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Feasibility assessment of longevity swap for the Korean life annuity market
Lee, Changsoo,Hong, Jimin,Kim, Seongmin The Korean Statistical Society 2021 Communications for statistical applications and me Vol.28 No.6
This study analyzes the premium risk of insurers in Korea, which is expected to experience the fastest population aging in the world. Based on the Lee-Carter model, we generate 10,000 scenarios for the number of future survivors in the group of the 10,000 policyholders of life annuity. According to the result of simulation study, the probability of insurer's loss for both groups of male and female policyholders is very low. This result indicates that the premium risk of insurers is not as great as the insurer's concern. This study also suggests introduction of the longevity swap as an alternative to manage the premium risk for the insurer which sells life annuity products. The longevity swap allows insurers to hedge premium risk and reduce capital burden due to the premium risk inherent in life annuity. This study also shows through examples that the counterparty of swap deal may have excess profit in exchange for taking premium risk.
이성민 ( Seongmin Lee ),조병효 ( Byeong-hyo Cho ),이강진 ( Kangjin Lee ),홍영기 ( Youngki Hong ),이기범 ( Ki-beom Lee ),김경철 ( Kyoung-chul Kim ) 한국농업기계학회 2023 한국농업기계학회 학술발표논문집 Vol.28 No.1
최근 온실 자동화에 대한 요구가 증가함에 따라 온실에 로봇을 적용하기 위한 연구가 활발히 수행되고 있다. 이를 위해 우선 작물의 품질이나 성숙도 등을 모니터링할 수 있는 기술이 필요하며, 디지털 영상 이외에도 초분광 영상과 같은 광학적 방법을 적용하여 작물을 모니터링하기 위한 시도가 이루어지고 있다. 그러나 초분광 영상은 조명에 크게 의존하며 저조도의 환경에서는 안정적인 데이터의 수집이 어렵다(Tang et al. 2023.). 특히 온실의 경우 자연광에 대한 의존도가 높아 안정적인 초분광 영상 취득이 어렵다. 따라서 본 연구에서는 향후 온실에서 안정적인 초분광 영상을 취득하기 위해 적정한 광 조건을 제시하고자 하였다. 보조광의 강도 및 거리에 따른 초분광 영상의 차이를 조사하기 위해 암실 조건에서 초분광 영상을 취득하였다. 초분광영상 취득을 위해 400-1,000 nm 밴드 영역을 제공하는 휴대용 초분광 카메라(SPECIM IQ, Oulu, Finland)를 이용하였으며, 보조광은 Light Bank (LS-F100HS, Shinkawa, Tokyo, Japan)를 사용하였다. 조명은 카메라 좌우 측면에 각각 설치하였고, 보조광의 강도 및 거리를 조절하여 95% 백색 표준판을 촬영하였다. 표준판과 조명의 거리는 세 단계(230mm, 260 mm, 295 mm), 광원의 강도는 여섯 단계(4.17-8.33 A)로 하여 실험을 진행하였다. 영상 취득 후 백색 표준판영역의 반사율만을 추출하여 분광 특성을 비교하였다. 그 결과, 모든 조건에서 Visible 영역의 스펙트럼이 안정적이었지만 상대적으로 NIR 영역에서는 노이즈가 나타났다. 그러나 보조광의 거리가 260 mm, 광원의 강도는 6.67 A 조건이 NIR 영역에서 상대적으로 노이즈가 적게 나타났다. 따라서 보조광의 강도 및 거리를 고려해야 안정적인 분광 정보를 얻을 수 있음을 확인하였다. 이를 기반으로 추후 실제 온실 환경에서 초분광 영상을 위해 보조광을 적용한 실험을 진행할 계획이다.
