木浦地方의 안개發生特性

蘇鮮燮,全閏南,申弘烈 공주대학교 사범대학 과학교육연구소 1996 과학교육연구 Vol.27 No.1

안개는 수증기의 供給源인 바다, 호수, 강, 인공댐 및 태양 에너지의 입사량 변화로 發生하게 된다. 목포지방은 三面이 바다로 둘러 싸여 있으며, 주변의 造成된 영산강 댐과 2개의 人工 호수 때문에 안개 發生에 좋은 조건을 갖추고 있다. 본 硏究는 목포지방의 안개 發生 特性을 밝히기 위하여 안개 發生日數, 特續時間, 風向, 風速, 氣溫과 水溫의 偏差를 비교 分析하였다. 또한 안개의 發生 및 消散시각의 분포에 따라 4가지 Case로 분류하고 氣象要素의 變化에 따른 안개의 視程 변화를 分析해 본 결과 夏節期에는 따뜻하고 수증기를 많이 포함한 空氣가 찬 바다 위로 이동하면서 移流안개가 발생하고 봄·가을에는 氣溫의 日較差에 의해 輻射안개와 ??發안개가 複合的으로 나타난다. A fog is variously induced by the sea, the lake, the river, the artificial dam and the solar energy which originate the vapor. The Mokpo area is surrounded by the sea, the Youngsan river and the artificial lakes which naturally tend to cause a dense fog. This research shows the analogy and comparison to prove the traits of what made a fog in the Mokpo area; how many days a month the fog originates; how many hours it lasts, both the direction and the velocity of the wind, and the anomaly between atmos-pheric temperature and the sea-water temperature. The types of the fog occurrence and the dstribution of the fog-clearing time are classified into four cases. This research also tells that as a result, the change of the fogcl-earing speed brings those facts as follows: (i) when the air, warm and vaporous, is d-rifted away over the cold sea-water in the summertime; (ii) it makes the advection fog and in the season of spring and fall, it makes both the evaporation fog and the radiati-on fog at the same time, due to the great daily temperature difference. The fog in Mokpo area has high occurrence-frequency both when the velocity of the wind runs below 3 m/s and when the direction of the wind indicates NNW,NW,SSW,SSE, etc...

A rare ginsenoside compound K (CK) induces apoptosis for breast cancer cells

Seun Eui Kim,Myoung-Hoon Lee,Hye-Myoung Jang,Wan-Taek Im,Joontaik Lee,Sang-Hwan Kim,Gwang Joo Jeon The Korean Society of Animal Reproduction and Biot 2023 한국동물생명공학회지 Vol.38 No.3

Background: A breast cancer is the second leading cause of cancer death in women worldwide and among different types of breast cancers, triple-negative breast cancer (TNBC) has a poor prognosis. Methods: We investigated the potential of ginsenoside compound K (CK), an active ingredient in the bio-transformed ginsenoside, to be used as a therapeutic ingredient by examining the effects of CK on cell proliferation, apoptosis, and cancer-related gene expressions in breast cancer cells. Results: From the results of treating MCF-7, an ER and PR-positive breast cancer cells, and MDA-MB-231 (TNBC) with CK at a concentration of 0-100 µM, the half maximal inhibitory concentration (IC₅₀) values for each cell were 52.17 µM and 29.88 µM, respectively. And also, it was confirmed that cell migration was inhibited above the IC50 concentration. In addition, fluorescence analysis of Apoptosis/Necrosis showed that CK induced apoptosis rather than necrosis of breast cancer cells. Through qPCR, it was confirmed that the expression of genes related to apoptosis and cell cycle arrest was increased in CK-treated breast cancer cells, and it acted more effectively on TNBC. However, the expression of genes related to tumor invasion and metastasis is also increased, so it is necessary to consider the timing of application of CK as a potential therapeutic anticancer compound. Conclusions: CK showed a stronger inhibitory effect in TNBC with poor prognosis but considering the high tumor invasion and metastasis-related gene expression, the timing of application of CK should be considered.

