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Samira Jebahi,Mongi Saoudi,Riadh Badraoui,Tarek Rebai,Hassane Oudadesse,Zoubaier Ellouz,Hassib Keskese,Abdelfattah El Feki,Hafed El Feki 대한병리학회 2012 Journal of Pathology and Translational Medicine Vol.46 No.1
Background: Carbonated hydroxyapatite (CHA) and related calcium phosphates have been studied for many years as implant materials due to their similarity with the mineral phase of bone. The main limitation of CHA ceramics as well as other bioactive materials is that they have poor mechanical proprieties. It is thought that the mechanical device can cause an increase in metabolic activity and bone healing. In this study we investigated the reactivity and tissue behaviour of implanted CHA biomaterial reinforced by mini external fixator. Methods: The evaluation of biomaterial biocompatibility and osteogenesis was performed on a rabbit model over a period of 6 weeks by radiological, histological and scanning electron microscopy (SEM) coupled with energy dispersive X-ray SEM-energy-dispersive X-ray (EDX) analysis. Results: While rabbits treated with CHA exhibited more bone formation, and fibrous tissue was observed when empty bone defects were observed. EDX analysis detected little calcium and phosphorus on the surface of the bone that was not implanted, while high content of calcium (62.7%) and phosphorus (38%) was found on the interface bone cement. Conclusions: Bone repairing showed that the mini external fixator stimulated the ossification which was pushed when grafted by CHA. This effect may play an important role in the prevention of implant loosening.
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Alotaibi, Sarah Rsheed Mohamed,Saoudi, Kamel Korean Mathematical Society 2020 대한수학회지 Vol.57 No.3
In this work we investigate the nonlocal elliptic equation with critical Hardy-Sobolev exponents as follows, $$(P)\;\{(-{\Delta}_p)^su={\lambda}{\mid}u{\mid}^{q-2}u+{\frac{{\mid}u{\mid}^{p{^*_s}(t)-2}u}{{\mid}x{\mid}^t}}{\hspace{10}}in\;{\Omega},\\u=0{\hspace{217}}in\;{\mathbb{R}}^N{\backslash}{\Omega},$$ where Ω ⊂ ℝ<sup>N</sup> is an open bounded domain with Lipschitz boundary, 0 < s < 1, λ > 0 is a parameter, 0 < t < sp < N, 1 < q < p < p<sup>∗</sup><sub>s</sub> where $p^*_s={\frac{N_p}{N-sp}}$, $p^*_s(t)={\frac{p(N-t)}{N-sp}}$, are the fractional critical Sobolev and Hardy-Sobolev exponents respectively. The fractional p-laplacian (-∆<sub>p</sub>)<sup>s</sup>u with s ∈ (0, 1) is the nonlinear nonlocal operator defined on smooth functions by $\displaystyle(-{\Delta}_p)^su(x)=2{\lim_{{\epsilon}{\searrow}0}}\int{_{{\mathbb{R}}^N{\backslash}{B_{\epsilon}}}}\;\frac{{\mid}u(x)-u(y){\mid}^{p-2}(u(x)-u(y))}{{\mid}x-y{\mid}^{N+ps}}dy$, x ∈ ℝ<sup>N</sup>. The main goal of this work is to show how the usual variational methods and some analysis techniques can be extended to deal with nonlocal problems involving Sobolev and Hardy nonlinearities. We also prove that for some α ∈ (0, 1), the weak solution to the problem (P) is in C<sup>1,α</sup>(${\bar{\Omega}}$).
