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SEO, SUNG-MIN,CHO, IL-HOON,JEON, JIN-WOO,CHO, HYUN-KYU,OH, EUN-GYOUNG,YU, HONG-SIK,SHIN, SOON-BUM,LEE, HEE-JUNG,PAEK, SE-HWAN International Association for Food Protection 2010 Journal of food protection Vol.73 No.8
<P>In this study, we constructed a rapid detection system for a foodborne pathogen, Vibrio parahaemolyticus, by using enzyme-linked immunosorbent assay (ELISA)-on-a-chip (EOC) biosensor technology to minimize the risk of infection by the microorganism. The EOC results showed a detection capability of approximately 6.2 × 105 cells per ml, which was significantly higher than that of the conventional rapid test kit. However, this high level of sensitivity required cultivation of the pathogen prior to analysis, which typically exceeded a day. To shorten the test period, we combined the EOC technology with immunomagnetic separation (IMS), which could enhance the sensitivity of the biosensor. IMS was carried out with magnetic particles coated with a monoclonal antibody specific to the microbe. To test the performance of the IMS-EOC method, fish intestine samples were prepared by artificially inoculating less than 1 or 5 CFU/10 g, allowing for enrichment over predetermined times, and analyzing the sample by using the EOC sensor after concentrating the culture 86-fold via IMS. Using this approach, the bacterium was detected after (at most) 9 h, which approximately corresponds to standard working hours. Thus, the IMS-EOC method allowed for the rapid detection of V. parahaemolyticus, which is responsible for foodborne diseases, and this method could be used for early isolation of contaminated foods before distribution.</P>
Seo, Sang Ho,Shin, Dong Yeok,Hong, Su Hyun,Park, Sang Eun,Choi, Yung Hyun,Hong, Sang Hoon D. A. Spandidos 2009 MOLECULAR MEDICINE REPORTS Vol.2 No.2
<P>In the present study, we investigated the effects of the water extract of Euphorbiae humifusae (WEEH), an oriental medicinal herb, on the growth of Hep3B human hepatocarcinoma cells. We found that WEEH treatment resulted in a significant decrease in the cell viability of Hep3B cells depending on dosage. This decrease was revealed to be apoptosis, evidenced by chromatin condensation, DNA fragmentation and an accumulation of apoptotic fraction. WEEH induced the expression of death receptor-related proteins such as Fas, tumor necrosis factor-related apoptosis-inducing ligand, death receptor (DR) 4 and DR5, which further triggered caspase-8 activation and truncated Bid cleavage. Mitochondrial dysfunction, the catalytic activation of caspase-9, down-regulation of anti-apoptotic Bcl-2 and Bcl-xL expression, and up-regulation of the pro-apoptotic Bax protein were also observed in WEEH-treated cells. In addition, the increase in apoptosis induced by WEEH was correlated with caspase-3 activation and the concomitant degradation of poly (ADP-ribose) polymerase. However, the cytotoxic effects and apoptotic characteristics induced by WEEH were significantly inhibited by z-DEVD-fmk, a caspase-3 inhibitor. This demonstrates the important role played by caspase-3 in the process. Collectively, our data indicate that WEEH induces Hep3B cell apoptosis through a signaling cascade of death receptor-mediated extrinsic and mitochondria-mediated intrinsic caspase pathways.</P>
Is propofol safe when administered to cirrhotic patients during sedative endoscopy?
