Multi‑tissue lipotoxicity caused by high‑fat diet feeding is attenuated by the supplementation of Korean red ginseng in mice

Seon‑A Jang,Seung Namkoong,이성률,Jin Woo Lee,Yuna Park,Gyeongseop So,Sung Hyeok Kim,Mi‑Ja Kim,Ki‑Hyo Jang,Alberto P. Avolio,Sumudu V. S. Gangoda,Hyun Jung Koo,Myung Kyum Kim,Se Chan Kang,Eun‑Hwa Sohn 대한독성 유전단백체 학회 2020 Molecular & cellular toxicology Vol.16 No.1

Background Excessive intake of fat, one of the causes of obesity, is associated with low-grade infammation in various susceptible organs and eventually causes tissue toxicity. This study examines the multifaceted suppressive efects of Korean red ginseng extract (KRG) on high-fat diet (HFD)-induced lipotoxicity and infammatory responses in the aorta, liver, and brain. Methods Male C57BL/6 mice were fed HFD with or without KRG for 12 weeks. The improvement efect in KRG on lipotoxicity and infammatory potential was determined in the blood and the aorta, liver, and brain tissues. Results KRG signifcantly inhibited 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase activity by >20% in vitro. KRG supplementation suppressed HFD-associated body weight gain, lipid profle changes, and excessive fat deposition in the liver and increased leptin, insulin, and ALT levels in the blood. Infammatory markers in the aorta, liver, and brain were also signifcantly reduced by KRG treatment. In microvascular endothelial cells, the 15% cyclic stretch-mediated upregulation of ICAM-1 and vascular cell adhesion protein-1 (VCAM-1) expression was signifcantly attenuated in the presence of KRG. Conclusion KRG supplementation attenuates HFD-mediated body weight gain, lipid profle changes, and multi-tissue infammatory responses.

적혈구 자가면역 항체에 대한 연구

구선회 충남대학교 의과대학 지역사회의학연구소 1989 충남의대잡지 Vol.16 No.2

The presence of autoantibody on RBC make diffculties in blood typing and crossmatching. In addition, If alloantibodies exist with autoantibody, transfusion reactions may be brought by masking the alloantibody. So it is important thing to identify the antibody specificity in blood bank working. We analysed 23 cases patients with auto and alloantibodies. The prevalence age with autoantibody were 10th and 50th. Antibodies identified in antiglobulin test were 4 cases of Rh specificities, and 1 case of kell specificity. Another 5 cases with warm antibodies were not identified. The Rh specificities consisted of 2 cases of anti-E, 1 case of anti-e and anti-c, 3 cases were cold antoantibody, bu the specificity were not identified. 6 case were idiopathic origin and other 7 case were secondary to other diseases. 3 cases show severe hemolysis, so transfusion was needed.

각종혈액 질환에서의 RDW의 연구

구선희 충남대학교 의과대학 지역사회의학연구소 1985 충남의대잡지 Vol.12 No.2

Morphologic studies of red blood cells have been reported by many investigators for the past decades. The method of blood smears for measuring RBC size is inappropriate because of artifact and poikilocytosis. Recently, an automated blood analyzer, Coulter Counter Model S plus Ⅱ was introduced and the RDW was easily calculated. Therefore, this study was begin to evaluate the clinical significance of RDW by determining the RDW in healthy person and various hematologic diseases. The following results were obtained. 1. The mean value of RDW in 100 healthy person was 12.74. 2. The diseases that disclosed normal RDW and low MCV: ITP, hypochromic microcytic anemia due to chronic disease. 3. The diseases that disclosed low MCV and high RDW: Iron def. anemia. 4. The diseases that disclosed normal MCV and normal RDW: Reactive marrow, Myeloid hyperplasia, Metastatic tumor and acute hemorrhage. 5. The diseases that disclosed high MCV and Normal RDW: Aplastic anemia, APL. 6. The diseases that disclosed high MCV and high RDW: ALL, CML, Refractory anemia, hemolytic anemia. From these results, RDW can be used as a valuable parameter in the diagnosis of various hematologic disorders.

