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Latifa Bulbul,S. M. Kamruzzaman,Md. Mostafizur Rahman 경희대학교 융합한의과학연구소 2017 Oriental Pharmacy and Experimental Medicine Vol.17 No.4
The present study was investigated the brain antioxidant status and the memory enhancing efficiency of methanolic extract of Aegiceras corniculatum (AC) leaves in mice. The effects of 7-day oral administration of extracts at doses of 50 and 100 mg/kg BW were examined in both adult and aged group of mice. The memory enhancing activity was assessed by passive avoidance (PA) test and Morris water maze test (MWM). Amnesia was induced by scopolamine in MWM test. Both groups were subdivided into three groups (n = 10/groups) for PA test and five groups (n = 5/groups) for MWM test. Instantly after experiment, mice brain homogenates were subjected to determination of acetyl cholinesterase (AChE), superoxide dismutase (SOD), catalase (CAT), thiobarbituric acid reactive substances (TBARS), glutathione peroxidase (GPx), glutathione reductase (GR), glutathione S-transferase (GST), reduced glutathione (GSH) and reactive oxygen species (ROS). In PA test, both doses were significantly increased step through and escape latencies in both group of mice, whereas in MWM test, AC extract also significantly attenuated the effects of scopolamine compared to negative control animals in respective models. Additionally, the highest levels of SOD, CAT, GSH and GST were observed in the aged groups, whereas GR and GSHpx were observed in the adult groups. Moreover, AChE, TBARS and ROS levels were significantly decreased in both groups of mice in a dose-dependent manner. Histopathological analysis also showed the protected effect of AC. These findings together that A. corniculatum has potent antioxidant properties, capable of enhancing cognitive function in both adult and aged mice.
A. S. M. Kamruzzaman,M. Zinnatul ALAM,M. Ramiz Uddin MIAH,Shafiquzzaman SIDDIQUEE 한국곤충학회 2013 Entomological Research Vol.43 No.4
Yellow mite, Polyphagotarsonemus latus [Banks] (Acari: Tarsonemidae) is one of the major pests of jute crops (Corchorus capsularis L.) in Bangladesh. In this study, indigenous varieties of jute were used for treatments, namely, CVL‐1, CVE‐3, BJC‐7370 and BJC‐83. The paired plot treatments (treated and untreated controls) were laid out under field conditions. The effects of yellow mite were studied at three stages of the jute plants: 60 days after sowing (DAS), 90 DAS and 120 DAS. A higher number of mite stages was observed up to 90 DAS and then declined up to 120 DAS in var. BJC‐7370 among two other varieties, Deshi and Tossa. The percentage of infestation and damage indexes (scale 0–5) were measured to relate yellow mite injuries to the number of leaves, leaf area, fresh leaf weight, dry leaf weight, soluble solids, plant height, base diameter, fiber weight, stick weight, number of flowers per plant, number of pods, pod weight per plant, seeds per pod, seed weight and 1000 seeds' weight of plants infested at three different phenological stages. The highest fiber yield loss was found in the variety BJC‐7370 (59.75%), followed by BJC‐83 (55.56%), CVE‐3 (54.30%) and CVL‐1 (50.05). The highest stick yield losses were found in the following order: BJC‐7370 (54.54%) > BJC‐83 (51.17%) > CVL‐1 (43.68%) > CVE‐3 (37.80%) and BJC‐7370 (30.33%) > CVL‐1 (27.83%) > BJC‐83 (24.16%) > CVE‐3 (22.11%) for the highest seed yield under field conditions for Corchorus capsularis. High yellow mite population in untreated checks decreased plant growth and showed significant losses in yield production for the variety BJC‐7370.
Lee, H.S.,Kim, S.D.,Lee, W.M.,Endale, M.,Kamruzzaman, S.M.,Oh, W.J.,Cho, J.Y.,Kim, S.K.,Cho, H.J.,Park, H.J.,Rhee, M.H. North-Holland ; Elsevier Science Ltd 2010 european journal of pharmacology Vol.627 No.1
Platelets, though anucleated, possess several transcription factors, including NF-κB, that exert non-genomic functions regulating platelet activation. Since platelets have not only been recognized as central players of homeostasis, but also participated in pathological conditions such as thrombosis, atherosclerosis, and inflammation, we examined rat platelet NF-κB expression and evaluated the effects of anti-inflammatory drug BAY 11-7082, an inhibitor of NF-κB activation, in platelet physiology. Western blotting revealed that rat platelets express NF-κB. BAY 11-7082, dose dependently, inhibited collagen- or thrombin-induced-platelet aggregation. ATP release, TXB<SUB>2</SUB> formation, P-selectin expression, and intercellular Ca<SUP>2+</SUP> concentration activated by collagen were reduced in BAY 11-7082-treated platelets. BAY 11-7082 elevated intracellular levels of cAMP, but not cGMP, and its co-incubation with cAMP-activating agent (forskolin) or its hydrolyzing enzyme inhibitor (3-isobutyl-1-methylxanthine, IBMX), synergistically inhibited collagen-induced-platelet aggregation. In addition, vasodilator-stimulated-phosphoprotein (VASP) phosphorylation was enhanced in BAY 11-7082-treated platelets, which was partially inhibited by a protein kinase A (PKA) inhibitor, H-89. Moreover, while p38 mitogen-activated protein kinase (MAPK) was not affected, BAY 11-7082 attenuated c-Jun N-terminal kinase 1 (JNK1) and extracellular-signal-regulated protein kinase 2 (ERK2) phosphorylations. In conclusion, BAY 11-7082 inhibits platelet activation, granule secretion, and aggregation, and that this effect is mediated by inhibition of JNK1 and ERK2 phosphorylations, and partially by stimulation of cAMP-dependent PKA VASP phosphorylation. The ability of BAY 11-7082 to inhibit platelet function might be relevant in cases involving aberrant platelet activation where the drug is considered as anti-atherothrombosis, and anti-inflammatory therapy.
