장기간 이별 후 고대하던 가족과의 재회를 통한 정서적 해소효과

유빈,석정호,김혜선,김병후,유계준 大韓神經精神醫學會 2008 신경정신의학 Vol.47 No.3

Objectives : Separation and reunion is common experiences in our life but enduring unwanted early-life separation from family members may be a distressful event. This study was executed to observe emotional resolution in the subjects who eagerly desire and experience reunion with their families after long-lasting separation. Methods : Thirty subjects who have participated in the reunion program of the Korean Broadcasting System (KBS) from April 2005 to July 2005 were interviewed to assess their demographic characteristics and memories about separation. Their anxiety and depressive mood were assessed using Spielberger’s State-Trait Anxiety Inventory, Beck Depression Inventory, Hamilton Depression Rating Scale and Hamilton Anxiety Rating Scale before the family reunion. At the time of the reunion, psychological states of 14 participants who were able to meet their family members were assessed again using the same assessment tools and the follow-up assessment was performed for one possible case at 7 months after the reunion. Results : The depression and anxiety levels of most subjects were significantly decreased after the reunion. Standardized T scores of their state-anxiety were mostly in abnormal range before the reunion but most of their anxiety levels were reduced within normal range after the reunion. Duration of education was negatively correlated with trait-anxiety level and duration of separation respectively even though trait-anxiety levels were not directly correlated with duration of separation. Emotional acceptability about childhood separation tended to contribute to the increased anxiety level. Conclusion : This is the first study to assess psychological distresses of the Korean people who have suffered from long-lasting separation with their families. The results in this study suggest that the eagerly desired reunion after long-lasting separation from family may have a resolutive effect for emotional distress, further study will be needed for larger population suffering from early-life separation.

공황 장애 환자에서 Venlafaxine Extended-release의 치료 효과와 안전성

유빈,김찬형,Ryu, Vin,Kim, Chan-Hyung 대한불안의학회 2006 대한불안의학회지 Vol.2 No.1

SSRIs have been considered as the first line of treatment for patients with panic disorder since 1990s along with cognitive behavioral treatments. High potency benzodiazepines (e.g. alprazolam, clonazepam) have had advantages in anti-panic effects. However, these drugs have limitations of treating panic disorder because of their dependency, tolerance and withdrawal. Serotonin and noradrenaline reuptake inhibitors (SNRIs) such as venlafaxine were introduced as antidepressants since 1990s. Recently, it is confirmed that SNRIs have the remarkable anti-panic effects although some concerns about its cost, tolerance, withdrawal, side effects such as dry mouth, constipation, and hypertension have emerged. In this regard, further study is required to confirm the efficacy of long term treatment of panic disorder. Despite these concerns, venla-faxine extended-release is an effective treatment in patients with panic disorder.

Enhanced Absorption Study of Ginsenoside Compound K (20- <i>O</i> - <i>β</i> -(D-Glucopyranosyl)-20(S)-protopanaxadiol) after Oral Administration of Fermented Red Ginseng Extract (HYFRG <i>™</i> ) in Healthy Korean Volunteers and Rats

Choi, Il-Dong,Ryu, Ju-Hee,Lee, Dong-Eun,Lee, Myoung-Hee,Shim, Jae-Joong,Ahn, Young-Tae,Sim, Jae-Hun,Huh, Chul-Sung,Shim, Wang-Seob,Yim, Sung-Vin,Chung, Eun-Kyoung,Lee, Kyung-Tae Hindawi Publishing Corporation 2016 Evidence-based Complementary and Alternative Medic Vol.2016 No.-

