deep venous thrombosis (DVT) and pulmonary embolism (PE) are lacking as studied by computed tomographic (CT) pulmonary angiography and indirect CT venography (CTPA-CTV). A prospective observational study was performed for 363 Korean patients undergoing major orthopedic surgery to determine the incidence of venous thromboembolism (VTE), especially proximal DVT and PE. The incidence of VTE was 16.3% (n=59). Of them, 8 patients (2.2%) were symptomatic. The rate of VTE was the highest in patients who underwent total knee replacement (40.4%), followed by hip fracture surgery (16.4%), and total hip replacement (8.7%; <I>P</I><0.001). The incidence of PE was 6.6% (n=24). Of them, 4 patients (1.1%) were symptomatic. Forty-one patients (11.3%) were in the proximal DVT or PE group. Based on multivariate analysis, total knee replacement and age ≥65 yr were significant risk factors for proximal DVT or PE in patients undergoing major orthopedic surgery (odds ratio [OR], 2.4; 95% confidence interval [CI], 1.1-5.1; <I>P</I>=0.025; and OR, 2.1; 95% CI, 1.0-4.4; <I>P</I>=0.046, respectively). Taken together, the overall incidence of PE was 6.6% and rate of symptomatic PE rate was 1.1%. Knee joint replacement and age ≥65 yr were significant risk factors for proximal DVT or PE.</P>

원발성 난관암 2예

오영승(Young Seung Oh),이상욱(Sang Wook Yi),허주엽(Chu Yeop Huh),김승보(Seung Bo Kim) 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.8

Carcinoma of the fallopian tube accounts for less than 1% of all cancers of the female genital tract. The histology and behavior of fallopian tube cancer are simillar to ovarian cancer; thus evaluation and treatment are also essentially the same. Unlike ovarian cancer, fallopian tube cancer begins in a hollow viscus, and early lesions may be less likely to be associated with extensive intraperitoneal carcinoma. Two postmenopausal women presented with a pelvic mass. Pathologic examination of the resected specimens revealed primary adenocarcinoma of the fallopian tube. We have experienced two cases of fallopian tube cancer and reported with brief review of literature

Genomic characterization of extensively drug-resistant <i>Acinetobacter baumannii</i> strain, KAB03 belonging to ST451 from Korea

Lee, Sang-Yeop,Oh, Man Hwan,Yun, Sung Ho,Choi, Chi-Won,Park, Edmond Changkyun,Song, Hyun Seok,Lee, Hayoung,Yi, Yoon-Sun,Shin, Juhyun,Chung, Chaeuk,Moon, Jae Young,Lee, Je Chul,Kim, Gun-Hwa,Kim, Seung Elsevier 2018 INFECTION GENETICS AND EVOLUTION Vol.65 No.-

<P><B>Abstract</B></P> <P>Extensively drug-resistant (XDR) <I>Acinetobacter baumannii</I> strains have emerged rapidly worldwide. The antibiotic resistance characteristics of XDR <I>A. baumannii</I> strains show regional differences; therefore, it is necessary to analyze both genomic and proteomic characteristics of emerging XDR <I>A. baumannii</I> clinical strains isolated in Korea to elucidate their multidrug resistance. Here, we isolated new sequence type of XDR <I>A. baumannii</I> clinical strain (KAB03) from Korean hospitals and performed comprehensive genome analyses. The strain belongs to new sequence type, ST451. Single nucleotide polymorphism (SNP) analysis with other types of <I>A. baumannii</I> strains revealed that KAB03 has unique SNP pattern in the regions of <I>gyrB</I> and <I>gpi</I> of MLST profiles. <I>A. baumannii</I> KAB03 harbours three antibiotic resistance islands (AbGRI1, 2, and 3). AbGRI1 harbours two copies of Tn<I>2006</I> containing <I>bla</I> <SUB>OXA-23</SUB>, which play an important role in antibiotic resistance. AbGRI2 possesses aminoglycoside resistant gene <I>aph(3′)-Ic</I> and class A β-lactamase <I>bla</I> <SUB>TEM</SUB>. AbGIR3 has macrolide resistant genes and aminoglycoside resistant gene <I>armA</I>. <I>A. baumannii</I> KAB03 harbours mutations in <I>pmrB</I> and <I>pmrC</I>, which are believed to confer colistin resistance. In addition, proteomic and transcriptional analysis of KAB03 confirmed that β-lactamases (ADC-73 and OXA-23), Ade efflux pumps (AdeIJK), outer membrane proteins (OmpA and OmpW), and colistin resistance genes (PmrCAB) were major proteins responsible for antibiotic resistance. Our proteogenomic results provide valuable information for multi-drug resistance in emerging XDR <I>A. baumannii</I> strains belonging to ST451.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Whole genome of an XDR <I>A. baumannii</I> KAB03 belonging to ST451, isolated in South Korea, was analyzed </LI> <LI> <I>A.s baumannii</I> strains belonging to ST451 have unique SNP pattern in the regions of <I>gyrB</I> and <I>gpi</I> of MLST profiles </LI> <LI> Antibiotic resistance proteins of <I>A. baumannii</I> KAB03 were suggested by proteomic and transcriptomic analysis </LI> </UL> </P>

