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Amato Santoro,Federico Alvino,Giovanni Antonelli,Maria Caputo,Margherita Padeletti,Matteo Lisi,Sergio Mondillo 한국심초음파학회 2014 Journal of Cardiovascular Imaging (J Cardiovasc Im Vol.22 No.4
Background: Intensive training induces two morphological myocardial typologies of athlete’s heart. Endurance training (ET)induces eccentric remodeling, bradycardia and better diastolic filling. Strength training (ST) determines concentric chamberremodelling maintaining a normal heart rate (HR). Aim of the study was to compare ET and ST athletes’ heart using speckletracking echocardiography (STE). Methods: 33 professional ET, 36 ST athletes, and 17 healthy controls (CT) were enrolled. All subjects underwent standardtransthoracic echocardiography at rest and STE. Results: In ET group, HR was lower than ST group and CT group (p < 0.001; p < 0.01). ET group had higher E/A ratio thanST group and CT group (p < 0.01; p < 0.001). The left ventricular apical circumferential strain in ET group was lower than STgroup and CT group (-21.6 ± 4.1% vs. -26.8 ± 7.7%, p < 0.05; vs. -27.8 ± 5.6%, p < 0.01). ET group had lower left ventriculartwist (LVT) and untwisting (UTW) than ST group (6.2 ± 0.1° vs. 12.0 ± 0.1°, p < 0.01; -67.3 ± 22.9°/s vs. -122.5 ± 52.8°/s, p< 0.01) and CT group (10.0 ± 0.1°, p < 0.01; -103.3 ± 29.3°/s, p < 0.01). The univariate analysis showed significant correlationbetween E/A ratio and HR (r = -0.54; p < 0.001), LVT (r = -0.45; p < 0.01), UTW (r = 0.24; p < 0.05). At the multivariateanalysis only HR was confirmed as independent predictor of diastolic function in all groups (Beta -0.52; p < 0.001). Conclusion: In ET there was a better global systolic and diastolic functional reserve at rest observed with strain analysis and itmaybe depended on autonomic modulation.
RET: A Multi-Faceted Gene in Human Cancer
Massimo Santoro,Francesca Carlomagno,Rosa Marina Melillo 대한내분비학회 2012 Endocrinology and metabolism Vol.27 No.3
REarranged during Transfection (RET) gene encodes a receptor tyrosine kinase and it was initially discovered as an in vitro transforming gene. For many years, RET has been involved in papillary thyroid carcinoma and medullary thyroid carcinoma. More recently,lung adenocarcinoma and chronic myelomonocytic leukemia samples have been found to display RET gene rearrangements. This knowledge is stimulating the search for protein kinase inhibitors to combat RET-driven malignancies.
Minimizing environmental impact from optimized sizing of reinforced concrete elements
Jair F. Santoro,Moacir Kripka 사단법인 한국계산역학회 2020 Computers and Concrete, An International Journal Vol.25 No.2
The construction field must always explore sustainable ways of using its raw materials. Studying the environmental impact generated by reinforced concrete raw materials during their production and transportation can contribute to reducing this impact. This paper initially presents the carbon dioxide emissions from reinforced concrete raw materials, quantified per kilo of raw material and per cubic meter of concrete with different characteristic strengths, for southern Brazil. Subsequently, reinforced concrete elements were optimized to minimize their environmental impact and cost. It was observed that lower values of carbon dioxide emissions and cost savings are generated for less resistant concrete when the structural element is a beam, and that reductions in the cross section dimensions of the beams, sized based on the use of higher strength concrete, may not compensate for the increased environmental impact and costs. For the columns, the behavior differed, presenting lower values of carbon dioxide emissions and costs for higher concrete strengths. The proposed methodology, as well as the results obtained, can be used to support structural projects that have less impact on the environment.
Interventional Radiological Treatment of Renal Transplant Complications: A Pictorial Review
Roberto Iezzi,Michele Fabio la Torre,Marco Santoro,Roberta Dattesi,Massimiliano Nestola,Alessandro Posa,Jacopo Romagnoli,Franco Citterio,Lorenzo Bonomo 대한영상의학회 2015 Korean Journal of Radiology Vol.16 No.3
Renal transplantation is the treatment of choice for patients with chronic renal failure, which produces a dramatic improvement in the quality of life and survival rates, in comparison to long-term dialysis. Nowadays, new imaging modalities allow early diagnosis of complications, and thanks to the recent developments of interventional techniques, surgery may be avoided in most cases. Knowledge in the types of renal transplant complications is fundamental for a correct pre-operative planning. In this article, we described the most common or clinically relevant renal transplant complications and explained their interventional management.