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Kim, Min Ju,Rehman, Shafiq Ur,Amin, Faiz Ul,Kim, Myeong Ok Elsevier 2017 Nanomedicine Vol.13 No.8
<P><B>Abstract</B></P> <P>Amyloid-beta (Aβ<SUB>1-42</SUB>) plaques and neurofibrillary tangles (NFTs) are the main hallmarks considered to be associated with neuroinflammation in Alzheimer's disease (AD). Recently, nanoparticle-based targeted drug delivery approaches have been found to be a useful tool in the neurotherapeutics field. Therefore, we examined and compared the neuroprotective effect of anthocyanins alone and anthocyanin-loaded poly (ethylene glycol)-gold nanoparticles (PEG-AuNPs) in Aβ<SUB>1-42</SUB>-injected mouse and <I>in vitro</I> models of AD. We determined that anthocyanins alone or conjugated with PEG-AuNPs (AnPEG-AuNPs) reduced Aβ<SUB>1-42</SUB>-induced neuroinflammatory and neuroapoptotic markers via inhibiting the p-JNK/NF-κB/p-GSK3β pathway in both <I>in vivo</I> and <I>in vitro</I> AD models. However, anthocyanins loaded with PEG-AuNPs were more effective compared to anthocyanins alone. Taken together, these results demonstrate that PEG-coated gold anthocyanins nanoparticles could be a new therapeutic agent in the field of nanomedicine to prevent neurodegenerative diseases such as AD.</P> <P><B>Graphical Abstract</B></P> <P>This study addresses the enhanced delivery of the anthocyanins loaded with PEG-gold nanoparticles in the mice brain. Herein, the particles can penetrate the BBB with less toxicity profiles and enhance neuroprotection against β-amyloid <SUB>1-42</SUB> induced neuroinflammation and neurodegeneration. In this study the anthocyanins loaded PEG-gold nanoparticles are more effective as compared to anthocyanins alone.</P> <P>[DISPLAY OMISSION]</P>
Kim, Young Ok,Lee, Yun Young,Kim, Myeong-Kyu,Woo, Young Jong Korean Society of Medical Genetics and Genomics 2019 대한의학유전학회지 Vol.16 No.2
Periventricular nodular heterotopia (PNH) is a malformation of cortical development in which normal neurons inappropriately cluster in periventricular areas. Patients with Mowat-Wilson syndrome (MWS) typically present with facial gestalt, complex neurologic problems (e.g., severe developmental delay with marked speech impairment and epilepsy), and multiple anomalies (e.g., Hirschsprung disease, urogenital anomalies, congenital heart defects, eye anomalies, and agenesis of the corpus callosum [CC]). MWS is mostly caused by haploinsufficiency of the gene encoding zinc-finger E-box-binding homeobox 2 (ZEB2) due to premature stops or large deletions. We present a case report of a 9-year-old girl with PNH, drug-responsive epilepsy, severe intellectual disability, and facial dysmorphisms only in whom we performed whole-exome sequencing and found a de novo heterozygous missense mutation (c.3134A>C; p.His1045Pro) of ZEB2 (NM_014795.3; NP_055610.1). This mild case of MWS caused by a rare novel missense mutation of ZEB2 represents the first report of MWS with isolated PNH.
Kim, Hyo-Sang,Jung, Han Young,Kim, Myeong-Ok,Joa, Kyung-Lim,Kim, Yeo Ju,Kwon, Su-Yeon,Kim, Chang-Hwan Wolters Kluwer Health 2015 Medicine Vol.94 No.5
<P><B>Abstract</B></P><P>Bisphosphonates have been commonly used for the treatment of osteoporosis. However, there have been recent case reports of atypical fractures citing their long-term use, which inhibits the turnover of bone components.</P><P>A 64-year-old woman visited the outpatient clinic with pain in her right thigh and ambulation difficulty. We found fractures at both pedicles of L4 vertebra. subtrochanteric region of right femur, and left femoral shaft upon a radiologic examination. She had taken intravenous ibandronic sodium for osteoporosis over 3 years.</P><P>We changed the bishophonates to a parathyroid hormone because it was suspected that the multiple fractures were caused by the medication. Further, rehabilitation, including progressive weight bearing, was started. After 3 months of the conservative treatment, she was able to walk independently.</P><P>In conclusion, it is necessary to evaluate the possibility of atypical fractures in osteoporotic patients when they complain of lower extremity pain and to consider alternative treatments instead of bisphosphonates.</P>
Complete Transection of a Silicon Double Lumen Tube during the Process of Extubation-A Case Report-
( Myeong Jae Han ),( Byung-sang Lee ),( Duk-hee Chun ),( Sun Ok Kim ),( Hyeonjeong Yang ),( Dong Wook Shin ) 경희대학교 경희의료원 2016 慶熙醫學 Vol.31 No.1
The frequency of use of silicon material double lumen tube (DLT) in one-lung ventilation anesthesia is increasing because of its several advantages over the existing usual polyvinyl chloride (PVC) DLT such as softer material and less frequency of malposition or displacement due to its structural characteristics. However, we recently experienced an unexpected and potentially disastrous event of complete transection of the distal bronchial portion of this tube during the process of emergence from anesthesia. Here, we report a case to contemplate the association of this event with the structural vulnerability of this tube which may be related to the characteristic process of manufacturing of the tube and describe some methods to prevent reoccurrence of the same event.
