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Ryan Urban,Justin Wong,Peter Lim,Susan Zhang,Ingrid Spadinger,Robert Olson,Francois Bachand,Clement Ho,Anna V. Tinker,Lovedeep Gondara,Sarah Nicole Hamilton 대한부인종양학회 2022 Journal of Gynecologic Oncology Vol.33 No.5
Objective: To evaluate gastrointestinal (GI) patient reported outcomes (PROs) in cervical cancer patients treated with definitive radiotherapy (RT), comparing 3D conformal RT (3DCRT) vs. intensity modulated/volumetric modulated arc therapy (IMRT/VMAT). Methods: An analysis of patients treated with definitive RT between 2015–2018 was performed. GI PROs were prospectively collected at baseline, during RT (acute), ≤12 weeks after RT (subacute), and >12 weeks after RT (late). GI PROs evaluated three symptom domains: bowel problems (BPs), bowel bother (BB), and abdominal problems (APs). Multiple linear regression analysis was performed to investigate associations between mean changes of symptom scores with clinical and dosimetric variables. Results: The cohort included 167 patients. A total of 100 (60%) patients were treated with IMRT/VMAT and 67 (40%) with 3DCRT. In the subacute phase, the mean change of symptom scores from baseline in 3DCRT vs. IMRT/VMAT were +0.9 vs. −1.15 (p=0.004) for BP, +2.18 vs. −0.10 (p=0.019) for BB, and +1.41 vs. −0.38 (p=0.021) for AP. Likewise, in the late phase, mean changes were +0.72 vs. −0.82 (p=0.014) for BP, +1.98 vs. −0.03 (p=0.008) for BB, and +1.29 vs. −0.31 (p<0.001) for AP. On multiple linear regression, use of 3DCRT vs. IMRT/VMAT was associated with greater mean changes in subacute BP (p=0.023) and late phase AP (p=0.019). A higher small bowel V50Gy was associated increased symptom scores in late AP (p=0.012). Conclusion: 3DCRT was associated with significantly greater worsening of GI PRO symptom scores in the subacute and late phase. These data support the ongoing use of IMRT/VMAT in routine practice
Comparison of Sapphire and Germanium Fibers for Erbium : Yag Lithotripsy
Ho Lee,Ji-Wook Yoon,Young-Dae Jung,JeeHyun Kim,Robert T. Ryan,Joel M.H. Teichman,A.J. Welch 한국광학회 2008 Current Optics and Photonics Vol.12 No.4
We studied the sapphire and germanium fibers to determine which optical fiber best transmits Erbium:YAG laser for intracorporeal lithotripsy. Human calculi were ablated with an Erbium:YAG laser in contact mode using two fibers. Optical outputs at the distal end of fibers were measured before and after laser lithotripsy. Upon the irradiation on the calculus with the 50 mJ and 100 mJ pulse energy, the output energy at the distal end of germanium fiber declined to approximately 50% of the input energy. For the sapphire fiber, the output energy at the distal end remained unchanged with 100 mJ input energy; however the output energy had dropped to 50% for 200 mJ input energy. In order to examine how the types of target tissue affect the fiber damage, the sapphire fiber was tested for the irradiation on soft tissue and water as well. No energy decline was observed during soft tissue and water irradiation. We also characterized ablation craters with both optical fibers. Both fibers produced similar craters on calculi in terms of depth and diameter. Sapphire fibers are better suited than germanium fibers for Erbium:YAG lithotripsy in terms of the fiber damage.
오련,송은희,박기호,조오현,김탁,윤귀준,손병석,성흥섭,김미나,김양수,우준희 대한감염학회 2008 감염과 화학요법 Vol.40 No.5
Cryptococcosis is a disseminated infection caused by Cryptococcus neoformans. It usually causes pulmonary infection and meningitis in immunocompromised patients. However, osteomyelitis due to C. neoformans is extremely rare. It is generally known that cryptococcal osteomyelitis is a complication of disseminated cryptococcosis, appearing in 5-10%. We experienced a case of cryptococcal osteomyelitis with paraspinal abscess in a liver transplant patient.
