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조강희,유재욱,김봉옥,윤승호 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.2
Fall-related accidents account for more than 800,000 injuries and 13,000 fatalities a year in North Americain. And also it is estimated that one-third of all persons 60 years old and older suffer falls each year. The Balance and posture are affected by vision, vestibular system and somatosensory system(proprioception). Three influences related to the older population's risk of falling are normal aging progress, pathology that increases with age and environmental conditions. In this study, to understand the effect of various environmental conditions on kinetic characteristics of initiation of gait and standing posture, vertical ground reaction forces(VGRF), center of pressurc(COP), postural analysis and psychologic index were evaluated in 20 men with no history of neuromusculoskeletal abnormality. The results are 1) VGRF according to various environmental conditions are not significant change. 2) Temporal analysis of IOG according to carpet and wood floor are significantly slowed in wooden floor. 3) Temporal analysis of IOG with or without shoes are not significnat change. 4) The effects of illumination to balance increased maximal oscillation by decreased of illumination
Seung Wook Ryu,Young Bae Ahn,Jong Ho Lee,Hyeong Joon Kim 대한전자공학회 2011 Journal of semiconductor technology and science Vol.11 No.3
Thermal stability of Ge2Sb2Te5 (GST) and SiO2 doped GST (SGST) films for phase change random access memory applications was investigated by observing the change of surface roughness, layer density and composition of both films after isothermal annealing. After both GST and SGST films were annealed at 325°C for 20 min, root mean square (RMS) surface roughness of GST was increased from 1.9 to 35.9 nm but that of SGST was almost unchanged. Layer density of GST also steeply decreased from 72.48 to 68.98 g/cm<SUP>2</SUP> and composition was largely varied from Ge : Sb : Te = 22.3 : 22.1 : 55.6 to 24.2 : 22.7 : 53.1, while those of SGST were almost unchanged. It was confirmed that the addition of a small amount of SiO2 into GST film restricted the deterioration of physical and chemical properties of GST film, resulting in the better thermal stability after isothermal annealing.
Ryu, Seung-Wook,Choi, Kyungsun,Park, Jong-Hwan,Park, Yeong-Min,Kim, Sunchang,Choi, Chulhee Elsevier 2012 Cancer letters Vol.323 No.1
<P><B>Abstract</B></P> <P>Mitochondrial fusion and fission are dynamically regulated during apoptotic cell death, and mitofusin (Mfn) and related proteins have been shown to be involved in apoptosis-associated changes in mitochondrial morphology and function. Here, we investigated the involvement of Mfn proteins in the conformational activation and mitochondrial translocation of Bax, a key molecule responsible for apoptosis-associated mitochondrial changes. When ectopically expressed, Mfn1 inhibited the amino-terminal activation, but not the mitochondrial translocation, of Bax during staurosporine-induced apoptosis; overexpression of Mfn2 had no effect. Overexpression of Mfn1 mutants carrying point mutations in the GTPase domain (Mfn1-K88T and Mfn1-T109A) did not inhibit the amino-terminal activation of Bax. Furthermore, staurosporine-induced amino-terminal activation of Bax was significantly delayed in Mfn1-shRNA transfected (Mfn1-depleted) HeLa cells compared to cells transfected with control shRNA. These results collectively suggest a role for Mfn1 in regulating the activation of Bax on the outer mitochondrial membrane in a GTPase-dependent manner.</P>
Ryu, Seung-Wook,Ahn, Young-Bae,Lee, Jong-Ho,Kim, Hyeong-Joon The Institute of Electronics and Information Engin 2011 Journal of semiconductor technology and science Vol.11 No.3
Thermal stability of $Ge_2Sb_2Te_5$ (GST) and $SiO_2$ doped GST (SGST) films for phase change random access memory applications was investigated by observing the change of surface roughness, layer density and composition of both films after isothermal annealing. After both GST and SGST films were annealed at $325^{\circ}C$ for 20 min, root mean square (RMS) surface roughness of GST was increased from 1.9 to 35.9 nm but that of SGST was almost unchanged. Layer density of GST also steeply decreased from 72.48 to 68.98 $g/cm^2$ and composition was largely varied from Ge : Sb : Te = 22.3 : 22.1 : 55.6 to 24.2 : 22.7 : 53.1, while those of SGST were almost unchanged. It was confirmed that the addition of a small amount of $SiO_2$ into GST film restricted the deterioration of physical and chemical properties of GST film, resulting in the better thermal stability after isothermal annealing.
Ryu, Seung-Wook,Han, Eun Chun,Yoon, Jonghee,Choi, Chulhee Korean Society for Molecular and Cellular Biology 2015 Molecules and cells Vol.38 No.1
The shape and activity of mitochondria are tightly regulated by fusion and fission processes that are essential for maintaining normal cellular function. However, little is known about the involvement of mitochondrial dynamics in the development of the immune system. In this study, we demonstrate that mitochondrial dynamics play a role in the differentiation and migration of immature dendritic cells (imDCs). We show that mitochondrial elongation is induced during GM-CSF-stimulated differentiation of bone marrow progenitors to imDCs accompanied by upregulation of mitochondrial fusion proteins. These processes precede the changes in mitochondrial morphology and connectivity that occur during differentiation. Mfn2 and OPA1, but not Mfn1, are transcriptionally upregulated during differentiation; however, knockdown of Mfn2 and OPA1 does not induce any change in expression of CD11c, CDC80, or CD86. Notably, knockdown of Mfn2 or OPA1 by siRNA in imDCs significantly reduces CCR7 expression and CCL19-mediated migration. These results suggest that the mitochondrial fusion-related proteins Mfn2 and OPA1 are upregulated during bone marrow progenitor differentiation and promote the migration of imDCs by regulating the expression of CCR7.