( Sang Jun Suh ),( Hyung Joon Yim ),( Eileen L Yoon ),( Beom Jae Lee ),( Jong Jin Hyun ),( Sung Woo Jung ),( Ja Seol Koo ),( Ji Hoon Kim ),( Kyung Jin Kim ),( Rok Son Choung ),( Yeon Seok Seo ),( Jong 대한내과학회 2014 The Korean Journal of Internal Medicine Vol.29 No.1
Background/Aims: In patients with liver cirrhosis, drugs acting on the central nervous system can lead to hepatic encephalopathy and the effects may be pro-longed. Recently, misuse of propofol has been reported and the associated risk of death have become an issue. Propofol is commonly used during sedative endoscopy; therefore, its safety in high-risk groups must be further investigated. We performed a pilot study of the safety and effi cacy of propofol during endos-copy in Korean patients with cirrhosis. Methods: Upper gastrointestinal endoscopy was performed under sedation with propofol along with careful monitoring in 20 patients with liver cirrhosis and 20 control subjects. The presence or development of hepatic encephalopathy was as-sessed using the number connection test and neurologic examination. Results: Neither respiratory depression nor clinically significant hypotension were observed. Immediate postanesthetic recovery at 5 and 10 minutes after the procedure was delayed in the cirrhotic patients compared with the control group; however, at 30 minutes, the postanesthetic recovery was similar in both groups. Baseline psychomotor performance was more impaired in cirrhotic patients, but propofol was not associated with deteriorated psychomotor function even in cir-rhotic patients with a minimal hepatic encephalopathy. Conclusions: Sedation with propofol was well tolerated in cirrhotic patients. No newly developed hepatic encephalopathy was observed.
Seo, Ji Hae,Cha, Jong-Ho,Park, Ji-Hyeon,Jeong, Chul-Ho,Park, Zee-Yong,Lee, Hye-Suk,Oh, Seung Hyun,Kang, Ju-Hee,Suh, Se Won,Kim, Kyoung Hoon,Ha, Jun Yong,Han, Sang Hee,Kim, Se-Hee,Lee, Ji-Won,Park, Jeo American Association for Cancer Research 2010 Cancer Research Vol.70 No.11
<P>The N-acetyltransferase arrest defective 1 (ARD1) is an important regulator of cell growth and differentiation that has emerged recently as a critical molecule in cancer progression. However, the regulation of the enzymatic and biological activities of human ARD1 (hARD1) in cancer is presently poorly understood. Here, we report that hARD1 undergoes autoacetylation and that this modification is essential for its functional activation. Using liquid chromatography-tandem mass spectrometry and site-directed mutational analyses, we identified K136 residue as an autoacetylation target site. K136R mutation abolished the ability of hARD1 to promote cancer cell growth in vitro and tumor xenograft growth in vivo. Mechanistic investigations revealed that hARD1 autoacetylation stimulated cyclin D1 expression through activation of the transcription factors beta-catenin and activator protein-1. Our results show that hARD1 autoacetylation is critical for its activation and its ability to stimulate cancer cell proliferation and tumorigenesis.</P>
Seo-Rin Jeong,Sehyun Kim,Soo Yong Kim,Sung-Hoon Lim 대한구강생물학회 2018 International Journal of Oral Biology Vol.43 No.2
Understanding the classification of malocclusion is a crucial issue in Orthodontics. It can also help us to diagnose, treat, and understand malocclusion to establish a standard for definite class of patients. Principal component analysis (PCA) and k-means algorithms have been emerging as data analytic methods for cephalometric measurements, due to their intuitive concepts and application potentials. This study analyzed the macro- and meso-scale classification structure and feature basis vectors of 1020 (415 male, 605 female; mean age, 25 years) orthodontic patients using statistical preprocessing, PCA, random matrix theory (RMT) and k-means algorithms. RMT results show that 7 principal components (PCs) are significant standard in the extraction of features. Using k-means algorithms, 3 and 6 clusters were identified and the axes of PC1~3 were determined to be significant for patient classification. Macro-scale classification denotes skeletal Class I, II, III and PC1 means anteroposterior discrepancy of the maxilla and mandible and mandibular position. PC2 and PC3 means vertical pattern and maxillary position respectively; they played significant roles in the meso-scale classification. In conclusion, the typical patient profile (TPP) of each class showed that the data-based classification corresponds with the clinical classification of orthodontic patients. This data-based study can provide insight into the development of new diagnostic classifications.
