http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Hyun Woo Goo,Dong Hun Kim,Seoung Soo Lee,Sung Bin Park,Tae-Hwan Lim 대한영상의학회 2002 Korean Journal of Radiology Vol.3 No.4
Objective: To determine whether the size of a perfusion defect seen at myocardial perfusion MR imaging represents the extent of irreversibly damaged myocardium in acute reperfused myocardial infarction. Materials and Methods: In nine cats, reperfused myocardial infarction was induced by occlusion of the left anterior descending coronary artery for 90 minutes and subsequent reperfusion for 90 minutes. At single-slice myocardial perfusion MR imaging at the midventricular level using a turbo-FLASH sequence, 60 short-axis images were sequentially obtained with every heart beat after bolus injection of gadomer-17. The size of the perfusion defect was measured and compared with both the corresponding unstained area seen at triphenyl tetrazolium chloride (TTC) staining and the hyperenhanced area seen at gadophrin-2-enhanced MR imaging performed in the same cat six hours after myocardial perfusion MR imaging. Results: The sizes of perfusion defects seen at gadomer-17-enhanced perfusion MR imaging, unstained areas at TTC staining, and hyperenhanced areas at gadophrin-2-enhanced MR imaging were 20.4±4.3%, 29.0±9.7%, and 30.7±10.6% of the left ventricular myocardium, respectively. The perfusion defects seen at myocardial perfusion MR imaging were significantly smaller than the unstained areas at TTC staining and hyperenhanced areas at gadophrin-2- enhanced MR imaging (p < .01). The sizes of both the perfusion defect at myocardial perfusion MR imaging and the hyperenhanced area at gadophrin-2-enhanced MR imaging correlated well with the sizes of unstained areas at TTC staining (r = .64, p = .062 and r = .70, p = .035, respectively). Conclusion: In this cat model, the perfusion defect revealed by myocardial perfusion MR imaging underestimated the true size of acute reperfused myocardial infarction. The defect may represent a more severely damaged area of infarction and probably has prognostic significance.
Lee, Janggeon,Hwang, Sunbin,Lee, Seoung-Ki,Ahn, Seokhoon,Jang, Se Gyu,You, Nam-Ho,Kim, Chae Bin,Goh, Munju Elsevier 2019 Polymer Vol.179 No.-
<P><B>Abstract</B></P> <P>Shape, size, and orientation of fillers within polymer matrix are important factors for realizing various composite functionalities. Here, we describe an industrially scalable approach to preparing composites bearing highly aligned model hexagonal boron nitride filler (<I>h</I>BN) by simple melt-pressing. This outcome is achieved by using a malleable but thermal stiffening polymer matrix. The matrix maintains or even increases its stiffness during processing at elevated temperatures, producing the composites with highly aligned <I>h</I>BN and consequently a high thermal conductivity (28 W/mK). Furthermore, the composite bearing aligned <I>h</I>BN exhibits a 62% reduction in oxygen permeation with only 2.7 vol% of <I>h</I>BN. Since the matrix can be chemically depolymerized with an aid of acid, it is also possible to recover the <I>h</I>BN from the composite without physical/chemical denaturation of the filler, thus the recovered filler can be re-used in the future.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A malleable but thermal stiffening polymer was used as matrix to produce the composites with highly shear aligned <I>h</I>BN. </LI> <LI> The composite exhibited exceptionally high isotropic thermal conductivity of 28 W/mK. </LI> <LI> The composite bearing highly aligned <I>h</I>BN exhibits a 62% reduction in oxygen permeation with only 2.7 vol% of the <I>h</I>BN. </LI> <LI> The filler could be recovered from the composite by depolymerizing the matrix, thus the filler is readily reusable. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Hong, Seong-Bin,Uhm, Wook-Hyun,Joo, Woo-Chul,Nam, Moon-Suk,Lee, Seoung-Woo,Song, Joon-Ho The Korean Society of Toxicogenomics and Toxicopro 2010 Molecular & cellular toxicology Vol.6 No.2
Alpha-lipoic acid (ALA) is a natural antioxidant that scavenges reactive oxygen species (ROS) and regenerates endogenous antioxidants. In the present study, plasma molecular markers of oxidative stress, inflammatory state, and endothelial cell injury was measured to investigate the effect of simultaneous blocking of both angiotensin (AT) II-and oxidative stress-mediated pathophysiologic pathways during the course of type II diabetic nephropathy in the clinical settings. Sixty-three diabetic subjects have carried out either of 12-month treatment course of AT-II receptor blocker (ARB) alone, ALA alone, or combination of both. Plasma malondialdehyde (MDA) level, a marker for oxidative stress, increased in ARB alone group whereas reduced to significantly lower level in ALA+ARB combination group. Plasma hs-CRP level, an inflammatory marker, decreased significantly in ARB+ALA group. Plasma thrombomodulin (TM) level, a marker of endothelial cell injury, increased in both ARB and ALA group. Twenty-four hour urinary protein excretion, as a marker of renal injury, decreased in ARB and ARB+ALA group. Finally, renal function was reserved well in ARB+ALA group in compared to others. The combined administration of ALA and ARB additively attenuated or reduced plasma markers of oxidative stress, inflammation and endothelial cell injury for one year. It suggests that the benefits in attenuating atherogenic process and vascular injury retard the progression of renal dysfunction.
