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RISS 인기검색어
- 검색키워드
- 저자 : Süleyman Demir (검색결과 3 건)
- 무료
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Decreased Prolidase Activity in Patients with Posttraumatic Stress Disorder
Süleyman Demir,Mahmut Bulut,Abdullah Atli,I·brahim Kaplan,Mehmet Cemal Kaya,Yasin Bez,Pınar Güzel Özdemir,Aytekin Sır 대한신경정신의학회 2016 PSYCHIATRY INVESTIGATION Vol.13 No.4
ObjectiveaaMany neurochemical systems have been implicated in the development of Posttraumatic Stress Disorder (PTSD). The prolidase enzyme is a cytosolic exopeptidase that detaches proline or hydroxyproline from the carboxyl terminal position of dipeptides. Prolidase has important biological effects, and to date, its role in the etiology of PTSD has not been studied. In the present study, we aimed to evaluate prolidase activity in patients with PTSD. MethodsaaThe study group consisted of patients who were diagnosed with PTSD after the earthquake that occurred in the province of Van in Turkey in 2011 (n=25); the first control group consisted of patients who experienced the earthquake but did not show PTSD symptoms (n=26) and the second control group consisted of patients who have never been exposed to a traumatic event (n=25). Prolidase activities in the patients and the control groups were determined by the ELISA method using commercial kits. ResultsaaProlidase activity in the patient group was significantly lower when compared to the control groups. Prolidase activity was also significantly lower in the traumatized healthy subjects compared to the other healthy group (p<0.01). ConclusionaaThe findings of the present study suggest that the decrease in prolidase activity may have neuroprotective effects in patients with PTSD.
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Geopolymerisation of un-calcined kaolin by the novel heat curing method
Selin Demir,Süleyman Yaşın 한양대학교 세라믹연구소 2022 Journal of Ceramic Processing Research Vol.23 No.1
In this study, heat curing technique (up to 320 oC) that allows the usage of sodium silicate solutions with un-calcined kaolinsto offer a durable geopolymeric binder in a short time was investigated. Samples containing up to 40 wt.% binder have beenproduced to observe the binder behaviour over a wide range of additions by heat curing for one hour. The cured samplesconsist of kaolinite and amorphous phase and crystallinity was decreased with increasing curing temperatures. 240 oC was thethreshold temperature for the strength development of the samples. Condensation reactions between Al-OH- units in uncalcinedkaolin and silanol groups in sodium silicate solution that yield sialate (Si-O-Al-O) bridges detected by infraredanalyses are the considered mechanisms of promoter effects of kaolinite. Optimum compressive strength (23.4 MPa.) wasobtained with the samples produced with 20 wt.% binder addition and 300 oC curing temperature.
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Mehmet Güneş,Mehmet Akif Camkurt,Mahmut Bulut,Süleyman Demir,Aslıhan Okan İbiloğlu,Mehmet Cemal Kaya,Abdullah Atlı,İbrahim Kaplan,Aytekin Sir 대한정신약물학회 2016 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.14 No.4
Objective: Human serum paraoxonase (PON1) prevents lipids from peroxidation and functions as an antioxidant mechanism. Malonyldialdehyde (MDA) is the final product of lipid peroxidation and can be used as an indicator of oxidative stress. The aim of this study was to investigate PON1, MDA, and arylesterase (ARY) levels in schizophrenic patients who are taking typical, atypical, or combined (typical and atypical) antipsychotic drug treatment, with respect to those of healthy controls. Methods: We evaluated 41 patients (11 taking typical antipsychotics, 19 taking atypical antipsychotics, 11 taking combined antipsychotics) and 43 healthy controls. Results: MDA levels were higher in schizophrenic patients taking typical antipsychotics compared with healthy controls (p=0.001). ARY levels were higher in patients taking atypical antipsychotics compared with healthy controls (p=0.005). PON1 activity was similar in all groups. Conclusion: Our results indicate that treatment with typical antipsychotic drugs could be related to increased MDA levels; and antipsychotic medication may increase PON1 levels in schizophrenic patients.
KCI
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