Anticancer activity of ginsenosides Rh2 on various cancer cells

Seun Eui Kim,Myoung-Hoon Lee,Hye-Myoung Jang,Wan-Taek Im,Joontaik Lee,Sang-Hwan Kim,Gwang Joo Jeon The Korean Society of Animal Reproduction and Biot 2023 한국동물생명공학회지 Vol.38 No.3

Background: This study has mainly focused on finding pharmacological effects of ginsenosides that can reduce the unwanted side effects of the cytotoxic anticancer drugs and are highly effective on prostate cancer, colorectal cancer, liver cancer, hormone-dependent breast cancer, triple-negative breast cancer, and brain cancer (neuroblastoma). Methods: Minor and rare ginsenosides (GS) of Rh2 which have a high absorption ability and excellent pharmacological actions were treated with the 6 different types of cancer cell lines and their anticancer activities were investigated by analyzing gene expressions associated with various cancers through qPCR and other relevant methods. Results: In cancer cells exposed to Rh2, cell viability and cell migration were reduced, and apoptosis was induced. Each cancer cell was divided into three groups according to the cell proliferation response by Rh2; 1) A group in which the cell viability decreases inversely to an increase in Rh2 treatment concentration; 2) A group in which the cell viability rapidly decreases in Rh2 treatment above a certain level of concentration; 3) A group in which the cell viability was not suppressed below 20-30% even with 100 μL of Rh2, the highest concentration used in this study. Conclusions: It was shown that Rh2 has a significant effect on inhibiting the proliferation of prostate cancer cells and hormone-dependent breast cancer cells.

Impact of parathyroidectomy on allograft outcomes in kidney transplantation

Jeon, Hee Jung,Kim, Yoon Jung,Kwon, Hyuk Yong,Koo, Tai Yeon,Baek, Seon Ha,Kim, Hyo‐,Jin,Huh, Woo Seong,Huh, Kyu Ha,Kim, Myoung Soo,Kim, Yu Seun,Park, Su‐,Kil,Ahn, Curie,Yang, Jaeseok Blackwell Publishing Ltd 2012 Transplant international Vol.25 No.12

<P><B>Summary</B></P><P>We performed retrospective, multi‐center study of the impacts of parathyroidectomy (PTX) after or before kidney transplantation on allograft outcomes. A total of 63 patients who underwent PTX after kidney transplantation were identified. Deterioration in eGFR by more than 25% at 1 month after PTX occurred in 20% of the patients. The baseline eGFR was significantly lower in impairment group than nonimpairment group [adjusted odds ratio (OR) 0.87, 95% confidence interval (CI) 0.77–0.99, <I>P </I>= 0.033]. Low iPTH concentration after PTX was also a significant risk factor for the renal impairment (OR 0.96, CI 0.94–0.99, <I>P</I> = 0.009). A total of 37 patients who underwent PTX before transplantation were identified. Thirty‐six percent of the patients had persistent hyperparathyroidism by 1 year after transplantation. A high iPTH level before PTX was a significant risk factor for persistent post‐transplant hyperparathyroidism (adjusted OR 1.002, CI 1.000–1.005, <I>P</I> = 0.039). Finally, eGFR values during the first 5 years after transplantation were significantly lower in the patients who underwent PTX at less than 1 year after transplantation, than the pretransplant PTX patients (<I>P</I> = 0.032). As PTX after kidney transplantation has a risk of deterioration of allograft function, pretransplant PTX should be considered for patients with severe hyperparathyroidism, who could undergo post‐transplant PTX.</P>

Bioactivity and Chemical Composition of the Essential oil of Tea Tree (Melaleuca alternifolia)

Seun-Ah Yang(양선아),Sang-Kyung Jeon(전상경),Eun-Jung Lee(이은정),Nam-Kyung Im(임남경),Ji-Young Jung(정지영),In-Seon Lee(이인선) 한국생명과학회 2008 생명과학회지 Vol.18 No.12

