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- 저자 : Dana Kremenakova (검색결과 1 건)
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Runnan Xu,MING ZHANG,Juming Yao,YAN WANG,Yafeng Ge,Dana Kremenakova,Jiri Militky,Guocheng Zhu 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.119 No.-
The efficient absorption of wound exudate and the prevention of soft tissue infection are major concernsin wound repair. Good antibacterial agents and unique wound dressing structures can effectively reducewound infection, thereby accelerating wound healing. In some double-layer asymmetric wound dressings,antimicrobial agents are incorporated in the hydrophilic layer, and only a small fraction of theantimicrobial agent penetrates the hydrophobic fibre layer towards the interior of the wound. Therefore, in this study, we chose curcumin (Cur.)/cellulose acetate (CA) as the hydrophobic inner layer. Not only does this effectively allow Cur. to make contact with the lining of the wound but it also preventsthe wound from sticking. However, the mechanical properties of a single CA/Cur. layer are not ideal. Using polyacrylonitrile as the outer hydrophilic substrate improves the fibre mat mechanical properties. In addition, to further improve the hydrophilicity, the water contact angle was reduced by introducing ahydrophilic group (2-hydroxypropyl-b-cyclodextrin, b-CD) and changing the fibre roughness (nano-TiO2). Thus, wound dressings with high biocompatibility, excellent antibacterial properties, and unidirectionalwater conduction were constructed for preventing secondary wound damage. In terms of performance, ittook 40 minutes for water to enter the hydrophilic fibre layer from the hydrophobic fibre layer (the watercontact angle decreased from 121.24 to 85.42), and it took 25 minutes for water to completely enter thefibre mats (the water contact angle decreased from 85.42-0), which is effective for draining wound exudate. In terms of antibacterial properties, the antibacterial rates of Cur. (8 wt%) against Escherichia coliand Staphylococcus aureus were 82.4% and 92.57%, respectively. The Cur./CA@PAN/b-CD/TiO2 bilayerasymmetric nanofibrous mats mimic the semipermeability of the extracellular matrix (ECM) and havehigh biocompatibility, which is effective for preventing secondary wound damage. It can be used as alow-cost, high-performance wound dressing with medical material potential.
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