Elevated Galectin-10 Expression of IL-22-Producing T Cells in Patients with Atopic Dermatitis
Noh, Seongmin,Jin, Shan,Park, Chang Ook,Lee, Yun Sun,Lee, Nara,Lee, Jungsoo,Shin, Jung U.,Kim, Seo Hyeong,Yun, Ki Na,Kim, Jin Young,Lee, Kwang Hoon Elsevier 2016 The Journal of investigative dermatology Vol.136 No.1
고체적률 TiB<sub>2</sub>-Al1050 금속복합재료의 미세조직 및 기계적 특성 연구
고성민 ( Seongmin Ko ),박현재 ( Hyeonjae Park ),이영환 ( Yeong-hwan Lee ),신상민 ( Sangmin Shin ),이동현 ( Donghyun Lee ),조일국 ( Ilguk Jo ),이상복 ( Sang-bok Lee ),이상관 ( Sang-kwan Lee ),조승찬 ( Seungchan Cho ) 한국복합재료학회 2019 Composites research Vol.32 No.1
본 연구에서는 액상가압성형공정을 이용하여 고체적률 TiB2 입자가 균일하게 분산된 알루미늄 복합재료를 제조하고 미세조직과 기계적 물성을 분석하였다. 제조된 알루미늄 복합재료 내에 TiB2는 약 56 Vol.% 존재하였으며 Al1050 기지재 내부에 TIB2 세라믹 강화재의 균일한 분산에 의한 분산강화 효과로 경도는 230.5 Hv로써 기지재(Al1050) 대비 약 10배, 인장강도는 306.4MPa로 약 4.5배, 압축항복강도는 581.7MPa로 약 9.8배 증가하였다. In this study, Al1050 composites reinforced with uniformly dispersed, high volume fraction TiB2 particles were fabricated by liquid pressing process and analyzed to microstructure, mechanical properties. Hardness, ultimate tensile strength and compressive yield strength of the 56 vol.% TiB2-Al1050 composite increased to 10, 4.5 and 9.8 times, respectively, compared with those of the Al1050 due to dispersion hardening effect of uniformly dispersed TiB2 in the Al matrix.
( Sae Mi Lee ),( Seongmin Kim ),( Kyung Jin Min ),( Sanghoon Lee ),( Jin Hwa Hong ),( Jae Yun Song ),( Jae Kwan Lee ),( Nak Woo Lee ) 대한산부인과학회 2020 대한산부인과학회 학술대회 Vol.106 No.-
Objective: Robotic single-site (RSS) surgery is being utilized in gynecologic surgery. However, its cost-effectiveness and limitations of the system make the application of the technique to benign surgery controversial. The aims of this study were to compare surgical outcomes of LESS and RSS surgeries for adnexal tumors and to investigate if RSS surgery is feasible for a patient with a benign adnexal mass. Methods: Patients who underwent ovarian cystectomy from January 2013 to December 2018 at Korea University Anam Hostital were divided into two groups according to the surgery: RSS or LESS. After exclusion of ineligible patients, 29 patients who underwent RSS surgery and 80 patients who underwent LESS surgery were included in this study. Surgical outcome data regarding bleeding, surgical time, length of stay, and the learning curves of surgical time were obtained using the cumulative sum method. Results: Patient demographics showed no differences between the groups except for tumor histology. There were no differences in bleeding, postoperative length of stay, surgical wound complication, or surgical preparation time between the groups. RSS surgery had a longer surgical time than LESS surgery (130.41 vs. 96.96 minutes; P<0.001). In a learning curve analysis, seven cases were required to be proficient in docking the RSS system. Comparing the learning curves of surgical time, RSS surgery required fewer cases to attain proficiency than LESS surgery (19 vs. 22 cases). Conclusion: In an analysis of the learning curve, the docking in RSS surgery did not require many cases to attain sufficient skills. In conclusion, RSS ovarian cystectomy is a feasible and safe option with the benefit of a quick learning curve. The longer surgical time could be overcome with further improvement of surgical techniques and development of the robotic instruments.
