경영교육, 나눔경영을 위한 ‘기부’를 생각해보다!: Q방법론을 활용하여

유영설(Yu, Young-Seol),이도희(Lee, Doh-Hee) 한국경영교육학회 2021 경영교육연구 Vol.36 No.3

백서 뇌에서의 Nitric Oxide Synthase를 함유한 신경세포의 분포에 관한 연구 : 해마 구조를 중심으로 An NADPH-diaphorase Histochemical Study

한설희 충북대학교 의과대학 충북대학교 의학연구소 1996 忠北醫大學術誌 Vol.6 No.1

뇌에 존재하는 어떤 종류의 신경세포는 nicotinamide adenin dinucleotide phosphate-diaphorase (NADPH-d) 활성을 함유하고 있어 조직화학 기법에 의해 특이성을 가지며 강하게 염색된다. NADPH-d에 염색되는 신경 세포들은 다양한 종류의 신경 독성과 퇴행성 신경변성에 대하여 강한 저항성을 나타내는 것으로 알려져 있다. 또한 NADPH-d는 formaldehyde에 저항성을 나타내는 조직화학적 특성을 가지고 있으며 이는 nitric oxide synthase (NOS) 성질과 동일하다. 따라서 NADPH-d는 formaldehyde로 고정된 신경조직에서 NOS의 활성을 가진 신뢰성 높은 조직화학지표로 생각된다. 본 연구에서는 백서 뇌조직 중 해마에서의 NOS표현을 알아보기 위해 NADPH-d 조직화학 기법을 사용하였다. Certain neurons in the brain are specifically and intensely stained by a histochemical method which demonstrates nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) activity. These NADPH-d positive neurons are known to exhibit high resistance to various neurotoxins and to neurodegeneration. NADPH-d is a formaldehyde-resistant histochemical activity which has been shown to be exerted by nitric oxide synthase (NOS). Thus NADPH-d serve as a reliable histochemical marker for NOS in formaldehyde-fixed sections of neural tissue, the present study uses NADPH-diaphorase histochemistry to see the expression of NOS in the rat hippocampus.

치매의 행동심리증상의 개관 : An Overview

한설희 대한치매학회 2004 Dementia and Neurocognitive Disorders Vol.3 No.1

Behavioral and psychological symptoms of dementia (BPSD) are among the most distressing manifestations of dementia and results in considerable social and economic burden. They are highly prevalent in Alzheimer's disease (AD) and other progressive degenerative dementias. BPSD are one of main reasons for premature institutionalization and are major causes of significant loss of quality-of-life for the patient and his/her family and caregivers. Recent investigations indicate that BPSD are not an epiphenomenona of cognitive impairment, but could be attributed to specific biological brain dysfunction. This brief review provides an overview of recent advances in the field of BPSD research.

경도인지장애 : 알쯔하이머병의 초기단계인가? Is it an Early Stage of Alzheimer's Disease?

한설희 대한치매학회 2003 Dementia and Neurocognitive Disorders Vol.2 No.2

Aging causes deterioration of various aspects of memory performance in norma adults In recent years. a great deal of interest has been generated around the concept of a boundary or transitional state between normal aging and dementia or, more specifically, Alzheimer's disease (AD). This condition has received a number of descriptions including incipient dementia. questionable dementia. age-associated cognitive decline, isolated memory impairment and mild cognitive impairment (MCI) Commonly accepted guidelines for MCI have been established-memory complaint, preferably corroborated by an informant. objective memory impairment for age and education. normal general cognition, preserved activities of daily living, and not demented The precise definitions need to be explicated. but these will probably simply be a refinement of a concept. rather than a major re-definition Importantly, clinical and neurobiological evidence suggests that patients with MCI are at an increased risk for developing AD. Current research efforts are geared with MCI are at an increased risk for developing AD. Current research efforts are geared towards intervention strategies aimed at preventing the development of AD among persons with MCI.

