Adaptive Neural Tracking Control for Uncertain Switched Nonlinear Non-lower Triangular System with Disturbances and Dead-zone Input

Rui-Bing Li,Xiao-Mei Wang,Xiao-Mei Liu,Ben Niu,Dong Yang 제어·로봇·시스템학회 2020 International Journal of Control, Automation, and Vol.18 No.6

This work investigates the adaptive neural tracking control problem for a class of uncertain switched nonlinear non-lower triangular systems with disturbances and dead-zone input. First, radial basis function (RBF) neural networks (NNs) serve as a flexible tool to approximate the unknown nonlinear functions. Then during the controller design, the dynamic surface control (DSC) method is used to avoid the issue of "explosion of complexity", and only one adaptive law is adopted to reduce the computational burden. What’s more, a few classical mathematical approaches are used to handle the design difficulties caused by dead-zone input, and the proposed controller guarantees the closed-loop system signals are semi-globally uniform ultimate boundedness (SGUUB). Finally, a simulation example is given to illustrate the availability of the proposed control scheme.

Comparative Lipidomic Analysis of Cephalosporium acremonium Insights into Industrial and Pilot Fermentations

Rui-Juan Xu,Bin Qiao,Bing-Zhi Li,Hua Lu,Yao Chen,Ying-Jin Yuan 한국생물공학회 2012 Biotechnology and Bioprocess Engineering Vol.17 No.2

Cephalosporium acremonium has been widely applied in industrial cephalosporin C fermentation. However,little is known about the molecular basis of fermentation behavior of this strain. In this study, comparative lipidomic analysis using LC/ESI/MSn technology was employed to investigate responses of Cephalosporium acremonium to multiple environment variations in realistic industrial cephalosporin C fermentation process and provide molecular basis for the discrepancies between industrial and pilot fermentations. Totally 77 phospholipids species were detected and 65 species were further quantified. Score plot revealed that phospholipids metabolism differed in industrial and pilot process. Loading pilot indicated that the main variables responsible for the discrimination of industrial and pilot process were phosphatidylinositols (PIs), phosphatidylserines (PSs) and phosphatic acids (PAs). Higher PIs content in industrial process indicated that cells were more vigorous in industrial process than those in pilot process. Larger increases of PSs, PAs and ratio of oleic acid to linoleic acid coincided well with the earlier and more thorough cellular morphological differentiation in industrial process. The synergetic reaction between cellular behavior and cells living environment led to titer discrepancies between industrial and pilot process. These findings provided lipidomic insights into industrial cephalosporin C production. Cephalosporium acremonium has been widely applied in industrial cephalosporin C fermentation. However,little is known about the molecular basis of fermentation behavior of this strain. In this study, comparative lipidomic analysis using LC/ESI/MSn technology was employed to investigate responses of Cephalosporium acremonium to multiple environment variations in realistic industrial cephalosporin C fermentation process and provide molecular basis for the discrepancies between industrial and pilot fermentations. Totally 77 phospholipids species were detected and 65 species were further quantified. Score plot revealed that phospholipids metabolism differed in industrial and pilot process. Loading pilot indicated that the main variables responsible for the discrimination of industrial and pilot process were phosphatidylinositols (PIs), phosphatidylserines (PSs) and phosphatic acids (PAs). Higher PIs content in industrial process indicated that cells were more vigorous in industrial process than those in pilot process. Larger increases of PSs, PAs and ratio of oleic acid to linoleic acid coincided well with the earlier and more thorough cellular morphological differentiation in industrial process. The synergetic reaction between cellular behavior and cells living environment led to titer discrepancies between industrial and pilot process. These findings provided lipidomic insights into industrial cephalosporin C production.

