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- 저자 : Runnan Xu (검색결과 2 건)
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Runnan Xu,MING ZHANG,Juming Yao,YAN WANG,Yafeng Ge,Dana Kremenakova,Jiri Militky,Guocheng Zhu 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.119 No.-
The efficient absorption of wound exudate and the prevention of soft tissue infection are major concernsin wound repair. Good antibacterial agents and unique wound dressing structures can effectively reducewound infection, thereby accelerating wound healing. In some double-layer asymmetric wound dressings,antimicrobial agents are incorporated in the hydrophilic layer, and only a small fraction of theantimicrobial agent penetrates the hydrophobic fibre layer towards the interior of the wound. Therefore, in this study, we chose curcumin (Cur.)/cellulose acetate (CA) as the hydrophobic inner layer. Not only does this effectively allow Cur. to make contact with the lining of the wound but it also preventsthe wound from sticking. However, the mechanical properties of a single CA/Cur. layer are not ideal. Using polyacrylonitrile as the outer hydrophilic substrate improves the fibre mat mechanical properties. In addition, to further improve the hydrophilicity, the water contact angle was reduced by introducing ahydrophilic group (2-hydroxypropyl-b-cyclodextrin, b-CD) and changing the fibre roughness (nano-TiO2). Thus, wound dressings with high biocompatibility, excellent antibacterial properties, and unidirectionalwater conduction were constructed for preventing secondary wound damage. In terms of performance, ittook 40 minutes for water to enter the hydrophilic fibre layer from the hydrophobic fibre layer (the watercontact angle decreased from 121.24 to 85.42), and it took 25 minutes for water to completely enter thefibre mats (the water contact angle decreased from 85.42-0), which is effective for draining wound exudate. In terms of antibacterial properties, the antibacterial rates of Cur. (8 wt%) against Escherichia coliand Staphylococcus aureus were 82.4% and 92.57%, respectively. The Cur./CA@PAN/b-CD/TiO2 bilayerasymmetric nanofibrous mats mimic the semipermeability of the extracellular matrix (ECM) and havehigh biocompatibility, which is effective for preventing secondary wound damage. It can be used as alow-cost, high-performance wound dressing with medical material potential.
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Lin Shen,Shen Runnan,Huang Jingqian,Liu Yanhan,Li Hongpeng,Xu Qingfang 한국유전학회 2023 Genes & Genomics Vol.45 No.12
Background Both epidemiological and clinical studies have suggested the comorbidity between cutaneous melanoma (CM) and obesity-related physical traits. However, it remains unclear about their shared genetic architecture. Objective To determine the shared genetic architecture between CM and obesity-related physical traits through conditional false discovery rate (cFDR) analysis. Method Quantile–quantile plots were firstly built to assess the pleiotropic enrichment of shared single nucleotide polymorphisms between CM and each trait. Then, cFDR and conjunctional cFDR (ccFDR) were used to identify the shared risk loci between CM and each trait. Moreover, the functional evaluation of shared risk genes was carried out through analyses of expression quantitative trait loci (eQTL), Kyoto Encyclopedia of Genes and Genomes and gene ontology, respectively. Finally, single-cell sequence analysis was performed to locate the expression of eQTL-mapped genes in tissues. Results Successive pleiotropic enrichment was found between CM and 5 obesity-related traits or height. 24 shared risk loci were identified between CM and 13 traits except appendicular lean mass using ccFDR analysis, with 17 novel and 4 validated loci. The functions of ccFDR-identified and eQTL-mapped genes were revealed to be mainly involved in cellular senescence, proliferation, meiotic nuclear division, cell cycle, and the metabolism of lipid, cholesterol and glucose. Single-cell sequence analysis showed that keratinocytes contribute to the occurrence and aggressiveness of CM through secreting paracrine cytokines. Conclusion Our findings demonstrate the significant genetic correlation between CM and obesity-related physical traits, which may provide a novel genetical basis for the pathogenesis and treatment of CM.
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