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RISS 인기검색어
- 검색키워드
- 저자 : Arash Goodarzi (검색결과 2 건)
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Majid Salehi,Keyvan Shahporzadeh,Arian Ehterami,Hodays Yeganehfard,Heliya Ziaei,Mohammad Moein Azizi,Saeed Farzamfar,Amirreza Tahersoltani,Arash Goodarzi,Jafar Ai,Akbar Ahmadi 한국섬유공학회 2020 Fibers and polymers Vol.21 No.8
In the current study, selenium particles were loaded into poly(ε-caprolactone)/gelatin nanofibrous matrices in orderto fabricate a potential wound dressing. The mats were produced by electrospinning of poly(ε-caprolactone)/Gelatin (1:1(w/w)) solution supplemented with 1 and 10 % (w/v) of selenium particles. Prepared wound dressings were investigatedregarding their morphology, mechanical properties, surface wettability, water-uptake capacity, water vapor permeability,porosity, blood compatibility, microbial penetration test and cellular response. Dressings containing 1 % and 10 % seleniumand selenium free mats were chosen to treat the full-thickness excisional wounds in Wistar rats. The study revealed that after14 days, the wound closure of the mat containing 1 % selenium was about 95.5±6.38 % while wound closure of the negativecontrol group was about 48.83±4.03 %. Our results showed the capability of nanofibrous containing selenium for successfulwound treatment.
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Majid Salehi,Arian Ehtrami,Farshid Bastami,Saeed Farzamfar,Sepanta Hosseinpour,Hamid Vahedi,Ahmad Vaez,Mostafa Rahvar,Arash Goodarzi 한국섬유공학회 2019 Fibers and polymers Vol.20 No.3
Peripheral nerve injury is a serious challenge which influences 2.8 percent of trauma patients. Tissue engineeringof peripheral nerves mainly focuses on axonal regeneration via various nerve guides. The aim of this study is to evaluate a novel polyurethane (PU)/gelatin nanofibers (GNFs) conduit’s potential combination with resveratrol (RVT) for sciatic nerve regeneration in the rat. Platelet-rich plasma (PRP) was used as a carrier for RVT. Different tests like contact angle, tensile strength etc. was used to evaluate properties of PU/GNFs conduits. In addition, the electron microscopy, MTT assay, and DAPI staining revealed its compatibility with Schwann cells. 24 male Wistar rats were allocated into four groups (n=6) (1) PU/GNF/PRP/Schwann cell, 2) PU/GNF/Schwann cell/PRP/RVT, 3) Positive control, and 4) Negative control in order to assess sciatic functional index (SFI), hot plate latency, electromyographical (EMG), the percentage of wet weight-loss of gastrocnemius muscle and histopathological studies using hematoxylin-eosin staining. The results represented sciatic functional index (SFI), hot plate latency, electromyographical improved significantly in group 1 and 2 compared to the negative control group. Histopathological findings showed remarkable improvements in myelin sheath regeneration and fibers condition in group 1 and 2 compared to the negative control group. Group 2 showed more resemblance to the normal sciatic nerve, with well-arranged fibers and an intact myelin sheath. This study successfully applied PU/GNFs/PRP/RVT conduits as a potential biocompatible nerve guide with proper mechanical properties, biocompatibility, and biodegradability that enhanced injured sciatic nerve’s recovery rate.
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