Ab initio MRCI+Q Investigations of Spectroscopic Properties of Several Low-lying Electronic States of S2+ Cation

Rui Li,Zhen Zhai,Xiaomei Zhang,Tao Liu,Mingxing Jin,Haifeng Xu,Bing Yan 대한화학회 2014 Bulletin of the Korean Chemical Society Vol.35 No.5

The complete active space self-consist field method followed by the internally contracted multireference configuration interaction method has been used to compute the potential energy curves of X2Πg, a4Πu, A2Πu, b4Σ− g, and B2Σ− g states of S2 + cation with large correlation-consistent basis sets. Utilizing the potential energy curves computed with different basis sets, the spectroscopic parameters of these states were evaluated. Finally, the transition dipole moment and the Franck-Condon factors of the transition from A2Πu to X2Πg were evaluated. The radiative lifetime of A2Πu is calculated to be 887 ns, which is in good agreement with experimental value of 805 ± 10 ns.

Transcriptome Analysis Reveals Molecular Mechanisms Underlying Methyl Jasmonate-mediated Biosynthesis of Protopanaxadiol-type Saponins in Panax notoginseng Leaves

Li Ying,Lin Yuan,Jia Bing,Chen Geng,Shi Huineng,Xu Rui,Li Xuejiao,Tang Junrong,Tang Qingyan,Zhang Guanghui,Yang Jianli,Fan Wei,Yang Shengchao 한국식물학회 2022 Journal of Plant Biology Vol.65 No.1

Methyl jasmonate (MeJA) has been widely used to improve the biosynthesis of secondary metabolites such as triterpenoid saponins in medicinal plants. However, the underlying molecular mechanisms remain poorly understood. Differing from roots that accumulate protopanaxatriol-type saponins, Panax notoginseng leaves with a lower biomass mainly contain protopanaxadiol (PPD)-type saponins. Therefore, it is interesting to explore whether MeJA can activate the biosynthesis of PPD-type saponins in P. notoginseng leaves. In this study, we found MeJA could effectively induce the accumulation of PPD-type saponins, including ginsenoside Rb1, Rc, Rb2, Rb3 and notoginsenoside Fa, Fe in P. notoginseng leaves based on a newly established high-performance liquid chromatography method. Transcriptome analysis showed that differentially expressed genes (DEGs) induced by MeJA were mainly enriched in “terpenoid backbone biosynthesis”, “biosynthesis of unsaturated fatty acids”, “sesquiterpenoid and triterpenoid biosynthesis”, “fatty acid metabolism”, and “phenylpropanoid biosynthesis”. Furthermore, the expression profile and quantitative real-time PCR analysis of DEGs showed that MeJA could positively induce the molecular response of endogenous jasmonic acid (JA) signaling pathway, and increased PPD-type saponins mediated by MeJA in P. notoginseng leaves may be related to the high expression of FPS, SS, SE, DS and UGTs, and the low expression of CYP716A53v2 and β-AS. The results provide a molecular understanding for MeJA-elicited biosynthesis of triterpenoid saponins and facilitate the further characterization of the genes responsible for biosynthesis of PPD-type saponins in P. notoginseng leaves.

Ab initio MRCI+Q Investigations of Spectroscopic Properties of Several Low-lying Electronic States of S₂⁺ Cation

Li, Rui,Zhai, Zhen,Zhang, Xiaomei,Liu, Tao,Jin, Mingxing,Xu, Haifeng,Yan, Bing Korean Chemical Society 2014 Bulletin of the Korean Chemical Society Vol.35 No.5

The complete active space self-consist field method followed by the internally contracted multireference configuration interaction method has been used to compute the potential energy curves of $X^2\prod_g$, $a^4\prod_u$, $A^2\prod_u$, $b^4\sum_{g}^{-}$, and $B^2\sum_{g}^{-}$ states of $S{_2}^+$ cation with large correlation-consistent basis sets. Utilizing the potential energy curves computed with different basis sets, the spectroscopic parameters of these states were evaluated. Finally, the transition dipole moment and the Franck-Condon factors of the transition from $A^2\prod_u$ to $X^2\prod_g$ were evaluated. The radiative lifetime of $A^2\prod_u$ is calculated to be 887 ns, which is in good agreement with experimental value of $805{\pm}10$ ns.

