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Sang-A Gim,Phil-Ok Koh 한국실험동물학회 2014 Laboratory Animal Research Vol.30 No.1
Ferulic acid is known to act as a protective agent in cerebral ischemia through its anti-oxidant activity. γ-Enolase is a neuron-specific enolase that also exerts a neuroprotective effect. Here, we investigated whether ferulic acid regulates the expression level of γ-enolase in middle cerebral artery occlusion (MCAO)-induced brain injury and glutamate exposure-induced neuronal cell death. Adult male rats were treated with either vehicle or ferulic acid (100 mg/kg, i.v.) after MCAO and cerebral cortex tissues were collected 24 h after MCAO. Using a proteomics approach, we found that γ-enolase expression was decreased in MCAO-injured animals treated with vehicle alone, whereas ferulic acid treatment attenuated this decrease. Reverse-transcription PCR and Western blot analyses confirmed that ferulic acid treatment prevented MCAO injury-induced decrease in γ-enolase. Furthermore, in hippocampal-derived cell lines, glutamate exposure also decreased γ-enolase expression and ferulic acid treatment attenuated this glutamate-induced decrease in γ-enolase. These findings suggest that ferulic acid mediates a neuroprotective effect by attenuating injury-induced decreases of γ-enolase expression in neuronal cells.
Sang-A Gim,Jin-Hee Sung,Fawad-Ali Shah,Myeong-Ok Kim,Phil-Ok Koh 한국실험동물학회 2013 Laboratory Animal Research Vol.29 No.2
Ferulic acid, a component of the plants Angelica sinensis (Oliv.) Diels and Ligusticum chuanxiong Hort, exerts a neuroprotective effect by regulating various signaling pathways. This study showed that ferulic acid treatment prevents the injury-induced increase of collapsin response mediator protein 2 (CRMP-2) in focal cerebral ischemia. Glycogen synthase kinase-3β (GSK-3β) regulates CRMP-2 function through phosphorylation of CRMP-2. Moreover, the pro-apoptotic activity of GSK-3β is inactivated by phosphorylation by Akt. This study investigated whether ferulic acid modulates the expression of CRMP-2 and its upstream targets, Akt and GSK-3β, in focal cerebral ischemia. Male rats were treated immediately with ferulic acid (100 mg/kg, i.v.) or vehicle after middle cerebral artery occlusion (MCAO), and then cerebral cortices were collected 24 hr after MCAO. MCAO resulted in decreased levels of phospho-Akt and phospho-GSK-3β, while ferulic acid treatment prevented the decrease in the levels of these proteins. Moreover, phospho-CRMP-2 and CRMP-2 levels increased during MCAO, whereas ferulic acid attenuated these injury-induced increases. These results demonstrate that ferulic acid regulates the Akt/GSK-3β/CRMP-2 signaling pathway in focal cerebral ischemic injury, thereby protecting against brain injury.
지리적 적절성을 기반으로 한 이주 노동자 대상 한국어 교육 정책 연구
공나형(Kong Na-hyung),주향아(Ju Hyang-a,),김주성(Gim Joo-sung),손동욱(Sohn Dong-wook),손현정(Son Hyun-jung) 한국사회언어학회 2013 사회언어학 Vol.21 No.3
This study focuses on the problem of Korean linguistics as social integration policy for foreign migrant workers. Particularly, we look into Korean Immigration & Integration Program(KIIP) to find out how foreign migrant workers can learn Korean language more effectively. In order to analyze the actual conditions of Korean language education for the foreign migrant workers, we adopt linguistic typological methods using Geographic Information System(GIS). Using GIS, we present the spread of the foreign migrant workers population and educational facilities enforcing the KIIP program. We also show some possibilities to improve the educational environment for foreign migrant workers such as the flexibility of class schedules, revision of textbooks and compensation of government. (112 words)
무릎 관절 각도에 따른 교각운동이 정적 균형과 동적 균형에 미치는 영향
배지영(Ji-Young Bae),김민아(Min-A Gim),김미경(Mi-Kyoung Kim),최정현(Jung-Hyun Choi),유경태(Kyung-Tae Yoo),이상빈(Sang-Bin Lee) 한국엔터테인먼트산업학회 2014 한국엔터테인먼트산업학회논문지 Vol.8 No.3