요로계 감염에서 Staphylococcus Saprophyticus의 검출에 관한 연구

구선회 충남대학교 의과대학 지역사회의학연구소 1986 충남의대잡지 Vol.13 No.2

S. saprophyticus has been considered contaminated bacteria. but recently it was reported that those organisms are capable of causing infection of urinary tract. So, the appreciation of the significance of coagulase negative staphylococci infection is being rapidly expanded. Thus, In clinical laboratories, it has become more important to accurately differentiate staphylococci from nonpathogenic micrococcus. This study was performed to investigate the status of infected patient with S. saprophyticus. Total 2,234 urine specimen was cultured and 71 young woman with urethritis symptom was studied by urine culture and urine sediment microscopy for evaluate the age prevalance. The results obtained are summarized as follows: 1. Among the total 2,234 urine culture, the growth the rate was 42.3%. The most common strain was E. coli and other Gram negative baccilli. The growth rate of S. saprophyticus was 0.2%. 2. Among the 71 young woman with urethritis symptom. The growth rate of S. saprophyticus was 4.2%. 3. The isolation of S. saprophyticus was from the patient with lung ca, sepsis, pregnancy and urethritis. Microscopic findings disclose epithelial cells and WBC. 4. Sensitivity pattern of S. saprophyticus disclosed that it was susceptible in penicillin, Sx, T., Ampicillin and sulfonamide, but resistant strain was founded in Amikacin, cephalothin, G. M. and K. M. From the above results, we could conclude that S. saprophyticus are not simple contaminant but important pathogen in young woman and other conditions. So, it need identify the S. saprophyticus by more simple and scientific method in clinical specimen.

最近 分離된 非醱酵性 그람 陰性 杆菌의 抗生劑 感受性

具善會 충남대학교 의과대학 지역사회의학연구소 1987 충남의대잡지 Vol.14 No.2

Nonfermentative bacilli were considered saprophyte previously. but, Their clinical significance is increasing now because they are etiologic agent of hospital infection and opportunistic infection. Generally it was known that their susceptibility of antibiotics are resistant to multiple antibiotics. So we did the test of antibiotic susceptibility about the Nonfermentative bacilli isolated recently from clinical specimens in order to help the physician to select the appropriate antibiotics. Following results were obtained. 1. Total 473 Nonfermentative bacilli were isolated. Among the Nonfermentative, Pseudomonas, Acinetobacter, Achromobacter, Alcaligenes were isolated in order. 2. Alcaligenes species were highly susceptible to carbenicillin and SxT. but, resistant to cephalothin, Gentamicin, Tobramycin and Kanamycin. 3. Pseudomonas aeruginosa revealed 47. 4% susceptibility to Amikacin but less susceptible in Carhenicilin, Gentamicin and Tobramycin. Pseudomonas maltophilia was highly susceptible to SxT. But showed no significant sensitivity in other drugs. 4. Achromobactor species and Moraxella species were moderately susceptible to Amikacin and Carbenicillin and Ampicillin. Flavobacteria species were highly susceptible to SxT. But, resistant to maiority of Antibiotics. 5. Acinetobacter species showed some response to Amikacin, carbenicillin, Gentamicin, Tobra mycin and SxT. But, less sensitive to ampicillin, Cephalothin and Tobramycin. From the above results, we found that Nonfermentative bacilli are isolated as clinically sigificant pathogen and they are relatively resistant to multiple drug. When we select the antibiotics, we should follow the results of susceptisbility test. If necessary combination test may be useful.

農業系高等學校 學生들의 農高 選擇 動機

강대구,이선하 順天大學校 師範大學 附屬 科學敎育硏究所 1994 科學과 敎育 Vol.2 No.-

To find a way to secure enough numbers of agricultural high school students, 355 agricultural high school students were polled on their motivation of entering the agricultural high school. Almost half of the students chose the school according to their poor academic grades and only 29% students entered properly the school to learn farming. The students preferred engineering technical high school, commercial high school to agricultural high school among vocational high schools. Since most of the students want to enter college, giving privilege in entering agricultural college could be an incentive method to make more students to choose agricultural high school.

커튼월 단열 앵커링 유닛의 난방에너지 성능 및 경제성 평가

강승희,구보경,주선경,송승영 대한건축학회 2003 대한건축학회논문집 Vol.19 No.12

Curtain wall system has been widely applied to the residential unit of high-rise complex building which is the new trend in a recent construction market. It is very important to improve the insulation performance of curtain wall anchoring unit since it is composed of materials with high thermal conductivity, such as aluminium, steel and so on. Thus this study aims to evaluate the heating energy performance and economical efficiency of various alternatives which are different in position and material of insulation. As results, alternative of inserting the urethane washer & pad and coating the anchoring unit with urethane foam can improve the heating energy performance and L.C.C(Life Cycle Cost) by 6.33% and 0.95%, respectively, as compared with the existing case.