일 초등학교 1·2학년 아동과 학부모의 시력관련 지식 및 행태에 관한 조사

김설이,강혜영 韓國學校保健學會 2002 韓國學校保健學會誌 Vol.15 No.1

The purpose of this study was to investigate the visual acuity and the degree of vision-related knowledge and behaviors of the 1st and 2nd graders of primary school and their parents in a city. The research design was a descriptive study and the subjects were 579 pupils and their parents in Namwon City, Chonbuk province. Children's vision screening was conducted with Han's test by author, school nurse according to the guidelines. The data were analyzed by frequency, percentage, mean, S.D., t-test, ANOVA, Pearson's correlation coefficient, χ^2-test with SAS program. Subnormal visual acuity group (SVAG) in children was 17.3%, and was higher in girls and in the 2nd graders, but there were no significant differences statistically. The mean score of the vision-related knowledge in children was 6.8 points out of 10 points and that of vision-related behaviors was 23.5 points out of 33 points. The mean scores of the vision-related knowledge were significantly higher in 2nd graders (p= .02), in girls (p= .02) and SVAG (p= .01) and the group of high scores in vision-related knowledge presented significantly high scores in vision-related behaviors(p= .001). The mean score of the vision-related knowledge in parents was 6.4 points out of 10 points and that of vision-related behaviors was 28.4 points out of 33 points. The group with high scores of vision-related knowledge in parents presented significantly high scores in vision-related behaviors (p= .003). As SVAG were higher in 2nd graders and the group of high scores of vision-related knowledge showed also high scores in vision-related behaviors in both children and their parents, From the above results, the author suggests a school-based visual health program for them.

초고속 HMC 주축계의 열특성 해석

김석일,김기상,김기태,나승표 한국공작기계학회 2001 한국공작기계학회 춘계학술대회논문집 Vol.2001 No.-

This paper presents the thermal characteristics analysis of a high-speed HMC spindle system with angular contact ball bearings, built-in motor, oil-jet lubrication method, oil jacket cooling method, and so on. The spindle system is composed of the main spindle and sub-spindle which are mechanically connected by a flexible coupling. The spindles are supported by two front and rear bearings, and the built-in motor is located between the front and rear bearings of the sub-spindle. The thermal analysis model of spindle system is constructed by the finite element method, and the thermal characteristics in the design stage are estimated based on temperature distribution and heat flow under the various testing conditions related to material of bearing ball, spindle speed and coolant temperature.

노인체조프로그램 참여가 뇌졸증으로 인한 거동장애노인의 신체조성과 생활동작능력에 미치는 영향

김설향 한국특수체육학회 2003 한국특수체육학회지 Vol.11 No.1

The study examined the effect of the body composition and life activity of seniors suffered from movement disturbances due to Cerebral Vascular Accident (C.V.A). The gymnastics was designed to improve the health of seniors. Twenty seniors were put into the exercise three times a week for twenty four weeks. In-Body 3.0 and Barthel's life movement index scal recorded the improvement in the seniors' health. The following changes in data was observed 1. The mean body weight from 64.1(±9.39)kg to 63.8(±8.62)kg 2. The mean body fat weight from 18.6(±3.24)kg to 17.8(±4.07)kg. the mean body fat percent from 29.3(±4.83)% to 27.9(±5.51)% 3. Lean body mass from 45.5(±9.39)kg to 46(±8.62)kg, Basal Metabolic Rate(BMR) from 1228.4(±157.69)Kcal to 1241.8(±140.51)Kcal 4. Through movement therapy the seniors acquired higher independent life activity index after program: (42.8±5.1); those who lacked had (20.8±5.3). 5. Higher movement index: (46.78±15.86) was observed in the seniors under movement therapy; those who lacked had (38.35±20.7).

