Thyroid Cancer Epidemiology in Iran: a Time Trend Study

Safavi, Ali,Azizi, Fereidoun,Jafari, Rozita,Chaibakhsh, Samira,Safavi, Amir Ali Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.1

Background: Considering the rising incidence of thyroid cancer worldwide, the aim of our study was to investigate the temporal trends in the incidence of this cancer in a large population of Iranian patients. Materials and Methods: We used the Iran Cancer Data System (ICDS) Registry to assess the thyroid cancer trend from 2004 to 2010 with regard to different genders, age groups, and morphologies. To do this we analyzed the data of 10,913 new cases of thyroid cancer that occurred during these years. Results: The incidence rate (per one year) of thyroid cancer was 2.20 per 100,000 persons between 2004 and 2010 in Iran. Papillary thyroid cancer was the most common histology type, with an annual rate of 0.29 in Iran. The highest rate of prevalence in thyroid cancer was observed at the age of 45 years at the time of diagnosis. We found a female-to-male ratio of 2 in Iran. A significant decrease was detected in the trend of thyroid cancer in children <19y, which was not correlated to the trend of older patients. Conclusions: As expected, the trend of thyroid cancer increased over the 7 years, primarily contributed by papillary thyroid cancer. A rising pattern of incidence was seen in all the age groups except patients aged under 19 years.

The Role of Low-Frequency Electromagnetic Fields on Mesenchymal Stem Cells Differentiation: A Systematic Review

Safavi Atiyeh Sadat,Sendera Anna,Haghighipour Nooshin,Banas-Zabczyk Agnieszka 한국조직공학과 재생의학회 2022 조직공학과 재생의학 Vol.19 No.6

BACKGROUND Low-frequency electromagnetic fields (EMFs) influence biological processes. This present study was aimed at the scientific literature on the use of EMFs in the mesenchymal stem cell differentiation process. MATERIALS AND METHODS The electronic search was carried out in PubMed and Web of Science, a database with a combination of the sinusoidal and pulsed low- and extremely low-frequency electromagnetic fields stimulation and mesenchymal stem cells differentiation, considering the period of publication until December 2021. The literature search identified 118 references in PubMed and Web of Science of which 46 articles were selected, respectively, according to the eligibility requirements. CONCLUSION The analysis of research indicated that EMFs are an easy-to-apply and practical way in cell therapy and tissue engineering when regulation of stem cells is required. Studies have shown that EMFs have positive effects on stem cell differentiation, accelerating its process regardless of the parameters and type of stem cells. However, the exact amplitude, frequency, duration of the electrical field, and application method remain elusive and need more study in future work.

Epidemiology of Nasopharyngeal Cancers in Iran: A 6-year Report

Safavi, Ali,Raad, Nasim,Raad, Neda,Ghorbani, Jahangir Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.10

Background: Nasopharyngeal cancer is a disease with distinct ethnic and geographical distribution. The aim of this review was to describe the epidemiological characteristics of nasopharyngeal cancer in Iran from 2004 to 2009 because no systematic study has been performed to evaluate the trends of its incidence yet. Materials and Methods: The data were derived from the databases of the National Cancer Data System Registry in the period of 2004-2009. Nasopharyngeal cancers were classified according to the International Classification of Diseases for Oncology. Incidence rates and trends were calculated and evaluated by gender, age decade, and histopathology types. Results: A total of 1,637 nasopharyngeal cancers were registered in Iran from 2004 to 2009 giving an incidence of 0.38 per 100,000. The male-to-female ratio was 2.08:1. The trend of incidence was found to have increased, with a significant increase observed in males. Undifferentiated carcinoma was the most common histopathology type in all the age decades. Conclusions: Because the incidence of nasopharyngeal cancers in Iran has increased, especially in males, further studies are recommended for understanding of the etiological factors involved in the rise of the disease.

der(1)t(1;1)(p36;q10) as a Rare Variant of 1q Gain in Fanconi Anemia-Associated Myelodysplastic Syndrome

Safavi Moeinadin,Vasei Mohammad 대한진단검사의학회 2021 Annals of Laboratory Medicine Vol.41 No.2

Reducing agent-free synthesis of curcumin-loaded albumin nanoparticles by self-assembly at room temperature

Safavi, M.S.,Shojaosadati, S.A.,Yang, H.G.,Kim, Y.,Park, E.J.,Lee, K.C.,Na, D.H. Elsevier/North Holland 2017 International Journal of Pharmaceutics Vol. No.