티트리 에센셜 오일은 호주 원주민들의 전통적인 피부 소독제나 치료제로 널리 사용되어 왔으며, 항균효과와 주요성분 등 많은 보고가 있으나 추출 방법이나 사용 부위 등에 따라 효능의 차이를 보인다. 본 연구에서는 아로마테라피 등에 현재 많이 이용되고 있는 시판 티트리 오일의 성분과 효능을 평가하여, 다른 에센셜 오일과의 비교 이용을 용이하게 하고자 하였다. 티트리 오일의 주요성분은 GC-MS 분석에 의하여 β-terpinene (20.87%), α-pinene (17.60%), p-cymene (11.23%), 3-carene (10.40%), trans-anethole (8.47%), limonene (4.65%)으로 밝혀졌으며, 5% 이하의 농도에서 3시간 미만까지는 피부세포에 독성이 없었다. 오일의 라디컬 소거능을 알아본 결과, DPPH와 ABTS의 양라디컬에 대하여 강한 소거능을 나타내어 강한 항산화능을 시사했다. 또한, 오일의 direct contact와 vapor-phase의 항균활성을 disc diffusion법으로 스크리닝 한 결과, direct contact 활성의 경우 그람음성균에 대하여 높은 활성을 나타내었으며, vapor는 S. aureus에 대하여 강한 효과를 나타내었다. 본 연구에서 실제 많이 사용되는 티트리 오일의 성분과 생물활성을 측정함으로써 허브 오일들의 정확한 선택과 활용을 위한 기본적인 결과를 얻었다. The essential oil of tea tree (Melaleuca alternifolia) is widely used in traditional Australian medicine for skin lesions and infected injuries. In the present study, we investigated the chemical composition, cytotoxicity and its biological activities. The composition of the oil was analyzed by GC-MS. β-Terpinene (20.87%), α-pinene (17.60%), p-cymene (11.23%), 3-carene (10.40%), trans-anethole (8.47%) and limonene (4.65%) were the major components in the oil. The results tested by MTT assay indicated that the oil showed no cytotoxic effect, at concentrations up to 5%, for less than 3h. The antiradical capacity was evaluated by measuring the scavenging activity of the essential oil on the 2,20-diphenylpicrylhydrazyl (DPPH) and 2,2'-azino-bis 3-ethyl benzothiazoline-6-sulfonic acid (ABTS) radicals. The oil was able to reduce the both radicals dose-dependently, and the concentration required for 50% reduction (RC??) against ABTS radicals (1.6±0.02%) was slightly lower than DPPH radicals (2.6±0.29%). The direct contact and vapor-phase antibacterial activity of the oil were also evaluated using disc diffusion method against Staphylococcus aureus, Streptococcus mutans, Listeria monocytogenes, Acinetobacter baumannii, Escherichia coli, and Vibrio parahaemolyticus. All the Gram-negative bacterial strains tested showed more sensibility to the oil than the Gram-positive strains when compare to the effect of gentamycin. On the other hand, the vapor phase of the essential oil against S. aureus exhibited strongest inhibitory effect.

Radical Scavenging Activity of the Essential Oil of Silver Fir ( <i>Abies alba</i> )

Yang, Seun-Ah,Jeon, Sang-Kyung,Lee, Eun-Jung,Im, Nam-Kyung,Jhee, Kwang-Hwan,Lee, Sam-Pin,Lee, In-Seon the Society for Free Radical Research Japan 2009 Journal of clinical biochemistry and nutrition Vol.44 No.3