참여 기반의 문화콘텐츠 개발 사례 분석 및 활성화 방안
나윤빈(Yun-Bin Na),권혁인(Hyeog-In Kwon),이승하(Seoung-Ha Lee) 한국콘텐츠학회 2014 한국콘텐츠학회논문지 Vol.14 No.2
오늘날 국내 다문화 사회는 동화에서 융화의 방향으로 인식의 전환이 요구되고 있다. 이와 같은 패러다임 은 서로 다른 문화적 배경에 대한 이해를 전제로 하며, 이질적인 그룹 간 이해와 인정의 연결고리로서 문화 콘텐츠의 역할이 어느 때보다 중요해지고 있다. 이러한 문화콘텐츠는 다문화 구성원 스스로가 프로젝트에 참여하여 개발할 때 그 효과가 높아질 수 있으며 사회적 의의에도 부합할 수 있다. 본 연구는 결혼이민자를 중심으로 한 외국인 그룹과 일러스트레이터, 동화작가 등 내국인 그룹과의 협력을 통해 콘텐츠를 제작한 다문화콘텐츠기획팀 ‘알토플라코’의 프로젝트 사례를 분석하고자 한다. 각 프로젝트는 공연, 전시, 앱북 등의 콘텐츠로 나타났으며 구체적으로 사례 선정 및 소개, 콘텐츠의 기획?개발, 평가, 활성화 방안 등을 살펴 보았다. Domestically multicultural society is being demanded a change in recognition today into the direction of harmony from assimilation. This change in paradigm is having a proposition as understanding about mutually different cultural background. A role of cultural contents is getting important more than ever as a link of understanding and recognition between heterogeneous groups. These cultural contents can be enhanced its effect when being developed on the basis of cooperation by which the multi-cultural members themselves participate in a project, and can conform even with social significance. The purpose of this study is to analyze a project case of a multicultural contents planning team Arto Placo, which produced contents through cooperation between a foreigner group including marriage immigrants and a local group such as illustrator and childrens book writer. Each project was indicated to be contents such as public performance, exhibition, ad APP book. The aim was to specifically examine Case Selection and Introduction, Contentss Planning?Development, Assessment and Activation plan.
키워드를 기반으로 마이너와 코사인 유사도를 이용한 컴퓨터 네트워크 관련 컨퍼런스 분석
권영빈(Young-Bin Kwon),이승도(Seoung-Do Lee),양현(Hyun Yang),주요한(Yo-Han Joo) 한국IT서비스학회 2012 한국IT서비스학회지 Vol.11 No.1
We have been provided with a plenty of information about IT through the conferences. However, it is hard to find enough information or the latest trends from conferences because there are too many conferences. In this situation, we analyzed the latest trends related to the field of IT by exploiting the Netminer which is one of the software for analysis of social networks and measuring the Cosine Similarity between conferences, based upon keywords which are included in the conferences. We analyzed keywords of 24 conferences related to the computer network part of the IEEE (Institute of Electrical and Electronics Engineers) in the case of foreign conferences. We also analyze keywords of the KIISE (Korean Institute of Information Scientists and Engineers) conferences in the case of domestic conferences, during 2009-2010. We identified the trends through the frequency of keywords, the change of top 10 keywords ranking and the similarity between conferences.
Jia, Lina,Lee, Hun Seok,Wu, Chun Fu,Kundu, Juthika,Park, Sang Gyu,Kim, Ryong Nam,Wang, Li-Hui,Erkin, Ö,zgü,r Cem,Choi, Jong-Sun,Chae, Seoung Wan,Yang, Ho Bin,Choi, Yoon-La,Shin, Young Kee American Association for Cancer Research 2014 Molecular Cancer Research Vol.12 No.12
<P>SMAD4 has been suggested to inhibit the activity of the WNT/β-catenin signaling pathway in cancer. However, the mechanism by which SMAD4 antagonizes WNT/β-catenin signaling in cancer remains largely unknown. Aurora A kinase (AURKA), which is frequently overexpressed in cancer, increases the transcriptional activity of β-catenin/T-cell factor (TCF) complex by stabilizing β-catenin through the inhibition of GSK-3β. Here, SMAD4 modulated AURKA in a TGFβ-independent manner. Overexpression of SMAD4 significantly suppressed AURKA function, including colony formation, migration, and invasion of cell lines. In addition, SMAD4 bound to AURKA induced degradation of AURKA by the proteasome. A luciferase activity assay revealed that the transcriptional activity of the β-catenin/TCF complex was elevated by AURKA, but decreased by SMAD4 overexpression. Moreover, target gene analysis showed that SMAD4 abrogated the AURKA-mediated increase of β-catenin target genes. However, this inhibitory effect of SMAD4 was abolished by overexpression of AURKA or silencing of AURKA in SMAD4-overexpressed cells. Meanwhile, the SMAD4-mediated repression of AURKA and β-catenin was independent of TGFβ signaling because blockage of TGFβR1 or restoration of TGFβ signaling did not prevent suppression of AURKA and β-catenin signaling by SMAD4. These results indicate that the tumor-suppressive function of SMAD4 is mediated by downregulation of β-catenin transcriptional activity via AURKA degradation in a TGFβ-independent manner.</P><P><B>Implications:</B> SMAD4 interacts with AURKA and antagonizes its tumor-promoting potential, thus demonstrating a novel mechanism of tumor suppression. <I>Mol Cancer Res; 12(12); 1779–95. ©2014 AACR</I>.</P>