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Sarah Rsheed Mohamed Alotaibi,Kamel Saoudi 대한수학회 2020 대한수학회지 Vol.57 No.3
In this work we investigate the nonlocal elliptic equation with critical Hardy-Sobolev exponents as follows, \[({\rm P}) \begin{cases} (-\Delta _p)^su = \lambda |u|^{q-2}u + \frac{|u|^{p^*_s(t)-2}u}{|x|^t} & \textrm{in} \ \Omega ,\\ u=0 & \textrm{in} \ \mathbb{R}^N\setminus\Omega, \end{cases} \] where $\Omega\subset\mathbb{R}^N$ is an open bounded domain with Lipschitz boundary, $0<s<1$, $\lambda >0$ is a parameter, $0<t<sp<N$, $1<q< p< p_s^*$ where $p^*_s = \frac{Np}{N-s p}$, $p^*_s(t) = \frac{p(N-t)}{N-s p}$, are the fractional critical Sobolev and Hardy-Sobolev exponents respectively. The fractional $p$-laplacian $(-\Delta_p)^s u$ with $s\in (0,1)$ is the nonlinear nonlocal operator defined on smooth functions by \[ (-\Delta_p)^s u(x)=2 \underset{\epsilon\searrow 0}{\lim}\int_{\mathbb{R}^{N}\backslash B_\epsilon}\frac{|u(x)-u(y)|^{p-2}(u(x)-u(y))}{|x-y|^{N+ ps}}\,{\rm d}y,\ \ x\in \mathbb{R}^N. \] The main goal of this work is to show how the usual variational methods and some analysis techniques can be extended to deal with nonlocal problems involving Sobolev and Hardy nonlinearities. We also prove that for some $\alpha\in (0,1)$, the weak solution to the problem ({\rm P}) is in $C^{1,\alpha}(\overline{\Omega})$.
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Sana Bakari,Marwa Ncir,Samir Felhi,Hafedh Hajlaoui,Mongi Saoudi,Neji Gharsallah,Adel Kadri 한국식품과학회 2015 Food Science and Biotechnology Vol.24 No.6
Total phenolic and flavonoid contents and antioxidant properties of extracts and essential oils of the aerial parts of Teucrium polium growing in Tunisia were evaluated. Total phenolic and flavonoid contents of extracts ranged from 48.88±0.01 to 400.00±0.01 mg of GAE/g and from 2.75±0.01 to 38.85±0.04mg of QE/g, respectively. GC/MS analysis of essential oils led to identification of 71 compounds representing 89.66% of the total composition. Antioxidant activities were assessed using the DPPH. (1,1-diphenyl-2-picrylhydrazyl) radical scavenging activity, β-carotene bleaching, and reducing power. The best overall antioxidant activity was recorded for acetone extracts, with a strong positive correlation between the total phenolic content and the IC50 value of DPPH (R²=0.9999), attributed to the polyphenolic content.
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Samira Jebahi,Hassane Oudadesse,Gada Ben Saleh,Mongi Saoudi,Sirrar Mesadhi,Tarek Rebai,Hassib Keskese,Abdelfattah Elfeki,Hafed El Feki 한국화학공학회 2014 Korean Journal of Chemical Engineering Vol.31 No.9
Tissue engineering has opened up a new therapeutic avenue promising a revolution in regenerative medicine. Considerable attention has been given to chitosan composite materials and their applications in the field of the bonegraft substitutes. We evaluated the antioxidative properties of chitosan-doped bioactive glass (BG-CH) with 17 wt%chitosan, and their applications in the guided bone regeneration. BG-CH was produced by a freeze-drying process andimplanted in the femoral condyles of ovariectomized rats. Grafted bone tissues were carefully removed to evaluate theoxidative stress analysis, histomorphometric profile and mineral bone distribution by using inductively coupled plasmaoptical emission spectrometry (ICP-OES). A significant decrease of thiobarbituric acid-reactive substances (TBARs)was observed after BG-CH implantation. Superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase(GPx) activities significantly increased in ovariectomized group implanted with chitosan-doped bioactive glass (OVX-BG-CH) as compared to ovariectomized group implanted with bioactive glass (OVX-BG). The histomorphometricanalysis showed that bone/tissue volume (BV/TV), osteoblast number (N.Ob) and osteoblast surface/bone surface (Ob.S/BS) were significantly higher in OVX-BG-CH group than in OVX-BG group. On the other hand, a rise in Ca and Pion concentrations in the implanted microenvironment was shown to lead to the formation/deposition of Ca-P phases. Trace elements such as Sr and Fe were detected in the newly formed bone and involved in bone healing. These resultssuggested that BG-CH composites could become clinically useful as a therapeutic and implantable material.
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