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      • 원발성진행성 실어증

        한설희 충북대학교 의과대학 충북대학교 의학연구소 1996 忠北醫大學術誌 Vol.6 No.2

        원발성진행성실어증은 수년간에 걸쳐 대뇌고위 기능중 언어영역만 고립적으로 침범되어 서서히 진행하는데 임상적으로 치매와 구별되어야 하는 비교적 드문 증후군이다. 저자는 최근에 62세 여자환자가 약 4년간에 걸쳐 서서히 진행한 언어장애를 주소로 본원 치매크리닉을 방문하여 신경심리검사, 뇌파검사, 뇌핵자기공면영상, 단일광자방출단층촬영술 등에서 전형적인 원발성진행성실어증으로 확인된 우리 나라 최초의 예를 경험하였기에 간단한 문헌고찰과 함께 보고하는 바이다. A 62-year-old right-handed woman presented with a progressive deterioration in her ability to name common object used in everyday life. Her initial language disturbance, word-finding difficulty, got worsened gradually over the next 4 years, She was able to point to the correct object when the word is provided by the examiner despite being unable to name it spontaneously. Her memory, attention, visuospatial skills and comportment were all intact. She is doing well in her daily living activities including taking care of herself, shopping and paying bills. MRI showed left perisylvian atrophy and dilated left frontal horn. SPECT study revealed decreased perfusion in left temporal lobe. Her clinical presentation together with the characteristic structural and functional neuroimaging findings were typical of 'primary progressive aphasia'.

      • KCI등재

        일 초등학교 1·2학년 아동과 학부모의 시력관련 지식 및 행태에 관한 조사

        김설이,강혜영 韓國學校保健學會 2002 韓國學校保健學會誌 Vol.15 No.1

        The purpose of this study was to investigate the visual acuity and the degree of vision-related knowledge and behaviors of the 1st and 2nd graders of primary school and their parents in a city. The research design was a descriptive study and the subjects were 579 pupils and their parents in Namwon City, Chonbuk province. Children's vision screening was conducted with Han's test by author, school nurse according to the guidelines. The data were analyzed by frequency, percentage, mean, S.D., t-test, ANOVA, Pearson's correlation coefficient, χ^2-test with SAS program. Subnormal visual acuity group (SVAG) in children was 17.3%, and was higher in girls and in the 2nd graders, but there were no significant differences statistically. The mean score of the vision-related knowledge in children was 6.8 points out of 10 points and that of vision-related behaviors was 23.5 points out of 33 points. The mean scores of the vision-related knowledge were significantly higher in 2nd graders (p= .02), in girls (p= .02) and SVAG (p= .01) and the group of high scores in vision-related knowledge presented significantly high scores in vision-related behaviors(p= .001). The mean score of the vision-related knowledge in parents was 6.4 points out of 10 points and that of vision-related behaviors was 28.4 points out of 33 points. The group with high scores of vision-related knowledge in parents presented significantly high scores in vision-related behaviors (p= .003). As SVAG were higher in 2nd graders and the group of high scores of vision-related knowledge showed also high scores in vision-related behaviors in both children and their parents, From the above results, the author suggests a school-based visual health program for them.

      • KCI등재

        노인체조프로그램 참여가 뇌졸증으로 인한 거동장애노인의 신체조성과 생활동작능력에 미치는 영향

        김설향 한국특수체육학회 2003 한국특수체육학회지 Vol.11 No.1

        The study examined the effect of the body composition and life activity of seniors suffered from movement disturbances due to Cerebral Vascular Accident (C.V.A). The gymnastics was designed to improve the health of seniors. Twenty seniors were put into the exercise three times a week for twenty four weeks. In-Body 3.0 and Barthel's life movement index scal recorded the improvement in the seniors' health. The following changes in data was observed 1. The mean body weight from 64.1(±9.39)kg to 63.8(±8.62)kg 2. The mean body fat weight from 18.6(±3.24)kg to 17.8(±4.07)kg. the mean body fat percent from 29.3(±4.83)% to 27.9(±5.51)% 3. Lean body mass from 45.5(±9.39)kg to 46(±8.62)kg, Basal Metabolic Rate(BMR) from 1228.4(±157.69)Kcal to 1241.8(±140.51)Kcal 4. Through movement therapy the seniors acquired higher independent life activity index after program: (42.8±5.1); those who lacked had (20.8±5.3). 5. Higher movement index: (46.78±15.86) was observed in the seniors under movement therapy; those who lacked had (38.35±20.7).