Hedgehog signaling between cancer cells and hepatic stellate cells in promoting cholangiocarcinoma.
Kim, Younjoo,Kim, Myeong-Ok,Shin, Jin Sun,Park, Sun Hoo,Kim, Sang Bum,Kim, Jin,Park, Su Cheol,Han, Chul Ju,Ryu, Ji Kon,Yoon, Yong Bum,Kim, Yong-Tae Raven Press 2014 Annals of Surgical Oncology Vol.21 No.8
<P>Aberrant Hedgehog (HH) signaling activation is important in cancer growth and mediates the interaction between cancer cells and the surrounding stromal cells. This study investigated the role of HH signaling on the growth of cholangiocarcinoma (CC), focusing on the interaction of CC cells with stromal cells.</P>
Kim, Ju Young,Kim, Jumi,Kang, Seok Hun,Shin, Dong Ok,Lee, Myeong Ju,Oh, Jimin,Lee, Young-Gi,Kim, Kwang Man Electronics and Telecommunications Research Instit 2020 ETRI Journal Vol.42 No.1
All-solid-state batteries are promising energy storage devices in which high-energy-density and superior safety can be obtained by efficient cell design and the use of nonflammable solid electrolytes, respectively. This paper presents a systematic study of experimental factors that affect the electrochemical performance of all-solid-state batteries. The morphological changes in composite electrodes fabricated using different mixing speeds are carefully observed, and the corresponding electrochemical performances are evaluated in symmetric cell and half-cell configurations. We also investigate the effect of the composite electrode thickness at different charge/discharge rates for the realization of all-solid-state batteries with high-energy-density. The results of this investigation confirm a consistent relationship between the cell capacity and the ionic resistance within the composite electrodes. Finally, a concentration-gradient composite electrode design is presented for enhanced power density in thick composite electrodes; it provides a promising route to improving the cell performance simply by composite electrode design.
Kim, Ok-Rye,Cho, Myeong-Cheoul,Kim, Byung-Dong,Huh, Jin-Hoe Korean Society for Molecular and Cellular Biology 2010 Molecules and cells Vol.30 No.6
Peppers (Capsicum spp.) display a variety of fruit colors that are reflected by the composition and amount of diverse carotenoid pigments accumulated in the pericarp. Three independent loci, c1, c2, and y, are known to determine the mature color of pepper fruits by their allelic combinations. We examined the inheritance of fruit color in recombinant inbred lines (RILs) derived from an interspecific cross between C. annuum cv. TF68 (red) and C. chinense cv. Habanero (orange). The c2 gene encodes phytoene synthase (PSY), a rate-limiting enzyme in the carotenoid biosynthesis pathway. TF68 has a dominant c2+ allele whereas Habanero is homozygous for the recessive c2 allele, which determined RIL fruit color. Here we report that the recessive c2 allele has a point mutation in the PSY gene that occurs at a splice acceptor site of the fifth intron leading to both a frame shift and premature translational termination, suggesting that impaired activity of PSY is responsible for orange fruit color. During ripening, PSY is expressed at a significantly high level in orange colored fruits compared to red ones. Interestingly, the PSY gene of red Habanero has a conserved splice acceptor dinucleotide AG. Further analysis suggests that red Habanero is a wild type revertant of the PSY mutant orange Habanero.