정상인과 혈액질환 환자에서의 혈소판 평균용적치에 관한 연구

김학현,구선회,박종우 충남대학교 의과대학 지역사회의학연구소 1986 충남의대잡지 Vol.13 No.1

Molphologic study of platelet have been done by many authors for the past years, they investigated that the heterogeneity of platelet size was shown even in normal person and various hematologic disorder. In the past the platelet size was not utilized in clinical medicine because of its technical difficulties of measuring. Recently, and automated blood cell counter, Coulter counter Model Splus Ⅱ®, was introduced and platelet size could be easily gained, which expressed by mean platelet volume(MPV). Therefore, this study was planned to evaluated the clinical significance of MPV in health person and various hematologic disease. The following results were obtained: 1. In healthy person, MPV was decreased along with increasing the platelet number. 2. In thrombocytopenic patients, MPV was decreased more than normal. 3. In various hematologic disease, MPV was decreased in acute leukemia, marrow failure and aplastic anemia, normal in iron deficiency. anemia, increased in reactive marrow, MPV was varied by platelet number in various hematologic disease. This disclosed that MPV was related with marrow function and production of megakaryocytes. From these results, MPV could be used as a valuable parameter in the evaluation of platelet together with measuring the platelet number. Particular relation-ship between MPV and various hematologic disease were not observed. We should be more study for MPV.

한국어판 모호한 의도-적개심 설문지 개발

장형윤,이선구,김경란,이수영,박진영,김은주,강지인,이은,안석균 大韓神經精神醫學會 2009 신경정신의학 Vol.48 No.1

Objectives We studied the psychometric properties of a Korean version of the Ambiguous Intentions Hostility Questionnaire (K-AIHQ), which measures hostile social-cognitive biases for use in the research on paranoia. Methods The translation and back-translation of the AIHQ with concern for the cultural differences were done according to the standard procedure. A sample of 83 healthy volunteers completed the K-AIHQ. Results The scores of the K-AIHQ were comparable to the results of the original studies. The Paranoia Scale was correlated with the K-AIHQ, but Magical Ideation and Perceptual Aberration scales were not correlated with the K-AIHQ. The interrater reliabilities of the items in each situation were in the acceptable range. Conclusion The KAIHQ seems to be a reliable and valid test to measure the hostile social Cognitive biases of patients with paranoia.

폐경기 여성에서 호르몬 대치 요법시 병행 투여된 프로제스토젠 투여 방법에 따른 골대사의 생화학적 지표에 미치는 영향

이권해,강선영,임경빈,이해혁,구도형,이석민 순천향의학연구소 1998 Journal of Soonchunhyang Medical Science Vol.4 No.1

Purpose : To evaluate the impact of added progestogen on biochemical markers of the bone turnover undergoing hormone replacement therapy in the postmenopausal women. Materials and Methods : There are 71 postmentopausal women who are divided into three groups (Group I, Group II, Group III). Group I(continuous combined)is given conjugated equine estrogen (CEE, 0.625mg, day 1-30) plus medroxyprogesterone acetate (MPA, 2.5mg, day 1-30), Group II(unopposed estrogen) is given conjugated equine estrogen (CEE, 0.625mg, day 1-30) plus medroxyprogesterone acetate (MPA, 5mg, day 1-12). And there were measured serum osteocalcin, serum total alkaline phosphatase and urinary deoxypyridinoline excretion before starting hormone replacement therapy and 12 months later. Results : The serum osteocalcin, serum total alkaline phosphatase and urinary deoxypyridinoline excretion significantly decreased after hormone replacement therapy (Group, I, II, III). And there was no significance in decreases in biochemical markers of the bone turnover among three groups. Conclusions : It was concluded that the impact of added progestogen on the biochemical markers of the bone turnover undergoing hormone replaced therapy in postmenopausal women was not significant than nothing added group. Thus we concluded that progestogen was not impact on decreasing on the biochemical markers of the bone turnover in postmenopausal women undergoing hormone replacement therapy.