Seo, Sang Hee,Shin, Dong Hoon,Kang, Hyun Jeong,Choi, Kyung Un,Kim, Jee Yeon,Park, Do Youn,Lee, Chang Hun,Sol, Mee Young,Lee, Jin Choon Lippincott Williams Wilkins, Inc. 2010 The American Journal of dermatopathology Vol.32 No.7
An ectomesenchymal chondromyxoid tumor (ECMT) is a rare neoplasm that exclusively occurs in the anterior dorsum of the tongue. The tumor consists of small round to fusiform or spindle cells with myxoid or chondroid stroma. The tumor consistently shows a positive reaction with glial fibrillary acidic protein antibodies, especially polyclonal antibodies. We report 2 cases of reticulated myxoid tumors arising in the tongue. One tumor occurred in the posterior dorsum of the tongue and another in the anterior. Both tumors showed characteristic morphology of ECMT; however, both were negative for reactions with monoclonal and polyclonal glial fibrillary acidic protein antibodies. On the basis of morphology, they are thought to be belonging to ECMT. Hence, we suggest that ECMT can show broader spectrum of clinical and immunophenotypic feature.
Thyroid follicular neoplasms: Can sonography distinguish between adenomas and carcinomas?
Seo, Hyung Suk,Lee, Dong Hoon,Park, Sung Hye,Min, Hye Sook,Na, Dong Gyu Wiley Subscription Services, Inc., A Wiley Company 2009 Journal of clinical ultrasound Vol.37 No.9
<B>Purpose</B><P>The purpose of this study was to determine whether sonography (US) can usefully differentiate thyroid follicular adenoma (FA) and follicular carcinoma (FC).</P><B>Methods</B><P>This retrospective study included 60 pathologically proven FAs and 66 FCs in 123 consecutive patients (17 males and 106 females) with a mean age of 47 ± 13 years, (17–73 years) who underwent thyroid surgery. We analyzed US features of each nodule, including maximum diameter, echogenicity, composition, presence of calcification, margins, and presence of halo. The frequencies of each US feature were compared by using the χ<SUP>2</SUP> test or Fisher's exact test between FAs and FCs. The relative risk of malignancy was evaluated by logistic regression analysis.</P><B>Results</B><P>Isohypoechoic echogenicity, predominantly solid or mixed echotexture, and presence of microcalcifications or rim calcifications were associated with FC (p < 0.05). Logistic regression analysis demonstrated that predominantly solid or mixed echotexture and microcalcifications or rim calcifications were associated with significant increases in relative risk for FC (odds ratio 8.1 and odds ratio 13.5, respectively, p < 0.01).</P><B>Conclusions</B><P>The US features of isohypoechoic echogenicity, predominantly solid or mixed echotexture, and microcalcifications or rim calcifications are more common in FC than in FA. © 2009 Wiley Periodicals, Inc. J Clin Ultrasound, 2009</P>
Seo, Yeon Seok,Kim, Youn Ho,Ahn, Sang Hoon,Yu, Sang Kyun,Baik, Soon Koo,Choi, Sung Kyu,Heo, Jeong,Hahn, Taeho,Yoo, Tae Woo,Cho, Se Hyun,Lee, Hyun Woong,Kim, Ju Hyun,Cho, Mong,Park, Sang Hoon,Kim, Byun The Korean Academy of Medical Sciences 2008 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.23 No.4
<P>With recent progress in treatment modalities, mortality from upper gastrointestinal (UGI) bleeding has decreased appreciably. The aim of this study was to establish how UGI bleeds are managed in Korean patients with cirrhosis and to evaluate treatment outcomes. A total of 479 episodes of acute UGI bleeding in 464 patients with cirrhosis were included during a six-month period at nine tertiary medical centers. Treatment outcomes were assessed by failure to control bleeding, rebleeding and mortality. The source of bleeding was esophagogastric varices in 77.7% of patients, nonvariceal lesions in 15.9%, and undefined in 6.5%. For control of bleeding, endoscopic and pharmacologic treatments were used in 74.7% and 81.9% of patients, respectively. Variceal ligation was a major technique for endoscopic treatment (90%), and terlipressin and somatostatin were the main pharmacologic agents used (96.4%). Initial hemostasis was achieved in 86.8% of cases, but rebleeding occurred in 3.8% and 16.8% of cases within five days and six weeks of hemorrhage, respectively. Five-day and six-week mortality were 11.3% and 25.9%, respectively. Survival of patients with variceal bleeding seems to be remarkably improved than previous reports, which may suggest the advances in hemostatic methods for control of variceal hemorrhage.</P>