Kim, Jung‐,Ae,Karadeniz, Fatih,Ahn, Byul‐,Nim,Kwon, Myeong Sook,Mun, Ok‐,Ju,Bae, Min Joo,Seo, Youngwan,Kim, Mihyang,Lee, Sang‐,Hyeon,Kim, Yuck Yong,Mi‐,Soon, Jang,Kong, C John Wiley Sons, Ltd 2016 Journal of the Science of Food and Agriculture Vol.96 No.3
<P>BACKGROUND: Health problems related to the lack of bone formation are a major problem for ageing populations in the modern world. As a part of the ongoing trend to develop natural substances that attenuate bone loss in osteoporosis, the effects of the edible brown alga Sargassum thunbergii and its active contents on adipogenic differentiation in 3T3-L1 fibroblasts and osteoblast differentiation inMC3T3-E1 pre-osteoblasts were evaluated. RESULTS: Treatment with S. thunbergii significantly reduced lipid accumulation and expression of adipogenic differentiation markers such as peroxisome proliferator-activated receptor gamma , CCAAT/enhancer- binding protein.. and sterol regulatory element binding protein 1c. In addition, S. thunbergii successfully enhanced osteoblast differentiation as indicated by increased alkaline phosphatase activity along raised levels of osteoblastogenesis indicators, namely bone morphogenetic protein-2, osteocalcin and collagen type I. Two compounds, sargaquinoic and sargahydroquinoic acid, were isolated fromactive extract and shown to be active by means of osteogenesis inducement. CONCLUSION: S. thunbergii could be a source for functional food ingredients for improved treatment of osteoporosis and obesity. (C) 2015 Society of Chemical Industry</P>
Kim, Eun-Ok,Yu, Myeong-Hwa,Lee, Yu-Jin,Leem, Hyun-Hee,Kim, Shin-Ae,Kang, Dae-Hun,Choi, Sang-Won The Korean Society of Food Science and Nutrition 2010 Preventive Nutrition and Food Science Vol.15 No.2
The seeds from two mulberry fruits [Morus alba (MA) and Cudrania tricuspidata (CT)] were examined for their oil content, and fatty acid, phytosterol and tocopherol compositions and contents. Moreover, polyphenolic compounds and biological activity of the two defatted seed residue extracts were also evaluated. Oil contents of MA and CT seeds were 29.36% and 16.69%, respectively, while MeOH extracts of the defatted MA and CT seed residues were 5.10% and 6.22%, respectively. The two seed oils were composed of 81.4 and 74.37% linoleic, 5.75 and 11.39% oleic, 8.40 and 10.18% palmitic acid, and 3.52 and 3.0% stearic acids, and two other minor fatty acids, such as linolenic and arachidic acids. MA seed had higher contents of phytosterols (507.59 mg/100 g of oil), tocopherols (99.64 mg/100 g of oil), and total flavonoid (106.50 mg/100 g of seed) than CT seed, whereas CT seed had higher levels of total polyphenol than MA seed. The MeOH extract of MA seed residue showed higher antioxidant, anti-diabetic, and anti-melanogenic activity than that of CT seed residue. trans-Resveratrol (9.62 mg/100 g), quercetin (54.83 mg/100 g), and 4-prenylmoracin (48.70 mg/100 g), were found to be the main polyphenolic components in the MeOH extract of MA seed residue. These results indicate that MA seeds are good sources of essential dietary phytochemicals with antioxidant, anti-diabetic and anti-melanogenic activity.
Kim, Myeong Ok,Lee, Jeoung Sook,Cho, Kyeong Je,Lee, Bong Hee,Lee, Byung Ju,Choi, Wan Sung 경상대학교 유전공학연구소 1992 遺傳工學硏究所報 Vol.11 No.-
hypothalamic GnRH neurons are originated from olfactory placode of embryo.They enter brain regions during embryonic development and are loosely distributed within hypothalamic area and other brain regions. In the adult animals, however, GnRH is yet not known to be locally expressed in the olfactory cortex. Therefore, present study initially aims to acertain whether GnRH mRNA in the rat brain with in situ hybridization histochemistry. Interestingly, GnRH mRNAs are highly concentrated in the olfactory cortex of brain. To further elucidate the nature of GnRH transcripts in the olfactory system involving olfactory cortex and bulbs, we employed Northern hybridization and PCR analysis. GnRH mRNA in the rat olfactory cortex and bulb is similar in size to that in hypothalamus. The size of PCR products of olfactory cortex and bulbs are same with that of hypothalamus. Therefore, we suggest that GnRH in the olfactory system is expressed through a similar machinery with hypothalamic GnRH.