치매환자의 비인지 기능장애에 관한 예비적 연구

한설희 충북대학교 의과대학 충북대학교 의학연구소 1999 忠北醫大學術誌 Vol.9 No.2

연구목적: 행동장애/행동이상(behavioral disturbances)는 치매환자에서 비교적 흔히 관찰되는 증상이기는 하나 기억장애와 같은 인지기능이상이 두드러진 현상이기 때문에 최근까지 연구대상에서 제외되어 있었다. 그러나 환자들이 나타내는 비인지기능 증상들 (non-cognitive symptoms; NCS)은 치매의 진단, 예후 및 치료에 있어 매우 중요한 의미를 갖는다. 본 연구의 목적은 치매환자의 NCS의 임상적 특징을 면밀히 파악하여 향후 치매환자의 치료에 있어 인지기능을 개선시키려는 노력 이외에 NCS에 대한 적극적인 치료방침을 마련하는 데 있다. 대상 및 방법: 충북대학교병원 치매크리닉에 내원한 환자중 DSM IV 및 NINDS-ADRDA 진단기준에 맞는 알쯔하이머형 치매환자 42명, NINDS-AIREN 진단기준에 적합한 혈관성치매환자 13명, 혼합형치매환자 12명을 대상으로하여 이상행동적도를 평가하였다. 결과: 치매척도인 Hasegawa scale과 행동척도인 Behavioral Rating Scalerks의 상관지수는 0.805로 상당한 유의성이 관찰되었다. 질병의 종류에 무관하게 과격한 행동, 밤-낮의 뒤바뀜, 초조증 등이 가장 흔히 관찰되는 행동장애이었다. 결론: 본 연구의 결과 치매환자의 치료에 있어 비인지기능장애의 중요성을 인식할 수 있었으며 이를 조기에 발견 치료해줌으로써 환자들를 돌보는 간호인력이나 보호자들의 삶의 질을 향상시키는데 많은 기여를 할 것으로 기대된다. 비인지기능 장애의 발병기전을 밝히기 위하여 향후 좀더 잘 기획된 전향적 방법으로 치매환자에서 비인지기능 장애가 어떻게 진행되는 가에 대한 추시 연구가 필요할 것으로 생각된다. Purpose: Behavioral symptoms in dementias, although common, have not received much attention until recently. This report attempts to describe the frequencies and characteristics of such symptoms in patients with dementia. Materials and Methods : The author cross-sectionally investigated the prevalence, phenomenolgy, and clinical correaltes of noncognitive symptoms (NCS) in a consecutive series of 67 patients with dementia (42 with Alzheimer's disease, 13 with vascular dementia, 12 with mixed dementia). Cognitive function was rated using the Hasegawa scale and NCS was measured with modified Behavioral Rating Scale (BRS). Results: The correlation between Hasegawa scale and BRS was 0.805 at the time of initial evaluation. Among various delusional symptoms, picture sign was noted only in patients with Alzheimer's disease. Aggressive behavior, day-night-disturbances, and agitation were most frequently observed NCS regardless of disease entities. Conclusion: The findings of the present study underlie the importance of NCS in the management of patients with dementia. Further longitudinal study using well-designed structured interview should be performed to clarify the evolution of NCS in patients with dementia.

원발성진행성 실어증

한설희 충북대학교 의과대학 충북대학교 의학연구소 1996 忠北醫大學術誌 Vol.6 No.2

원발성진행성실어증은 수년간에 걸쳐 대뇌고위 기능중 언어영역만 고립적으로 침범되어 서서히 진행하는데 임상적으로 치매와 구별되어야 하는 비교적 드문 증후군이다. 저자는 최근에 62세 여자환자가 약 4년간에 걸쳐 서서히 진행한 언어장애를 주소로 본원 치매크리닉을 방문하여 신경심리검사, 뇌파검사, 뇌핵자기공면영상, 단일광자방출단층촬영술 등에서 전형적인 원발성진행성실어증으로 확인된 우리 나라 최초의 예를 경험하였기에 간단한 문헌고찰과 함께 보고하는 바이다. A 62-year-old right-handed woman presented with a progressive deterioration in her ability to name common object used in everyday life. Her initial language disturbance, word-finding difficulty, got worsened gradually over the next 4 years, She was able to point to the correct object when the word is provided by the examiner despite being unable to name it spontaneously. Her memory, attention, visuospatial skills and comportment were all intact. She is doing well in her daily living activities including taking care of herself, shopping and paying bills. MRI showed left perisylvian atrophy and dilated left frontal horn. SPECT study revealed decreased perfusion in left temporal lobe. Her clinical presentation together with the characteristic structural and functional neuroimaging findings were typical of 'primary progressive aphasia'.

부검으로 확진된 알쯔하이머병 1예 : An Autopsy Report

한설희,이건국,양기화,장순환 대한치매학회 2002 Dementia and Neurocognitive Disorders Vol.1 No.1

While the clinical diagnostic accuracy of probable Alzheimer′s disease (AD) is 87-96% with a diagnostic sensitivity/specificity of 0 81-0 87, the unequivocal diagnosis of AD rests on histopathological evidence at brain autopsy and/or biopsy We report here a 92-year-old woman whose clinical presentation suggested a far advanced Alzheimer′s disease Formal neuropsychological evaluations were not applicable due to severe cognitive impairments With a relatively good general physical condition she could walk with aid during her last days no focal neurological signs were noted on a detailed examination Brain MRI revealed a diffuse cortical atrophy with a marked reduction in the hippocampal volume The brain obtained weighted 780g The cerebral hemispheres examined after fixation disclosed moderately severe atrophy in prefrontal and temporal lobes on coronal section, the hippocampus was likewise severely atrophied the lateral ventricles were moderately dilated On microscope examination, there were numerous senile plaques and neurofibrillary tangles in the neocortices. hippocampus and amyglada, compatible with advanced Alzheimer′s disease In summary we report the first Korean autopsy-proven case with advanced Alzheimer′s disease.