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- 저자 : S. Amber (검색결과 4 건)
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Surveying the Impact of Work Hours and Schedules on Commercial Motor Vehicle Driver Sleep
Adam Hege,Michael Perko,Amber Johnson,유창호,Sevil Sönmez,Yorghos Apostolopoulos 한국산업안전보건공단 산업안전보건연구원 2015 Safety and health at work Vol.6 No.2
Background: Given the long hours on the road involving multiple and interacting work stressors (i.e., delivery pressures, irregular shifts, ergonomic hazards), commercial drivers face a plethora of health and safety risks. Researchers goal was to determine whether and to what extent long-haul trucker work schedules influence sleep duration and quality. Methods: Survey and biometric data collected from male long-haul truck drivers at a major truckstop in central North Carolina over a six month period. Results: Daily hours worked (mean ¼ 11 hours, 55 minutes) and frequency of working over governmentmandated daily HOS regulations (23.8% “frequently or always”) were statistically significant predictors of sleep duration. Miles driven per week (mean ¼ 2,812.61), irregular daily hours worked (63.8%), and frequency of working over the daily hour limit (23.8% “frequently or always”) were statistically significant predictors of sleep quality. Conclusion: Implications of findings suggest a comprehensive review of the regulations and operational conditions for commercial motor vehicle drivers be undertaken.
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Chris Sedgwick,STEPHEN SERJEANT,CHRIS PEARSON,I. Yamamura,S. Makiuti,N. Ikeda,Y. Fukuda,S. Oyabu,T. Koga,S. Amber,Glenn J. White 한국천문학회 2017 天文學論叢 Vol.32 No.1
We have identified 22 quasars in the AKARI far-infrared all-sky Bright Source Catalogue, using a matching radius of < 10 “, and excluding matches which are close to foreground extended sources or cirrus. We have confirmed a relation between quasar optical luminosity and far-infrared luminosity which was found in an earlier study. In addition, we have found that the 11 sources which are at redshift z > 1 are magnified with respect to the predicted far-infrared luminosity, and consider this may be due to gravitational lensing. If confirmed, this would provide a new way to identify lenses; if not, we may have identified an interesting new population of extreme starbursting quasars. %We are currently seeking spectroscopic confirmation of the redshifts and improved imaging for these sources.
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Metabolomics Approach in the Study of the Well-Defined Polyherbal Preparation Zyflamend
Eric D. Tague,Allen K. Bourdon,Amber MacDonald,Maggie S. Lookadoo,Edward D. Kim,Wesley M. White,Paul D. Terry,Shawn R. Campagna,Brynn H. Voy,Jay Whelan 한국식품영양과학회 2018 Journal of medicinal food Vol.21 No.3
Zyflamend is a highly controlled blend of 10 herbal extracts that synergistically impact multiple cell signaling pathways with anticancer and anti-inflammatory properties. More recently, its effects were shown to also modify cellular energetics, for example, activation of fatty acid oxidation and inhibition of lipogenesis. However, its general metabolic effects in vivo have yet to be explored. The objective of this study was to characterize the tissue specific metabolomes in response to supplementation of Zyflamend in mice, with a comparison of equivalent metabolomics data generated in plasma from humans supplemented with Zyflamend. Because Zyflamend has been shown to activate AMPK, the “energy sensor” of the cell, in vitro, the effects of Zyflamend on adiposity were also tested in the murine model. C57BL/6 mice were fed diets that mimicked the macro- and micronutrient composition of the U.S. diet with and without Zyflamend supplementation at human equivalent doses. Untargeted metabolomics was performed in liver, skeletal muscle, adipose, and plasma from mice consuming Zyflamend and in plasma from humans supplemented with Zyflamend at an equivalent dose. Adiposity in mice was significantly reduced in the Zyflamend-treated animals (compared with controls) without affecting body weight or weight gain. Based on KEGG pathway enrichment, purine and pyrimidine metabolism (potential regulators of AMPK) were particularly responsive to Zyflamend across all tissues, but only in mice. Consistent with the metabolomics data, Zyflamend activated AMPK and inhibited acetyl CoA-carboxylase in adipose tissue, key regulators of lipogenesis. Zyflamend reduces adipose tissue in mice through a mechanism that likely involves the activation of AMPK.
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Impaired Thermosensation in Mice Lacking TRPV3, a Heat and Camphor Sensor in the Skin
Moqrich, Aziz,Hwang, Sun Wook,Earley, Taryn J.,Petrus, Matt J.,Murray, Amber N.,Spencer, Kathryn S. R.,Andahazy, Mary,Story, Gina M.,Patapoutian, Ardem American Association for the Advancement of Scienc 2005 Science Vol.307 No.5714
<P>Environmental temperature is thought to be directly sensed by neurons through their projections in the skin. A subset of the mammalian transient receptor potential (TRP) family of ion channels has been implicated in this process. These “thermoTRPs” are activated at distinct temperature thresholds and are typically expressed in sensory neurons. TRPV3 is activated by heat (>33°C) and, unlike most thermoTRPs, is expressed in mouse keratinocytes. We found that TRPV3 null mice have strong deficits in responses to innocuous and noxious heat but not in other sensory modalities; hence, TRPV3 has a specific role in thermosensation. The natural compound camphor, which modulates sensations of warmth in humans, proved to be a specific activator of TRPV3. Camphor activated cultured primary keratinocytes but not sensory neurons, and this activity was abolished in TRPV3 null mice. Therefore, heat-activated receptors in keratinocytes are important for mammalian thermosensation.</P>
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