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류마티스 활막염에 있어 염증매개물질에 의한 Transforming Growth Factor-β-inducible Gene-h3 (βig-h3) 생산 조절 기전
강영모 ( Young Mo Kang ),김성일 ( Sung Il Kim ),김정섭 ( Jeong Seup Kim ),유동완 ( Dong Wan You ),사금희 ( Kheum Hee Sa ),박은주 ( Eun Ju Park ),김성욱 ( Sung Uk Kim ),서재석 ( Jae Seok Seo ),한승우 ( Seung Woo Han ),남언정 ( Eon 대한류마티스학회 2005 대한류마티스학회지 Vol.12 No.2
Objective: To investigate the expression pattern of transforming growth factor-β-inducible gene-h3 (βig-h3) within rheumatoid synovial tissue and the regulation of βig-h3 synthesis in fibroblast-like synoviocyte (FLS). Methods: Synovial tissues obtained from patients with rheumatoid arthritis and osteoarthritis were obtained during joint replacement surgery. βig-h3 expression was evaluated with immunohistochemical stain. FLS was isolated from synovial tissues and stimulated with cytokines including TGF-β, TNF-α, IL-1β, IFN-γ, IL-6, IL-4, and IL-10. βig-h3 synthesis was measured using semiquantitative RT-PCR, ELISA, immunofluorescence stain, and flow cytometry. Results: Expression of βig-h3 was diffuse and abundant in both lining and sublining layers of rheumatoid synovium, which was more prominent than those of osteoarthritis. Production of βig-h3 in FLS was regulated by TGF-β1 in a dose-dependent manner and was highest at 5 ng/mL of TGF-β1. TNF-α and IL-1β upregulated the production of βig-h3 from FLS synergistically with TGF-β1 but other cytokines such as IL-4, IL-6, IL-10 did not affect. βig-h3 synthesis was efficiently inhibited by dexamethasone at higher dose (100 nM) but not by cyclosporine-A. Conclusion: Production of βig-h3, which is highly upregulated in rheumatoid synovitis, is differentially regulated by inflammatory cytokines.
송유림,Jang Mi Hee,Jang Boyun,Bae Su Jin,Bak Seon Been,Lee Sung Min,Yun Un-Jung,Lee Ju Hee,Park Sang Mi,Jung Dae Hwa,Sa Bok Suk,Song Jong Kuk,이은혜,김광연,Park Kwang-Il,김영우,김상찬 대한독성 유전단백체 학회 2022 Molecular & cellular toxicology Vol.18 No.2
Background Herbal prescriptions have various effects and their efficacy is potentiated by the use of combinations of medicinal herbs. Objective Jageum-Jung (JGJ) is a traditional oriental medical prescription composed of five herbs. It has been used for detoxifi cation, and as an anti-inflammatory and antitumor agent. However, the effect of JGJ on hepatic fibrogenesis is unclear. Results We investigated the role of JGJ in TGF-β1/smad signaling, which is implicated in fibrogenesis, and its hepatoprotective effect in CCl 4 -treated mice with liver fi brosis. Treatment of LX-2 cells with TGF-β induced expression of mediators (α-SMA, PAI-1, and MMP-2) of fibrogenesis and activation of proinflammatory cytokines (TNF-α, IL-1β, and IL-6). However, these were downregulated by pretreatment with JGJ. In mice, oral administration of JGJ prevented liver injury induced by CCl 4 , as indicated by decreases in the ALT and AST levels. Conclusions JGJ inhibits hepatic fibrogenesis and TGF-β1/Smad signaling.
세라믹/고분자 1-3형 복합압전체 초음파 트랜스듀서를 사용한 근접거리변동 측정용 레벨Limit스위치에 관한 연구
사공건,김흥근,박경일 東亞大學校 2003 東亞論叢 Vol.40 No.-
In this study, an ultrasonic transducer is fabricated with 1-3 type composite resonators. Pulse-echo responses of an ultrasonic transducer are investigated in underwater dependent on the variable designated water-level. LED Output signals of a level limit with changing a water level are obtained by the 1-3 type self-made ceramics/polymer composite transducer and electric measuring unit. LED is turned on at above the up-limit level with increasing a water level, and LED is turned on at less level than the down-limit level with decreasing a water level. There was good agreement between the virtual water level and output LED signal by using the self-made water-detecting system.
글라스 아이오노머와 레진수복물 변연의 우식내성에 관한 비교실험연구
사우경,손일수,김용기 단국대학교 치의학연구소 1992 논문집 Vol.4 No.-
Standardized cavities were prepared on 60 permanent teeth which had been selected according to inherent fluoride ion content of enamel and several glass ionomers and composite resins were restored. After classification and deposition for 1, 2 and 3 weeks, artificial caries was made on these specimens and resulting histologic appearances and depths of the lesions were observed by a polarizing microscope. Then caries resistant effects of each materials were compared and analyzed. In groups of Ketac-Fil and Fuji Ⅱ, the depth of lesion was increased markedly as the distance had been far away from the margin of restoration materials, wherease in the control group(Silux Plus), lesion depth was deeper than the experimental group and uniform depth of lesion was made despite of the distance from the margin. Fluoride ion content released in solution was higher in Ketac-Fil, Fuji Ⅱ, Silux Plus by descending order and statistically significant difference between groups could be found.
초음파 트랜스듀서용 PZT-고분자 1-3-0형 복합압전체의 유전 및 압전특성
양윤석,최헌일,사공건 東亞論叢 1999 東亞論叢 Vol.36 No.-
In this study, piezoelectric composites with 1-3-0 connectivity have been studied. A piezoelectric ceramic PZT prepared by the Wet-Dry Combination method is used as a filler phase in mixture of the third filler phase and Eccogel polymer matrix. The density and stiffness of 1-3-0 type composites were decreased with increasing the third phase.
박수강,최낙일,백형래,임양수,이기용,신사현 조선대학교 에너지.자원신기술연구소 1998 에너지·자원신기술연구소 논문지 Vol.20 No.1
A single phase induction motor(SPIM) with two windings, main and auxiliary, is probably the most widely used motor in the world due to their ruggedness, low maintenance and simplicity of construction There are several ways of starting single phase motors The most popular arrangements is centrifugal switch An auxiliary winding connected in series with a capacitor, is brought into the circuit during starting The closing and opening of the switch must be speed dependant The switch meets the speed requirements, but it also has many drawback random switching, arcing, many models necessary for different speeds and shaft diameters, space required inside the motors and limited lifetime to name some of them. In this paper, the starting current of single phase induction motor was detected by a small detector and determined TRIAC gate signal. The strategy of current control is based on limited main and auxiliary current angle during starting period in the closed-loop control. The experimental result show the motor's starting characteristics of the proposal starting system and are compared with centrifugal switch starting motor.