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- 검색키워드
- 저자 : Earley, Taryn J. (검색결과 6 건)
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The “Sleep Well, Lincolnshire” Project: Evaluation of an Online Sleep Practitioner Clinic
Heather Elphick,Claire Earley,Karen Tyas,Lowri Thomas,Lisa Artis,Vicki Dawson 대한수면연구학회 2021 Journal of sleep medicine Vol.18 No.3
Objectives: Poor sleep is associated with adverse outcomes during childhood. Behavioral insomnia is the most common sleep difficulty experienced by children. The coronavirus disease 2019 (COVID-19) global pandemic in 2020 has profoundly affected children’s sleep patterns. This project aimed to evaluate a one-toone sleep service delivered via online clinics by community sleep practitioners in the UK.Methods: This was an observational pre- and post-evaluation study over a 12-month period. The intervention derived from aspects of cognitive-behavioral therapy for insomnia. The evaluation was questionnaire-based and assessed sleep parameters and well-being.Results: 104 parents returned completed questionnaires. The average time of sleep onset was 1 hour and 39 minutes pre-intervention and 20 minutes post-intervention. The average number of nights per week that children woke up was 3.9 pre-intervention and 0.9 post-intervention; the number of night awakenings fell from 1.9 to 0.5 and the time that children were awake after sleep onset fell from 66.8 minutes to 5.8 minutes. The average time that children were asleep was 8.0 hours per night pre-intervention and 10.2 hours post-intervention. The improvement in all sleep parameters was statistically significant (p<0.05). All parameters of parental and children’s well-being improved significantly (p<0.05), except for perceived ability to drive (p=0.07). All parents stated that they would recommend sleep support and 20% already had done so.Conclusions: The COVID-19 pandemic has accelerated the development of remote health care solutions, and in the case of children’s sleep clinics, the online mode of intervention delivery that is as effective, acceptable, and accessible as face-to-face delivery.
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Impaired Thermosensation in Mice Lacking TRPV3, a Heat and Camphor Sensor in the Skin
Moqrich, Aziz,Hwang, Sun Wook,Earley, Taryn J.,Petrus, Matt J.,Murray, Amber N.,Spencer, Kathryn S. R.,Andahazy, Mary,Story, Gina M.,Patapoutian, Ardem American Association for the Advancement of Scienc 2005 Science Vol.307 No.5714
<P>Environmental temperature is thought to be directly sensed by neurons through their projections in the skin. A subset of the mammalian transient receptor potential (TRP) family of ion channels has been implicated in this process. These “thermoTRPs” are activated at distinct temperature thresholds and are typically expressed in sensory neurons. TRPV3 is activated by heat (>33°C) and, unlike most thermoTRPs, is expressed in mouse keratinocytes. We found that TRPV3 null mice have strong deficits in responses to innocuous and noxious heat but not in other sensory modalities; hence, TRPV3 has a specific role in thermosensation. The natural compound camphor, which modulates sensations of warmth in humans, proved to be a specific activator of TRPV3. Camphor activated cultured primary keratinocytes but not sensory neurons, and this activity was abolished in TRPV3 null mice. Therefore, heat-activated receptors in keratinocytes are important for mammalian thermosensation.</P>
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Epidemiology of Insomnia in Korean Adults: Prevalence and Associated Factors
조용원,신원철,윤창호,홍승봉,김주한,Christopher J. Earley 대한신경과학회 2009 Journal of Clinical Neurology Vol.5 No.1
Background and PurposeaaInsomnia is a common complaint in adults. However, large epidemiologic studies of insomnia involving Asian populations are rarely reported. We performed an epidemiologic study of insomnia in a large Korean adult population. MethodsaaA total of 5,000 subjects (2,470 men and 2,530 women) were interviewed by telephone. A representative sample of subjects aged 20 to 69 years was constituted according to a stratified, multistage random sampling method. Insomnia was defined as either any difficulty getting to sleep or getting back to sleep after waking in the night. ResultsaaMore than one fifth (n=1,141, 22.8%) of the 5,000 subjects complained of insomnia, with the prevalence being significantly higher in women (25.3%) than in men (20.2%, p<0.001). Logistic regression revealed that the prevalence of insomnia increased significantly with age (p<0.001), being higher in those aged 60-69 years than in those aged 20-29 years (OR=2.368, 95% CI=1.762-3.182, p<0.001), and was lower in those with a monthly income of >4.5 million Korean won than in those with an income of <1.5 million Korean won (OR=0.689, 95% CI= 0.523-0.906, p<0.01). ConclusionsaaInsomnia is a common complaint in Korean adults, and its prevalence is similar to that in adults in Western countries.
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Diurnal variation of default mode network in patients with restless legs syndrome
Ku, Jeonghun,Lee, Yeong Seon,Chang, Hyuk Won,Earley, Christopher J.,Allen, Richard P.,Cho, Yong Won Elsevier 2018 SLEEP MEDICINE Vol.41 No.-
<P><B>Abstract</B></P> <P><B>Objective</B></P> <P>Restless legs syndrome (RLS) patients compared to controls have been found to have abnormal patterns in the default mode network (DMN) in the morning when symptom threshold is the highest and symptoms are least likely to occur. If these morning abnormalities in DMN are pertinent to disease expression, then similar or further detectable differences may be expected on a nighttime assessment when RLS symptom threshold is at its lowest. The purpose of this study was to elucidate the potential neural mechanisms underlying the circadian aspect of RLS symptom expression by assessing diurnal changes in DMN.</P> <P><B>Methods</B></P> <P>Fifteen drug-naïve subjects with idiopathic RLS and 15 age- and gender-matched healthy subjects had fMRI scans in the morning and evening. The DMN patterns were compared both for differences between morning and evening and between RLS and controls.</P> <P><B>Results</B></P> <P>RLS patients compared to the healthy controls showed significant differences in morning and evening DMN. In particular, RLS patients showed consistent increased connectivity in the parietal lobule in both the morning and evening. In contrast, connectivity in the thalamus was increased in the morning and reduced in the evening. In addition, there were negative correlations between thalamic connectivity and the Korean versions of the international RLS scale and the quality-of-life subscore.</P> <P><B>Conclusions</B></P> <P>The results indicated diurnal disturbances of the DMN in RLS subjects are consistent with both the circadian rhythm and severity of RLS. The circadian expression of RLS may relate to changes in arousal cortical-activation thresholds occurring with diurnal changes in the thalamic circuits of the DMN.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Diurnal changes in the brain with RLS symptoms could elucidate symptom dynamics. </LI> <LI> Daytime DMN, thalamic, and sensorimotor networks suggest solutions for RLS symptoms. </LI> <LI> Evening thalamic reduction with sustained sensorimotor activation controls symptom emergence. </LI> <LI> The results suggest RLS is a disorder of the disturbed sensory activation/threshold. </LI> <LI> The results could provide clinical provision for symptom emergence and treatment. </LI> </UL> </P>
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Chang, Yongmin,Paik, Jong Soo,Lee, Hui Joong,Chang, Hyuk Won,Moon, Hye-Jin,Allen, Richard P,Earley, Christopher J,Cho, Yong Won Butterworths [etc.] 2014 Neurological research Vol.36 No.8
<P>A prior diffusion tensor imaging (DTI) of restless legs syndrome (RLS) subjects found alterations in brain white matter (WM). The aim of this study was to explore the possible mechanism of altered integrity of brain WM in RLS patients.</P>
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