<P>To evaluate the pharmacokinetics of compound K after oral administration of HYFRG and RG in humans, an open-label, randomized, single-dose, fasting, and one-period pharmacokinetic study was conducted. After oral administration of a single 3 g dose of HYFRG and RG to 24 healthy Korean males, the mean (±SD) of AUC<SUB>0–<I>t</I></SUB> and <I>C</I><SUB>max</SUB> of compound K from HYFRG were 1466.83 ± 295.89 ng·h/mL and 254.45 ± 51.20 ng/mL, being 115.2- and 80-fold higher than those for RG (12.73 ± 7.83 ng·h/mL and 3.18 ± 1.70 ng/mL), respectively; in case of Sprague Dawley rats the mean (±SD) of AUC<SUB>0–<I>t</I></SUB> and <I>C</I><SUB>max</SUB> of compound K from HYFRG was 58.03 ± 32.53 ng·h/mL and 15.19 ± 10.69 ng/mL, being 6.3- and 6.0-fold higher than those from RG (9.21 ± 7.52 ng·h/mL and 2.55 ± 0.99 ng/mL), respectively. <I>T</I><SUB>max</SUB> of compound K in humans and rats was 2.54 ± 0.92 and 3.33 ± 0.50 h for HYFRG and 9.11 ± 1.45 and 6.75 ± 3.97 hours for RG, respectively. In conclusion, the administration of HYFRG resulted in a higher and faster absorption of compound K in both humans and rats compared to RG.</P>

Reliability and Validity of the Korean Version of Disruptive Behavior Disorders Rating Scale, DSM-5 Version-Parent Form

Eun Sol Lee,Vin Ryu,Jungwon Choi,Yunhye Oh,Jin Woong Yoon,Hyeree Han,Hyeon Hong,Hye Jung Son,Ji Hyun Lee,Subin Park 대한신경정신의학회 2022 PSYCHIATRY INVESTIGATION Vol.19 No.11

Objective Disruptive behavior disorder (DBD) adversely impacts children and adolescents. However, a comprehensive and cost-effective scale to assess DBD is lacking in Korea. Therefore, this study translated the Disruptive Behavior Disorders Rating Scale (DBDRS) into Korean and analyzed its psychometric properties.Methods Parents and primary caregivers of non-clinical (n=429) and clinical (n=28) children and adolescents aged 6–15 years were included in the analysis. Confirmatory factor analysis was conducted; further, concurrent validity and internal consistency were investigated using correlation analysis and Cronbach’s alpha, respectively. Furthermore, discriminative capacity was estimated using receiver operating characteristic curve analysis.Results The four-factor model of K-DBDRS showed good model fit indices and factor loadings, which supported the construct validity of the scale. Strong correlations between K-DBDRS and related measurements were observed, and a robust level of Cronbach’s alpha was confirmed (0.891–0.933). The discriminative capacity of the scale was good, based on the area under the curve values (0.933–0.953).Conclusion This study indicated that the K-DBDRS is an appropriate screening tool for Korean children and adolescents. Thus, this scale can be applied in clinical and community settings to identify children and adolescents with disruptive behavior disorders.

Circadian Rhythms, Depressive and Anxiety Symptoms, and Chronotype: Interaction and Implication for Mental Health in Healthy Subjects

You Jung Won,Nam Yoonyoung,Yu Rina,Ryu Vin 대한우울조울병학회 2024 우울조울병 Vol.22 No.1

ackground: Circadian rhythms have gained importance in the field of psychiatry because of their involvement in overall body functions and their association with mental health. This study investigated the relationship between circadian rhythms, depressive symptoms, anxiety symptoms, and chronotype. Methods: Circadian rhythms, depression and anxiety symptoms, hypomanic symptoms, quality of life, hopelessness, and chronotype were evaluated in 30 healthy adults. Results: Multiple linear regression analysis revealed statistically significant correlations between Biological Rhythms Interview of Assessment in Neuropsychiatry (BRIAN) scores and certain factors. Particularly, Quick Inventory of Depressive Symptomatology (p=0.009), Beck Anxiety Inventory (p=0.03), and Morningness-Eveningness Questionnaire (p<0.001) were found to be significant predictors of the degree of circadian rhythm disruption, as measured by BRIAN. The results showed that irregularity in circadian rhythms was associated with depression and anxiety symptoms, and no significant correlation was observed between chronotype and irregularity in the circadian rhythms. The findings indicated that misalignment between an individual’s chronotype and societal norms, such as work schedules and meal times, could contribute to circadian rhythm disruption, particularly in individuals with an evening chronotype. In contrast, this disruption was associated with an increased risk of anxiety and depression. Conclusion: These findings provide important information to better understand the impact of circadian rhythms on mental health.