Reply: Multiple Large Cysts Arising from Nevus Comedonicus

정희선,이혜경,Seung-Hyun Lee,Hyoung-Suk Kim,Sang-Yeop Yi 대한성형외과학회 2012 Archives of Plastic Surgery Vol.39 No.3

Curvature-aware Filtering of Point-Set Surface

Min Ki Park,Seung Joo Lee,In Yeop Jang,Yong Yi Lee,Kwan H. Lee (사)한국CDE학회 2013 한국CAD/CAM학회 국제학술발표 논문집 Vol.2010 No.8

Thermoneutral Housing Exacerbates Liver Fibrosis In Mice

( Nga Thi Ha ),( Ho Yeop Lee ),( Hyon-seung Yi ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1

Aims: Thermoneutral condition has been had a significant impact on metabolic studies. The roles of brown adipose tissue (BAT) on metabolic disease including obesity or fatty liver is receiving increasing attention. Here, we investigated the impact of thermoneutral condition on hepatic fibrosis as well as the contribution of BAT on regulation liver fibrosis in mice. Methods: In this study, we used carbon tetrachloride (CCl4) induced liver fibrosis mouse model and hepatic stellate cells isolated from mice in order to checked fibrotic marker in mice livers housed under room temperature and thermoneutral condition for three weeks. We also compared the changes in the population of hepatic immune cells and the deposition of collagen in mice livers between two kinds of housing conditions. Furthermore, we investigated the effect of secreted factors from brown adipocytes-conditioned media on hepatic stellate cells (HSC) activation process. Results: Serum levels of liver injury and the expression of Col1a1, Acta2 and inflammatory cytokines were up-regulated in the liver of mice under thermoneutral condition compared to room temperature. Moreover, inactivation of BAT by thermoneutrality aggravated hepatic collagen deposition as well as promoted the activation of hepatic stellate cells during CCl4-induced liver fibrogenesis. In consistent with these findings, we also found that the population of infiltrating liver immune cells and pro-inflammatory cytokine-producing T cells was significantly increased in thermoneutral housing mice livers. Treatment of brown adipocytes-conditioned media attenuated HSC activation through down-regulated expression of a-SMA at day 4, day 7 and day 10 cultured HSC. Conclusions: These results suggest that BAT inactivation by thermoneutrality contributes to the activation of pro-inflammatory and pro-fibrotic pathways in CCl4-induced liver fibrogenesis. Secreted factors released from BAT have potential roles on inhibiting HSC activation. Thus, BAT-liver axis may serve as a potential therapeutic target for liver fibrosis.

Multiple Large Cysts Arising from Nevus Comedonicus

Jeong, Hii-Sun,Lee, Hye-Kyung,Lee, Seung-Hyun,Kim, Hyoung-Suk,Yi, Sang-Yeop Korean Society of Plastic and Reconstructive Surge 2012 Archives of Plastic Surgery Vol.39 No.1

Nevus comedonicus is a type of hamartoma that arises from a developmental anomaly of the mesodermal part of the pilosebaceous gland. In most cases of nevus comedonicus, an acne-like skin condition develops. Repeated inflammation can cause a morphological change to the cyst, papule, to abscess. We experienced a case of congenital nevus comedonicus, which led to the formation of large multiple cysts. A 50-year-old man was referred with a $12.5{\times}10cm$ lobulated mass on the posterior neck and upper back. The patient had a widespread presence of nevus comedonicus in the region ranging from the right superior chest to the posterior neck. The patient had a 30-year history of six prior excisions. A magnetic resonance imaging review led to a diagnosis of nevus comedonicus. Surgical treatment consisted of excision of the mass and wide excision for the patch type of nevus comedonicus around the neck. On histopathology, multiple masses were diagnosed as typical cysts containing keratinized tissue. The diffuse comedone lesions were diagnosed as nevus comedonicus. This case shows that large, multiple cysts can occur as a long-term complication of nevus comedonicus, and also highlights the importance of radical resection to prevent its further invagination.

