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- 저자 : Abdelfattah El Feki (검색결과 2 건)
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Samira Jebahi,Mongi Saoudi,Riadh Badraoui,Tarek Rebai,Hassane Oudadesse,Zoubaier Ellouz,Hassib Keskese,Abdelfattah El Feki,Hafed El Feki 대한병리학회 2012 Journal of Pathology and Translational Medicine Vol.46 No.1
Background: Carbonated hydroxyapatite (CHA) and related calcium phosphates have been studied for many years as implant materials due to their similarity with the mineral phase of bone. The main limitation of CHA ceramics as well as other bioactive materials is that they have poor mechanical proprieties. It is thought that the mechanical device can cause an increase in metabolic activity and bone healing. In this study we investigated the reactivity and tissue behaviour of implanted CHA biomaterial reinforced by mini external fixator. Methods: The evaluation of biomaterial biocompatibility and osteogenesis was performed on a rabbit model over a period of 6 weeks by radiological, histological and scanning electron microscopy (SEM) coupled with energy dispersive X-ray SEM-energy-dispersive X-ray (EDX) analysis. Results: While rabbits treated with CHA exhibited more bone formation, and fibrous tissue was observed when empty bone defects were observed. EDX analysis detected little calcium and phosphorus on the surface of the bone that was not implanted, while high content of calcium (62.7%) and phosphorus (38%) was found on the interface bone cement. Conclusions: Bone repairing showed that the mini external fixator stimulated the ossification which was pushed when grafted by CHA. This effect may play an important role in the prevention of implant loosening.
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Samira Jebahi,Hassane Oudadesse,Gada Ben Saleh,Mongi Saoudi,Sirrar Mesadhi,Tarek Rebai,Hassib Keskese,Abdelfattah Elfeki,Hafed El Feki 한국화학공학회 2014 Korean Journal of Chemical Engineering Vol.31 No.9
Tissue engineering has opened up a new therapeutic avenue promising a revolution in regenerative medicine. Considerable attention has been given to chitosan composite materials and their applications in the field of the bonegraft substitutes. We evaluated the antioxidative properties of chitosan-doped bioactive glass (BG-CH) with 17 wt%chitosan, and their applications in the guided bone regeneration. BG-CH was produced by a freeze-drying process andimplanted in the femoral condyles of ovariectomized rats. Grafted bone tissues were carefully removed to evaluate theoxidative stress analysis, histomorphometric profile and mineral bone distribution by using inductively coupled plasmaoptical emission spectrometry (ICP-OES). A significant decrease of thiobarbituric acid-reactive substances (TBARs)was observed after BG-CH implantation. Superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase(GPx) activities significantly increased in ovariectomized group implanted with chitosan-doped bioactive glass (OVX-BG-CH) as compared to ovariectomized group implanted with bioactive glass (OVX-BG). The histomorphometricanalysis showed that bone/tissue volume (BV/TV), osteoblast number (N.Ob) and osteoblast surface/bone surface (Ob.S/BS) were significantly higher in OVX-BG-CH group than in OVX-BG group. On the other hand, a rise in Ca and Pion concentrations in the implanted microenvironment was shown to lead to the formation/deposition of Ca-P phases. Trace elements such as Sr and Fe were detected in the newly formed bone and involved in bone healing. These resultssuggested that BG-CH composites could become clinically useful as a therapeutic and implantable material.
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