( Seongmin Kim ),( Kyung Jin Min ),( Sanghoon Lee ),( Jin Hwa Hong ),( Jae Kwan Lee ),( Nak Woo Lee ),( Jae Yun Song ) 대한산부인과학회 2018 대한산부인과학회 학술대회 Vol.104 No.-
Objective: Genomic analysis of circulating tumor cell-free DNA (cfDNA) represents a non-invasive method of assessing genomic alterations using peripheral blood. But its efficacy of clinical use in patients with ovarian cancer is not established yet. We compared the concordance of genomic alterations between cfDNA and tissue biopsies in patients with advanced ovarian cancer. Methods: 7 patients with advanced epithelial ovarian cancers were included, The cfDNA biopsy was done just before surgery, and the tumor tissue was obtained during surgery. Both samples were analyzed by next-generation sequencing. Concordance was defined as the presence or absence of the identical genomic alteration(s) in a single gene on both molecular platforms. Results: The cfDNA amount was 107.3 in average, and showed positive correlation with advancing stage (p=0.029). Total 54 gene mutations were identified in both groups. the average number of alterations per patient for tissue and cfDNA analysis was 1.71 and 7.43, respectively. The overall concordance was 96.1% but the rate decreased to 16.6% when considering only genes with reported genomic alterations in both assays. 66.67% of mutations detected in tissue was found in cfDNA, and 16.56% of alterations detected in cfDNA was detected in tissue, indicating a potential complementary role of each assay. But the variant allele frequency (VAF) was significantly higher in concordant genes than discordant genes (p<0.001). Most frequently detected genes (TP53, BRCA1, MED12, PTCH1) showed sensitivity and specificity were 100% and 44% respectively. Conclusion: The cfDNA could detect critical mutations with high VAF in several patients. The discordancy between two samples could be explained by tumor heterogeneity, possible germline contamination of cfDNA, and difference in assay platform. The prospective studies to evaluate concordance of genomic alterations between two platforms would be necessary to determine clinical significance of cfDNA in ovarian cancer. Acknowledgements: This study was supported by Korea University Anam Hospital grant.
( Seongmin Kim ),( Sung Hye Jeon ),( Kyung Jin Min ),( Sanghoon Lee ),( Jin Hwa Hong ),( Jae Kwan Lee ),( Nak Woo Lee ),( Jae Yun Song ) 대한산부인과학회 2018 대한산부인과학회 학술대회 Vol.104 No.-
Objective: Borderline ovarian tumors (BOTs) occur in younger, fertile women, with a more favorable prognosis. This study aimed to evaluate the risk of recurrence according to the type of surgery in BOTs. Methods: This retrospective study included patients with BOTs treated between August 2007 and August 2017 at our institution. Patients were divided into two groups according to the type of surgery: cystectomy and oophorectomy with or without salpingectomy. The disease-free survival (DFS) was compared using KaplanMeier curves. Differences in surgical outcomes were also analyzed. Results: Of the 169 patients enrolled, 134 (79.3%) had an oophorectomy with or without salpingectomy and 35 (20.7%) had an ovarian cystectomy. Eight patients (4.7%) developed recurrence of disease: six (4.5%) patients in the oophorectomy group and two (5.7%) in the cystectomy group and one patient died. Median disease-free months were 30 months for oophorectomy patients and 40 months for cystectomy patients, while the two-year disease-free rate was 97.6% and 94.7%, respectively. DFS was not different between the groups (p=0.886). The surgical approach (minimally invasive surgery or laparotomy) was not associated with disease recurrence (p=0.881). None of the parameters increased risk of recurrence on univariate analysis. In patients with cystectomy, the cumulative recurrence was higher in subgroup with optimally removed tumor (p=0.025). Conclusion: Ovarian cystectomy in BOTs was not associated with an increased recurrence of disease. It can be considered a safe and effective option in surgical management of BOTs in young women who desire fertility preservation. Best effort to remove all visible cystic wall is necessary to prevent the recurrence of BOTs managed by ovarian cystectomy.