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Sanchez, Cesar,Camus, Mauricio,Medina, Lidia,Oddo, David,Artigas, Rocio,Sepulveda, Alejandra Perez,Domainguez, Francisco,Razmilic, Dravna,Navarro, Maria Elena,Galindo, Hector,Acevedo, Francisco Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.12
Background: Pathological factors, based mainly on immunohistochemistry (IHC) and histological differentiation, are mostly used to differentiate breast cancer (BC) subtypes. Our present aim was to describe the characteristics and survival of a relapsing BC patient cohort based on clinico-pathologic subtypes determined for the primary tumors. Methods: We used a clinico- pathological definition of BC subtypes based on histological grade (HG), estrogen receptor (ER), progesterone receptor (PgR),and epidermal growth factor receptor type 2 (HER2) expression assessed by IHC. We determined variables associated with loco-regional recurrence (LRR), second primaries (SP), systemic recurrence (SR) and post-recurrence survival (PRS). Results: Out of 1,702 patients, 240 (14%) had an event defined as recurrence. Those with recurrent disease were significantly younger than those without,and were initially diagnosed at more advanced stages, with larger tumors, greater lymph nodal involvement and higher HG. With a median follow up of 61 months (1-250), 4.6% of patients without recurrence and 56.6% of patients with an event defined as recurrence had died. The median PRS for the LRR group was 77 months; 75 months for those who developed a SP and 22 months for patients with an SR (p <0.0001). In SR cases, the median PRS was shorter for ER- tumors than for ER+ tumors (15 vs. 26 months, respectively; p = 0.0019, HR 0.44; CI: 0.25-0.44). Conclusions: Subtype, defined through classic histopathologic parameters determined for primary tumors, was found to eb related to type of recurrence and also to prognosis after relapse.
Martha Hilda Navarro-Salcedo,Jorge Ivan Delgado-Saucedo,Victor Hugo Siordia-Sanchez,Luis J. Gonzalez-Ortiz,Gustavo Adolfo Castillo-Herrera,Ana M. Puebla-Perez 한국식품영양과학회 2017 Journal of medicinal food Vol.20 No.11
We investigated the cytotoxic and antitumor effects of nine leaf extracts from Artemisia dracunculus (Tarragon). Five extracts were obtained using different organic solvents and four by supercritical CO2. The cytotoxic effects were expressed as IC50 in 100, 80, 80, 100, and 80 μg/mL by respective solvents: hexane, ethyl acetate, acetone, ethanol, and acetonitrile in L5178Y lymphoma cells. For supercritical CO2 extract A, IC50 was 100 μg/mL; for extracts C and D, IC50 was 150 μg/mL. The antitumor activity was assessed through a tumor growth inhibition test that measured ascites fluid volume and tumor cell counts of BALB/c mice (2 × 104 cells L5178Y i.p.). Twenty-four hours after inoculation, mice were treated with 100 mg/kg of acetonitrile extract or extract SF-A daily for 15 days in independent groups of five mice, using two administration routes. We observed tumor evolution with and without treatment. Without treatment, tumor evolution was 17,969 × 106 ± 5485 L5178Y cells in 2.6 mL ascites volume, whereas the orally treated acetonitrile extract group showed 0.1 × 106 ± 0.07 L5178Y cells (P < .05). The oral SF-A group showed 12.9 × 106 ± 243 L5178Y cells, and intraperitoneal (i.p.)-treated SF-A group showed 0.1 × 106 ± 0.05 L5178Y cells (P < .05) without any ascites volume development. The acetonitrile extract contains abundant polyphenols and possibly a flavone with antioxidant activity. The SF-A contains abundant alkamides. Both extracts are complexes and the identity of the compounds responsible for observed antitumor activity remains unknown.
Trichuris vulpis (Froelich, 1789) Infection in a Child: A Case Report
Adrian Marquez-Navarro,Gudelio Garcia-Bracamontes,Blanca E. Alvarez-Fernandez,Luz P. Avila-Caballero,Isabel Santos-Aranda,Dylan L. Diaz-Chiguer,Rosa M. Sanchez-Manzano,Elvia Rodriguez-Bataz,Benjamin N 대한기생충학열대의학회 2012 The Korean Journal of Parasitology Vol.50 No.1
E2E Network Slice Management Framework for 5G Multi-tenant Networks
Chirivella-Perez, Enrique Chirivella,Salva-Garcia, Pablo,Sanchez-Navarro, Ignacio,Alcaraz-Calero, Jose,Wang, Qi 한국통신학회 2023 Journal of communications and networks Vol.25 No.3
Network slicing is one of the cornerstone featuresof the fifth generation (5G) networks to enable the multiplexingof virtualised logical networks over the same physical networkinfrastructure for various vertical business services. Architecturesbased on network slicing enable network operators to offer end-to-end (E2E) vertical services whilst assuring fulfilling tailoredservice level agreement (SLA) requirements. Despite the numer-ous benefits that this concept offers, the need for efficient, scalableand holistic E2E management of network slicing significantlycomplicates network operators’ network management and im-poses significant challenges in the quality of service (QoS). Thispaper proposes a novel intent-based slice manager frameworkover a service base 5G architecture that allows flexible definitionsto customise network slices, automates all essential managementtasks for 5G network slice providers, manages the life cycles ofall sorts of network slices, and guarantees their QoS in a unifiednetwork slice management framework. The proposed frameworkis empirically validated in a realistic large-scale 5G multi-tenantinfrastructure. The high scalability of the framework is basedon the empirical results supporting more than 512 physicalmachines, 534288 virtual machines and more than two millionnetwork interfaces.