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Kim, Shin-Hyun,Park, Hyo Sung,Choi, Jae Hoon,Shim, Jae Won,Yang, Seung-Man WILEY-VCH Verlag 2010 Advanced materials Vol.22 No.9
<B>Graphic Abstract</B> <P>The cover shows a schematic illustration of patterned colloidal photonic crystals with different bandgap positions. When an unknown light source impinges on the patterned photonic crystals, the light information can be identified from the reflection intensity profile of the constituent photonic crystals. The two optical microscopy images and background image display integrated photonic crystals with 20 different bandgaps spanning the entire visible range, and the SEM image shows the cross-section of the photonic crystal stripes, as reported by Shin-Hyun Kim, Seung-Man Yang, and co-workers on p. 946. <img src='wiley_img_2010/09359648-2010-22-9-ADMA201090022-content.gif' alt='wiley_img_2010/09359648-2010-22-9-ADMA201090022-content'> </P>
( Hyun Su Baek ),( Hye Sung Lee ),( Bok Joo Kim ),( In Kyo Chung ),( Chul Hoon Kim ),( Sun Mi Jin ),( Hie Sung Hwang ),( Sang Hun Shin2 ) 한국조직공학·재생의학회 2011 조직공학과 재생의학 Vol.8 No.6
The objective of this study was to evaluate platelet-rich fibrin (PRF)’s effectiveness in repairing articular disc defect in the temporomandibular joint (TMJ) of rabbits. Eight rabbits were divided into four groups of two rabbits each, corresponding to groups A, B, C, and D. Both TMJs of all of the rabbits were used in the experiments: the right joints comprised the experimental groups, and the left ones, the control groups. The disc defect was circular and 2 mm in diameter. In the experimental groups, the PRF was compressed into the defect, whereas the control group defects were left untreated. A, B, C, and D groups were sacrificed at the 1st, 2nd, 4th and 6th weeks, respectively. The defects of each control group exhibited no specific changes. Contrastingly, in each experimental group, there was an increased number of chondroblasts at the margins of the defects, along with accelerated cell differentiation and a columnar cell arrangement observable at the time of cell differentiation. The experimental groups showed inflammatory cell infiltrations and fibrosis by the 1st week, maturation of chondrocytes by the 2nd week, and proliferation by the 4th week, after which the defects began to be filled with chondrocytes, a process that was complete after the 6th week. In the histological evaluation (H-E), the experimental groups showed significant increases of chondroblasts after the 2nd and 4th weeks, as well as regular columns of chondrocyte arrays observable during cell division. After 6 weeks, the defects were filled with chondrocytes.
Prevention of Hypoglycemia-Induced Neuronal Death by Hypothermia
Shin, Byung Seop,Won, Seok Joon,Yoo, Byung Hoon,Kauppinen, Tiina M,Suh, Sang Won SAGE Publications 2010 Journal of cerebral blood flow and metabolism Vol.30 No.2
<P> Hypothermia reduces neuronal damage after cerebral ischemia and traumatic brain injury, while hyperthermia exacerbates damage from these insults. Previously we have shown that temperature-dependent modulation of excitotoxic neuronal death is mediated in part by temperature-dependent changes in the synaptic release/translocation of Zn<SUP>2+</SUP>. In this study, we hypothesize that brain temperature also affects hypoglycemia-induced neuronal death by modulation of vesicular Zn<SUP>2+</SUP> release from presynaptic terminals. To test our hypothesis, we used a rat model of insulin-induced hypoglycemia. Here we found that hypoglycemia-induced neuronal injury was significantly affected by brain temperature, that is, hypothermia inhibited while hyperthermia aggravated neuronal death. To investigate the mechanism of temperature-dependent neuronal death after hypoglycemia, we measured zinc release/translocation, reactive oxygen species (ROS) production, and microglia activation. Here we found that hypoglycemia-induced Zn<SUP>2+</SUP> release/translocation, ROS production, and microglia activation were inhibited by hypothermia but aggravated by hyperthermia. Even when the insult was accompanied by hyperthermic conditions, zinc chelation inhibited ROS production and microglia activation. Zinc chelation during hyperthermia reduced neuronal death, superoxide production, and microglia activation, which was comparable to the protective effects of hypothermia. We conclude that neuronal death after hypoglycemia is temperature-dependent and is mediated by increased Zn<SUP>2+</SUP> release, superoxide production, and microglia activation. </P>
A Case of Spinal Extradural Angiolipoma
Shin, Byoung-Gook,You, Seung Hoon,Kim, Eun-Sang,Eoh, Whan 대한척추신경외과학회 2004 Neurospine Vol.1 No.1
We present a case of an extradural thoracic spinal angiolipoma in a 37-year-old woman. She presented with 4-month history of progressive numbness and pain of trunk and both legs. Her neurological examination revealed weakness of both lower extremities, hypesthesia under the T4 level with saddle anesthesia and voiding difficulty. The epidural tumor was evaluated with magnetic resonance imaging scans. The patient improved remarkably after subtotal resection of the epidural tumor and decompression of cord. There were no signs of recurrence of the tumor or neurological deficit within the 2 year follow up.