본 연구는 무릎 관절 각도를 달리한 교각운동이 정적균형과 동적균형에 미치는 영향을 알아보기 위하여 용인시 소재 O병원과 Y대학교에 재직, 재학 중인 건강한 직원과 학생 54명을 선정하여, 18명씩 3개의 그룹(60°, 90°, 120°)으로 나누어 주 5회 2주 동안 진행하였다. 정적균형 중 EO(Eye Open) C90A는 60°, 90°, EC(Eye Close) C90A는 60°, 90°, 120°, EO TL은 60°, 90°, EC TL은 60°, 90°, 120°에서 운동 전, 후에 유의한 차이가 있었으며(p<.05) 각도 사이에는 유의한 차이가 없었다. 동적균형은 전 방향에서 운동 전, 후와 각도 사이에 유의한 차이가 있었다(p<.05). 위의 결과로 보아, 교각운동은 60°, 90°, 120°에서 운동 전, 후에 모두 효과가 있었지만, 90°에서 시행하는 것이 가장 유의한 차이가 있었음을 알 수 있었다. The purpose of this study is to examine the effects of bridging exercises performed with different knee-joint angles on static and dynamic balance between before and after the exercises; it ultimately looks to present more effective bridging exercise methods. A total of 54 staff members and students at Yongin-si’s Y University, respectively, were selected as the subjects of this study. The subjects were divided into three knee-joint angle groups of 18 members each (60°, 90°, 120°), and both static balance After being measured before the exercise, the values were remeasured after the subjects performed bridging exercises five times repeatedly for 10 s each, five times a week for two weeks, at the various individual angles. The results of the study are as follows. Among static balance items, EO C90A showed significant differences between before and after the exercises at 60° and 90°; EC C90A showed significant differences at 60°, 90°, and 120°; EO TL showed significant differences at 60° and 90°; and EC TL showed significant differences at 60°, 90°, and 120°(p < 0.05). However, there were no significant differences among the angles. Among dynamic balance items, the forward direction showed significant differences between before and after the exercises, as well as among the various angles (p < 0.05).
발목관절의 등속성, 등척성 운동 방법이 균형에 미치는 영향
김미경(Mi-Kyoung Kim),김민아(Min-A Gim),배지영(Ji-Young Bae),최정현(Jung-Hyun Cho),이상빈(Sang-Bin Lee),유경태(Kyung-Tae Yoo) 한국엔터테인먼트산업학회 2014 한국엔터테인먼트산업학회논문지 Vol.8 No.2
본 연구의 목적은 등속성, 등척성 운동을 발목 관절에 시행하여 이러한 운동방법이 균형에 미치는 영향을 알아보고자 하였다. 본 연구의 대상은 젊고 건강한 성인 20명으로 이들을 운동 방법에 따라 무작위로 각 10명씩 그룹 설정 후, 등속성, 등척성 운동을 비우세측 발목관절에 실시하여 근피로를 유발하였다. 등속성 운동그룹은 60°/sec의 각속도로 10회 운동 후 1회 휴식을 1세트로 3세트, 등척성 운동 그룹은 15초 운동 후 1회 휴식을 3회 반복하는 것을 1세트로 3세트 실시하였다. 운동 중 각 세트 사이 휴식 시간은 1분을 가졌다. 측정은 운동전후 수행하였고, 균형은 eyes open one-leg stand test를 실시하여 측정하였다. 균형에 대한 차이를 알아보기 위하여 다변량분산분석(MANOVA)을 실시하였고, 다변량분산분석 결과, 균형에서 운동방법과 시기에 따른 상호작용효과와 운동방법에 따른 주효과가 면적, 길이, 속도에서 나타났으며, 시기에 따른 주효과가 길이, 속도에서 나타났다. 이러한 결과는 두 운동 방법으로 인한 근피로가 균형 감소에 영향을 미치며, 교차피로효과로 인해 운동을 시행하지 않은 쪽에도 영향을 미치는 것으로 사료된다. The purpose of this study was to analyze the effect of isokinetic and isometric exercise on the balance of ankle joint. The participants of this study were 20 young healthy adults (10 men, 10 women) and were divided into two groups (isokinetic=10, isometric=10). The isokinetic exercise group was performed 3 sets of 60°/sec 10 contractions. The isotonic exercise groups was performed 3 sets of 100% MVIC plantarflexion and 70% MVIC dorsiflexion 4 repetitions of 15s contractions 5s rests. The rest time was 1 min between sets. The balance was evaluated by using eyes open one-leg stand test and the balance was measured before and immediately after their exercises. Multivariate analysis of variance (MANOVA) was used to analyze the differences of the balance between two groups. The change in the balance between pre-test and post-test for the groups had the interaction effect in the area, length, velocity between group and time. The main effect of the groups appeared in the area, length, velocity. The main effect of time was found in the length, velocity. In conclusion, muscle fatigue induced by isokinetic and isotonic exercise on non-dominant side caused decreasing balance not only of exercised leg but also of non-exercised leg.