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- 검색키워드
- 저자 : S. Elayaraja (검색결과 3 건)
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Harb Samarah V.,Kolanthai Elayaraja,Backes Eduardo H.,Beatrice Cesar A. G.,Pinto Leonardo A.,Nunes Ana Carolina C.,Selistre-de-Araújo Heloisa S.,Costa Lidiane C.,Seal Sudipta,Pessan Luiz Antonio 한국조직공학과 재생의학회 2024 조직공학과 재생의학 Vol.21 No.2
Background: Poly (lactic acid) (PLA) is a biodegradable polyester that has been exploited for a variety of biomedical applications, including tissue engineering. The incorporation of β-tricalcium phosphate (TCP) into PLA has imparted bioactivity to the polymeric matrix. Methods: We have modified a 90%PLA-10%TCP composite with SiO2 and MgO (1, 5 and 10 wt%), separately, to further enhance the material bioactivity. Filaments were prepared by extrusion, and scaffolds were fabricated using 3D printing technology associated with fused filament fabrication. Results: The PLA-TCP-SiO2 composites presented similar structural, thermal, and rheological properties to control PLA and PLA-TCP. In contrast, the PLA-TCP-MgO composites displayed absence of crystallinity, lower polymeric molecular weight, accelerated degradation ratio, and decreased viscosity within the 3D printing shear rate range. SiO2 and MgO particles were homogeneously dispersed within the PLA and their incorporation increased the roughness and protein adsorption of the scaffold, compared to a PLA-TCP scaffold. This favorable surface modification promoted cell proliferation, suggesting that SiO2 and MgO may have potential for enhancing the bio-integration of scaffolds in tissue engineering applications. However, high loads of MgO accelerated the polymeric degradation, leading to an acid environment that imparted the composite biocompatibility. The presence of SiO2 stimulated mesenchymal stem cells differentiation towards osteoblast; enhancing extracellular matrix mineralization, alkaline phosphatase (ALP) activity, and bone-related genes expression. Conclusion: The PLA-10%TCP-10%SiO2 composite presented the most promising results, especially for bone tissue regeneration, due to its intense osteogenic behavior. PLA-10%TCP-10%SiO2 could be used as an alternative implant for bone tissue engineering application. Background: Poly (lactic acid) (PLA) is a biodegradable polyester that has been exploited for a variety of biomedical applications, including tissue engineering. The incorporation of β-tricalcium phosphate (TCP) into PLA has imparted bioactivity to the polymeric matrix. Methods: We have modified a 90%PLA-10%TCP composite with SiO2 and MgO (1, 5 and 10 wt%), separately, to further enhance the material bioactivity. Filaments were prepared by extrusion, and scaffolds were fabricated using 3D printing technology associated with fused filament fabrication. Results: The PLA-TCP-SiO2 composites presented similar structural, thermal, and rheological properties to control PLA and PLA-TCP. In contrast, the PLA-TCP-MgO composites displayed absence of crystallinity, lower polymeric molecular weight, accelerated degradation ratio, and decreased viscosity within the 3D printing shear rate range. SiO2 and MgO particles were homogeneously dispersed within the PLA and their incorporation increased the roughness and protein adsorption of the scaffold, compared to a PLA-TCP scaffold. This favorable surface modification promoted cell proliferation, suggesting that SiO2 and MgO may have potential for enhancing the bio-integration of scaffolds in tissue engineering applications. However, high loads of MgO accelerated the polymeric degradation, leading to an acid environment that imparted the composite biocompatibility. The presence of SiO2 stimulated mesenchymal stem cells differentiation towards osteoblast; enhancing extracellular matrix mineralization, alkaline phosphatase (ALP) activity, and bone-related genes expression. Conclusion: The PLA-10%TCP-10%SiO2 composite presented the most promising results, especially for bone tissue regeneration, due to its intense osteogenic behavior. PLA-10%TCP-10%SiO2 could be used as an alternative implant for bone tissue engineering application.
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Finite Element Modeling of Beam with Piezoelectric/Piezomagnetic Sensors under Uniform Temperature
Dhanasekaran Rajagopal,A. Kumaravel,S. Arunprasath,M. Dinesh Babu,S. Elayaraja 한양대학교 청정에너지연구소 2024 Journal of Ceramic Processing Research Vol.25 No.1
The present study aims to investigate the behaviour of mild steel beams subjected to multi-phase magnetoelectroelastic,piezoelectric, or magnetostrictive patches, taking into account the effects of temperature. A finite element method wasemployed to analyze the electric and magnetic potential of the structure while considering the coupling effects. The findingsof this study could provide valuable insights into the behaviour of such structures under varying temperature conditions andcontribute to the development of advanced technologies in the field of material science and engineering. Under homogeneoustemperature load, the current formulation shows the ability to anticipate the thermal deformation and sensor behaviour of thepiezoelectric/ piezo magnetic, magnetostrictive patches. A distinct variation characterizes the positioning of the sensor layer inthe beam, and the upper surface of the layer is plotted with transverse displacement, electric potential, and magnetic potentialalong its length. A comparative numerical analysis was conducted to assess the behaviour of multiphase magneto-electroelastic,magnetostrictive, and piezoelectric sensor materials concerning magnetic and electric potential. The investigation hasbeen conducted under various boundary conditions.
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In vitro sustained release of amoxicillin from lanthanum hydroxyapatite nano rods
M.I. Ahymah Joshy,K. Elayaraja,R.V. Suganthi,Sarath Chandra Veerla,S. Narayana Kalkura 한국물리학회 2011 Current Applied Physics Vol.11 No.4
Nano rods (∼100 nm) of pure hydroxyapatite [Ca_10(PO_4)_6(OH)_2)-HAp] and lanthanum doped HAp was synthesized by sol-gel route using calcium nitrate and diammonium hydrogen phosphate as precursors. The samples were without La_2O_3 or β-TCP phases, which were present in samples prepared by solid state and co-precipitation technique. Increase in the concentration of lanthanum lead to the enhancement of crystallinity and crystallite size. In addition, increase in specific surface area (31%) and hardness (14%)was observed in doped samples. The studies using PBS revealed a decrease in the dissolution of the samples as the dopant concentration increased. Further, the doping extended the amoxicillin release from the samples. Bactericidal effect against Gram positive and Gram negative bacteria indicated high antimicrobial resistant activity of these samples.
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