<P>The essential oil of silver fir (<I>Abies alba</I>) is known to help respiratory system and have easing and soothing effect for muscle. In the present study, we investigated the chemical composition, cytotoxicity and its biological activities of silver fir (<I>Abies alba</I>) essential oil. The composition of the oil was analyzed by GC-MS and bornyl acetate (30.31%), camphene (19.81%), 3-carene (13.85%), tricyclene (12.90%), dl-limonene (7.50%), α-pinene (2.87%), caryophyllene (2.18%), β-phellandrene (2.13%), borneol (1.74%), bicyclo[2.2.1]hept-2-ene,2,3-dimethyl (1.64%) and α-terpinene (1.24%) were the major components in the oil. The results tested by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay indicated that the oil showed no cytotoxic effect, at concentrations of 1 and 5%, for as long as 24 and 3 h, respectively. The antiradical capacity was evaluated by measuring the scavenging activity of the essential oil on the 2,20-diphenylpicrylhydrazyl (DPPH) and 2,2'-azino-bis 3-ethyl benzothiazoline-6-sulfonic acid (ABTS) radicals. The oil was able to reduce the both radicals dose-dependently, and the concentration required for 50% reduction (RC<SUB>50</SUB>) against DPPH radicals (2.7 ± 0.63%) was lower than ABTS radicals (8.5 ± 0.27%). The antibacterial activity of the oil was also evaluated using disc diffusion method against <I>Staphylococcus aureus</I>, <I>Streptococcus mutans</I>, <I>Listeria monocytogenes</I>, <I>Acinetobacter baumannii</I>, <I>Escherichia coli</I>, and <I>Vibrio parahaemolyticcus</I>. The oil exhibited no antibacterial activity against all the bacterial strains tested except <I>S. aureus</I> of mild activity.</P>

回轉水槽에서 나타나는 傾壓不安定波의 內部構造

소선섭(Seun-Seup So),신홍렬(Hong-Ryeol Shim),김명환(Myoung-Hwan Kim),윤성석(Sung-Suk Yun),손정호(Jeong-Ho Son),윤진석(Jin-Seok Yoon),진수광(Su-Kwang Jin),전창근(Chang-Koun Jeon) 한국기상학회 1997 Asia-Pacific Journal of Atmospheric Sciences Vol.33 No.4

라벤더, 실버퍼, 그레이프후룻 정유 흡입이 마우스의 구속 스트레스에 미치는 효과

양선아(Seun-Ah Yang),전상경(Sang-Kyung Jeon),이은정(Eun-Jung Lee),임남경(Nam-Kyung Im),심창현(Chang-Hyun Shim),이인선(In-Seon Lee) 한국생명과학회 2010 생명과학회지 Vol.20 No.8

천연 허브에서 추출된 정유의 스트레스 완화능이 알려지면서 화장품, 식품 산업뿐 아니라 다양한 기능성 제품에 활용되고 있다. 본 연구에서는 정유 향 흡입의 스트레스 완화 효과에 대한 과학적인 근거를 마련하기 위하여 마우스의 구속 스트레스에 대한 3가지 정유의 흡입 효과를 비교 하였다. 마우스를 1시간 구속한 경우 혈청 코티졸 농도의 유의적인 상승, 체온의 저하 및 혈중 중성지질의 상승을 확인하였으며, 10% 라벤더 오일을 30분간 흡입 한 경우, 혈청 코티졸 농도 상승 및 체온 저하가 유의적으로 억제되어 스트레스 완화 효과가 가장 좋았다. 한편 혈중 중성지질의 증가 억제효과는 실버퍼 오일 흡입에서 유의적으로 감소하였다. 본 연구에서는 폭넓게 사용되는 정유를 이용하여 정유 향 흡입의 스트레스 완화 효과를 측정 함으로서 앞으로의 연구와 활용에 대한 기본적인 과학적 근거를 마련하였다. The effects of inhaling three essential oils (lavender [Lavendular angustifolia], silver fir [Abies alba], and grapefruit [Citrus paradise]) against restraint stress were investigated in mice. Serum cortisol levels were significantly increased in the 1h-restraint group. Also, silver fir and grapefruit oils prevented the elevation of cortisol levels under experimental conditions. Inhalation of 10% lavender oil for 30 min before inducing stress significantly inhibited restraint-induced hypothermia. We also investigated the effects of restraint stress on triglycerides, total cholesterol, and high-density lipoprotein cholesterol. It was found that the concentration of triglycerides in the serum samples increased after restraint stress. Silver fir essential oil inhibited elevation of triglyceride levels. Taken all together, the correlation of herb essential oil inhalation against restraint stress in animals can partly be explained.