      • 결절성경화증 환자에서의 SPECT 뇌영상 : 예비적 연구 A preliminary report

        한설희,이상수,정승연 충북대학교 의과대학 충북대학교 의학연구소 1991 忠北醫大學術誌 Vol.1 No.1

        간질발작을 포함한 전형적인 삼징후가 동반된 결절성경화증 환자를 대상으로 뇌파검사, 뇌전산화단층촬영술 및 단일광자방출단층촬영술을 시행하였다. 뇌전산화단층촬영술에서는 상의하석회화병소와 조영제증강이 뚜렷하지 않은 피질에 연한 저음영 소견이 관찰되었으며 이어서 시행한 단일광자방출단층촬영술에서는 뇌전산화단층촬영술 소견보다 더 광범위한 부위에 관류결손이 관찰되었다. 단일광자방출단층촬영술은 결절성경화증 환자에서 간질발현 병소인 피질결절을 발견하는데 있어서 전산화단층촬영술 및 뇌파검사보다 더 유용한 방법이며 치료방침 결정이나 예후판정에 있어서도 큰 도움을 줄 것으로 기대된다. Two patients with a well-established diagnosis of tuberous sclerosis and epilepsies as their principal clinical symptom were examined by conventional surface electroencephalography(EEG), computed tomography, and single photon emission computed tomography(SPECT) using the 99mTc hexamethyl prophyleneamine oxime(99mTc-HMPAO). The interictal EEG showed various abnormalities of poor localizing value. Brain computed tomography surely demonstrated subependymal calcifications, although the cortical lesions were not so conspicuous. However, the SPECT images of each patient clearly demonstrated decreased cerebral perfusion in cortical areas. It may be assumed that such perfusion defect areas represent the epileptic cortical tubers or those of altered myelination, which are characteristics of the disease.

      • 백서 뇌에서의 Nitric Oxide Synthase를 함유한 신경세포의 분포에 관한 연구 : 해마 구조를 중심으로 An NADPH-diaphorase Histochemical Study

        한설희 충북대학교 의과대학 충북대학교 의학연구소 1996 忠北醫大學術誌 Vol.6 No.1

        뇌에 존재하는 어떤 종류의 신경세포는 nicotinamide adenin dinucleotide phosphate-diaphorase (NADPH-d) 활성을 함유하고 있어 조직화학 기법에 의해 특이성을 가지며 강하게 염색된다. NADPH-d에 염색되는 신경 세포들은 다양한 종류의 신경 독성과 퇴행성 신경변성에 대하여 강한 저항성을 나타내는 것으로 알려져 있다. 또한 NADPH-d는 formaldehyde에 저항성을 나타내는 조직화학적 특성을 가지고 있으며 이는 nitric oxide synthase (NOS) 성질과 동일하다. 따라서 NADPH-d는 formaldehyde로 고정된 신경조직에서 NOS의 활성을 가진 신뢰성 높은 조직화학지표로 생각된다. 본 연구에서는 백서 뇌조직 중 해마에서의 NOS표현을 알아보기 위해 NADPH-d 조직화학 기법을 사용하였다. Certain neurons in the brain are specifically and intensely stained by a histochemical method which demonstrates nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) activity. These NADPH-d positive neurons are known to exhibit high resistance to various neurotoxins and to neurodegeneration. NADPH-d is a formaldehyde-resistant histochemical activity which has been shown to be exerted by nitric oxide synthase (NOS). Thus NADPH-d serve as a reliable histochemical marker for NOS in formaldehyde-fixed sections of neural tissue, the present study uses NADPH-diaphorase histochemistry to see the expression of NOS in the rat hippocampus.

