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- 저자 : Satya Narayan Sankhwar (검색결과 4 건)
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SRD5A2 Gene Polymorphisms and the Risk of Benign Prostatic Hyperplasia but not Prostate Cancer
Choubey, Vimal Kumar,Sankhwar, Satya Narayan,Carlus, S. Justin,Singh, Anand Narayan,Dalela, Divakar,Thangaraj, Kumarasamy,Rajender, Singh Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.3
Background: Testosterone, a primary androgen in males, is converted into its most active form, dihydrotestosterone (DHT), by $5{\alpha}$-reductase type 2 (encoded by the SRD5A2 gene) in the prostate. DHT is necessary for prostatic growth and has five times higher binding affinity than testosterone for androgen receptors. We hypothesized that polymorphic variations in the SRD5A2 gene may affect the risk of benign prostatic hyperplasia and prostate cancer. Materials and Methods: We analyzed SRD5A2 gene polymorphisms in 217 BPH patients, 192 PCa cases, and 171 controls. Genotyping was undertaken using direct DNA sequencing. Genotype data were compared between cases and controls using a Chi square statistical tool. Results: We found that the A49T locus was monomorphic with 'AA' genotype in all subjects. At V89L locus, the presence of 'VV' showed a marginally significant correlation with increased BPH risk (p=0.047). At the $(TA)_n$ locus, longer TA repeats were found to be protective against BPH (p=0.003). However, neither of these polymoprhisms correlated with the risk of PCa. Conclusions: We conclude that A49T is monomorphic in the study population, VV marginally correlates with BPH risk, and longer $(TA)_n$ repeats are protective against BPH. None of these polymorphisms affect the risk of PCa.
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Ankur Bansal,Priyank Yadav,Manoj Kumar,Satya Narayan Sankhwar,Bimalesh Purkait,Ankur Jhanwar,Siddharth Singh 대한배뇨장애요실금학회 2016 International Neurourology Journal Vol.20 No.3
Purpose: This study was performed to characterise the nature, clinical presentation, mode of insertion, and management of intravesical foreign bodies in patients treated at our hospital. Methods: Between January 2008 and December 2014, 49 patients were treated for intravesical foreign bodies at King George Medical University, Lucknow. All records of these patients were retrospectively analysed to characterise the nature of the foreign body, each patient’s clinical presentation, the mode of insertion, and how the case was managed. Results: A total of 49 foreign bodies were retrieved from patients’ urinary bladders during the study period. The patients ranged in age from 11 to 68 years. Thirty-three patients presented with complaints of haematuria (67.3%), 29 complained of frequency of urination and dysuria (59.1%), and 5 patients reported pelvic pain (10.2%). The circumstances of insertion were iatrogenic in 20 cases (40.8%), self-insertion in 17 cases (34.6%), sexual abuse in 4 cases (8.1%), migration from another organ in 4 cases (8.1%), and assault in 4 cases (8.1%). Of the foreign bodies, 33 (67.3%) were retrieved by cystoscopy, while transurethral cystolitholapaxy was required in 10 patients (20.4%), percutaneous suprapubic cystolitholapaxy was performed in 4 patients (8.1%), and holmium laser lithotripsy was performed in 2 patients (4.08%). Conclusions: Foreign bodies should always be included in the differential diagnosis when evaluating a patient who presents with chronic lower urinary tract symptoms. A large percentage of foreign bodies can be retrieved using endoscopic techniques. Open surgical removal may be performed in cases where endoscopic techniques are unsuitable or have failed.
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Prevention of Prostate Cancer with Vitamins - Current Perspectives
Garg, Manish,Dalela, Divakar,Goel, Apul,Kumar, Manoj,Sankhwar, Satya Narayan Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.5
Cancer prostate is the most common solid malignancy in males of developed countries. With increasing knowledge of the aetiology, pathogenesis and natural history of the disease, influences of dietary factors on prostate cancer development have become more evident. There is ample evidence in the literature of significance of dietary constituents for prostate cancer including vitamins A, D and E. Different vitamins have been found to effect the growth and proliferation of prostate cancer cells as evident in epidemiological, experimental and clinical studies. Various factors play the major role in determining the relationship between these vitamins and prostate cancer in terms of environmental, pharmacological, or genetic aspects. To explore these aspects, the present article reviews the literature on the present status of vitamin use for prevention and management of prostate cancer.
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Leiomyosarcoma, a Nonurothelial Bladder Tumor: A Rare Entity With Therapeutic Diversity
Dheeraj Kumar Gupta,Vishwajeet Singh,Rahul Janak Sinha,Vijay Kumar,Deepak Sharanappa Nagathan,Satya Narayan Sankhwar 대한비뇨의학회 2013 Investigative and Clinical Urology Vol.54 No.6
A 22-year-old young woman presented with dysuria and lower urinary tract symptoms that had persisted for 6 months. She was diagnosed with a tumor near the bladder neck. Transurethral resection was done under anaesthesia. The histopathological examination with immunohistochemical staining showed the tumor to be a low-grade leiomyosarcoma. Adjuvant chemoradiation was given, and the patient has been doing well for 12 months of follow-up. Nonurothelial tumors of the bladder are rare and consensus is lacking regarding their definitive treatment. Furthermore, little is known about the natural history and prognosis of this type of bladder sarcoma. We present a minimally invasive treatment for this relatively rare tumor in which bladder preservation was achieved with no evidence of local or distant recurrences during the follow-up to date.
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