Comparative study of the chemical composition and antioxidant activity of six essential oils and their components

Yang, Seun-Ah,Jeon, Sang-Kyung,Lee, Eun-Jung,Shim, Chang-Hyun,Lee, In-Seon Taylor Francis 2010 Natural product research Vol.24 No.2

<P> The antioxidant activities and the determined major components of six popular and commercially available herb essential oils, including lavender (Lavendular angustifolia), peppermint (Mentha piperita), rosemary (Rosmarius officinalis), lemon (Citrus limon), grapefruit (Citrus paradise), and frankincense (Boswellia carteri), were compared. The essential oils were analysed by GC-MS and their antioxidant activities were determined by testing free radical-scavenging capacity and lipid peroxidation in the linoleic acid system. The major components of the essential oils of lavender, peppermint, rosemary, lemon, grapefruit, and frankincense were linalyl acetate (28.2%), menthol (33.4%), 1,8-cineole (46.1%), limonene (64.5 and 94.2%), and p-menth-2-en-ol (34.5%), respectively. The highest DPPH radical-scavenging activity was obtained by the lavender essential oil and limonene, with RC50 values of 2.1 ± 0.23% and 2.1 ± 0.04%, respectively. Radical-scavenging activity against the ABTS radical was highest in peppermint essential oil (1.6 ± 0.09). Lavender oil was most effective for inhibiting linoleic acid peroxidation after 10 days.</P>

급성신우신염 환자에서 균혈증의 위험 인자 분석 -단일기관 분석-

황선덕 ( Seun Duk Hwang ),박경석 ( Kyoung Suk Park ),전병수 ( Byung Soo Jeon ),김윤지 ( Yoon Ji Kim ),이상헌 ( Sang Hun Lee ),이꽃실 ( Kkot Sil Lee ),윤수영 ( Soo Young Yoon ),이상철 ( Sang Choel Lee ) 대한신장학회 2009 Kidney Research and Clinical Practice Vol.28 No.5

Purpose: Acute pyelonephritis (APN) is among the most common infectious diseases. Most APN occurs in young women and easily treated. Bacteremia has been associated in approximately 20-30% of those with APN. But recent documents demonstrated that blood cultures provide no useful information toward the clinical management of acute pyelonephritis. Thus we compared demographic and clinical characteristics as related to the bacteremic status, and investigated the risk factors for bacteremia. Methods: One hundred sixty five patients, who visited myongji hospital for APN from January, 2004 to December, 2006 were included. Retrospective data were analyzed by medical record review. Results: Bacteremic patients (N=51, 30.9%) were significantly older than those in nonbacteremic group (p<0.0001), had elevated serum creatinine (p=0.008), decreased platelet counts (p=0.029), lower serum protein (p=0.010), and lower serum albumin (p=0.011) than those without bacteremia. Hematuria was more severe in bacteremic patients (p<0.0001). The bacteremic cases were observed more frequently in patients with complicated APN patients than uncomplicated patients (46.7% vs. 21.4%, p=0.001). No significant difference existed between the bacteremic and non-bacteremic patients in the prevalence of resistance to quinolone of E. coli. In multivariate logistic regression analysis, serum albumin (p=0.023), hematuria (p=0.003), and age (p=0.003) at presentation were found to be independent risk factors for bacteremia in acute pyelonephritis. Conclusion: Our study reveals that patients with bacteremia have different clinical characteristics compared to those without bacteremia. It is recommended to concern about the presence of bacteremia in the treatment of APN.