An Energy Efficient Multichannel MAC Protocol for QoS Provisioning in MANETs
( S. M. Kamruzzaman ),( Md. Abdul Hamid ) 한국인터넷정보학회 2011 KSII Transactions on Internet and Information Syst Vol.5 No.4
This paper proposes a TDMA-based multichannel medium access control (MAC) protocol for QoS provisioning in mobile ad hoc networks (MANETs) that enables nodes to transmit their packets in distributed channels. The IEEE 802.11 standard supports multichannel operation at the physical (PHY) layer but its MAC protocol is designed only for a single channel. The single channel MAC protocol does not work well in multichannel environment because of the multichannel hidden terminal problem. Our proposed protocol enables nodes to utilize multiple channels by switching channels dynamically, thus increasing network throughput. Although each node of this protocol is equipped with only a single transceiver but it solves the multichannel hidden terminal problem using temporal synchronization. The proposed energy efficient multichannel MAC (EM-MAC) protocol takes the advantage of both multiple channels and TDMA, and achieves aggressive power savings by allowing nodes that are not involved in communications to go into power saving “sleep mode”. We consider the problem of providing QoS guarantee to nodes as well as to maintain the most efficient use of scarce bandwidth resources. Our scheme improves network throughput and lifetime significantly, especially when the network is highly congested. The simulation results show that our proposed scheme successfully exploits multiple channels and significantly improves network performance by providing QoS guarantee in MANETs.
Inhibitory Activities of Red Ginseng Acidic Polysaccharide in Platelet Aggregation
Lee, Whi-Min,Kamruzzaman, S.M.,Song, Yong-Bum,Cho, Jae-Youl,Park, Hwa-Jin,Rhee, Man-Hee The Korean Society of Ginseng 2008 Journal of Ginseng Research Vol.32 No.1
Red ginseng acidic polysaccharide (RGAP), isolated from Korean red ginseng (Panax ginseng C.A. Meyer), has been shown to have a variety of biological functions such as immunostimulating and anti-tumor activities. In the present study, we investigated whether RGAP inhibited ligand-induced platelet aggregation. The washed platelet-rich plasma was prepared from male SD rats with successive centrifugation. The platelets $(10^8/ml)$ were preincubated with 1 mM of $CaCl_2$ for 2 min either in the presence or in the absence of RGAP $(10{\sim}50\;{\mu}g/ml)$ and were stimulated with collagen (2.5 ${\mu}g/ml$) and thrombin (0.1 U/ml). RGAP dose-dependently inhibited thrombin-induced platelet aggregation with $IC_{50}$ value of $26.2{\pm}2.0$ ${\mu}g/ml$. In collagen-induced platelet aggregation, RGAP inhibited the reaction with an $IC_{50}$ value of $31.5{\pm}3.0\;{\mu}g/ml$. RGAP potently suppressed the intracellular calcium ion, which was stimulated by thrombin (0.1 U/ ml). Among mitogen-activated protein kinase (MAPK) subtypes, the extracellular signal-regulated kinase (ERK) 1/2 and p38 MAPK were analyzed in the present study. RGAP inhibited the phosphorylation of ERK2 and p38 MAPK, which was activated by collagen (2.5 ${\mu}g/ml$). Finally, these results suggested that besides saponin fraction, RGAP take an important role in the preventive effect of Korean red ginseng against cardiovascular disease such as thrombosis and atherosclerosis.
Inhibitory Activities of Red Ginseng Acidic Polysaccharide in Platelet Aggregation
Whi Min Lee,S.M. Kamruzzaman,Yong Bum Song,Jae Youl Cho,Hwa Jin Park,Man Hee Rhee 고려인삼학회 2008 Journal of Ginseng Research Vol.32 No.1
Red ginseng acidic polysaccharide (RGAP), isolated from Korean red ginseng (Panax ginseng C.A. Meyer), has been shown to have a variety of biological functions such as immunostimulating and anti-tumor activities. In the present study, we investigated whether RGAP inhibited ligand-induced platelet aggregation. The washed platelet-rich plasma was prepared from male SD rats with successive centrifugation. The platelets (10?/ml) were preincubated with 1 mM of CaCl₂for 2 min either in the presence or in the absence of RGAP (10 ~ 50 ㎍/ml) and were stimulated with collagen (2.5 ㎍/ml) and thrombin (0.1 U/ml). RGAP dose-dependently inhibited thrombin-induced platelet aggregation with IC50 value of 26.2±2.0 ㎍/ml. In collagen-induced platelet aggregation, RGAP inhibited the reaction with an IC50 value of 31.5±3.0 ㎍/ml. RGAP potently suppressed the intracellular calcium ion, which was stimulated by thrombin (0.1 U/ml). Among mitogen-activated protein kinase (MAPK) subtypes, the extracellular signal-regulated kinase (ERK) 1/2 and p38 MAPK were analyzed in the present study. RGAP inhibited the phosphorylation of ERK2 and p38 MAPK, which was activated by collagen (2.5 ㎍/ml). Finally, these results suggested that besides saponin fraction, RGAP take an important role in the preventive effect of Korean red ginseng against cardiovascular disease such as thrombosis and atherosclerosis.