      • Gerstmann 증후군을 동반한 교차 실어증 1례 : MRI 및 SPECT를 이용한 연구

        한설희 충북대학교 의학연구소 2001 忠北醫大學術誌 Vol.11 No.1

        교차실어증이란 오른손잡이 환자에서 우측 대뇌 반구 손상후에 언어장애(실어증)가 발생한 경우를 말한다.오른손잡이 실어증 환자의 약 1%-2%에서 교차실어증이 발생하는 것으로 알려져 있으나 구조적 병변이 잘 밝혀진 예는 드물다.더욱이 우뇌 손상과 관련된 좌, 우 지남력 상실, 수지 실인증, 계산불능증, 필기불능증의 4 가지 임상 특징을 가지는 Gerstmann 증후군의 예는 더욱 드물다.저자는 MRI 및 SPECT 뇌영상 검사로 우뇌 경색이 확인된 오른손잡이 환자에서 Gerstmann 증후군과 교차실어증이 동시에 발생한 드문 예를 경험하였기에 문헌 고찰과 함께 보고하는 바이다. Crossed aphasia refers to disturbance of language following a right hemisphere lesion in right handed individuals.Although it is estimated to occur in 1% to 2% of all dextral aphasic, well documented cases of crossed aphasia continue to be rare.Moreover, it is also rare to see a Gerstmann's syndrome (left-right disorientation, finger agnosia, dyscalculia, and dysgraphia) in right hemispheric lesion.In this paper, the author presents one case of crossed aphasia associated with Gerstmann syndrome in monolingual right handed patient. This case is found interesting to be reported because it is a extremely rare condition where a crossed aphasia and a Gerstmann syndrome are simultaneously seen in the same patient.

      • 초고속 HMC 주축계의 열특성 해석

        김석일,김기상,김기태,나승표 한국공작기계학회 2001 한국공작기계학회 춘계학술대회논문집 Vol.2001 No.-

        This paper presents the thermal characteristics analysis of a high-speed HMC spindle system with angular contact ball bearings, built-in motor, oil-jet lubrication method, oil jacket cooling method, and so on. The spindle system is composed of the main spindle and sub-spindle which are mechanically connected by a flexible coupling. The spindles are supported by two front and rear bearings, and the built-in motor is located between the front and rear bearings of the sub-spindle. The thermal analysis model of spindle system is constructed by the finite element method, and the thermal characteristics in the design stage are estimated based on temperature distribution and heat flow under the various testing conditions related to material of bearing ball, spindle speed and coolant temperature.

      • KCI등재

        경도인지장애 : 알쯔하이머병의 초기단계인가? Is it an Early Stage of Alzheimer's Disease?

        한설희 대한치매학회 2003 Dementia and Neurocognitive Disorders Vol.2 No.2

        Aging causes deterioration of various aspects of memory performance in norma adults In recent years. a great deal of interest has been generated around the concept of a boundary or transitional state between normal aging and dementia or, more specifically, Alzheimer's disease (AD). This condition has received a number of descriptions including incipient dementia. questionable dementia. age-associated cognitive decline, isolated memory impairment and mild cognitive impairment (MCI) Commonly accepted guidelines for MCI have been established-memory complaint, preferably corroborated by an informant. objective memory impairment for age and education. normal general cognition, preserved activities of daily living, and not demented The precise definitions need to be explicated. but these will probably simply be a refinement of a concept. rather than a major re-definition Importantly, clinical and neurobiological evidence suggests that patients with MCI are at an increased risk for developing AD. Current research efforts are geared with MCI are at an increased risk for developing AD. Current research efforts are geared towards intervention strategies aimed at preventing the development of AD among persons with MCI.

      • Henigway의 主人公들에 關한 考察

        鄭卨秀 忠州大學校 1976 한국교통대학교 논문집 Vol.8 No.1

        When we read Hemingway's works, we can find that Hemingway offers three Patterns of his heroes in his works. One is the pattern of Nick Adams, another is the pattern of Jake Barnes, a third is the pattern of Frederic Henry. Hemingway's heroes have 'moral code' which Hemingway made in his works in order to express his literary ideas. Nick Adams does not have moral code, but Nick experiences, Violence, evil and death which man has in this world. Jake has moral code receiving and enduring his conditions given him. Henry has moral code conquering his conditions. Hemingway's heroes must conduct acoording to these codes. If heroes and charaters in his works do not observe them, he regard as a coward. Hemingway exoressed all his literary ideas through his heroes. And we can guess Hemingway's heroes are Hemingway himself because all the contents of his works agree with his practical life.

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