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유리나,김서희,이진아 대한의학회 2017 Journal of Korean medical science Vol.32 No.1
It is important to use vancomycin in a proper manner to ensure optimal drug exposure. Despite extensive use of vancomycin in children, studies on its optimal trough concentration (Ctrough) in the pediatric population remained rare. This retrospective study included children < 18 years old with culture-confirmed methicillin-resistant Staphylococcus aureus (MRSA) bacteremia who were hospitalized in our institute from January 2010 to April 2014. Clinical characteristics, initial vancomycin dose, Ctrough and clinical/microbiological outcomes were retrospectively collected from medical records. Forty-six MRSA bacteremia cases occurring to the patients with a mean age of 22.0 ± 46.9 months were included and all of them were healthcare-associated. Severe diseases requiring intensive care unit (ICU) stay, mechanical ventilation and/or resulting in death were observed in 57.8% (26/45); all-cause 30-day fatality was 11.1% (5/45). An initial Ctrough ≥ 15 μg/mL was achieved in only 4 (8.7%) cases with an average vancomycin dosage of 40.6 ± 7.9 mg/kg/day. Persistent bacteremia at 48 hours after initiation of vancomycin was observed more frequently in children with initial Ctrough < 10 μg/mL than in those with Ctrough ≥ 10 μg/mL (P = 0.032). However, there was no statistically significant difference between the two groups in terms of 30-day mortality and recurrent bacteremia (P = 0.899, and P = 0.754, respectively). Although initial Ctrough may be a useful parameter for minimizing early microbiological failure, it does not predict 30-day fatality or recurrence in pediatric MRSA bacteremia. Further prospective data on vancomycin dosing are needed to find the optimal drug exposure and clarify its impact on clinical outcomes in pediatric populations.
사회적 농업의 사회적 경제 특성에 관한 연구 - 사회혁신 가능성의 탐색 -
유리나,황수철 한국농촌계획학회 2019 농촌계획 Vol.25 No.4
The aim of this paper is to identify the characteristics of social economy in social farming practices, and to explore three core factors of experiment, openness and locality, which have a significant impact on the working-mechanism of social innovation. Though a few social farming practice appear nowadays in Korea, it can be witnessed social economic factors such as cooperation between networks and solidarity actors, pursuing social values in social farming. On the basis of the conceptual framework on the social economy characteristics, this study examines case analysis in order to find the possibilities as a social innovation of the social farming. Three farms perform multiple functions of care, labour integration, training in farming area, and sometimes make collaboration work with artists and local residents. Social farming can be social innovation practices in the view of the interaction of experiments, openness and locality within the context of an innovation process, networking, enhancing social capital.
염증수용체/리간드를 타깃으로 한 비만성 염증/대사질환 제어
유리나 대한비만학회 2014 The Korean journal of obesity Vol.23 No.2
Obesity-induced inflammation is considered to be a potential cause of metabolic disorders such as insulin resistance, type 2 diabetes, and cardiovascular diseases. Various inflammatory components involved in obesity-induced inflammation are known, but the biomolecules and mechanisms underlying the obesity-related inflammation/metabolic diseases remain to be elucidated. Cell surface membrane receptors TNFRSFs (Tumor Necrosis Factor Receptor Superfamily) and their counterpart ligands provide important inflammatory signals through their interaction, and thus have been exploited for therapeutic targets for treating various inflammatory diseases. Recent studies demonstrate that some of the inflammatory receptors/ligands are associated with obesity-induced inflammation and metabolic diseases. In this mini-review, the role of four different inflammatory receptors/ligand (CD40/CD40L, 4-1BB/4-BBL, FN14/TWEAK, HEVM/LIGHT) interactions are discussed along with their potential for therapeutic targets against obesity-related inflammation and metabolic diseases. 비만으로 유도된 염증은 인슐린 저항성, 제2형 당뇨, 동맥경화와 같은 비만성 대사질환의 발생원인 또는 촉진자 역할을 한다. 비만성 염증반응을 매개하는 여러 가지 염증 구성요소들이 알려져 있음에도불구하고 비만성 염증/대사질환을 유도/조절하는 생체분자와 그 메커니즘에 대해서는 아직 모르는 점이 많다. 면역세포 표면에 존재하는막 수용체인 Tumor Necrosis Factor Receptor Superfamily (TNFRSF)와 그 리간드들은 염증반응 유도/조절에 중요한 신호를 제공하며, 다양한 염증성 질환의 치료를 위한 타깃 분자로 활용된다. 최근 이들 염증수용체/리간드가 비만성 지방조직 염증반응을 조절하며, 이들 분자들의 상호작용의 차단이 비만성 염증/대사질환의 개선을 가져온다고 보고되고 있다. 본 미니리뷰에서는 비만성 염증/대사질환에 관여하는 네 종류의 염증수용체/리간드(CD40/CD40L, 4-1BB/4-BBL,FN14/TWEAK, HEVM/LIGHT)들에 대해 살펴보고, 이들 분자들이비만성 염증 및 대사질환 제어를 위한 타깃이 될 가능성에 대해 검토해 보았다.
텍스트마이닝 기법을 이용한 국내 농식품 유통 연구동향 분석
유리나,황수철 韓國食品流通學會 2016 한국식품유통학회 학술대회 Vol.- No.하계
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