Kepler, Ryan M.,Sung, Gi-Ho,Harada, Yukio,Tanaka, Kazuaki,Tanaka, Eiji,Hosoya, Tsuyoshi,Bischoff, Joseph F.,Spatafora, Joseph W. Wiley (John WileySons) 2012 American journal of botany Vol.99 No.3
<P>This research seeks to advance understanding of conditions allowing movement of fungal pathogens among hosts. The family Clavicipitaceae contains fungal pathogens exploiting hosts across three kingdoms of life in a pattern that features multiple interkingdom host shifts among plants, animals, and fungi. The tribe Ustilaginoideae potentially represents a third origin of plant pathogenesis, although these species remain understudied. Fungal pathogens that cause ergot are linked morphologically with Clavicipitaceae, but are not yet included in phylogenetic studies. The placement of Ustilaginoideae and ergot pathogens will allow differentiation between the host habitat and host relatedness hypotheses as mechanisms of phylogenetic diversification of Clavicipitaceae.</P>
Sung-Ho Park,Doo-Sang Park,Kyung-Seop Ahn,Sei-Ryang Oh,Hyun-Woo Oh 한국응용곤충학회 2011 한국응용곤충학회 학술대회논문집 Vol.2011 No.10
A total of 5,000 ethanolic and methanolic extracts of different plant species from 23 nations including Costa Rica, Vietnam, Philippines, India, South Africa, Pakistan and Peru were evaluated for their larvicidal activities against Aedes aegypti, the major vector of dangue, dangue hemorhagic fever and yellow fever. The larval mortalities were observed 24h after treating the larvae to the extracts. At 500 ppm, 179 extracts showed >80% larval mortality in the 24h exposure. Among the extracts tested, the highest larval mortality was observed in the extracts of Piper guianense, Piper nigrum, Piper mocropodum, Piper sem-immersum, Piper magen and Piper pubicatulum. The LC50 value of extract P. guianense, P. nigrum, P. mocropodum, P. sem-immersum, P. magen and P. pubicatulum were 8.84, 11.48, 8.84, 13.86, 9.48 and 10.12 ppm against Ae. aegypti. It is suggested that P. guianense, P. nigrum, P. mocropodum, P. sem-immersum, P. magen and P. pubicatulum can be developed as potent larvicidal agents against Ae. aegypti.
신이식 환자에서 발생한 Nocardia elegans 폐농양 1예
박기호,고선영,오련,김탁,조오현,김양수,우준희,한덕종,성흥섭,김미나 대한감염학회 2008 감염과 화학요법 Vol.40 No.2
노카르디아는 면역 저하 환자에서 발생하는 기회 감염균으로 배양과 균 동정이 복잡하기 때문에 시기 적절한 진단과 치료가 어려울 때가 흔하다. 그러나 최근 16S 리보좀 RNA 염기서열 분석과 같은 새로운 분자생물학적 방법이 도입되면서 노카르디아 감염의 진단과 치료에 많은 도움이 되고 있다. 저자들은 신이식을 받은 39세 남자에서 발생한 N. eleeans에 의한 폐농양을 경험하였기에 보고하는 바이다. 환자는 항균제 감수성 결과에 따라 적절한 항균제로 치료하였고, 치료 종료 후 1년 동안 재발 없이 외래 경과 관찰 중이다. 본 증례를 통하여 이식 환자와 같은 면역 저하 환자에서 노카르디아 감염의 가능성을 고려하여야 하겠고 분자생물학적 방법에 의한 빠른 균 동정과 적절한 항균제 치료가 중요함을 기억하여야 하겠다. Nocardiosis is well-known opportunistic infection in immunocompromised patients. The timely diagnosis and treatment, however, is stilt a difficult problem. Recently, as newer molecular techniques, particularly 16S rRNA sequencing, are implemented, the diagnosis and management of the infection are improving. We report a case of lung abscess in a 39-year-o1d-man who underwent kidney transplantation. He was diagnosed of Nocardia elegans by 16S rRNA sequencing and was cured of the infection with appropriate antibiotic therapy.
Education satisfaction and self-assessment of competency among new general dentists in Korea
Young-A Ji,Ho-Beom Kwon,Ryan JinYoung Kim,Seungho Baek 대한치과의사협회 2019 대한치과의사협회지 Vol.57 No.9
Dental education is gradually transitioning to competency-based education system, which aims to help dentists achieve certain core competencies by means of various systems, such as curriculum accreditation. This study examined satisfaction with dental school education and the differences in the perceived importance and self-assessment of competencies among general dentists, in an attempt to propose a desirable direction for dental education. A questionnaire was administered to new general dentists who graduated from a dental school within the past 10 years. The results of the survey were analyzed using the Importance-Performance Analysis to understand differences in dentists’ perceptions. Overall satisfaction with education was low in terms of the curriculum’s relevance to actual practice and its capacity for cultivating required competencies. Furthermore, many of the respondents strongly perceived the need to improve dental education. Additional investigations into the satisfaction with education showed no difference. Among the seven key competency domains, dentists perceived Health Promotion to be important and also assessed themselves as having high competence. However, regarding the perceived importance of the remaining domains, self-assessment of competence was low for Professionalism, Communication & Interpersonal Skills, Knowledge Base, Information Handling & Critical Thinking, Clinical Information Gathering, Diagnosis & Treatment Planning, and Establishment & Maintenance of Oral Health. The results of this study suggest that a competency-based education model should be developed and incorporated into dental education to set performance standards and to promote systematic self-assessment in order to foster the development of competence in dental students.