선행 제왕절개 후의 질식 분만시 성공군과 실패군의 비교연구

최현수(Hyun Soo Choi),이상욱(Sang Wook Yi),오영승(Young Seung Oh),진규섭(Kyu seop Jin),이보연(Bo yon Lee),이선경(Seun Kyung Lee),허주엽(Chu Yeop Huh),김승보(Seung Bo Kim) 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.10

제왕 절개의 비율은 최근 까지 지난 20년동안 증가되어 왔으며 이러한 증가는 반복 제왕 절개의 증가와 관련된 것이다. 최근 제왕 절개후 질식 분만에 관한 연구에서는 반복 제왕절개시 올 수 있는 수술 후 합병증, 산모 및 태아의 이환율의 증가 등과 비교해 이 시도가 비교적 안전한 방법으로 등을 보고 하고있는 반면 또한 제왕 절개후 질식 분만시 올 수 있는 자궁 파열과 이로 인한 태아와 산모의 위험성에 관한 보고도 있다. 이에 본원에서는 제왕 절개후 질식 분만을 원해 내원한 산모를 대상으로 성공군과 실패군 사이에 여러 요인을 비교 분석하여 성공에 관여한 인자를 예측하고자 하였다. 연구 대상은 1997년 3월부터 1999년 3월까지 선행 제왕 절개 후 질식 분만을 위해 내원한 환자중 질식 분만 시도시 위험성이 적다고 판단되는 120명의 산모를 대상으로 했으며 성공군과 실패군 사이에 산모의 나이, 제태 연령, 질식 분만한 과거력의 유무, 선행 제왕 절개의 적응증, 초음파로 예측한 태아 몸무게, 신생아 몸무게, 입원시 자궁 경부 상태, Bishop score, CPD index(Cephalopelvic disproportion Index)를 비교 분석 하였다. 120명의 산모중 87명(72.5%)이 성공 하였으며 33명(27.5%)이 실패 하였고 자궁 파열이나 열개와 같은 합병증은 발견되지 않았다. 두 대조군 사이에 산모의 나이(P=0.012), Bishop score(P=0.002), CPD index(P=0.015)에서 의미있는 차이를 보였으며 기타 요인에서는 의미있는 차이를 보이지 않았다. 결론적으로 선행 제절 이후 질식 분만 시도 시에 금기가 아닌 경우 입원시 X선 골반 계측을 통한 CPD index와 Bishop score을 통해 성공 가능성에 대한 예측에 도움을 줄 수 있으며 앞으로 이 요인들과 함께 다른 요인들과의 연관성에 대한 연구를 통해 선행 제왕 절개후 질식 분만 시도시에 올 수 있는 위험성을 줄일 수 있을 것으로 생각된다. 이상과 같은 연구 결과로 또한 추후 성공의 예후 인자로 사용되어 질 수 있고, 앞으로 이 시도의 성공과 관련된 다른 인자와의 연관성을 통한 면밀한 검토가 필요할 것으로 사료된다. Objectives: Vaginal birth or trial of labor after previous cesarean section has become one of the most remarkable changes in obstetric practice. The safety and efficacy of a trial of labor and vaginal birth after previous cesarean are well documented. The purpose of this report is to predict the likelihood of vaginal birth in patients undergoing a trial of labor after previous cesarean delivery using factors known at the time of hospital admission. Method: In this retrospective study, 120 women who attempted vaginal birth at Kyung-Hee University Hospital from March 1997 to March 1999. An attempt to identify possible prognostic factors for success of such a trial was made and we evaluated the variables of significant predictive value and the patients' characteristics in the success group and failure group of women who attempted VBAC. Result: 87 cases(72.5%) in 120 cases succeeded in VBAC and 33 cases(27.5%) failed. In this comparative groups in VBAC, there was significant difference in CPD index(cephalopelvic disproportion index) and Bishop score, but no significant difference in gestational age, the estimated fetal weight by sonography and newborn birth weight. Conclusion: In this study, Bishop score and CPD index and age may be useful and valid predictor of success in VBAC and this information could be particularly valuable. The CPD index may prove most important in determining if a vaginal birth should occur after a cesarean section because it can clearly identify some patients who need a repeat cesarean section.

점 기반 기하곡면의 특징점 인지 디노이징 필터

박민기(Min Ki Park),이승주(Seung Joo Lee),장인엽(In Yeop Jang),이용이(Yong Yi Lee),이관행(Kwan H. Lee) 한국컴퓨터그래픽스학회 2013 한국컴퓨터그래픽스학회 학술대회 Vol.2013 No.6