Pollen record of the centennial climate changes during 9-7 cal ka BP in the Changjiang (Yangtze) River Delta plain, China

Song, Bing,Li, Zhen,Lu, Houyuan,Mao, Limi,Saito, Yoshiki,Yi, Sangheon,Lim, Jaesoo,Li, Zhen,Lu, Anqing,Sha, Longbing,Zhou, Rui,Zuo, Xinxin,Pospelova, Vera Cambridge University Press 2017 Quaternary research Vol.87 No.2

<B>Abstract</B><P>We reconstructed the centennial climate changes for the period of 9-7 cal ka BP in the upper region of the Changjiang (Yangtze) River Delta plain. A general warming and wetting trend from 8560 to 7220 cal yr BP was indicated by the decrease in <I>Quercus</I> (deciduous) and increases in <I>Quercus</I> (evergreen), <I>Pinus</I>, and Polypodiaceae spores. However, there were several brief climate fluctuations. A notable palynological change, from regional assemblages dominated by arboreal pollen to local assemblages mainly consisting of nonarboreal pollen, reflects climate fluctuations. The key indices of <I>Quercus</I> (deciduous), <I>Pinus</I>, herbs, fern spores, and palynological concentrations showed similar signs of centennial climate fluctuations. We suggest that the climate changes of the Dongge Cave and Yangtze River Delta regions were mainly affected by the East Asian summer monsoon (EASM) during the period of 9-7 cal ka BP. The general warming trend may be associated with an intensified EASM, and solar activity may be one of the important factors driving the centennial climate changes. The ~8.2 ka event was also recorded in the Yangtze River Delta region, which suggests that there was a close relationship between the EASM and Greenland climate during the early Holocene.</P>

Streptomyces lushanensis sp. nov., a novel actinomycete with anti-cyanobacterial activity

Zhang, Bing-Huo,Cheng, Juan,Chen, Wei,Li, Han-Quan,Yang, Jian-Yuan,Park, Dong-Jin,Kim, Chang-Jin,Shen, Rui,Duan, Yan-Qin,Li, Wen-Jun Nature Publishing Group 2015 The Journal of Antibiotics Vol. No.

<P>Strain JXJ 0135(T), an anti-cyanobacterial actinomycete, was isolated from a soil sample collected from Lushan Mountain, south China, and identified by using polyphasic approach. Phylogenetic analysis of the near-complete 16S rRNA gene sequence indicated that strain JXJ 0135(T) belongs to the genus Streptomyces and exhibited distinct subclade and also highest similarity (98.6%) to Streptomyces scopuliridis RB72(T). The strain developed well-branched substrate and aerial mycelia, and produced spiral spore chains. Spores were elliptical and the spore surface was smooth. The strain contained LL-diaminopimelic acid with whole-cell sugars of mannose, rhamnose, glucose and galactose. Phospholipids were diphosphatidylglycerol, phosphatidylethanolamine, phosphatidylinositol mannosides, phosphotidylinositol dimannoside, an unidentified aminophospholipid and an unknown phospholipid. The menaquinones were MK-9(H6) and MK-9(H8). The major components of the fatty acids were anteiso-C15:0, iso-C16:0, anteiso-C17:0, iso-C15:0, C16:0, iso-C17:0 and iso-C14:0. The G+C content was 69.3?mol%. The DNA-DNA hybridization value between JXJ 0135(T) and S. scopuliridis RB72(T) was 41.21.4%. On the basis of the polyphasic data, strain JXJ 0135(T) represents a novel species of the genus Streptomyces, for which the name Streptomyces lushanensis sp. nov. is proposed. The type strain is JXJ 0135(T) (=DSM 42121(T)=JCM 19628(T)=KCTC 29261(T)=KACC 17834(T)=NRRL B-24994(T)).</P>

Metastasis associated genomic aberrations in stage II rectal cancer

Hong Zhao,Zhi-Zhou Shi,Rui Jiang,Dong-Bing Zhao,Hai-Tao Zhou,Jian-Wei Liang,Xin-Yu Bi,Jian-Jun Zhao,Zhi-Yu Li,Jian-Guo Zhou,Zhen Huang,Ye-Fan Zhang,Jian Wang,Xin Xu,Yan Cai,Ming-Rong Wang,Yu Zhang 한국유전학회 2016 Genes & Genomics Vol.38 No.11