Cortical Volumetric Correlates of Childhood Trauma, Anxiety, and Impulsivity in Bipolar Disorder

Song Hyehyun,Chon Myong-Wuk,Ryu Vin,Yu Rina,Lee Dong-Kyun,Lee Hyeongrae,Lee Wonhye,Lee Jung Hyun,Park Dong Yeon 대한신경정신의학회 2020 PSYCHIATRY INVESTIGATION Vol.17 No.7

Objective More recently, attention has turned to the linkage between childhood trauma and emotional dysregulation, but the evidence in bipolar disorder (BD) is limited. To determine neurobiological relationships between childhood trauma, current anxiety, and impulsivity, we investigated cortical volumetric correlates of these clinical factors in BD.Methods We studied 36 patients with DSM-5 BD and 29 healthy controls. Childhood trauma, coexisting anxiety, and impulsivity were evaluated with the Korean version-Childhood Trauma Questionnaire (CTQ), the Korean version-Beck Anxiety Inventory (BAI), and the Korean version-Barratt Impulsiveness Scale (BIS). Voxel-based morphometry (VBM) was used to assess gray matter volume (GMV) alterations on the brain magnetic resonance imaging (MRI). Partial correlation analyses were conducted to examine associations between the GMV and each scale in the BD group.Results Childhood trauma, anxiety, and impulsivity were interrelated in BD. BD patients revealed significant inverse correlations between the GMV in the right precentral gyrus and CTQ scores (r=-0.609, p<0.0003); between the GMV in the left middle frontal gyrus and BAI scores (r=-0.363, p=0.044). Moreover, patients showed similar tendency of negative correlations between the GMV in the right precentral gyrus and BIS scores; between the GMV in the left middle frontal gyrus and CTQ scores.Conclusion The present study provides evidence for a neural basis between childhood trauma and affect regulations in BD. The GMV alterations in multiple frontal lobe areas may represent neurobiological markers for anticipating the course of BD.

단보 : 인체 혈장중 라베프라졸의 정량을 위한 LC-MS/MS 분석법 검증 및 단일 용량 투여에 의한 약물동태 연구

탁성권 ( Sung Kwon Tak ),서지형 ( Ji Hyung Seo ),류주희 ( Ju Hee Ryu ),최상준 ( Sang Joon Choi ),이명재 ( Myung Jae Lee ),강종민 ( Jong Min Kang ),이진성 ( Jin Sung Lee ),홍승재 ( Seung Jae Hong ),임성빈 ( Sung Vin Yim ),이경태 ( 한국약제학회 2009 Journal of Pharmaceutical Investigation Vol.39 No.1

모빅캡슐(멜록시캄 7.5mg)에 대한 멜록시펜캡슐의 생물학적 동등성

이진성 ( Jin Sung Lee ),탁성권 ( Sung Kwon Tak ),서지형 ( Ji Hyung Seo ),강종민 ( Jong Min Kang ),류주희 ( Ju Hee Ryu ),임성빈 ( Sung Vin Yim ),홍승재 ( Seung Jae Hong ),이경태 ( Kyung Tae Lee ) 韓國藥劑學會 2009 Journal of Pharmaceutical Investigation Vol.39 No.6

정상인을 통해 알아본 우울 증상과 불안 증상이 특정 인지 기능에 미치는 영향

김규호,남윤영,한지연,유리나,유빈,Kim, Kyuho,Nam, Yoon-Young,Han, Jiyeon,Yu, Rina,Ryu, Vin 한국정신신체의학회 2021 정신신체의학 Vol.29 No.1

