흉수 손상 환자에서 기능적 전기자극에 의한 근력의 변화

진미령,박창일,박은숙 大韓再活醫學會 1995 Annals of Rehabilitation Medicine Vol.19 No.3

Crystal Form of Celecoxib: Preparation, Characterization and Dissolution

진미령,손영택 대한화학회 2018 대한화학회지 Vol.62 No.5

Celecoxib (4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide) is a cyclooxygenase- 2 inhibitor used in the treatment of arthritis, acute pain, and dysmenorrhoea. Celecoxib is a Biopharmaceutics Classification System (BCS) class II compound whose oral bioavailability is highly limited owing to its poor aqueous solubility. Several polymorphs of celecoxib have been identified as Form I, Form II, and Form III with melting points of about 162.8 °C, 161.5 °C, and 160.8 °C, respectively. Form IV was generated from the precipitated suspension in the presence of HPMC (Hydroxypropyl methylcellulose) and Polysorbate 80. A rapid rate of dissolution is useful because the rate of dissolution of a drug typically increases its bioavailability. The aim of this study was to investigate the possibility of production of new crystal form of celecoxib that has higher solubility than Form III. New crystal form of celecoxib (Form A) has been isolated by recrystallization and characterized by differential scanning calorimetry (DSC), thermogravimetric (TG) analysis and powder X-ray diffractometry (PXRD). Form A was dissolved faster than Form III. At 30 minutes, the dissolution of Form A was 97.3%, whereas the dissolution of Form III was 82.2% (p < 0.1). After storage of three months at 20 °C, in 24% RH (Relative Humidity), the crystal form was not transformed.

따로 밤을 지낸 후

진미령 샘터사 1997 월간 샘터 Vol.28 No.2

코로나 팬데믹 이후 한국-멕시코 교역 활성화에 관한 연구: 주요 산업과 진출 방향 모색

진미령,윤준모 사단법인 한국융합기술연구학회 2024 아시아태평양융합연구교류논문지 Vol.10 No.2

Mexico's strategic location to the south of the United States, the largest market in the world, has allowed it easy access to the North American market. It has also diversified its commerce by establishing Free Trade Agreements (FTA) with other nations. Historically, Mexico's manufacturing sector was built on the North American Free Trade Agreement (NAFTA). Today, through the United States-Mexico-Canada Agreement (USMCA) program, Mexico serves as a manufacturing base in North America and attracts foreign capital investment due to its superior technology, lower labor and logistics costs than rival nations, and superior technological capabilities. South Korea imports crude oil, mineral resources, auto parts, steel, semiconductors, and display modules from Mexico and exports auto parts, steel, car components, and medical diagnostic devices to Mexico. The two countries have held several negotiations to establish economic cooperation and FTA but without any success. This study examines commerce after the COVID-19 Pandemic between South Korea and Mexico, the country's biggest trading partner in Latin America. By examining Mexico's main industries and the economic policy framework of the current Mexican government, this paper suggests ways for Korea to enter the Mexican industry and market in the areas of vehicle manufacturing, semiconductor cluster development, and mining development. 멕시코는 세계 최대 시장인 미국의 남쪽에 자리 잡고 있으며, 이런 지정학적 특징으로 북미 시장 진출이 용이하다는 이점을 가졌고, 세계 다수 국가와 FTA를 체결해 무역을 다각화했다. 과거 북미자유무역협정 NAFTA를 바탕으로 제조업이 발달해 우수한 기술력을 보유하고 경쟁국에 비해 값싼 인건비, 물류비를 앞세워 오늘날 USMCA 프로그램을 통해 북미 제조 산업 기지 역할을 하며 해외 자본 투자를 이끌고 있다. 한국은 멕시코에 자동차 부품, 철강, 반도체, 디스플레이 모듈 등을 수출하고 있고, 멕시코에서 원유, 광물자원, 자동차 및 부품, 의료진단기기를 수입하고 있다. 양국은 경제협력과 자유무역협정 체결을 위해 여러 차례 협상을 진행했으나 성과를 거두지는 못했다. 본 논문은 우리나라의 중남미 최대 무역국 멕시코의 교역 현황과 팬데믹 이후 한국과의 교역 현황 및 내용을 살펴보고 멕시코 주력산업과 멕시코 현 정부의 경제 정책 기조를 고찰하여 향후 운송수단 제조 산업, 반도체 클러스터 육성, 광산개발 산업 분야로의 멕시코 산업 및 시장 진출 방향과 협력 방안을 제시하였다.