The purpose of this study was to prepare curcumin-loaded bovine serum albumin nanoparticles (CCM-BSA-NPs) by reducing agent-free self-assembly at room temperature. A 2<SUP>4</SUP> factorial design approach was used to investigate the CCM-BSA-NP preparation process at different pH values, temperatures, dithiothreitol amounts, and CCM/BSA mass ratios. Increasing the ionic strength enabled preparation of CCM-BSA-NPs at 25<SUP>o</SUP>C without reducing agent. CCM-BSA-NPs prepared under the optimized conditions at 25<SUP>o</SUP>C showed a particle size of 110+/-6nm, yield of 88.5%, and drug loading of 7.1%. The CCM-BSA-NPs showed strong antioxidant activity and neuroprotective effects in glutamate-induced mouse hippocampal neuronal HT22 cells. This study suggests that ionic strength can be a key parameter affecting the preparation of albumin-based NPs.

Application of a new neutronics/thermal-hydraulics coupled code for steady state analysis of light water reactors

Safavi Amir,Esteki Mohammad Hossein,Mirvakili Seyed Mohammad,Arani Mehdi Khaki 한국원자력학회 2020 Nuclear Engineering and Technology Vol.52 No.8

Due to ever-growing advancements in computers and relatively easy access to them, many efforts have been made to develop high-fidelity, high-performance, multi-physics tools, which play a crucial role in the design and operation of nuclear reactors. For this purpose in this study, the neutronic Monte Carlo and thermal-hydraulic sub-channel codes entitled MCNP and COBRA-EN, respectively, were applied for external coupling with each other. The coupled code was validated by code-to-code comparison with the internal couplings between MCNP5 and SUBCHANFLOW as well as MCNP6 and CTF. The simulation re-sults of all code systems were in good agreement with each other. Then, as the second problem, the core of the VVER-1000 v446 reactor was simulated by the MCNP4C/COBRA-EN coupled code to measure the capability of the developed code to calculate the neutronic and thermohydraulic parameters of real and industrial cases. The simulation results of VVER-1000 core were compared with FSAR and another nu-merical solution of this benchmark. The obtained results showed that the ability of the MCNP4C/COBRA-EN code for estimating the neutronic and thermohydraulic parameters was very satisfactory.

Cyanide removal simulation from wastewater in the presence of titanium dioxide nanoparticles

Safavi, Banafshe,Asadollahfardi, Gholamreza,Darban, Ahmad khodadadi Techno-Press 2017 Advances in nano research Vol.5 No.1

One of the methods of removing cyanide from wastewater is surface adsorption. We simulated the removal of cyanide from a synthetic wastewater in the presence of Titanium dioxide nano-particles absorbent uses VISUAL MINTEQ 3.1 software. Our aim was to determine the factors affecting the adsorption of cyanide from synthetic wastewater applying simulation. Synthetic wastewater with a concentration of 100 mg/l of potassium cyanide was used for simulation. The amount of titanium dioxide was 1 g/l under the temperature of $25^{\circ}C$. The simulation was performed using an adsorption model of Freundlich and constant capacitance model. The results of simulation indicated that three factors including pH, nanoparticles of titanium dioxide and the primary concentration of cyanide affect the adsorption level of cyanide. The simulation and experimental results had a good agreement. Also by increasing the pH level of adsorption increases 11 units and then almost did not change. An increase in cyanide concentration, the adsorption level was decreased. In simulation process, rising the concentrations of titanium dioxide nanoparticles to 1 g/l, the rate of adsorption was increased and afterward no any change was observed. In all cases, the coefficient of determination between the experimental data and simulation data was above 0.9.

