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니시무라, 신야,보다, 사토시,테라다, 신지,사쿠라이, 노리코,Nishimura, Shin-ya,Boda, Satoshi,Terada, Shinji,Sakurai, Noriko The Korean Housing Association 2015 한국주거학회 논문집 Vol.26 No.6
Since 1997, Dr. Shin-ya Nishimura has been developing an actual town planning project named the "Gangi Project". Students, inhabitants and local professionals walk around Omotemachi, examine the characteristics of the environment and the inhabitants' way of life, discuss plans and designs for traditional wooden arcades called locally "gangi". Students and inhabitants build the gangi together every year. The purpose of this study is to clarify how an experimental project aiming to preserve a living environment obtains sustainability as an actual town planning exercise. The research hypothesizes that sustainable town planning should include strategies for financial autonomy, active participation of inhabitants, supports from local professionals, an acceptance of changing environments, and responsible construction. The project has been carried out as a part of actual town planning, and continues to create a daily living environment based on the recent economical and industrial situation of the town. By focusing on the influences of the project on the town and inhabitants, the study has revealed the possibility of an actual town planning with small budget, and importance of a collaborative relationship with various participants in order to foster a sense of responsibility regarding the construction. The project also highlights the implication that sustainable town planning creates not only a participatory system but also a collaborative one in which participants take responsibility for the issues involved in the construction process.
Genetic Screening for Spinocerebellar Ataxia Genes in a Japanese Single-Hospital Cohort
Ryuji Sakakibara,Fuyuki Tateno,Masahiko Kishi,Yohei Tsuyusaki,Yosuke Aiba,Hitoshi Terada,Tsutomu Inaoka,Setsu Sawai,Satoshi Kuwabara,Fumio Nomura 대한파킨슨병및이상운동질환학회 2017 Journal Of Movement Disorders Vol.10 No.3
Objective: Diagnosis of sporadic cerebellar ataxia is a challenge for neurologists. A wide range of potential causes exist, including chronic alcohol use, multiple system atrophy of cerebellar type (MSA-C), and sporadic late cortical cerebellar atrophy. Recently, an autosomal-dominant spinocerebellar ataxia (SCA) mutation was identified in a cohort of patients with non-MSA-C sporadic cerebellar ataxia. The aim of this study is to genetically screen genes involved in SCA in a Japanese single-hospital cohort. Methods: Over an 8-year period, 140 patients with cerebellar ataxia were observed. There were 109 patients with sporadic cerebellar ataxia (no family history for at least four generations, 73 patients with MSA-C, and 36 patients with non-MSA-C sporadic cerebellar ataxia) and 31 patients with familial cerebellar ataxia. We performed gene analysis comprising SCA1, 2, 3, 6, 7, 8, 12, 17, 31, and dentatorubro-pallidoluysian atrophy (DRPLA) in 28 of 31 non-MSA-C sporadic patients who requested the test. Familial patients served as a control. Results: Gene abnormalities were found in 57% of non-MSA-C sporadic cerebellar ataxia cases. Among patients with sporadic cerebellar ataxia, abnormalities in SCA6 were the most common (36%), followed by abnormalities in SCA1 (7.1%), SCA2 (3.6%), SCA3 (3.6%), SCA8 (3.6%), and DRPLA (3.6%). In contrast, gene abnormalities were found in 75% of familial cerebellar ataxia cases, with abnormalities in SCA6 being the most common (29%). For sporadic versus familial cases for those with SCA6 abnormalities, the age of onset was older (69 years vs. 59 years, respectively), and CAG repeat length was shorter (23 vs. 25, respectively) in the former than in the latter (not statistically significant). Conclusion: Autosomal-dominant mutations in SCA genes, particularly in SCA6, are not rare in sporadic cerebellar ataxia. The reason for the frequency of mutations in SCA6 remains unclear; however, the reason may reflect a higher age at onset and variable penetrance of SCA6 mutations.