동물매개치료 프로그램이 지적장애 청소년의 정서지능, 사회성 및 주관적 안녕감에 미치는 영향

진미령 ( Meiling Chan ),김윤주 ( Yoonjoo Kim ) 사단법인 아시아문화학술원 2021 인문사회 21 Vol.12 No.5

본 연구의 목적은 동물매개치료 프로그램이 지적장애 청소년의 정서지능, 사회성 및 주관적 안녕감에 미치는 영향을 검증하는 데 있다. 이를 위하여 서울시에 위치한 일반 중학교의 특수학급과 사회복지시설을 이용한 지적장애 중학생을 대상으로 무선할당하여 치료집단 30명과 통제집단 30명을 배정하였다. 프로그램은 주 1회, 60분씩 총 8회기에 걸쳐 진행되었고 통계적 분석 방법으로 SPSS 25.0을 사용하였다. 측정도구로는 정서지능, 사회적 기술 및 주관적 안녕감 척도를 사용하였고, 사전·사후에 설문지를 실시하였다. 통계분석은 두 집단의 치료효과 양상을 비교하기 위해 반복측정 변량분석(repeated measure, ANOVA)을 실시하였다. 연구 결과는 치료집단의 정서지능, 사회성 및 주관적 안녕감에서 유의미한 차이가 나타났다. 본 연구에서 동물매개치료 프로그램을 통해 얻은 동물과의 유대관계가 지적장애 청소년의 정서지능, 사회성 및 주관적 안녕감에 긍정적인 영향을 미친 것으로 확인이 되었고 향후 지적장애 청소년을 대상으로 한 동물매개치료 프로그램을 연구할 때 유용하게 활용할 수 있는 기초자료가 된다는 것에 의의가 있다. In this study, we investigated how animal assisted therapy (AAT) program affects on emotional intelligence, sociality and subjective well-being of adolescents with intellectual disabilities. The participants of study were randomly assigned by 30 treatment group and 30 control group who were in special classes of the middle school and using social welfare facilities in Seoul. The AAT program was conducted 8 sessions and an hour per session. The treatment group and control group for effect verification were analyzed by performing the emotional intelligence scale, the social skills ration system, concise measure of subjective well-being were measured before and after the fact. SPSS 25.0 was used as a statistical analysis for data processing and in order to compare the interaction effects of two groups, a repeated measure ANOVA was conducted. As a result, significant differences were found in the emotional intelligence, sociality and subjective well-being of treatment group. Through this study, we confirmed that the intimate relationship with animal acquired by animal assisted therapy had a positive effect on emotional intelligence, sociality and subjective well-being in adolescents with intellectual disabilities and this study is meaningful in that can be used on a basic data when studying the effectiveness of animal assisted therapy programs for the adolescents with intellectual disabilities.

상지 단순반복 작업자의 수근관증후군에 대한 연구

진미령,최용휴,이세휘,김규상 大韓産業醫學會 1998 대한직업환경의학회지 Vol.10 No.4

The objectives of this study were to investigate the prevalence and risk factors of occupationally related carpal tunnel syndrome(CTS) among workers employed in services and manufacturing industries analysing the sensitivity and specificity of clinical symptoms and signs. Three surveys were made for this study. The first survey was done for 1,447 workers employed by 25 companies. The jobs of the employees were repetitive works at VDT and assembly lines. Therefore, employees could be divided to two groups, doing repetitive works and non repetitive works. The second survey was made for 189 workers who were randomly selected from 517 workers complained some symptoms at their hands and wrists. We examined their symptoms and carried out neurological examinations for CTS(Tinel's sign, Phalen's sign, pin prick test, carpal compressive test, toniquet compression test). The third survey was made for nerve conduction study(NGS) for 57 workers who had shown positive signs for CTS. The main results of this study were as follow: 1. From the first survey, we have found that there were significant statistical differences in getting uncomfortable neuromuscular symptoms by sex, job type, total working hours during a week, duration of current work, and kinds of work. Odds ratio in male vs female, repetitive vs non repetitive, service vs manufacturing companies, total working hours during a week, and duration of current work were 1.867(95% CI=1.467-2.377), 1,680(95% CI=1.121-2.279), 1.663(95% CI=1.123-2.279), 1.016(95% CI=1.006-1.027) and 1.283(95% CI=1.097-1.501) respectively. 2. From the second survey, we have found that 46 peoples (25.0%) were positive for one or more than one signs in neurological examination of NIOSH criteria. Positive findings from neurological examinations were high among workers of low level of education(p-value=0.008), manufacturing jobs(p-value=0.00), long hours a week(p-value=0.028), and long duration of current work(p-value=0.00). 3. From the third survey, we diagnosed 35 peoples (61.4%) had CTS by NCS. They had abnormally delayed latent period or velocity in median nerve conduction velocity.

가수분해형 탄닌 1-desgalloylrugosin-F 에 의한 100kDa 세포질 포스포리파아제 A2 활성억제효과

진미령(Mi Reyoung Chin),신혜숙(Hye Sook Shin),정광묵(Kwang Mook Jung),강미선(Mi Sun Kang),이민원(Min Won Lee),김대경(Dae Kyong Kim) 대한약학회 2000 약학회지 Vol.44 No.1

To examine whether DGRF inhibits cPLA2 activity in vitro, we purified a 100kDa cPLA2 enzyme from porcine spleen and performed an inhibition study at two concentrations of 5.0 and 50.0mcM 1-stearoyl-2-[1-14C]arachidonoyl-sn-glycero-3-phosphocholine as a substrate to rule out an apparent inhibition due to "substrate depletion". Here we reported that DGRF inhibited cPLA2 activity with ID50 of 3.2mcM and virtually complete inactivation of the enzyme occurred at 60mcM. Interaction experiment between enzyme protein and inhibitor by ultrafiltration method indicated that 1-desgalloylrugosin-F inactivates cPLA2 enzyme by an irreversible mechanism.

화학기상응축법과 가스침탄에 의한 나노구조 WC-Co 복합분말의 제조

김진천,진미령,김병기 한국분말야금학회 2003 한국분말야금학회 학술대회논문집 Vol.2003 No.1

경수 손상 환자의 기능 회복

박창일,박은숙,진미령,강민정,우하정 大韓再活醫學會 1994 Annals of Rehabilitation Medicine Vol.18 No.2

심박변동의 Power Spectrum 분석에 의한 정상 성인의 자율신경기능 평가

전중선,전세일,조경자,진미령,김태선,김덕용,안준,정기삼,신근수 大韓再活醫學會 1997 Annals of Rehabilitation Medicine Vol.21 No.5