The synthesis of tamoxifen-loaded albumin nanoparticles by homogenizers: Optimization and in vitro characterization

Safavi, M.S.,Shojaosadati, S.A.,Dorkoosh, F.A.,Jo, H.J.,Kwon, Y.,Lee, K.C.,Yang, H.G.,Park, E.J.,Na, D.H. Association de pharmacie galénique industri 2017 Journal of drug delivery science and technology Vol.41 No.-

The aim of this study was to develop mechanical homogenization processes to fabricate protein-based nanoparticles. The high-pressure homogenizer (HPH) and high-speed homogenizer (HSH); were used to encapsulate the hydrophobic drug, tamoxifen, in albumin nanoparticles. The results revealed that the rotational speed with HSH and the pressure with HPH were the main factors affecting the size, while increasing the residence time led to more homogenous nanoparticles. Seven homogenization cycles at 14917 psi and 8.24 min of mixing at 17360 rpm ensured a drug loading of 14.2 +/- 1.9% and 11.6 +/- 2.3% for HPH and HSH, respectively. We found a direct correlation between the obtained size and energy input and retention time with both homogenizing devices. The characteristics of the optimized nanoparticles were within the desired range to meet the requirements of intravenous injection. The surface morphology of the nanoparticles determined by transmission electron microscopy showed semi-spherical nanoparticle shapes. Further, the secondary structure of albumin in nanoparticles was determined via circular dichroism, which showed only slight structural changes versus native albumin, making it a promising, self-targeted drug delivery system. Finally, BT474 viability assays and western blot analysis showed the effectiveness of the tamoxifen-loaded albumin nanoparticles prepared via homogenization.

Protective Effects of Citicoline and Benfotiamine Each Alone and in Combination on Streptozotocin-induced Memory Impairment in Mice

Maryam Safavi,Ali Hosseini-Sharifabad,Yasaman Seyed-Yousefi,Mohammad Rabbani 대한정신약물학회 2020 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.18 No.1

Objective: Diabetes mellitus is associated with cognitive disorders such as Alzheimer’s disease. Studies have shown that citicoline and benfotiamine can improve memory and learning through different mechanism of actions. The aim of this study was to compare the individual effects of benfotiamine (100, 200, 300 mg/kg) and citicoline (50, 100, 250, 500 mg/kg, gavage) and their co-administration on memory impairments in diabetic mice. Methods: Diabetes was induced by a single dose of streptozotocin (STZ, 140 mg/kg, intraperitoneal) and benfotiamine and/or citicoline were administered for three weeks. Memory was evaluated using the object recognition task (ORT) and passive avoidance test (PAT). Results: Results from ORT shows that citicoline at 50, 100, 250, and 500 mg/kg and benfotiamine at 100, 200, and 300 mg/kg and their combination (benfotiamine at 100 mg/kg added to citicoline at 50, 100, and 250 mg/kg) are equally effective in reversing the memory loss induced by STZ (p < 0.001). PAT results demonstrate that citicoline at 100, 250, and 500 mg/kg and benfotiamine at above doses did not improve the latency time when administered separately, but benfotiamine at a fixed dose of 100 mg/kg in the presence of citicoline at 50, 100, and 250 mg/kg increased the latency time and improved memory significantly. Conclusion: In conclusion, in PAT, co-administration of benfotiamine and citicoline was more effective than either alone in improving memory. Regarding ORT, although benfotiamine added to citicoline improved memory notably, the difference between combination therapy and single-drug therapy was not considerable

A Mathematical Model for Dynamic Thermal Behavior of Multilayer Clothing System Incorporated with Microencapsulated Phase Change Materials

Ali Safavi,Mohsen Gorji,Roohollah Bagherzadeh,SAEEDEH MAZINANI,Masoud Latifi 한국섬유공학회 2023 Fibers and polymers Vol.24 No.11

In this research, the thermoregulation behavior of layered arrangement of fabric containing microencapsulated phase change materials (mPCMs) is mathematically modeled based on a previously developed theoretical model of monolayer fabric—mPCMs. This work considers a thermal range for mPCMs instead of just a melting point. The skin temperature is calculated for a simulated situation when a person moves from 35 to 0 °C atmosphere. The results show that the location of layers containing mPCMs has the primary effect on skin temperature. This study defines the effectiveness intensity index (EII) and effectiveness time index (ETI) to describe the dynamic thermal behavior of fabric settings. The proposed model, which is also validated by experimental results, can be used to estimate the thermal behavior of clothing systems containing mPCMs and design protective clothing systems with proper dynamic thermal insulation for different climates. This study presents the model that can be useful for design the garment layers containing mPCMs. Due to considering the melting range instead of just melting point for mPCMs, it seems that this simple model can predict the thermal behavior of garments close to real condition.