Association of ZDHHC8 polymorphisms with smooth pursuit eye movement abnormality
Shin, Hyoung Doo,Park, Byung Lae,Bae, Joon Seol,Park, Tae Joon,Chun, Ji Yong,Park, Chul Soo,Sohn, Jin-Wook,Kim, Bong-Jo,Kang, Yeo-Hwa,Kim, Jae Won,Kim, Ki-Hoon,Shin, Tae-Min,Woo, Sung-Il Wiley Subscription Services, Inc., A Wiley Company 2010 American Journal of Medical Genetics. Part B Vol.b153 No.6
<P>The zinc finger DHHC domain-containing protein 8 (ZDHHC8) is located in the 22q11 microdeletion region and may contribute to the behavioral deficit associated with 22q11 deletion syndrome. Although polymorphisms of ZDHHC8 have been reported to be associated with the risk of schizophrenia, those associations are still controversial. This study was performed to validate the genetic association of ZDHHC8 polymorphisms with the risk of schizophrenia, and also to scrutinize the association with smooth pursuit eye movement (SPEM) abnormality in a Korean population. Five SNPs of ZDHHC8 were genotyped by TaqMan assay. Their genetic effects on the risk of schizophrenia were analyzed in 354 patients and 396 controls using allele-based χ<SUP>2</SUP> analyses. Association of ZDHHC8 polymorphisms with SPEM abnormality among 166 schizophrenic patients were analyzed using multiple regressions. No ZDHHC8 polymorphisms were found to be associated with the risk of schizophrenia. However, four SNPs and one haplotype (ht4) were strongly associated with the risk of SPEM abnormality even after multiple correction (P = 0.00005–0.0007, P<SUP>corr</SUP> = 0.0001–0.002). The results of the present study provide the first evidence that ZDHHC8 on the 22q11 locus might have influence on SPEM function of schizophrenia patients in a Korean population and may provide a new clue for understanding differential effects of candidate genes in schizophrenia. © 2010 Wiley-Liss, Inc.</P>
Production of low antigenic cheese whey protein hydrolysates using mixed proteolytic enzymes
Shin, Hyun Soo,Kim, Sang Bum,Kang, Soo Cheol,Khan, Muhammad Ajmal,Kim, Hyeon Shup,Shin, Hyun Jung,Chang, Chi Hoon John Wiley Sons, Ltd. 2007 Journal of the Science of Food and Agriculture Vol.87 No.11
<P>This study examined the effect of different proteolytic enzymes on the production of cheese whey protein (CWP) hydrolysates with low antigenicity. Four enzyme combinations (1:1) trypsin + papain W-40 (TP), trypsin + neutrase 1.5 (TN), papain W-40 + protease S (PP) and papain W-40 + neutrase 1.5 (PN) were added at the rate of 1% of the CWP and it was incubated for 15, 30, 60, 90, 120 and 180 min at 50 °C. CWP hydrolysis and its non-protein nitrogen concentrations were higher with TP and TN compared with PP and PN at all incubation times. The SDS-PAGE revealed complete removal of α-lactalbumin (α-LA) and β-lactoglobulin (β-LG) from hydrolysates produced by trypsin-containing enzyme mixtures. Reverse-phase HPLC analysis ascertained the CWP hydrolysis and SDS-PAGE results. The lowest antigenicity in CWP hydrolysates was observed with the use of trypsin-containing enzyme mixtures compared with other enzyme combinations. Present results suggested that TP and TN combinations were the most effective for CWP hydrolysis for the removal of β-LG from CWP. Further research is warranted to identify the peptides in CWP hydrolysates produced with these enzyme combinations that may help enhance the utilisation of whey protein in human food. Copyright © 2007 Society of Chemical Industry</P>
Preparation of YSZ Electrolyte for SOFC by Electron Beam PVD
Shin, Tae Ho,Yu, Ji Heang,Lee, Shi Woo,Han, In Sub,Woo, Sang Kuk,Jang, Byung Koog,Hyun, Sang Hoon Trans Tech Publications, Ltd. 2006 Key Engineering Materials Vol.317 No.-
<P>Yttria stabilized zirconia (YSZ) films with the thickness of up to 12 μm were prepared on alumina and NiO-YSZ substrates by electron beam physical vapor deposition (EB-PVD). The films showed nano-scaled columnar structures depending on the substrate temperature. Electrical conductivity of the YSZ films on alumina was also investigated at the temperature between 700 and 1000oC in oxidizing atmosphere. High activation energy of the conductivity (>1.03eV) indicated that the conduction via grain boundary controlled the ionic conduction in the films prepared by EB-PVD. La0.6Sr0.4CoO3-δ as a cathode was applied on the YSZ/NiO-YSZ in order to evaluate the performance of the YSZ electrolyte.</P>
Fuzzy Control Method for Balancing Left and Right Cardiac Output in Total Artificial Heart
Shin, In-Sun,Kim, Bo-Yeon,Lee, Sang-Hoon,Choi, Jin-Wook,Min, Byoung-Goo The Korean Society of Medical and Biological Engin 1991 의공학회지 Vol.12 No.3
Balancing left/right cardiac output is essential for the automatic control of total artificial hearts(TAH). A fuzzy logic-based control method is presented. We use left atrial pressure( LAP) ann right a'rial pressure( RAP ) as indicators for left/right balancing. The fuzzy controller has four input variables which are measured LAP and RAP and their gradients. Desired variations in left cardiac output(LCO) and right cardiac output(RCO) are cal- culated to keep LAP and RAP within the Physiological limlts. Computer simulations were performed to adjust fuzzy membership functions for variables and verify this control method. Results from simulations showed that LAP and RAP returned to the physiological limits while AoP and PAP stayed within the physiological limits.