Objectives : Based on the fact that cognitive functions decline known as comorbid symptoms of depression can precede depression, this study seeks to observe the effects of depressive symptoms and anxiety symptoms on cognitive function in healthy subjects. Methods : To recruit 50 general populations to evaluate cognitive and clinical symptoms and to find out the effects of clinical symptoms on cognitive functions, Pearson correlation and multivariate regression were conducted. Correlation analysis of subdomain cognitive function was conducted for reliability analysis. Results : Trail making test-B that evaluates the execution function correlates with depressive symptoms (r=0.300, p=0.03) and age (r=0.323, p=0.02). Depressive symptoms (β=0.304, p=0.03) and age (β=0.335, p=0.01) were significantly related to Trail making test -B (Adjusted R²=0.148). Subjective cognitive tests correlates with anxiety symptoms (r=0.434, p=0.002). In the correlation between cognitive functional items, Subjective cognitive tests was found to be correlated with other test except Spotter. Conclusions : In this study, depressive symptoms contribute independently to executive functions in addition to demographic characteristics such as age and duration of education. Given that cognitive decline is a common long-term clinical outcome in depression, we expect active early intervention and evaluation of cognitive function to be helpful. 연구목적 본 연구는 우울증의 동반증상으로 알려진 인지 기능 저하가 우울증보다 선행될 수 있다는 점에 착안하여 정상인에게서 우울 증상과 불안 증상이 인지 기능에 미치는 영향을 관찰하고자 한다. 방 법 일반인 50명을 모집하여 인지 기능 및 임상 증상에 대한 평가와 임상 증상이 인지 기능에 미치는 영향을 알아보기 위해 피어슨 상관분석과 다변량 회귀분석을 시행하였다. 우울증에서 흔히 저하되는 인지 영역을 평가하는 검사 소항목간의 상관성을 알아보기 위해 위해 소항목간 상관분석을 시행하였다. 결 과 선로잇기검사(B형)는 우울 증상(r=0.300, p=0.03)과 나이(r=0.323, p=0.02)와 상관 관계를 보였고 이에 영향을 미치는 독립변수는 우울 증상(β=0.304, p=0.03)과 나이(β=0.335, p=0.01)이며 선로잇기검사(B형)에 대해 14.8%의 설명력을 보여주었다. 주관적 인지 기능 검사는 불안 증상(r=0.434, p=0.002)과 상관 관계가 있었다. 인지 기능 소항목간 상관분석에서 주관적 인지 기능검사는 주의력검사를 제외한 나머지 항목과 상관 관계가 있었다. 결 론 본 연구에서 우울 증상은 나이, 교육기간 같은 인구학적 특성 외에 독립적으로 실행기능에 기여하는 것을 알 수 있었다. 우울증에서 인지 기능 저하가 흔한 장기적인 임상 결과임을 감안할 때 인지 기능에 대한 적극적인 조기 개입과 평가가 도움이 될 것으로 기대한다.

양극성 장애 환자의 자서전적 기억

선자연,하라연,이수진,유빈,하규섭,조현상,Sun, Ja-Yeun,Ha, Ra-Yeon,Lee, Su-Jin,Ryu, Vin,Ha, Kyoo-Seob,Cho, Hyun-Sang 대한생물정신의학회 2012 생물정신의학 Vol.19 No.1

Objectives : Autobiographical memory (ABM) is a special type of episodic memory, containing events that have occurred in a personal life. Overgeneral tendency of ABM refers to the retrieval of memory with only general and categorical descriptions rather than specific events. ABM specificity in depression and posttraumatic stress disorder is a robust finding with relation to cognitive vulnerability, affect regulation, problem-solving ability. It is also implicated in bipolar disorder with frequent relapses. In this study, we investigated whether ABM specificity was related to manic or euthymic mood states in patients with bipolar disorder. Methods : Forty bipolar patients with manic and euthymic episodes and 25 healthy controls participated in this study. Prompted by 5 positively and 5 negatively valenced emotional cue words, each participant was instructed to recall positive or negative memories and describe them in detail. The One-way ANOVA was used to compare ABM scores and post-hoc analyses were done. Results : Comapred to the healthy persons, the bipolar patients reported significantly more general than specific negative memories in both manic and euthymic episodes (p = 0.003). However, there was no significant difference between manic and euthymic patients (p = 0.074). Conclusions : These results suggest that overgeneral tendency of negative ABM may be a trait abnormality in bipolar disorder. Moreover, this phenomenon might be related to underlying cognitive deficits or affect regulation irrespective of the mood state.