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IGRINS SPECTROSCOPY OF CLASS I SOURCES: IRAS 03445+3242 AND IRAS 04239+2436
Lee, Seokho,Lee, Jeong-Eun,Park, Sunkyung,Lee, Jae-Joon,Kidder, Benjamin,Mace, Gregory N.,Jaffe, Daniel T. American Astronomical Society 2016 The Astrophysical journal Vol.826 No.2
<P>We have detected molecular and atomic line emission from the hot and warm disks of two Class I sources, IRAS 03445+3242 and IRAS 04239+2436, using the high-resolution Immersion GRating INfrared Spectrograph (IGRINS). CO overtone band transitions and near-IR lines of Na I and Ca I, all in emission, trace the hot inner disk, while CO rovibrational absorption spectra of the first overtone transition trace the warm gas within the inner few AU of the disk. The emission-line profiles for both sources show evidence for Keplerian disks. A thin Keplerian disk with power-law temperature and column density profiles with a projected rotational velocity of similar to 60-75 km s(-1) and a gas temperature of similar to 3500 K at the innermost annulus can reproduce the CO overtone band emission. Na I and Ca I emission lines also arise from this disk, but they show complicated line features possibly affected by photospheric absorption lines. Multi-epoch observations show asymmetric variations of the line profiles on one-year (CO overtone bandhead and atomic lines for IRAS 03445+3242) or on one-day (atomic lines for IRAS 04239+2436) timescales, implying non-axisymmetric features in disks. The narrow CO rovibrational absorption spectra (v = 0 -> 2) indicate that both warm (>150 K) and cold (similar to 20-30 K) CO gas are present along the line of sight to the inner disk. This study demonstrates the power of IGRINS as a tool for studies of the sub-AU-scale hot and AU-scale warm protoplanetary disks with its simultaneous coverage of the full H and K bands with high spectral resolution (R = 45,000) allowing many aspects of the sources to be investigated at once.</P>
Seokho Nam,Woo Seung Lee,Jeyull Lee,Haeryoung Jeon,Seunghak Han,Yojong Choi,Jiho Lee,Tae Kuk Ko Institute of Electrical and Electronics Engineers 2017 IEEE transactions on applied superconductivity Vol.27 No.4
<P>A current lead is a connecting device between the superconducting magnet and the power supply. A large amount of heat transfer ocurrs through the current lead because the cold-end in a superconducting system is thermally linked with the warm-end part. Therefore, high-Tc superconductor (HTS) is used in the current lead for a tokamak system. However, it is hard to consider the dependance of HTS's critical current with respect to temperature because the conventional HTS current leads consist of the HTS tapes with the same width and thickness, and their critical currents can differ from their temperature. For this reason, cold-end of the HTS section in current lead is designed excessively than necessary specifications. This generates the additional heat transfer between cold-end and warm-end within the HTS current lead. In this paper, a study on the HTS current leads with asymmetric structure is conducted to reduce the heat transfer by reducing the cross-sectional area of the HTS current lead. Asymmetric current leads are fabricated considering the design parameters about heat transfer within the HTS current lead. Current transporting tests on the conventional, symmetrical, and asymmetrical HTS current leads are performed to confirm the feasibility of the suggested design. And then, heat load of the asymmetric current lead is compared with the symmetric current lead. From this study, it is found that heat load of the current lead is reduced by using the asymmetric HTS current lead.</P>
Lee, Jaemin,Kang, Tae Heung,Yoo, Wonbeak,Choi, Hyunji,Jo, Seongyea,Kong, Kyungsu,Lee, Sang-Rae,Kim, Sun-Uk,Kim, Ji-Su,Cho, Duck,Kim, Janghwan,Kim, Jeong-Yoon,Kwon, Eun-Soo,Kim, Seokho AMERICAN ASSOCIATION FOR CANCER RESEARCH 2019 CANCER IMMUNOLOGY RESEARCH Vol.7 No.2
<P>The homing of natural killer (NK) cells is often inhibited by pancreatic cancer tumors. A mesothelin-directed antibody conjugated to a cleavable NK cell—recruiting chemokine increased NK-cell infiltration of PDAC tumors, reduced tumor burden, and improved survival.</P><P>Natural killer (NK) cells are primary immune cells that target cancer cells and can be used as a therapeutic agent against pancreatic cancer. Despite the usefulness of NK cells, NK-cell therapy is limited by tumor cell inhibition of NK-cell homing to tumor sites, thereby preventing a sustained antitumor immune response. One approach to successful cancer immunotherapy is to increase trafficking of NK cells to tumor tissues. Here, we developed an antibody-based NK-cell–homing protein, named NK-cell–recruiting protein-conjugated antibody (NRP-body). The effect of NRP-body on infiltration of NK cells into primary and metastatic pancreatic cancer was evaluated <I>in vitro</I> and in murine pancreatic ductal adenocarcinoma models. The NRP-body increased NK-cell infiltration of tumors along a CXCL16 gradient (CXCL16 is cleaved from the NRP-body by furin expressed on the surface of pancreatic cancer cells). CXCL16 induced NK-cell infiltration by activating RhoA via the ERK signaling cascade. Administration of the NRP-body to pancreatic cancer model mice increased tumor tissue infiltration of transferred NK cells and reduced the tumor burden compared with that in controls. Overall survival of NRP-body–treated mice (even the metastasis models) was higher than that of mice receiving NK cells alone. In conclusion, increasing NK-cell infiltration into tumor tissues improved response to this cancer immunotherapy. The combination of an NRP-body with NK-cell therapy might be useful for treating pancreatic cancer.</P>
Estimation of the critical current of race-track HTS magnet considering angular dependency
Lee, Kyubong,Sim, Kideok,Lee, Changyoung,Kim, Seokho The Korea Institute of Applied Superconductivity a 2015 한국초전도저온공학회논문지 Vol.17 No.3
The high temperature superconducting (HTS) magnet has been developed for the high magnetic field applications such as NMR, MRI and other industrial machinery. In designing process of these HTS magnets, the accurate estimation on the critical current (Ic) is essential to predict and secure the electromagnetic performance. The critical current of 2G HTS tape has anisotropic Ic degradation characteristics with the application of magnetic field - angular dependency of critical current. It is known that the perpendicular magnetic field to the face of HTS tape makes dominant degradation on the critical current for conventional 2G HTS tape. However, recently developed 2G HTS tape has more complex characteristics due to the artificial pinning center. Therefore, the method for Ic estimation reflecting such characteristics of 2G HTS tape needs to be devised. The method considering the angular dependency is introduced in this paper. And the result of newly devised method is compared with that of previous method.
Principal Component Regression by Principal Component Selection
Lee, Hosung,Park, Yun Mi,Lee, Seokho The Korean Statistical Society 2015 Communications for statistical applications and me Vol.22 No.2
We propose a selection procedure of principal components in principal component regression. Our method selects principal components using variable selection procedures instead of a small subset of major principal components in principal component regression. Our procedure consists of two steps to improve estimation and prediction. First, we reduce the number of principal components using the conventional principal component regression to yield the set of candidate principal components and then select principal components among the candidate set using sparse regression techniques. The performance of our proposals is demonstrated numerically and compared with the typical dimension reduction approaches (including principal component regression and partial least square regression) using synthetic and real datasets.