Interlayer-assisted atomic layer deposition of MgO as a magnetic tunneling junction insulators
Ryu, Seung Wook,Song, Jeong-Gyu,Kim, Hyun Gu,Kim, Hyungjun,Lee, Han-Bo-Ram Elsevier 2018 JOURNAL OF ALLOYS AND COMPOUNDS Vol.747 No.-
<P><B>Abstract</B></P> <P>The growth behavior of MgO deposited on a Mg interlayer by plasma-enhanced atomic layer deposition (PE-ALD) was investigated to improve the MgO layer quality for magnetic tunneling junction (MTJ) applications. The Mg interlayer was inserted beneath the PE-ALD MgO film to prevent the oxidation of the bottom substrate layer. The chemical bonding status, elemental depth profile, and electron microscopy results for the PE-ALD Mg/MgO stack indicate that the Mg interlayer successfully blocked the oxidation of the substrate via its transformation to MgO. In addition, a change of the preferred orientation from (111) to (200) was observed in the X-ray diffraction pattern when the Mg interlayer was applied. This was attributed to the (200)-preferred orientation of the MgO formed through the oxidation of the Mg interlayer. The use of Mg interlayer is aim to prevent the degradation of the tunneling magneto-resistance properties by not only protecting the bottom layer (i.e., = CoFeB film in MTJs) from oxidation but also changing the preferred orientation from (111) to (200).</P> <P><B>Highlights</B></P> <P> <UL> <LI> ALD Mg interlayer suppresses oxidation of sublayer against the oxidant in ALD MgO. </LI> <LI> Oxidized ALD Mg interlayer has (200)-preferred orientation essential for MTJ barrier. </LI> <LI> ALD MgO on Mg interlayer is grown with (200)-preferred orientation. </LI> <LI> Insertion of ALD Mg interlayer is effective method to form ALD MgO barrier in MTJ. </LI> </UL> </P>
Atomic layer deposition of 1D and 2D nickel nanostructures on graphite
Ryu, Seung Wook,Yoon, Jaehong,Moon, Hyoung-Seok,Shong, Bonggeun,Kim, Hyungjun,Lee, Han-Bo-Ram IOP Pub 2017 Nanotechnology Vol.28 No.11
<P>One-dimensional (1D) nanowires (NWs) and two-dimensional (2D) thin films of Ni were deposited on highly ordered pyrolytic graphite (HOPG) by atomic layer deposition (ALD), using NH<SUB>3</SUB> as a counter reactant. Thermal ALD using NH<SUB>3</SUB> gas forms 1D NWs along step edges, while NH<SUB>3</SUB> plasma enables the deposition of a continuous 2D film over the whole surface. The lateral and vertical growth rates of the Ni NWs are numerically modeled as a function of the number of ALD cycles. Pretreatment with NH<SUB>3</SUB> gas promotes selectivity in deposition by the reduction of oxygenated functionalities on the HOPG surface. On the other hand, NH<SUB>3</SUB> plasma pretreatment generates surface nitrogen species, and results in a morphological change in the basal plane of graphite, leading to active nucleation across the surface during ALD. The effects of surface nitrogen species on the nucleation of ALD Ni were theoretically studied by density functional theory calculations. Our results suggest that the properties of Ni NWs, such as their density and width, and the formation of Ni thin films on carbon surfaces can be controlled by appropriate use of NH<SUB>3</SUB>.</P>
Selumetinib Inhibits Melanoma Metastasis to Mouse Liver via Suppression of EMT-targeted Genes
RYU, SEUNG-HEE,HEO, SEUNG-HO,PARK, EUN YOUNG,CHOI, KYUNG-CHUL,RYU, JE-WON,LEE, SEOK HO,LEE, SANG-WOOK Potamitis Press 2017 Anticancer research Vol. No.
<P>Aim: We investigated the therapeutic effects of a mitogen-activated protein (MEK) inhibitor, selumetinib, in a hepatic melanoma metastasis model and studied its possible mechanism of action. Materials and Methods: Melanoma cell lines were exposed to selumetinib under different experimental conditions. We established a mouse model of liver metastasis and treated mice orally with vehicle or selumetinib and then evaluated metastasis progress. Results: Growth inhibition was observed in melanoma cells as a consequence of G(1)-phase cell-cycle arrest and the subsequent induction of apoptosis in a doseand time-dependent manner. Mice with established liver metastases that were treated with selumetinib exhibited significantly less tumor progression than vehicle-treated mice. c-Myc expression in metastasized liver tissues were suppressed by selumetinib. Moreover, oral treatment with selumetinib modulated expression of epithelial-tomesenchymal transition-and metastasis-related genes, including integrin alpha-5 (ITGA5), jagged 1 (JAG1), zinc finger E-box-binding homeobox 1 (ZEB1), NOTCH, and serpin peptidase inhibitor clade E (SERPINE1). Conclusion: We established a mouse model of hepatic metastasis using a human melanoma cell line, such models are essential in elucidating the therapeutic effects of anti-metastatic drugs. Our data suggest the possibility that selumetinib presents a new strategy to treat liver metastasis in patients with melanoma by suppressing epithelial-to-mesenchymal transition-related genes.</P>