Genomic aberrations of rectal carcinoma, especially DNA copy number changes associated with metastasis were largely unclear. We aim to identify the metastasis associated biomarkers in stage II rectal cancer. Formalin-fixed, paraffin-embedded primary tumor tissues of stage II rectal carcinoma were analyzed by array-based comparative genomic hybridization, and genomic aberrations were identified by Genomic Workbench and SAM software. Copy number changes and mRNA expressions were validated by Real-time PCR in an independent rectal cancer samples. The results showed that the most frequent gains in stage II rectal cancer were at 1q21.2-q23.1, 3p21.31, 11q12.2-q23.3, 12q24.11-q24.31, 12q13.11-q14.1 and losses in 18q11.2-q23, 17q21.33-q22, 13q31.1-q31.3, 21q21.1-q21.3, 8p23.3-p23.1 and 4q22.1-q23. Twenty-two amplifications and five homozygous deletions were also identified. We further found that S100A1 (1q21.3-q23.1), MCM7 (7q22.1) and JUND (19p13.11) were amplified and overexpressed in stage II rectal cancer. Interestingly, the genomic aberrations affected 14 signaling pathways including VEGF signaling pathway and fatty acid metabolism. Most importantly, loss of 13q31.1-q34 and gain of 1q44 were associated with distant metastasis. Our results indicated that these metastasis associated genomic changes may be useful to reveal the pathogenesis of rectal cancer metastasis and identify candidate biomarkers.

Effect of Coagulating Agents on Lignin and Sugar Contents in Acid Prehydrolysis Liquor

Chao-Jun Wu,Dong-Mei Yu,Shu-Ping Li,Li-Juan Bing,Rui-Ping Tong 한국펄프·종이공학회 2016 한국펄프·종이공학회 학술발표논문집 Vol.2016 No.10

Chinese Society of Allergy Guidelines for Diagnosis and Treatment of Allergic Rhinitis

Lei Cheng,Jianjun Chen,Qingling Fu,Shaoheng He,Huabin Li,Zheng Liu,Guolin Tan,Zezhang Tao,Dehui Wang,Weiping Wen,Rui Xu,Yu Xu,Qintai Yang,Chonghua Zhang,Gehua Zhang,Ruxin Zhang,Yuan Zhang,Bing Zhou,Do 대한천식알레르기학회 2018 Allergy, Asthma & Immunology Research Vol.10 No.4

Allergic rhinitis (AR) is a global health problem that causes major illnesses and disabilities worldwide. Epidemiologic studies have demonstrated that the prevalence of AR has increased progressively over the last few decades in more developed countries and currently affects up to 40% of the population worldwide. Likewise, a rising trend of AR has also been observed over the last 2-3 decades in developing countries including China, with the prevalence of AR varying widely in these countries. A survey of self-reported AR over a 6-year period in the general Chinese adult population reported that the standardized prevalence of adult AR increased from 11.1% in 2005 to 17.6% in 2011. An increasing number of original articles and imporclinical trials on the epidemiology, pathophysiologic mechanisms, diagnosis, management and comorbidities of AR in Chinese subjects have been published in international peer-reviewed journals over the past 2 decades, and substantially added to our understanding of this disease as a global problem. Although guidelines for the diagnosis and treatment of AR in Chinese subjects have also been published, they have not been translated into English and therefore not generally accessible for reference to non-Chinese speaking international medical communities. Moreover, methods for the diagnosis and treatment of AR in China have not been standardized entirely and some patients are still treated according to regional preferences. Thus, the present guidelines have been developed by the Chinese Society of Allergy to be accessible to both national and international medical communities involved in the management of AR patients. These guidelines have been prepared in line with existing international guidelines to provide evidence-based recommendations for the diagnosis and management of AR in China.